Ingredients | 1 g Contains |
---|---|
(Conium maculatum )
(herb)
(2X)
(Conium maculatum PlantPart: herb Genus: Conium Species: maculatum Note: 2X )
|
0.1 Gram(s) |
(Calendula officinalis )
(herb)
|
0.02 Gram(s) |
(Colchicum autumnale )
(seed)
(4X)
(Colchicum autumnale PlantPart: seed Genus: Colchicum Species: autumnale Note: 4X )
|
0.01 Gram(s) |
Hydrargyrum Bijodatum
(Mercurius Bijodatus)
(5X)
(Hydrargyrum Bijodatum (Alt. Name: Mercurius Bijodatus) Note: 5X )
|
0.001 Gram(s) |
Stibium sulfuratum nigrum
(Antimony Trisulfide)
(1X)
(Stibium sulfuratum nigrum (Alt. Name: Antimony Trisulfide) Note: 1X )
|
0.001 Gram(s) |
purified Water, emulsifying Cetostearyl Alcohol, Petroleum, Ethanol, Oleyl Oleate
In 2004, Canada began regulating natural medicines as a category of products separate from foods or drugs. These products are officially recognized as "Natural Health Products." These products include vitamins, minerals, herbal preparations, homeopathic products, probiotics, fatty acids, amino acids, and other naturally derived supplements.
In order to be marketed in Canada, natural health products must be licensed. In order to be licensed in Canada, manufacturers must submit applications to Health Canada including information about uses, formulation, dosing, safety, and efficacy.
Products can be licensed based on several criteria. Some products are licensed based on historical or traditional uses. For example, if an herbal product has a history of traditional use, then that product may be acceptable for licensure. In this case, no reliable scientific evidence is required for approval.
For products with non-traditional uses, some level of scientific evidence may be required to support claimed uses. However, a high level of evidence is not necessarily required. Acceptable sources of evidence include at least one well-designed, randomized, controlled trial; well-designed, non-randomized trials; cohort and case control studies; or expert opinion reports.
Finished products licensed by Health Canada must be manufactured according to Good Manufacturing Practices (GMPs) as outlined by Health Canada.
Below is general information about the effectiveness of the known ingredients contained in the product Lymphdiaral Drainage-Cream. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
There is insufficient reliable information available about the effectiveness of autumn crocus.
INSUFFICIENT RELIABLE EVIDENCE to RATE
There is insufficient reliable information available about the effectiveness of hemlock.
Below is general information about the safety of the known ingredients contained in the product Lymphdiaral Drainage-Cream. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
UNSAFE ...when consumed orally as a food or medicine. Autumn crocus is associated with significant and potentially fatal adverse effects (33947,99056,99057,99058,99059,99060,99061,111190). Accidental poisoning has occurred when the autumn crocus plant is mistaken for onions, wild garlic, or wild leeks (99057,99060).
PREGNANCY AND LACTATION: UNSAFE
when used orally.
Autumn crocus is a potential mutagen and is associated with significant and potentially fatal adverse effects (500,33947,99056,99057,99058,99059,99060,99061); avoid using.
LIKELY SAFE ...when the flower preparations are used orally or topically and appropriately (4,19779,36931,39503,93552,93557,96647,105088).
PREGNANCY: LIKELY UNSAFE
when used orally; contraindicated due to spermatocide, antiblastocyst, and abortifacient effects.
There is insufficient reliable information available about the safety of calendula when used topically during pregnancy (4).
LACTATION:
Insufficient reliable information available; avoid using.
UNSAFE ...when used orally (6338). All parts of hemlock including seeds, flowers, and fruits are considered poisonous (6338,6339). Death has resulted after ingestion of hemlock (6340,54711). Damage to the tubule cells of the kidneys (acute tubular necrosis), rapid breakdown of muscle tissue and release of muscle tissue byproducts into the blood (rhabdomyolysis), and subsequent kidney failure, as well as respiratory arrest, have also been reported following ingestion of hemlock (54709,54716,54718,54727). Prompt medical attention is advised after ingestion of hemlock (6341).
CHILDREN: UNSAFE
when used orally (6340).
Acute, sometimes lethal poisoning has resulted after ingestion of leaf material (6340) or when hollow stems are used as peashooters, flutes, or whistles (6338).
PREGNANCY AND LACTATION: UNSAFE
when used orally because ingestion can be lethal (6338); avoid using.
Below is general information about the interactions of the known ingredients contained in the product Lymphdiaral Drainage-Cream. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Avoid concomitant use of autumn crocus with colchicine. Autumn crocus contains colchicine. Concomitant use will increase the adverse effects (2).
|
Theoretically, calendula might have additive effects when used with CNS depressants, although this appears to be unlikely.
Details
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Below is general information about the adverse effects of the known ingredients contained in the product Lymphdiaral Drainage-Cream. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Autumn crocus is generally regarded as unsafe for use.
Any benefits of therapy may not outweigh the risk of toxicity. Autumn crocus contains colchicine and can cause acute poisoning. Accidental poisoning has occurred after oral ingestion when autumn crocus is mistaken for onions, wild garlic, or wild leeks (99057,99060). Long-term use of prescription colchicine is associated with agranulocytosis, aplastic anemia, and peripheral neuritis (6).
Topically, handling fresh slices of autumn crocus corms can cause finger numbness (6).
Cardiovascular ...Predominant cardiovascular symptoms of oral autumn crocus poisoning include tachycardia, hypotension, and reduced cardiac output (99057,99058,99059,99060,111190). Arrhythmias can also occur, and cardiovascular collapse, refractory cardiogenic shock, or sudden asystole have been reported as causes of death within 30-72 hours after poisoning (33947,99057,99058,99059). Acute myocardial injury is associated with an elevated troponin 1 level, which can be used as a marker of severe toxicity (111190).
Dermatologic ...Alopecia has been reported during the recovery phase from acute oral autumn crocus poisoning, about 7-21 days after oral ingestion (33947,99057,99060).
Endocrine ...Predominant endocrine symptoms of autumn crocus poisoning include metabolic acidosis, hyponatremia, hypocalcemia, and hypoglycemia (99057,99058).
Gastrointestinal ...Gastrointestinal symptoms are often the first signs of autumn crocus poisoning and include burning of the mouth, vomiting, diarrhea, abdominal pain, and ileus. These symptoms typically occur within 2-12 hours after oral ingestion, with early onset indicating a poorer prognosis (33947,99056,99057,99058,99059,99060,111190). Pancreatitis has also been reported with severe autumn crocus poisoning (33947,99057). In fatal cases of poisoning, the gastrointestinal mucosa is inflamed and the intestinal villi are found to be shortened and blunted (99057,99059).
Hematologic ...Predominant hematologic symptoms of autumn crocus poisoning include pancytopenia, thrombocytopenia, leukopenia or leukocytosis, and coagulopathy (33947,99056,99058,99059,99060). Long-term use of colchicine, a constituent of autumn crocus, is associated with aplastic anemia (6).
Hepatic ...Predominant hepatic symptoms of autumn crocus poisoning include elevated liver function tests (LFTs) and liver failure with necrosis (33947,99056,99057,99058,99059).
Musculoskeletal ...Autumn crocus poisoning can cause rhabdomyolysis, with serum myoglobin and creatine kinase elevated to twice the upper limit of normal (111190).
Neurologic/CNS
...Predominant neurologic symptoms of autumn crocus poisoning include hemiparesis, encephalopathy, brain edema, coma, and death (99056,99057,99059).
Peripheral neuropathy has occurred as a long-term consequence of autumn crocus poisoning (33947,111190).
Topically, handling fresh slices of autumn crocus corms can cause finger numbness (6).
Pulmonary/Respiratory ...Predominant pulmonary symptoms of autumn crocus poisoning include tachypnea, respiratory distress or failure, and pleural effusions (99057,99058,99059,33947). Some patients require mechanical ventilation or extracorporeal membrane oxygenation (ECMO) for life support (99060).
Renal ...Predominant renal symptoms of autumn crocus poisoning include acute renal failure and anuria, with elevated serum creatinine (33947,99056,99058,111190).
General
...Orally and topically, calendula is generally well tolerated.
Serious Adverse Effects (Rare):
All ROAs: Allergic reactions.
Dermatologic ...Topically, a preparation containing calendula powder 0. 1% resulted in inflammation around the wound to which it was applied (96647). Burning sensation, itching, redness, and scaling were reported rarely in patients applying a combination of calendula, licorice, and snail secretion filtrate to the face. The specific role of calendula is unclear (110322).
Immunologic ...Orally, calendula can cause allergic reactions. Topically, calendula can cause eczematous allergic reactions. Calendula-specific patch testing is recommended prior to usage to determine allergenic potential. Testing is particularly necessary in individuals sensitive to the Asteraceae/Compositae family (10691,11458,96647). Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many other herbs. A preparation containing calendula powder 0.1% resulted in hives in a patient with a ragweed allergy (96647). Despite the widespread use of calendula and the occurrence of allergies to other family members, there has been only one report of anaphylaxis (11152).
General ...Hemlock is generally regarded as unsafe for use. Any benefits of therapy may not outweigh the risk of toxicity. Orally, hemlock can cause burning of the mouth, throat, and abdomen, nausea, vomiting, excessive urination, salivation, drowsiness, mydriasis, muscle pain, rapid muscle swelling and stiffness, rhabdomyolysis, and tachycardia followed by bradycardia. It can also cause loss of speech, paralysis, encephalopathy, unconsciousness, rapid respiration and respiratory arrest, cardiovascular collapse, renal toxicity, and death (6340,6341,54709,54711,54712,54716,54717,54718,96877,96878).
Cardiovascular
...Orally, hemlock can cause tachycardia followed by bradycardia, cardiovascular collapse, and death (6340,6341,54712,96877).
In one case report, a 6-year old girl had prolonged coagulation tests after accidental ingestion of hemlock (96877). It can also cause hypertension (110410).
Intravenously, hemlock resulted in a brief cardiac arrest followed by return of spontaneous circulation in one case report (96876).
Gastrointestinal ...Orally, hemlock causes burning of the mouth, throat, and abdomen (6341,96877). It can also cause nausea, vomiting, and increased salivation (54712,96878,110410).
Genitourinary ...Orally, hemlock can cause excessive urination (54712).
Musculoskeletal ...Orally, hemlock can cause muscle pain, rapid muscle swelling and stiffness, and rhabdomyolysis (6340,6341,54712,110410). Plasma exchange effectively improved the signs of rhabdomyolysis in one case of hemlock poisoning (54727).
Neurologic/CNS
...Orally, hemlock can cause drowsiness, fatigue, lethargy, dizziness, numbness, loss of speech, tremors, paralysis, seizures, encephalopathy, unconsciousness, and death (6340,6341,10778,54711,54712,54716,96877,110410).
Death from hemlock toxicity is usually due to respiratory paralysis (96879,96877).
A case report describes prolonged status epilepticus in a 41-year-old, previously healthy female who mistook hemlock root for parsnip. She developed severe vomiting and drowsiness, followed by prolonged status epilepticus which was refractory to multiple drugs. Seizures and the abnormal electroencephalogram were ultimately controlled with thiopental, gradually weaning to long-term oral treatment with lacosamide and perampanel, which returned the patient to her baseline level of functioning (110411).
Ocular/Otic ...Orally, hemlock can cause blurred vision and mydriasis (54712,110410).
Pulmonary/Respiratory ...Orally, hemlock can cause rapid respiration (54712) as well as acute respiratory arrest (54709,96878). In one case report, a 45-year old woman required mechanical ventilation after accidental ingestion of hemlock (96878). Death from hemlock toxicity is usually due to respiratory paralysis (96876,96877).
Renal ...Orally, hemlock has been reported to cause myoglobinuria, acute tubular necrosis, and acute renal failure (54716,54717,54718,54728). Plasma exchange effectively improved the signs of renal failure in one case of hemlock poisoning (54727).