Ingredients | Amount Per Serving |
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Proprietary Extract Blend
(Extraction rate 187 mg fresh herb & 84 mg dry herb per 0.7 ml.)
(Proprietary Extract Blend Note: Extraction rate 187 mg fresh herb & 84 mg dry herb per 0.7 ml. )
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654 mg |
(Lycopus spp. )
(flowering herb)
((certified organic) (sustainably wildcrafted))
(Bugleweed PlantPart: flowering herb Genus: Lycopus Species: spp. Note: (certified organic) (sustainably wildcrafted) )
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(Leonurus cardiaca )
(leaf & flowering top)
(certified organic)
(Motherwort PlantPart: leaf & flowering top Genus: Leonurus Species: cardiaca Note: certified organic )
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(Selenicereus spp. )
(stem)
((sustainably wildcrafted) (fresh (undried)))
(Cactus PlantPart: stem Genus: Selenicereus Species: spp. Note: (sustainably wildcrafted) (fresh (undried)) )
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(Melissa officinalis )
(leaf & flowering top)
((certified organic) (fresh (undried)))
(Lemon Balm PlantPart: leaf & flowering top Genus: Melissa Species: officinalis Note: (certified organic) (fresh (undried)) )
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certified organic Cane Alcohol Note: 53-63%, distilled Water, Vegetable Glycerin
Below is general information about the effectiveness of the known ingredients contained in the product Thyroid Calming. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
There is insufficient reliable information available about the effectiveness of cereus.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Thyroid Calming. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
There is insufficient reliable information available about the safety of bugleweed when used orally.
PREGNANCY: LIKELY UNSAFE
when used orally (12,19).
Bugleweed has anti-gonadotropic and anti-thyrotropic activity (7,19); avoid using.
LACTATION: POSSIBLY UNSAFE
when used orally (12,19) because it might have anti-prolactin activity (7,19); avoid using.
POSSIBLY SAFE ...when the flower or stem is used orally for non-cardiac conditions (12). Although it contains cactine, which may have a digitalis-like effect, there are no reports of human toxicity (12).
POSSIBLY UNSAFE ...when used orally to self-medicate for cardiac conditions. There is insufficient reliable information available about the safety of cereus for its other uses.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
LIKELY SAFE ...when used orally in amounts commonly found in foods. Lemon balm has Generally Recognized as Safe (GRAS) status in the US (4912).
POSSIBLY SAFE ...when used orally and appropriately, short-term. Lemon balm extract has been used with apparent safety at a dose of 500 mg daily for 6 months or at a dose of 3000 mg daily for 2 months (9993,9994,104435,104435,110136). ...when used topically and appropriately, short-term. Lemon balm 1% dried leaf extract has been used up to 4 times daily with apparent safety for a few days (790,9995).
CHILDREN: POSSIBLY SAFE
when used orally and appropriate, short-term.
A single dose of lemon balm extract 3-6 mg/kg has been safely used in children aged 6-7 years (19525). A specific combination product providing lemon balm leaf extract 80 mg and valerian root extract 160 mg (Euvegal forte, Dr. Willmar Schwabe Pharmaceuticals) 1-2 tablets once or twice daily has been safely used in children under 12 years of age for 30 days (14416). In infants up to 4 weeks old, multi-ingredient products (ColiMil, ColiMil Plus) containing lemon balm 64-97 mg daily have been used with apparent safety for up to 7 days (16735,96278).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
POSSIBLY SAFE ...when used orally and appropriately. A motherwort extract in soybean oil has been used with apparent safety at doses of 1200 mg daily for up to 28 days (94209) ...when administered intramuscularly, short-term. One or more intramuscular injections have been used with apparent safety in total combined doses of 40-200 mg over 48 hours or less to prevent and/or stop postpartum bleeding (94203,101890,101891,101892). Post-marketing surveillance of over 8000 females found that a specific motherwort product (Chengdu No 1 Pharma Company Ltd) has been used without significant adverse effects for a duration of 48 hours or less (104855) ...when administered by intrauterine injection, short-term. Post-marketing surveillance of over 1800 patients found that a specific motherwort product (Chengdu No 1 Pharma Company Ltd) has been used without significant adverse effects for a duration of 48 hours or less (104855).
PREGNANCY: LIKELY UNSAFE
when used orally or by injection.
Alkaloids present in motherwort have uterine stimulant effects (4,12,19).
LACTATION:
Insufficient reliable information available; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Thyroid Calming. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, bugleweed may alter thyroid function.
Details
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Cereus may potentiate the actions of cardiac glycosides and may enhance the effect of other cardiac drugs (6002).
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Theoretically, excessive doses of cereus may interact with MAOIs, because of the tyramine content (4).
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Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Details
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Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
Details
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity (19727,19728). In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion (19726).
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Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Details
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Below is general information about the adverse effects of the known ingredients contained in the product Thyroid Calming. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...There is limited information available about the safety of bugleweed.
Serious Adverse Effects (Rare):
Orally: Decreased thyroid function.
Cardiovascular ...Orally, disturbances of the cardiac rhythm have been reported for one patient in a clinical trial taking oral bugleweed (100065).
Endocrine ...Orally, bugleweed can cause thyroid enlargement during extended therapy or with large amounts, but this is rare (7). The sudden discontinuation of bugleweed might result in a sudden increase in thyroid function (2) and prolactin secretion (7).
General
...Orally, lemon balm seems to be well tolerated in food amounts and larger, medicinal amounts.
Topically, lemon balm seems to be well tolerated.
Serious Adverse Effects (Rare):
Orally: Wheezing has been rarely reported.
Cardiovascular ...Orally, a case of transient complete atrioventricular block and QT prolongation is reported in a 25-year-old female following the post-workout use of a specific product (Muscle Eze Advanced) containing lemon balm and several other ingredients. Symptoms of fatigue and lightheadedness started 1 week into use of the product. Product discontinuation led to restoration of normal sinus rhythm within 24 hours and normalization of the electrocardiogram within 2 weeks (112556). It is unclear whether this occurrence is due to lemon balm, other ingredients, or the combination.
Dermatologic ...Topically, lemon balm 1% cream applied 5 times daily to cold sores has been associated with two cases of irritation and one case of cold sore exacerbation. However, these effects do not appear to occur more often with lemon balm than with placebo (790).
Gastrointestinal ...Orally, lemon balm might increase appetite in some patients (91732,104433). Nausea, vomiting, and abdominal pain have been reported rarely and do not seem to occur more often than in patients taking placebo (9993).
Neurologic/CNS ...Orally, lemon balm has been reported to cause dizziness and sedation; however, it does not seem to occur more often with lemon balm than placebo (9993,104433). Additionally, other clinical research shows that using lemon balm in conjunction with alcohol does not affect reaction time or influence cognitive performance (19427,19723).
Pulmonary/Respiratory ...Orally, lemon balm has been associated with rare cases of wheezing (9993).
General
...Orally or via intramuscular or intrauterine injection, motherwort appears to be generally well tolerated.
Most Common Adverse Effects:
Orally: Diarrhea, stomach irritation.
Topically: Contact dermatitis, photosensitivity.
Intramuscular / Intrauterine: Abdominal pain, erythema, eyelid edema, fever, nausea, pruritus, rash.
Dermatologic ...Motherwort leaves can cause contact dermatitis, and the oil may cause photosensitivity reactions (4). Intramuscularly and via intrauterine injection, mild erythema, rash, and pruritus have been reported (101892,104855).
Gastrointestinal ...Orally, use of motherwort in amounts greater than 3 grams can cause diarrhea and stomach irritation (12). Intramuscularly and via intrauterine injection, abdominal pain and nausea have been reported (104855).
Genitourinary ...Orally, use of motherwort in amounts greater than 3 grams can cause uterine bleeding (12).
Immunologic ...Motherwort can also cause allergic reactions in sensitive individuals (4). Intramuscularly and via intrauterine injection, transient fever and chills lasting less than 24 hours have been reported (104855).
Ocular/Otic ...Intramuscularly and via intrauterine injection, transient eyelid edema lasting less than 24 hours has been reported (104855).