Ingredients | Amount Per Capsule |
---|---|
Galactomune(TM) Prebiotic Blend
|
550 mg |
(GOS)
(Galactooligosaccharides Note: natural, allergen-free )
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(purified from Saccharomyces cerevisiae)
(Beta-Glucan (Form: purified from Saccharomyces cerevisiae Genus: Saccharomyces Species: cerevisiae) )
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Vegetarian Capsule (Form: Hydroxypropyl Methylcellulose, Water), L-Leucine, Cellulose
Below is general information about the effectiveness of the known ingredients contained in the product Galactomune. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Galactomune. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when used orally in amounts commonly found in foods. Beta-glucans derived from oat bran, baker's yeast, or brewer's yeast (Saccharomyces cerevisiae) have Generally Recognized as Safe (GRAS) status in the US (4912).
POSSIBLY SAFE ...when used orally and appropriately, short-term in medicinal amounts. There is some evidence that yeast-derived beta-glucans 15 grams daily can be used safely for up to 8 weeks (7272). Oat-derived beta-glucans 3-10 grams daily can also be used safely for up to 12 weeks (7272,5796,17129,34700,34727,34729,34765,34766,34811,34812)(34876,107935,109206). ...when used topically and appropriately. A specific beta-glucans serum and emulsion (Awake; Hangzhou Songyang Biotechnical) combination has been used with apparent safely for up to 12 weeks in clinical research (109210). A specific beta-glucans cream (Imunoglukan P4H, PLEURAN s.r.o.) has been used with apparent safety 2-3 times daily for up to 6 months (98201).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
LIKELY SAFE ...when consumed in amounts commonly found in foods. GOS are found in various foods, including dairy products, legumes, and some root vegetables (26702,26732).
POSSIBLY SAFE ...when used orally and appropriately, short-term. GOS or foods fortified with GOS up to 20 grams daily have been safely used in clinical research for up to 30 days (21191,26706,26712,26727,99224,106526,106529,107715,107729). The European Food Safety Authority has concluded that consuming food products providing GOS up to 16.2 grams daily does not present safety concerns (106530). This agency has not evaluated the safety of higher doses in food products.
CHILDREN: POSSIBLY SAFE
when used orally in breast milk or infant formulas containing up to 7.
2 grams/L of GOS provided as the sole prebiotic or in combination with other prebiotics, including fructo-oligosaccharides or polydextrose, daily for 4-12 months (26708,26709,26710,26720,99211,99212,99215,99218,99222,99223,106527). ...when used in doses of up to 10 grams daily for 3 weeks in females 10-13 years of age (99210).
PREGNANCY AND LACTATION: LIKELY SAFE
when consumed in amounts commonly found in foods.
PREGNANCY AND LACTATION: POSSIBLY SAFE
when used orally.
GOS have been safely used in clinical research in doses of about 4.5 grams daily from week 25 of pregnancy until delivery (26721).
Below is general information about the interactions of the known ingredients contained in the product Galactomune. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Details
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Theoretically, beta-glucans might interfere with immunosuppressive therapy.
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Theoretically, GOS might reduce the effects of immunosuppressants.
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Below is general information about the adverse effects of the known ingredients contained in the product Galactomune. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally and topically, beta-glucans seem to be well-tolerated.
Most Common Adverse Effects:
Topically: Contact dermatitis, skin reactions.
Dermatologic ...Topically, a specific beta-glucans cream r.o.) has been reported to cause skin reactions and contact dermatitis in one clinical trial. These reactions occurred in 27% of patients; reactions were mild and self-limiting in 12% of patients (98201).
Hematologic ...In one clinical trial of children and young adults with neuroblastoma, one of 44 patients developed transient elevations of aspartate transaminase and alanine transaminase within five days of starting oral beta-glucans 120 mg/kg daily (109203).
General
...Orally, GOS seem to be well tolerated in infants, children, and adults.
Most Common Adverse Effects:
Orally: Bloating, constipation, diarrhea, flatulence, and increased stool frequency.
Serious Adverse Effects (Rare):
Orally: Anaphylaxis in sensitive individuals.
Dermatologic ...Orally, giving a formula supplemented with 4 grams/L of GOS and polydextrose (1:1 ratio) to infants has been associated with an increased incidence of atopic dermatitis in one clinical study (26709). However, most other clinical research in infants at risk of atopy shows that GOS-containing formula may actually reduce the risk of developing atopic dermatitis (26707,26708,99223).
Gastrointestinal ...Orally, galacto-oligosaccharides may cause bloating, flatulence, and increased stool frequency (26706,26709,26724,99217,99222). Giving a formula supplemented with 4 grams/L of GOS and polydextrose (1:1 ratio) to infants has been associated with an increased incidence of gastrointestinal adverse effects, primarily constipation and diarrhea, in one clinical study (106527). However, it is unclear if this was due to GOS, polydextrose, or the combination.
Immunologic ...Orally, GOS have been rarely associated with allergic reactions, including anaphylaxis. Research in these patients shows that people who are previously sensitized to Blomia tropicalis, a common dust mite in Southeast Asia, may also experience allergic reactions after consumption of GOS. Blomia tropicalis contains glycosylated allergens that have IgE mediated cross-reactivity to GOS (102508).
Psychiatric ...Orally, giving infants a formula supplemented with 8 grams/L of a 50:33:17 mixture of polydextrose, GOS, and lactulose has been associated with increased infant irritability when compared with control formula (26709). However, it is not known if this was related to the GOS, other ingredients, or the combination. An increase in irritability did not occur in infants given a formula supplemented with 4 grams/L of polydextrose and GOS (1:1 ratio) (26709,106527).