IGF-1 [Discontinued] by NOW

INSUFFICIENT RELIABLE EVIDENCE to RATE

• Aging. Although there has been interest in using oral deer velvet for anti-aging effects, there is insufficient reliable information about the clinical effects of deer velvet for this purpose.
• Anemia of chronic disease. Although there has been interest in using oral deer velvet for anemia of chronic disease, there is insufficient reliable information about the clinical effects of deer velvet for this purpose.
• Asthma. Although there has been interest in using oral deer velvet for asthma, there is insufficient reliable information about the clinical effects of deer velvet for this purpose.
• Athletic performance. It is unclear if oral deer velvet extract or powder is effective for improving athletic performance. Details: One small clinical study in active adult males participating in a strength training program shows that taking deer velvet extract 300 mg or deer velvet powder 1.5 grams daily for 10 weeks does not improve squat strength or aerobic capacity when compared with placebo. However, taking deer velvet might produce modest improvements in knee extension strength and endurance (47108).
• Cardiovascular disease (CVD). Although there has been interest in using oral deer velvet for CVD, there is insufficient reliable information about the clinical effects of deer velvet for this purpose.
• Cognitive function. Although there has been interest in using oral deer velvet to improve cognitive function, there is insufficient reliable information about the clinical effects of deer velvet for this purpose.
• Erectile dysfunction (ED). Although there has been interest in using oral deer velvet for ED, there is insufficient reliable information about the clinical effects of deer velvet for this purpose.
• Fatigue. Although there has been interest in using oral deer velvet for fatigue, there is insufficient reliable information about the clinical effects of deer velvet for this purpose.
• Hypertension. Although there has been interest in using oral deer velvet for hypertension, there is insufficient reliable information about the clinical effects of deer velvet for this purpose.
• Osteoporosis. Although there has been interest in using oral deer velvet for osteoporosis, there is insufficient reliable information about the clinical effects of deer velvet for this purpose.
• Sexual desire. It is unclear if oral deer velvet powder is effective for improving sexual desire. Details: One small clinical study in adult males shows that taking deer velvet powder 1 gram daily for 12 weeks does not improve sexual function or desire in males or their female partners when compared with placebo (47106).
• Uterine fibroids. Deer velvet has only been evaluated in combination with other ingredients; its effect when used alone is unclear. Details: A meta-analysis of nine small clinical trials shows that taking traditional Chinese medicine decoctions containing deer velvet or ejiao, a gelatin product extracted from donkey skin, along with other herbal ingredients plus mifepristone reduces uterine fibroid volume and improves symptoms associated with uterine fibroids when compared with mifepristone alone (106850). It is unclear if these findings are due to deer velvet, other ingredients, or the combination.
• Wound healing. Although there has been interest in using oral deer velvet for wound healing, there is insufficient reliable information about the clinical effects of deer velvet for this purpose. More evidence is needed to rate deer velvet for these uses.

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POSSIBLY SAFE ...when used orally and appropriately, short-term. Deer velvet powder has been used with apparent safety at a dose of 1-1.5 grams daily for up to 10-12 weeks (47106,47108).

PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.

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CONTRACEPTIVE DRUGS Interaction Rating = Minor Be watchful with this combination. Severity = Moderate •  Occurrence = Unlikely •  Level of Evidence = D Theoretically, deer velvet might interfere with the effectiveness of contraceptive drugs.  Details Laboratory research shows that deer velvet contains small quantities of estradiol and testosterone (47110). While clinical research shows that taking deer velvet extract does not raise testosterone levels, estradiol levels were not measured (47108).

ESTROGENS Interaction Rating = Minor Be watchful with this combination. Severity = Moderate •  Occurrence = Unlikely •  Level of Evidence = D Theoretically, deer velvet might increase the effects and side effects of estrogens.  Details Laboratory evidence shows that deer velvet contains small quantities of estradiol and testosterone (47110). While clinical research shows that taking deer velvet extract does not raise testosterone levels, estradiol levels were not measured (47108).

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General ...Orally, deer velvet powder or extract seems to be well tolerated, short-term. However, a thorough evaluation of safety outcomes has not been conducted.

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