Ingredients | Amount per Serving |
---|---|
150 mg |
Idebenone, Cellulose, Plant, Magnesium Stearate Note: vegetable, Plant Cellulose Capsule
Below is general information about the effectiveness of the known ingredients contained in the product Idebenone 150 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Idebenone 150 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
POSSIBLY SAFE ...when used orally and appropriately. Idebenone has been safely used in clinical research at doses up to 2250 mg daily for up to 2 years or 900 mg daily for up to 5 years (11410,11413,11421,11424,11427,15703,105705,105706,105707,105708). Doses as high as 75 mg/kg daily have been safely used for up to a month (15703). ...when used topically, short-term. Lotions containing idebenone in concentrations up to 1% have been safely used for up to 6 weeks (96036).
CHILDREN: POSSIBLY SAFE
when used orally and appropriately.
Idebenone has been safely used at doses of 300 mg three times daily for up to 12 months in children at least 7 years-old (96028,96031,96032,96034) and for up to 6 years in children at least 10 years-old (105706). Higher doses of 450 mg three times daily in children ≥45 kg and 750 mg three times daily in children >45 kg has been safely used for up to 6 months (96031,96034).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Idebenone 150 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Below is general information about the adverse effects of the known ingredients contained in the product Idebenone 150 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, idebenone seems to be well-tolerated (11410,11413,11421,11424,11427,15703,105705,105707,105708).
In clinical studies, there have been no reports of serious adverse effects occurring more frequently than with placebo. Some people who take idebenone have experienced nausea and vomiting, abdominal pain, elevated alkaline phosphatase, and loose stools (96028,96034,105705,105708); however, these side effects are not common. High doses up to 2250 mg or 75 mg/kg per day have also been well-tolerated without a clinically significant increase in side effects (15703,105707).
Topically, contact allergic dermatitis has been reported, but this adverse effect is uncommon (96035).
Cardiovascular ...In a clinical trial, tachycardia was reported by a single person taking idebenone orally. Treatment was not required (11410).
Gastrointestinal ...Orally, adverse effects related to idebenone have included nausea and vomiting, abdominal pain, elevated alkaline phosphatase, and loose stools (96028,96034,105705,105708). Increased appetite leading to weight gain has also been reported (11413).
Hematologic ...Neutropenia in a single person in a clinical trial was considered to be possibly related to the oral intake of idebenone. Levels resolved within one week of discontinuation (96031).
Immunologic ...There is a case report of allergic contact dermatitis related to topical use of a cream containing idebenone. The 38-year old woman applied a facial cream (Prevage MD, Elizabeth Arden, Inc.) with reactions appearing with the second dose. Symptoms included a red, itchy, burning, swollen face. She was treated with topical hydrocortisone. She reacted to idebenone with patch testing. This was the fourth known topical allergic reaction to idebenone (96035).