Dwarf Elder Vanilla Flavor by TerraVita

INSUFFICIENT RELIABLE EVIDENCE to RATE

• Atopic dermatitis (eczema). It is unclear if topical dwarf elder is beneficial in patients with atopic dermatitis. Details: A small clinical study in patients with atopic dermatitis of the hand shows that applying dwarf elder extract cream to the hands twice daily for 4 weeks improves eczema severity, itching severity, and rate of healing to a similar degree as hydrocortisone 1% cream. However, dwarf elder was found to significantly improve quality of life scores when compared with hydrocortisone (108539).
• Contact dermatitis. It is unclear if topical dwarf elder is beneficial in patients with contact dermatitis. Details: A small clinical study in patients with contact dermatitis due to Paederus beetles shows that applying dwarf elder fruit extract 5% in ethanol solution three times daily, in addition to hydrocortisone cream three times daily, reduces symptoms such as burning and inflammation, but not itching or pain, when compared with applying only ethanol solution and hydrocortisone cream (96577).
• Osteoarthritis. It is unclear if topical dwarf elder is beneficial in patients with osteoarthritis. Details: A small clinical study in patients with knee osteoarthritis shows that applying a fingertip amount of gel containing dwarf elder leaf extract 10% to the affected knee three times daily for 4 weeks modestly reduces pain and stiffness and slightly improves physical function when compared with applying diclofenac 1% gel (96578). The validity of these results is limited by the fact that it was not clearly stated whether therapeutic amounts of diclofenac gel were administered or if symptom severity between treatment groups was equal at baseline.
• Wound healing. Although there has been interest in using topical dwarf elder for wound healing, there is insufficient reliable information about the clinical effects of dwarf elder for this purpose. More evidence is needed to rate dwarf elder for these uses.

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POSSIBLY SAFE ...when dwarf elder leaf extract is used topically and appropriately, short-term. Gels, creams, and solutions containing dwarf elder leaf extracts up to 10% have been applied to the skin with apparent safety for up to 4 weeks (96578,108539).

LIKELY UNSAFE ...when large quantities of any part of the plant are used orally. It can cause loss of consciousness and death (18). There is insufficient reliable information available about the safety of the oral use of dwarf elder in small amounts.

PREGNANCY AND LACTATION: LIKELY UNSAFE
when used orally in large quantities (18).

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General ...Orally, ingestion of large quantities of any plant part of dwarf elder may be unsafe. Topically, dwarf elder seems to be well tolerated.
Serious Adverse Effects (Rare):
Orally: Bloody diarrhea, cyanosis, vomiting, and unconsciousness when taken in large amounts.

Dermatologic ...Topically, dwarf elder leaf extract cream might cause a slight burning sensation after initial application, but this appears to be transient (108539).

Gastrointestinal ...Orally, ingestion of large quantities of any plant part of dwarf elder may cause vomiting and bloody diarrhea (18).

Neurologic/CNS ...Orally, ingestion of large quantities of any plant part of dwarf elder may cause cyanosis, dizziness, headache, and unconsciousness (18).

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