Dimethyl Sulfoxide (DMSO) 70%. Other Ingredients: Cream Base.
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Below is general information about the effectiveness of the known ingredients contained in the product DMSO Cream. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product DMSO Cream. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when used by intravesical instillation (5692,5694,5695,5696,5697,47827,47895). An aqueous 50% solution of DMSO is approved by the US Food and Drug Administration (FDA) for intravesical use in the treatment of interstitial cystitis (5692,5694).
POSSIBLY UNSAFE ...when used topically. It has been reported that industrial-grade DMSO is being used topically for self-treatment of several conditions. Industrial-grade DMSO may contain impurities and is not of the same quality as DMSO used for drug research purposes. DMSO readily penetrates the skin and enhances the absorption of impurities and other substances, which may be hazardous to health (6326). There is insufficient reliable information available about the safety of DMSO when used orally or intravenously.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
Below is general information about the interactions of the known ingredients contained in the product DMSO Cream. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, DMSO might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
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In vitro evidence shows that DMSO inhibits adenosine diphosphate- and thrombin-induced platelet aggregation (6330).
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Theoretically, DMSO might increase the risk of cholinergic adverse effects when taken with cholinergic drugs.
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In vitro and animal research suggests that DMSO inhibits acetylcholinesterase activity (6330).
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Theoretically, using DMSO as a solvent for platinum-based chemotherapeutic agents may reduce chemotherapeutic effects.
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In vitro research shows that DMSO reduces the cytotoxicity of cisplatin, carboplatin, and oxaliplatin by inducing ligand displacement (94017).
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DMSO might reduce the effectiveness of sulindac and increase the risk of peripheral neuropathy.
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Taking DMSO orally with sulindac has been reported to reduce the metabolism of sulindac into its active metabolite. This might reduce the effectiveness of sulindac. Furthermore, using topical DMSO concomitantly with sulindac has been linked with peripheral neuropathy (103089).
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Topical DMSO might increase the effects and adverse effects of topical drugs.
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Evidence from animal studies and limited human studies suggests that DMSO may potentiate the action of numerous topical medications by increasing their absorption through the skin (6330,103092,103093). This increase in absorption seems to depend on the concentration of DMSO and the molecular weight of the medication (103092).
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Theoretically, DMSO might reduce the effects of verteporfin.
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Below is general information about the adverse effects of the known ingredients contained in the product DMSO Cream. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Intravesical instillation of DMSO seems to be well tolerated.
Topical use of industrial-grade DMSO may be unsafe due to the presence of impurities. A thorough evaluation of safety outcomes with oral or intravenous use has not been conducted.
Most Common Adverse Effects:
Topically: Blistering, burning, erythema, pruritus, scaling.
All routes of administration: Garlic-like taste, breath, and body odor.
Cardiovascular ...Infusion of hematopoietic stem cells cryopreserved with DMSO might cause hypertension with tachycardia, bradycardia, chest tightness, and ventricular extrasystoles (5695,5696,5697,6318,6320). Intravenously, DMSO can cause vasodilation, facial flushing, hypotension, chest pains, and sinus tachycardia (6300,6301,6315,6325).
Dermatologic ...Topically, DMSO can cause erythema, pruritus, burning, blistering, and drying and scaling skin (6303,6304,6306,6308,6309,6311,6312,6313). Skin reactions are usually reversible after discontinuing the drug (4668,47893).
Gastrointestinal
...Topically, DMSO might cause nausea, vomiting, diarrhea, constipation, and anorexia (6303,6304,6306,6308,6309,6311,6312,6313).
Infusion of hematopoietic stem cells cryopreserved with DMSO might cause nausea, vomiting, and abdominal cramps (5695,5696,5697,6318,6320).
Genitourinary
...Intravesical instillation of DMSO may cause a chemical cystitis, bladder discomfort, and spasm (9).
Intravenously, DMSO might cause diuresis and hematuria (6300,6301,6315,6325).
Hematologic
...Orally, DMSO has been linked to a case of recurrent cerebral hemorrhage (109634).
Topically, DMSO might cause eosinophilia (6303,6304,6306,6308,6309,6311,6312,6313).
Intravenously, DMSO might cause fluid overload, electrolyte disturbances, increased serum osmolality, eosinophilia, hemolysis, and increased serum creatinine (6300,6301,6315,6325).
Infusion of hematopoietic stem cells cryopreserved with DMSO might cause electrolyte disturbances and decreased hemoglobin (5695,5696,5697,6318,6320).
Neurologic/CNS
...Topically, DMSO might cause sedation, headache, dizziness, and drowsiness (6303,6304,6306,6308,6309,6311,6312,6313).
Intravenously, DMSO might cause weakness, confusion, lethargy, disorientation, agitation, dysarthria, hypoactive reflexes, decreased consciousness, and encephalopathy (6300,6301,6315,6325).
Infusion of hematopoietic stem cells cryopreserved with DMSO might cause rigors and chills (5695,5696,5697,6318,6320).
Pulmonary/Respiratory ...Topically, DMSO might cause dry or sore throat, cough, dry nasal passages, dyspnea, worsening of bronchial asthma, and an influenza-like syndrome (6303,6304,6306,6308,6309,6311,6312,6313).
Other
...Infusion of hematopoietic stem cells cryopreserved with DMSO can cause fever (5695,5696,5697,6318,6320).
Garlic-like taste, breath, and garlic-onion-oyster body odor may be experienced with all routes of administration (10625,17127).