Ingredients | Amount Per Serving |
---|---|
300 mg | |
(leaf)
(Hederacoside)
|
50 mg |
Lysozyme Hydrochloride
|
1 mg |
Polylysine Hydrochloride
|
150 mcg |
Gelatin, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate
Below is general information about the effectiveness of the known ingredients contained in the product Monocombo. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
There is insufficient reliable information available about the effectiveness of American ivy.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Monocombo. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
There is insufficient reliable information available about the safety of American ivy.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
POSSIBLY SAFE ...when the leaf extract is used orally and appropriately, short-term. Two specific products containing dried English ivy leaf extract 7 mg/mL (Prospan, PendoPharm; Prospanex, Engelhard Arzneimittel GmbH and Co. KG), taken in doses of 7.5 mL three times daily, have been used with apparent safety for up to 7 days (29903,106055). There is insufficient reliable information available about the safety of topical English ivy.
CHILDREN: POSSIBLY SAFE
when the leaf extract is used orally and appropriately, short-term.
Two specific products containing dried English ivy leaf extract 7 mg/mL (Prospan, PendoPharm; Prospanex, Engelhard Arzneimittel GmbH and Co. KG), taken in doses of 2.5-7.5 mL three times daily, has been used with apparent safety for up to 7 days in infants and children up to 18 years of age (29903,106055).
PREGNANCY:
Insufficient reliable information available; avoid using.
A small retrospective study suggests that taking English ivy leaf extract at an unknown dose or duration during pregnancy is not associated with changes in pregnancy duration, the rate of preterm birth, infant health complications, or infant deaths (110402). However, due to its small size, retrospective design, and insufficient information regarding dose and duration, further research is needed to determine the safety of English ivy during pregnancy.
LACTATION:
Insufficient reliable information available; avoid using.
LIKELY SAFE ...when used orally in amounts commonly found in foods. Monolaurin has Generally Recognized as Safe (GRAS) status in the US (7705). There is insufficient reliable information available about the safety of monolaurin when used orally or topically in medicinal amounts.
PREGNANCY AND LACTATION: LIKELY SAFE
when used orally in amounts commonly found in foods (7705).
There is insufficient reliable information available about the safety of monolaurin when used in medicinal amounts during pregnancy or lactation.
Below is general information about the interactions of the known ingredients contained in the product Monocombo. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C19.
Details
In vitro research shows that English ivy inhibits CYP2C19 enzymes (96682). So far, this interaction has not been reported in humans.
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Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C8.
Details
In vitro research shows that English ivy inhibits CYP2C8 enzymes (96682). So far, this interaction has not been reported in humans.
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Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
Details
In vitro research shows that English ivy inhibits CYP2D6 enzymes (96682). So far, this interaction has not been reported in humans.
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Below is general information about the adverse effects of the known ingredients contained in the product Monocombo. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General ...Orally, no adverse effects have been reported. However, a thorough evaluation of safety outcomes has not been conducted.
General
...Orally and topically, English ivy leaf extract seems to be generally well tolerated.
Most Common Adverse Effects:
Orally: Abdominal pain, diarrhea, nausea, skin irritation, vomiting.
Topically: Allergic reactions, contact dermatitis.
Dermatologic
...Orally, English ivy and fresh English ivy leaves can cause skin irritation (7,29903).
Topically, fresh English ivy leaves can cause contact dermatitis and rash, with frequent exposure increasing the risk of sensitization (29910,29912,29913,29914,91301,96620,96636,96681). Occupational airborne exposure to English ivy can also cause contact dermatitis (96600).
Gastrointestinal ...Orally, English ivy can cause abdominal pain, diarrhea, nausea, and vomiting (29903,106055). The saponin constituents of English ivy can produce an acrid and/or bitter taste (7).
General ...No adverse effects have been reported. However, a thorough evaluation of safety outcomes has not been conducted.