| Ingredients | Amount Per Serving |
|---|---|
|
(seed)
(certified organic)
(dried Khella seed extract PlantPart: seed Note: certified organic )
|
1 mL |
distilled Water, Ethyl Alcohol Note: certified organic
Below is general information about the effectiveness of the known ingredients contained in the product Khella. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Khella. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
POSSIBLY UNSAFE ...when used orally in high doses or for an extended duration. High doses of khella or use over an extended period of time can cause increases in liver enzymes and possible liver damage (2). There is insufficient reliable information available about the safety of khella when applied topically.
PREGNANCY: LIKELY UNSAFE
when used orally.
The active constituent, khellin, has uterine stimulant activity (19); contraindicated.
LACTATION:
Insufficient reliable information available; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Khella. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, khella might decrease the effectiveness of cardiac glycosides like digoxin. The khella constituent visnadin has negative inotropic effects that might counter the effects of cardiac glycosides (19,869).
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Theoretically, khella might have additive adverse effects on the liver when used with hepatotoxic drugs. Khella can increase liver transaminases (2,2522). Some drugs that can adversely affect the liver include acetaminophen (Tylenol), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), and many others.
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Theoretically, concomitant use might result in increased photosensitivity. Khella constituents can cause photosensitivity (2521,7162). Some drugs that cause photosensitivity include amitriptyline (Elavil), quinolones (Ciprofloxacin, others), sulfa drugs (Septra, Bactrim, others), and tetracycline.
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Below is general information about the adverse effects of the known ingredients contained in the product Khella. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General ...Orally, prolonged use or use of high doses of khella can cause nausea, dizziness, constipation, lack of appetite, headache, itching, and insomnia. In some patients, khella can cause elevated liver transaminase and gamma-glutamyltransferase (GGT) levels (2). There is also some concern that khella might cause photosensitivity (2,7162).
Dermatologic ...Orally, prolonged use or use of high doses of khella can cause itching (2). There is also some concern that khella might cause photosensitivity because of the constituents khellin and furocoumarin (2,7162).
Gastrointestinal ...Orally, prolonged use or use of high doses of khella can cause nausea, constipation, and lack of appetite (2).
Hepatic ...Orally, in some patients, prolonged use or use of high doses of khella can cause elevated liver transaminase and gamma-glutamyltransferase (GGT) levels (2), probably due to its khellin constituent, which is known to affect liver enzymes (6,2522).
Neurologic/CNS ...Orally, prolonged use or use of high doses of khella can cause dizziness, headache, and insomnia (2).
