Cascara Sagrada 450 mg [Discontinued] by Sunshine Naturals

POSSIBLY INEFFECTIVE

• Bowel preparation. Taking cascara sagrada orally with magnesium sulfate or magnesium hydroxide prior to colonoscopy does not appear to improve bowel cleansing when used alone or as an adjunct to polyethylene glycol. Details: Some clinical research shows that taking a specific combination of cascara sagrada plus magnesium sulfate (Pico-Salax) orally along with polyethylene glycol (GoLYTELY) is not more effective than polyethylene glycol alone for bowel preparation prior to colonoscopy (40086). Other clinical research shows that taking cascara sagrada plus magnesium sulfate orally, alone or in combination with polyethylene glycol (GoLYTELY), is actually less effective than polyethylene glycol alone (40087,40088). Additionally, some clinical research shows that taking a combination of cascara sagrada 5 mL plus milk of magnesia 30 mL orally does not improve bowel cleansing or examination quality when compared with no bowel preparation (40090,40093).

INSUFFICIENT RELIABLE EVIDENCE to RATE

• Constipation. It is unclear if oral cascara sagrada is beneficial in patients with constipation. Details: Cascara sagrada has a history of use for its laxative effects in patients with constipation (272). In fact, cascara sagrada was formerly approved by the US Food and Drug Administration (FDA) as a safe and effective over-the-counter (OTC) laxative; however, this designation was removed in 2002 due to a lack of supporting evidence (8229). More evidence is needed to rate cascara sagrada for this use.

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POSSIBLY SAFE ...when used orally and appropriately, short-term. Cascara sagrada seems to be safe when used for less than one week (272,25023,40087). Cascara sagrada was formerly approved by the US Food and Drug Administration (FDA) as a safe and effective over-the-counter (OTC) laxative, but this designation was removed in 2002 due to a lack of supporting evidence (8229).

POSSIBLY UNSAFE ...when used orally, long-term. Using cascara sagrada for more than 1-2 weeks can lead to dependence, electrolyte loss, and hypokalemia (272).

CHILDREN: POSSIBLY UNSAFE
when used orally in children. Cascara sagrada should be used cautiously in children due to the risk of electrolyte loss and hypokalemia (272).

PREGNANCY:
Insufficient reliable information available; avoid using.

LACTATION: POSSIBLY UNSAFE
when used orally. Cascara sagrada is excreted into breast milk and might cause diarrhea (272).

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CORTICOSTEROIDS Interaction Rating = Moderate Be cautious with this combination. Severity = High •  Occurrence = Possible •  Level of Evidence = D Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with corticosteroids.  Details Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia (2,4).

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES Interaction Rating = Minor Be watchful with this combination. Severity = Insignificant •  Occurrence = Possible •  Level of Evidence = D Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.  Details In vitro research suggests that cascara sagrada can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer (110704).

DIGOXIN (Lanoxin) Interaction Rating = Moderate Be cautious with this combination. Severity = High •  Occurrence = Possible •  Level of Evidence = D Theoretically, cascara sagrada might cause hypokalemia, potentially increasing the risk of digoxin toxicity.  Details Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia (4,19).

DIURETIC DRUGS Interaction Rating = Moderate Be cautious with this combination. Severity = High •  Occurrence = Possible •  Level of Evidence = D Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.  Details Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia (4,19).

STIMULANT LAXATIVES Interaction Rating = Moderate Be cautious with this combination. Severity = High •  Occurrence = Possible •  Level of Evidence = D Theoretically, cascara sagrada might have additive adverse effects when taken with stimulant laxatives.  Details Cascara sagrada has stimulant laxative effects and might compound fluid and electrolyte losses when taken with stimulant laxatives (19).

WARFARIN (Coumadin) Interaction Rating = Moderate Be cautious with this combination. Severity = High •  Occurrence = Possible •  Level of Evidence = D Theoretically, cascara sagrada might increase the risk of bleeding when taken with warfarin.  Details Cascara sagrada has stimulant laxative effects (19). In some people, cascara sagrada can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding.

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General ...Orally, cascara sagrada seem to be well tolerated when used appropriately, short-term.
Most Common Adverse Effects:
Orally: Mild abdominal discomfort and cramps.
Serious Adverse Effects (Rare):
Orally: Hepatotoxicity. Fresh or improperly aged cascara sagrada bark can cause severe vomiting.

Endocrine ...Orally, long-term use of cascara sagrada can lead to potassium depletion (4).

Gastrointestinal ...Orally, cascara sagrada can commonly cause mild abdominal discomfort, colic, and cramps (4). In some cases, chronic use can cause pseudomelanosis coli. Pseudomelanosis coli (pigment spots in intestinal mucosa) is believed to be harmless, usually reverses with discontinuation, and is not directly associated with an increased risk of developing colorectal adenoma or carcinoma (6138).
Fresh or improperly aged cascara sagrada bark can cause severe vomiting due to the presence of free anthrone constituents (2,92307).

Genitourinary ...Orally, long-term use of cascara sagrada can lead to albuminuria and hematuria (4).

Hepatic ...There is some concern about potential liver problems with cascara sagrada. In some cases, cascara sagrada bark 750-1275 mg (containing approximately 21 mg cascaroside) daily in divided doses for three days resulted in cholestatic hepatitis, ascites, and portal hypertension. Symptoms resolved following discontinuation of cascara sagrada (6895,92306).

Musculoskeletal ...Orally, long-term use of cascara sagrada can lead to muscle weakness and finger clubbing (4).

Other ...Orally, long-term use of cascara sagrada can lead to cachexia (4).

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