Ingredients | Amount Per Serving |
---|---|
Proprietary Extract Blend
|
1360 mg |
(Coptis chinensis )
(rhizome)
(Huang lian (zhi))
|
|
(Aucklandia lappa )
(root)
(mu xiang)
|
Magnesium Silicate, Hydrated (Alt. Name: Mg Silicate), Microcrystalline Cellulose, Dextrin, China Wax
Below is general information about the effectiveness of the known ingredients contained in the product Aucklandia & Coptis Teapills. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
There is insufficient reliable information available about the effectiveness of goldthread.
Below is general information about the safety of the known ingredients contained in the product Aucklandia & Coptis Teapills. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when used in amounts commonly found in foods. Costus oil has Generally Recognized As Safe (GRAS) status for use in foods in the US (4912).
UNSAFE ...when aristolochic acid-contaminated costus products are used orally. Costus root is commonly contaminated with aristolochic acid, which is nephrotoxic and carcinogenic. The US Food and Drug Administration (FDA) considers all products containing aristolochic acid to be unsafe and adulterated. Only products analytically verified to be aristolochic acid-free should be used (6118). There is insufficient reliable information available about the safety of non-contaminated costus when used orally or topically in medicinal amounts.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
There is insufficient reliable information available about the safety of goldthread when used in adults in medicinal amounts.
CHILDREN: LIKELY UNSAFE
when used orally in newborns.
The berberine constituent of goldthread can cause kernicterus in newborns, particularly preterm neonates with hyperbilirubinemia (2589).
PREGNANCY: LIKELY UNSAFE
when used orally.
Berberine is thought to cross the placenta and may cause harm to the fetus. Kernicterus has developed in newborn infants exposed to berberine (2589). Preliminary evidence suggests that maternal intake of goldthread during the first trimester increases the risk of congenital malformations of the central nervous system (15129).
LACTATION: LIKELY UNSAFE
when used orally.
Berberine and other harmful constituents can be transferred to the infant through breast milk (2589).
Below is general information about the interactions of the known ingredients contained in the product Aucklandia & Coptis Teapills. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Berberine, a constituent of goldthread, can reduce metabolism of cyclosporine and increase serum levels. It might inhibit cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine (13524).
|
There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme (13524). So far, this interaction has not been reported in humans. However, watch for an increase in the levels of drugs metabolized by CYP3A4 in patients taking goldthread. Some drugs metabolized by CYP3A4 include lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), and numerous others. Use goldthread cautiously or avoid in patients taking these drugs.
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Below is general information about the adverse effects of the known ingredients contained in the product Aucklandia & Coptis Teapills. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General ...There is limited reliable information available about the adverse effects of costus when used orally or topically.
Immunologic ...Orally and topically, costus might cause allergic reactions, including contact dermatitis (11,73140,73155,73281,73284,73288).
Oncologic ...Costus root is commonly contaminated with aristolochic acid, which is carcinogenic (6118).
Renal ...Costus root is commonly contaminated with aristolochic acid, which is nephrotoxic (6118).
General ...No adverse effects have been reported in adults. However, a thorough evaluation of safety outcomes has not been conducted.