Bugleweed by Herb Pharm

INSUFFICIENT RELIABLE EVIDENCE to RATE

• Hyperthyroidism. It is unclear if oral bugleweed is beneficial in patients with hyperthyroidism. Details: A small, preliminary clinical study shows that taking a bugleweed herb preparation (Thyreo-loges N tablets, Pharm. Firm Loges) 40 mg daily for an average of 15 weeks does not improve serum levels of thyroid hormones or symptoms of hyperthyroidism in patients with TSH levels of less than 1 mU/L and hyperthyroidism-associated symptoms (100065).
• Insomnia. Although there is interest in using oral bugleweed for insomnia, there is insufficient reliable information about the clinical effects of bugleweed for this purpose.
• Premenstrual syndrome (PMS). Although there is interest in using oral bugleweed for PMS, there is insufficient reliable information about the clinical effects of bugleweed for this purpose. More evidence is needed to rate bugleweed for these uses.

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There is insufficient reliable information available about the safety of bugleweed when used orally.

PREGNANCY: LIKELY UNSAFE
when used orally (12,19). Bugleweed has anti-gonadotropic and anti-thyrotropic activity (7,19); avoid using.

LACTATION: POSSIBLY UNSAFE
when used orally (12,19) because it might have anti-prolactin activity (7,19); avoid using.

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THYROID HORMONE Interaction Rating = Moderate Be cautious with this combination. Severity = Moderate •  Occurrence = Probable •  Level of Evidence = D Theoretically, bugleweed may alter thyroid function.  Details Concomitant use of bugleweed may reduce the effects of thyroid hormones by blocking peripheral conversion of thyroxine (T4) to triiodothyronine (T3) (2,7,19).

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General ...There is limited information available about the safety of bugleweed.
Serious Adverse Effects (Rare):
Orally: Decreased thyroid function.

Cardiovascular ...Orally, disturbances of the cardiac rhythm have been reported for one patient in a clinical trial taking oral bugleweed (100065).

Endocrine ...Orally, bugleweed can cause thyroid enlargement during extended therapy or with large amounts, but this is rare (7). The sudden discontinuation of bugleweed might result in a sudden increase in thyroid function (2) and prolactin secretion (7).

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