Ingredients | Amount Per Serving |
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(seed)
(1:5)
|
0.13 mL |
Glycerin, Strawberry flavor
Below is general information about the effectiveness of the known ingredients contained in the product Annatto Seed Strawberry Flavor. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Annatto Seed Strawberry Flavor. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when annatto seed extract is used orally in amounts commonly found in foods. Annatto has Generally Recognized As Safe (GRAS) status for use as a color in foods in the US, with an acceptable daily intake of 2.5 mg/kg (4912,109549).
POSSIBLY SAFE ...when annatto leaf powder is used orally and appropriately. Annatto leaf powder 750 mg daily has been used with apparent safety in clinical trials for up to 1 year (31612). There is insufficient reliable information available about the safety of annatto seed extract when used orally in medicinal amounts or annatto plant parts when used topically.
PREGNANCY AND LACTATION:
There is insufficient reliable information available about the safety of annatto during pregnancy and breast-feeding.
Below is general information about the interactions of the known ingredients contained in the product Annatto Seed Strawberry Flavor. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Animal studies suggest that certain annatto extracts may have hypoglycemic or hyperglycemic effects (19,31588,31605,31610,31616). Theoretically, taking annatto with antidiabetes drugs could reduce the therapeutic effects of these drugs or increase the risk for additive hypoglycemia. Monitor blood glucose levels closely.
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Animal research suggests that annatto induces cytochrome P450 1A1 (CYP1A1) (31591). Theoretically, annatto might increase the metabolism of CYP1A1 substrates.
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Below is general information about the adverse effects of the known ingredients contained in the product Annatto Seed Strawberry Flavor. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General ...Orally, annatto leaf seems to be well tolerated. Rarely, annatto has been reported to cause constipation (31612). When used as a coloring agent, annatto has been reported to cause allergic reactions, including anaphylaxis (31619,31621,95158,95157).
Gastrointestinal ...Orally, annatto leaf powder has been reported to cause constipation (31612). Annatto food coloring has been associated with an increase in symptoms of irritable bowel syndrome (IBS) in one case report. A woman with frequent symptoms of diarrhea, bloating, and abdominal pain experienced an improvement in all symptoms upon elimination of annatto-containing products; symptoms returned after these products were added back into her diet (95142).
Immunologic ...When used as a food coloring, annatto causes rare cases of allergic reactions in children and adults. Reactions have occurred after consumption of cereal, cheese, ice cream, and other foods containing annatto food coloring, and use of cosmetics containing annatto. Symptoms include urticaria, angioedema, severe hypotension, and anaphylaxis (31619,31621,95157.109549). One patient with a history of urticaria after using cosmetics, or ingesting food containing annatto, was given oral doses of annatto gradually increasing from 1 mg to 100 mg at hourly intervals. Severe urticaria requiring treatment with antihistamines and corticosteroids occurred with doses of 50-100 mg, while milder reactions started at around 20 mg (109549). Reactions to annatto food coloring are possibly due to traces of seed protein (95157).