Ingredients | Amount Per Serving |
---|---|
Superfood Blend
|
1.3 Gram(s) |
(Cordyceps )
(mycelium)
(Regenerative Organic Certified)
|
|
(leaf)
(Organic)
|
|
Thyme, Fermented
(leaf)
(Organic)
|
|
(whole plant)
(Regenerative Organic Certified)
|
|
(leaf)
(Regenerative Organic Certified)
|
|
(Pinus virginiana )
(needle)
(Regenerative Organic Certified)
|
|
(Bacillus subtilis AB22 )
(1 Billion CFU at time of manufacture)
|
2.15 mg |
Pullulan, Copernicia cerifera PlantPart: wax Genus: Copernicia Species: cerifera, Apple Cider Vinegar
Below is general information about the effectiveness of the known ingredients contained in the product Respiratory Health. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
There is insufficient reliable information available about the effectiveness of Asian water plantain.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
There is insufficient reliable information available about the effectiveness of buckhorn plantain.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Respiratory Health. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
There is insufficient reliable information available about the safety of Asian water plantain.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
POSSIBLY SAFE ...when taken orally and appropriately. Some strains of B. subtilis are considered "generally regarded as safe" (GRAS) for use in food (110841). Bacillus subtilis has been used with apparent safety in clinical studies. B. subtilis strains BS50, B2335, CU1, MB40, MY02, or R0179 have been used with apparent safety in doses of 2-10 billion colony forming units (CFUs) daily for 2-8 weeks (107611,110841,110843,110846,110847,110848,110854,110859). One specific product, B. subtilis DE111, has been used with apparent safety in doses of one billion CFUs daily for 12 weeks or 5 billion CFUs daily for 10 weeks (110850). Another specific product (Medilac-S), containing a combination of B. subtilis R0179 and Enterococcus faecalis, has been used with apparent safety in doses providing up to 300 million CFUs of B. subtilis daily for up to 96 weeks (110853,110860).
CHILDREN:
There is insufficient reliable information available about the safety of Bacillus subtilis in children of any age.
Cases of bacteremia have occurred rarely in preterm infants given other probiotics (102416,111610,111612,111613,111850,111852,111853). The US Food and Drug Administration (FDA) has issued a warning about cases of serious infections caused by probiotics reported in very preterm or very low birth weight infants under 1000 grams (111610). Similarly, the American Academy of Pediatrics does not support the routine administration of probiotics to these infants due to conflicting data on safety and efficacy (111608).
PREGNANCY AND LACTATION:
Insufficient reliable information available when used in doses higher than those found in foods; avoid using.
LIKELY SAFE ...when used in the amounts commonly found in food.
POSSIBLY SAFE ...when the leaves are applied topically and appropriately (93456). There is insufficient reliable information available about the safety of the other parts of the banana plant when used orally or topically as a medicine.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using amounts greater than those found in food.
LIKELY SAFE ...when used orally with appropriate fluid intake, short-term (12,272). Black psyllium has been used with apparent safety in doses of 15-30 grams daily for up to 6 months (19156,10091,93215,102826). The U.S. Food and Drug Administration (FDA) requires over-the-counter medicines that contain dry or incompletely hydrated psyllium to carry a warning that they should be taken with at a least a full glass of liquid to reduce the risk of choking. This labeling also applies to foods containing psyllium that are marketed with a claim of reducing the risk of coronary heart disease (93217,93218).
LIKELY UNSAFE ...when black psyllium is used orally without adequate fluid intake due to the risk for choking and gastrointestinal obstruction (2,18,93218). ...when granular dosage forms containing black psyllium are used as over-the-counter (OTC) laxatives. The U.S. Food and Drug Administration (FDA) states that these granular dosage forms are not generally recognized as safe and effective (GRASE) as OTC laxatives due to an increased risk of choking and gastrointestinal obstruction (93219).
PREGNANCY AND LACTATION: LIKELY SAFE
when used orally with appropriate fluid intake (272).
POSSIBLY SAFE ...when used orally and appropriately (2). ...when used topically (2).
PREGNANCY: LIKELY UNSAFE
when used orally or topically.
Some evidence suggests buckhorn plantain affects muscle tone of the uterus (4275).
LACTATION:
Insufficient reliable information available; avoid using.
POSSIBLY SAFE ...when great plantain seed is used orally, short-term. Great plantain seed has been used with apparent safety at doses up to 3600 mg daily for up to 8 weeks and 2000 mg daily for up to 12 weeks (106644,106645). ...when used topically, short-term. Topical great plantain 10% has been used with apparent safety for up to 2 weeks (106643,110088,110090). There is insufficient reliable information available about the safety of great plantain leaf or leaf extract when used orally.
PREGNANCY: LIKELY UNSAFE
when used orally because it can increase uterine tone (4).
LACTATION:
Insufficient reliable information available; avoid using.
LIKELY SAFE ...when used in amounts commonly found in foods. Lemon has Generally Recognized as Safe (GRAS) status in the US (4912).
POSSIBLY SAFE ...when inhaled in amounts used for aromatherapy, short-term. Lemon essential oil has been used with apparent safety as aromatherapy for up to 2 weeks in clinical research (93475,98128,98129). There is insufficient reliable information available about the safety of lemon when used topically, or when used orally or intranasally in medicinal amounts.
PREGNANCY AND LACTATION:
Insufficient reliable information available.
Avoid using in amounts greater than those typically found in foods.
POSSIBLY SAFE ...when used orally and appropriately, short-term. A specific product containing Monterey pine bark extract (Enzogenol, ENZO Nutraceuticals) has been used with apparent safety at a dose of 1000 mg daily for up to 12 weeks (63614,63618,63620,105777) or 480 mg daily for up to 6 months (105778). There is insufficient reliable information available about the safety of Monterey pine when used topically.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
LIKELY SAFE ...when used orally in amounts commonly found in foods. Sage is approved for use as a food in the United States (4912).
POSSIBLY SAFE ...when used orally in medicinal doses, short-term. Common sage (Salvia officinalis) and Spanish sage (Salvia lavandulaefolia) have been used with apparent safety when taken orally in doses of 280 mg daily for up to 8 weeks (10334,10810,17177,105338). ...when used topically. Common sage (Salvia officinalis) has been used with apparent safety as a single agent or in combination products for up to one week (10437,72619,107023). ...when the essential oil is inhaled as aromatherapy, short-term (72658).
POSSIBLY UNSAFE ...when used orally in high doses or long-term (12,1304). Some species of sage, including common sage (Salvia officinalis), contain a thujone constituent that can be toxic if consumed in large enough quantities (12,1304).
PREGNANCY: LIKELY UNSAFE
when used orally.
The constituent thujone can have menstrual stimulant and abortifacient effects (19).
LACTATION: POSSIBLY UNSAFE
when used orally; sage is thought to reduce the supply of mother's milk (19).
Below is general information about the interactions of the known ingredients contained in the product Respiratory Health. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Details
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms (1740). Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.
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Taking banana may reduce the effectiveness of levodopa.
Details
A case report describes apparent wearing off in a patient with Parkinson disease after eating a banana every day. The wearing off subsided after removing dietary bananas (110618).
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Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Details
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug (539). This interaction may also occur with black psyllium.
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Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Details
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Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Details
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant (12421).
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Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
Details
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped (540,92194). This interaction may also occur with black psyllium.
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Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Details
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin (99433). This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.
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Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
Details
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped (106858).
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Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Details
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol (12421,99433). Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine (12,18,272,93214,106858). Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin (12420,103940). Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.
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Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Details
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Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Details
Animal and in vitro research suggests that cordyceps stimulates the immune system (3403,3404,3414,3431,3432). However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine (92828), which suggests that cordyceps may have an immunosuppressive effect.
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Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Details
Animal research suggests that cordyceps can increase testosterone levels (46087). The clinical significance of this finding is unclear.
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Theoretically, consuming large amounts of great plantain leaves, which contain vitamin K, might decrease the clinical effects of warfarin.
Details
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Theoretically, taking itraconazole capsules or tablets with a beverage containing lemon might increase the levels and clinical effects of itraconazole.
Details
In one case report, dissolving itraconazole tablets in a small amount of specific beverages containing lemon prior to administration increased the level of itraconazole in a lung transplant patient. In this case, the increased bioavailability was desirable and was likely due to improved tablet dissolution in the acidic beverage (110781).
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Theoretically, sage might decrease the clinical effects of anticholinergic drugs.
Details
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Theoretically, sage might interfere with the clinical effects of anticonvulsant drugs.
Details
Some species of sage can cause convulsions when consumed in large quantities (10812).
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Theoretically, taking sage with antidiabetes drugs might increase the risk of hypoglycemia.
Details
In patients with polycystic ovary syndrome (PCOS) or inadequately controlled type 2 diabetes, common sage (Salvia officinalis) has demonstrated hypoglycemic activity (91971,103380). However, other clinical research in patients with inadequately controlled type 2 diabetes shows that common sage extract does not lower fasting blood glucose levels (105340).
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Theoretically, sage might increase or decrease the effects of antihypertensive drugs.
Details
Animal research suggests that common sage (Salvia officinalis) can cause prolonged blood pressure reduction (4152). However, clinical research suggests that Spanish sage (Salvia lavandulaefolia) can increase blood pressure in some people with hypertension (10334). Until more is known, use with caution.
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Theoretically, taking sage might increase the sedative and adverse effects of benzodiazepines.
Details
In vitro evidence suggests that certain components of common sage (Salvia officinalis) can bind to benzodiazepine receptors (72588). This effect has not been reported in humans.
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Theoretically, sage might have additive effects when used with cholinergic drugs.
Details
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Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.
Details
Some constituents of sage have CNS depressant activity (10334).
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Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C19.
Details
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2C19 (10848). So far, this interaction has not been reported in humans.
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Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C9.
Details
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2C9 (10848). So far, this interaction has not been reported in humans.
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Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Details
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Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Details
Animal research suggests that drinking common sage (Salvia officinalis) tea increases the expression of CYP2E1 (72627). So far, this interaction has not been reported in humans.
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Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Details
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Theoretically, sage might interfere with hormone therapy.
Details
In vitro evidence suggests that geraniol, a constituent of Spanish sage (Salvia lavandulaefolia), exerts estrogenic activity (39572). The clinical significance of this effect is unclear.
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Theoretically, sage might increase levels of drugs transported by P-glycoprotein.
Details
In vitro research suggests that common sage (Salvia officinalis) can inhibit the multi-drug transporter protein, P-glycoprotein (72641). This effect has not been reported in humans.
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Below is general information about the adverse effects of the known ingredients contained in the product Respiratory Health. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General ...There is limited information available about the potential adverse effects of Asian water plantain. Orally, it has been used as a part of Traditional Chinese Medicine (TCM) with apparent safety; there have been no reported adverse effects in most patients. However, one case of hepatotoxicity and nephrotoxicity has been reported with the use of a combination TCM product containing Asian water plantain (99434).
Hepatic ...One case report of drug-induced systemic toxicity, including hepatotoxicity, has occurred in a 59-year-old man with chronic hepatitis B who had taken six doses of a combination product containing Asian water plantain 3 weeks prior to admission. He presented with gum bleed and petechiae, and his admission lab values indicated fulminant liver failure. His condition progressed to include renal failure and eventual death after 4 weeks. It is not clear if Asian water plantain, the other ingredients, or the combination caused this toxicity. However, the authors identified Asian water plantain as the likely causative ingredient based on animal research (99434).
Renal ...One case report of drug-induced systemic toxicity, including nephrotoxicity, has occurred in a 59-year-old man with chronic hepatitis B who had taken six doses of a combination product containing Asian water plantain 3 weeks prior to admission. He initially presented with hepatic failure, which progressed to include renal failure and eventual death after 4 weeks. It is not clear if Asian water plantain, the other ingredients, or the combination caused this toxicity. However, the authors identified Asian water plantain as the likely causative ingredient based on animal research (99434).
General
...Orally, Bacillus subtilis seems to be well tolerated by most patients.
Serious Adverse Effects (Rare):
Orally: There is concern that B. subtilis may cause bacteremia in certain patients.
Dermatologic ...Orally, itching and redness were reported rarely (110848).
Gastrointestinal ...Orally, diarrhea has been reported rarely (110846).
Immunologic
...There are cases of Bacillus subtilis var.
natto bacteremia and meningitis in patients with frequent consumption of natto, soybeans fermented with B. subtilis var. natto (110844,110862). A 70-year-old female recovered from bacteremia after this consumption was stopped and she was treated with vancomycin. It was hypothesized that this infection was due to an immunocompromised state related to age, type 2 diabetes, kidney failure, multiple myeloma, coronavirus disease 2019 (COVID-19), and treatment with immunosuppressive therapy (110844). In a 67-year-old female, bacterial entry was suspected to be related to erosion of her esophagus (110862).
There have been other rare cases of bacteremia or infections due to B. subtilis. These cases are unlikely to be related to intake or supplementation but to an immunocompromised state and/or introduction of bacteria to the body via non-oral routes. Cases of bacteremia include a newborn infant with sepsis, an adult with esophageal perforation, and a patient undergoing bone marrow transplantation subjected to contaminated materials (110834,110837,110840). There is also a case of cholangitis in a 15-year-old child with a recent kidney transplant related to polycystic kidney disease (110838).
Neurologic/CNS ...Orally, one case of headache was reported in a clinical trial (110847).
Pulmonary/Respiratory ...Orally, two cases of nasal obstruction were reported in a clinical trial (110847).
Other ...Orally, an acute episode of mild pain was reported in a clinical trial (110847).
General
...Orally, bananas are well tolerated when consumed as food.
Most Common Adverse Effects:
Orally: Bloating, cramping, gas.
Topically: Urticaria.
Serious Adverse Effects (Rare):
Orally: Anaphylaxis, intestinal obstruction.
Endocrine ...In one case report, an adolescent girl who consumed nothing other than 20 bananas daily developed hyperkalemia and hyperdopaminemia. These changes in the blood resulted in pseudoaldosteronism and dysthymia (93780).
Gastrointestinal
...Orally, banana starch isolated from green bananas has resulted in bloating, gas, cramping, and softer feces (93448,93449,110619).
When consumed prior to exercise, fullness and bloating during exercise have been reported (93459). In children, nausea, vomiting, and abdominal distension have been reported when banana is used in the treatment of diarrhea (93461). Cases of intestinal obstruction due to banana seeds have been reported (93777).
In one case report, food protein-induced enterocolitis syndrome (FPIES) has been associated with banana consumption (93778).
Immunologic ...Orally, banana has been reported to cause allergic reaction, including urticaria and redness, abdominal pain and nausea, dyspnea (93779,93781,93782,93797,93798,93803), and anaphylaxis (93783,93793,93802,93803). Topically, contact urticara has also been reported (93784). Skin testing is not always accurate, even for patients with severe banana allergy (93793).
Psychiatric ...Orally, high banana consumption has been associated with a higher likelihood of depressive symptoms in females, but not males, in a cross-sectional study of the general Chinese adult population (106471).
General
...Orally, black psyllium is generally well tolerated when taken with adequate fluids.
Most Common Adverse Effects:
Orally: Bloating, flatulence.
Serious Adverse Effects (Rare):
Orally: Bowel obstruction, esophageal obstruction.
Gastrointestinal ...Black psyllium can cause flatulence and bloating. These effects are generally transient and can be reduced by increasing the daily dose gradually (93214). Taking black psyllium with too little fluid can lead to esophageal or intestinal obstruction (18,93217,93218).
Immunologic ...Several psyllium species have been associated with sensitization and allergic reactions, especially in people exposed to airborne psyllium dust, such as nurses preparing doses of psyllium powder, and workers in psyllium processing plants (93214). Symptoms of occupational exposure include rhinitis, conjunctivitis, wheezing, asthma, and urticarial rashes (18,93214). Severe anaphylactic reactions have been reported in individuals with occupational exposure who then ingest psyllium products (2329,8079,9246).
General ...Orally, topically, or by inhalation, buckhorn plantain can cause allergic reactions (3901,98010).
Dermatologic ...There are case reports of phototoxic reactions on sun-exposed skin after oral ingestion of buckhorn plantain, or skin contact with the plant. An erythematous, burning rash develops, with vesicles and bullae, followed by necrotic crusting (98010).
Immunologic ...Buckhorn plantain can cause allergic reactions after oral ingestion, skin contact, or inhalation of pollen (3901,98010).
General
...Orally, cordyceps seems to be generally well tolerated when used for up to 1 year.
Most Common Adverse Effects:
Orally: Abdominal discomfort, constipation, diarrhea.
Gastrointestinal ...Orally, cordyceps has been associated with diarrhea, constipation, abdominal discomfort, dry mouth, and throat discomfort in clinical research. However, these events were uncommon, and in some cases symptoms could be reduced by taking cordyceps after eating (92829,105076,109705).
Hematologic ...Two cases of lead poisoning, characterized by loss of appetite and other symptoms, have been reported for patients taking cordyceps powder. After discontinuing cordyceps supplementation, both patients were treated with chelating agents (46135).
Hepatic ...There is a case report of acute cholestatic hepatitis probably associated with the use of a product containing cordyceps. The 64-year-old male was asymptomatic except for jaundice and laboratory markers and recovered once the supplement was stopped. However, it is unclear whether the hepatitis is associated with the cordyceps or with an unknown contaminant (109704).
Renal ...One case of a mild increase in serum creatinine level (< 30%) has been reported (95905).
General
...Orally and topically, great plantain seems to be well tolerated.
However, a thorough evaluation of safety outcomes has not been conducted.
Most Common Adverse Effects:
Topically: Contact dermatitis in sensitive individuals.
Dermatologic ...Topically, application can cause allergic contact dermatitis in some individuals (4).
Gastrointestinal ...Theoretically, great plantain may have laxative effects when used orally in excessive amounts (4).
General
...Orally, lemon is well tolerated in amounts commonly found in foods.
A thorough evaluation of safety outcomes has not been conducted on the use of larger amounts.
Most Common Adverse Effects:
Orally: Epigastralgia and heartburn with the regular consumption of fresh lemon juice.
Dermatologic ...Topically, the application of lemon oil might cause photosensitivity, due to furocoumarin derivative content. This occurs most often in fair-skinned people (11019).
Gastrointestinal ...Orally, fresh lemon juice, taken as 60 mL twice daily, has been reported to cause gastrointestinal disturbances in 37% of patients in one clinical trial, compared with 8% of patients in the placebo group. Specifically, of the patients consuming lemon juice, 21% experienced heartburn and 8% experienced epigastralgia, compared to 1% and 3%, respectively, in the placebo group (107489).
General ...Orally, Monterey pine seems to be well tolerated. Topically, no adverse effects have been reported. However, a thorough evaluation of safety outcomes has not been conducted.
Dermatologic ...Contact dermatitis from Monterey pine sawdust has been reported (63615).
Immunologic ...Monterey pine pollen may cause seasonal rhinoconjunctivitis (63612).
General
...Orally, topically, and when inhaled, sage seems to be well tolerated.
Most Common Adverse Effects:
Orally: Abdominal pain, agitation, diarrhea, dizziness, nausea, and vomiting.
Topically: Burning, dermatitis, pain.
Serious Adverse Effects (Rare):
Orally: Generalized tonic-clonic seizures associated with the thujone, camphor, and/or cineol constituents.
Cardiovascular ...By inhalation, sage essential oil has been reported to increase the blood pressure of hypertensive patients (10334).
Dermatologic
...Orally, sage extract has been reported to cause acneiform skin eruptions in one patient in a clinical trial (91970).
Topically, sage leaves can cause contact dermatitis (46902,72661,72710). Sage extract can cause burning and pain (10437).
Gastrointestinal
...Orally, sage can cause nausea, vomiting, abdominal pain, and diarrhea (10810,17177).
Topically, sage extract sprayed into the mouth and throat can cause dryness or mild burning of the throat (72619).
Neurologic/CNS ...Orally, sage can cause dizziness or agitation (10810,17177). Thujone, a constituent of common sage (Salvia officinalis), is a neurotoxin and can cause seizures (10812,12868). Camphor and cineol, constituents of common sage and Spanish sage, can also cause neurotoxicity and seizures in high doses (10334,12868). Generalized tonic-clonic seizures have been reported in adults, children, and infants after ingestion of sage oil (12868,72666).
Pulmonary/Respiratory
...Orally, sage can cause wheezing (10810,17177).
Occupational exposure to sage dust can cause reduction in ventilatory capacity and chronic respiratory impairment (72672,72682,72686).