Below is general information about the effectiveness of the known ingredients contained in the product Lime. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Lime. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when used orally in amounts commonly found in foods. Lime has Generally Recognized As Safe status (GRAS) for use in foods in the US (4912).
POSSIBLY UNSAFE ...when used topically. Lime oil and lime juice contain photosensitizing constituents (12,11019,40894,59925,59928,100125,100126,100129). ...when used intravaginally. Lime juice has caused mild to moderate adverse effects in women using lime juice-soaked tampons or as a douche, especially in concentrations of 20% or more (100127,100128). There is insufficient reliable information available about the safety of lime when used orally in medicinal amounts.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using in amounts greater than those typically found in foods.
Below is general information about the interactions of the known ingredients contained in the product Lime. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Lime juice inhibits cytochrome P450 3A4, causing increased drug levels and potentially increasing the risk of adverse effects (11976). Some drugs metabolized by CYP3A4 that might be affected are some benzodiazepines such as alprazolam (Xanax), diazepam (Valium), midazolam (Versed), triazolam (Halcion); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, others), felodipine (Plendil), verapamil (Calan, Verelan, others); cyclosporine (Neoral, Sandimmune); some HIV antivirals such as indinavir (Crixivan), ritonavir (Norvir), saquinavir (Fortovase, Invirase); some HMG CoA reductase inhibitors such as atorvastatin (Lipitor), lovastatin (Mevacor); some macrolide antibiotics such as erythromycin and clarithromycin (Biaxin); quinidine; and many others.
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Theoretically, concomitant use of lime oil with photosensitizing drugs may increase the risk of phototoxicity (11019).
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Below is general information about the adverse effects of the known ingredients contained in the product Lime. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, lime juice may cause diarrhea or tooth sensitivity and wear, but these adverse effects are rare (59927,100123,100131).
Topically, lime oil and lime juice can cause allergic contact dermatitis (12,4058,100122,100132). Phytophotodermatitis is common when topical exposure to lime is followed by exposure to the sun (40894,59925,59928,100125,100126,100129).
Intravaginally, 20% to 100% lime juice can cause burning, dryness, pain, itching, erythema, edema, or abnormal bleeding (100127).
Dental ...Orally, tooth sensitivity and erosion of teeth have been reported for a woman who had consumed 150-300 mL of lime juice each night before bed for 3 years without brushing her teeth (100123). Tooth sensitivity has also been reported in a clinical trial (100131).
Dermatologic ...Topically, lime can cause phytophotodermatitis hours to days after exposure (40894,59925,59928,100125,100126,100129). Lime phytophotodermatites related to shaking of Mexican beer and the preparation of mojitos or sangria have been reported. Symptoms include redness, swelling, bullae, and later hyperpigmentation (100125,100126,100129).
Gastrointestinal ...Orally, diarrhea has been reported as an adverse effects in a clinical trial (59927).
Genitourinary ...Intravaginally, 20% lime juice has resulted in burning, dryness, erythema, and edema (100127). Higher doses of 25%, 50%, or 100% lime juice were dose-dependently related to vaginal, cervical, or vulval symptoms, especially pain, itching, and abnormal bleeding. The abnormal bleeding was most common in women that had applied 100% lime juice with a tampon. Peeling, erythema, discharge, and tenderness also occurred (100128).
Immunologic ...Topically, lime can rarely contribute to allergic contact dermatitis (4058,100122,100132).