Ingredients | amount per serving |
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(Coleus forskohlii )
(root)
(standardized to 10% Forskolin)
(Coleus forskohlii root extract (Form: standardized to 10% Forskolin) PlantPart: root Genus: Coleus Species: forskohlii )
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90 mg |
Rice powder, Vegetable Cellulose Capsule, Silica
Below is general information about the effectiveness of the known ingredients contained in the product Coleus Forskohlii 90 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Coleus Forskohlii 90 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
POSSIBLY SAFE ...when used orally and appropriately, short-term. Coleus extract 500 mg daily has been used for up to 3 months without significant adverse effects (91885,100851). ...when used intravenously and appropriately, short-term. Intravenous forskolin, a constituent of coleus, seems to be safe when given at an appropriate rate of 0.5 mcg/kg/minute and increased at 15 minute intervals to 1.0, 2.0, and 3.0 mcg/kg/minute up to 1 hour (7278,7279). ...when used by inhalation and appropriately. Single-dose inhalation of forskolin powder 10 mg from a Spinhaler inhalator seems to be safe and well-tolerated (7281). ...when used ophthalmologically and appropriately. Coleus suspension eye drops (1%) have been safely used in clinical studies (7282,7283,7284,7402,7403,7405).
POSSIBLY UNSAFE ...when used orally in higher doses. Although coleus extracts have been used with apparent safety in doses up to 1.4 grams daily for 2 months (91884), taking coleus extract in doses exceeding 500 mg daily has been associated with an increased incidence of adverse effects, which are primarily gastrointestinal (100851).
PREGNANCY: POSSIBLY UNSAFE
when used orally.
Evidence from animal research suggests that high doses of coleus can inhibit embryo implantation and/or delay fetal development (25174); avoid using.
LACTATION:
Insufficient reliable information available; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Coleus Forskohlii 90 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
There is some evidence forskolin, a constituent of coleus, can inhibit platelet aggregation and adhesion (7410,7411,7412). Theoretically, concomitant use of coleus and anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding. Some anticoagulant and antiplatelet drugs include abciximab (ReoPro), anagrelide (Agrylin), antithrombin III (Thrombate III), ardeparin (Normiflo), cilostazol (Pletal), clopidogrel (Plavix), dalteparin (Fragmin), danaparoid (Orgaran), dicumarol, dipyridamole (Persantine), enoxaparin (Lovenox), eptifibatide (Integrilin), heparin, lepirudin (Refludan), tirofiban (Aggrastat), and warfarin (Coumadin).
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Animal research shows that forskolin, a constituent of coleus, may lower blood pressure (7278,7279,44424,44431). Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension. Some antihypertensive drugs include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others.
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Using forskolin, a constituent of coleus, with calcium channel blockers such as verapamil (Calan, Covera-HS, Verelan), nifedipine (Procardia), and diltiazem (Cardizem, Dilacor, Tiazac) might cause additive coronary vasodilatory effects (7278,7279).
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Research on the effect of coleus on cytochrome P450 2C9 (CYP2C9) is conflicting. Some animal research shows that coleus extract can induce CYP2C9, while in vitro research shows that coleus can inhibit CYP2C9 (91891). Theoretically, taking coleus with drugs metabolized by CYP2C9 might affect drug levels and the risk of adverse effects. Until more is known, advise patients that taking coleus might increase or decrease levels of drugs metabolized by CYP2C9.
Details
Some drugs metabolized by CYP2C9 include celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), and S-warfarin (Coumadin).
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In vitro research shows that coleus can activate the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4 (44399,44412). Theoretically, coleus might induce CYP3A4 and decrease levels of drugs metabolized by this enzyme. Although the clinical significance of this is not known, use caution when considering concomitant use of coleus and other drugs affected by these enzymes. Drugs that might be affected include some calcium channel blockers (diltiazem, nicardipine, verapamil), chemotherapeutic agents (etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), glucocorticoids, cisapride (Propulsid), alfentanil (Alfenta), fentanyl (Sublimaze), losartan (Cozaar), fluoxetine (Prozac), midazolam (Versed), omeprazole (Prilosec), ondansetron (Zofran), propranolol (Inderal), fexofenadine (Allegra), and numerous others.
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Using forskolin, a constituent of coleus, with nitrates such as nitroglycerin (Nitro-Bid, Nitro-Dur, Nitrostat) and isosorbide (Imdur, Isordil, Sorbitrate) might cause additive coronary vasodilatory effects (7278,7279,44424).
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Preliminary research assessing the effect of coleus on warfarin metabolism is conflicting. Animal research shows that coleus extract induces cytochrome P450 2C9 (CYP2C9) enzymes and increases metabolism of warfarin; however, in vitro research shows that coleus inhibits CYP2C9 enzymes and might reduce warfarin metabolism (91891). Until more is known, advise patients to use coleus cautiously or avoid it if they taking warfarin.
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Below is general information about the adverse effects of the known ingredients contained in the product Coleus Forskohlii 90 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General ...Orally, intravenously, ophthalmologically, and by inhalation, coleus seems to be well tolerated (7278,7279,7282,7283,7284). Orally, coleus extract may cause dose-related gastrointestinal effects, including diarrhea, loose stools, nausea, vomiting, or constipation (91885,100851). Intravenously, the coleus constituent, forskolin, can cause tachycardia, flushing, and hypotension (7279,44424,44431). Inhalation of forskolin may cause tremor, restlessness, and irritation of the respiratory tract (7281). Ophthalmologically, forskolin may cause stinging of the eyes and conjunctival hyperemia (7283).
Cardiovascular ...Intravenously, the coleus constituent, forskolin, can cause tachycardia, flushing and hypotension (7279,44424,44431).
Dermatologic ...Two cases of contact dermatitis have been reported following airborne exposure to coleus (44426,44418).
Gastrointestinal ...Orally, coleus can cause dose-related diarrhea and other gastrointestinal symptoms. Increased bowel movements and loose stools have been reported in 1 of 15 patients taking coleus extract in a clinical trial (91885). Some retrospective evidence reports about a 10% rate of gastrointestinal adverse effects from oral coleus use; 81% of these adverse effects were related to diarrhea. Other reported adverse effects which occurred at a much lower rate, include nausea, vomiting, and/or constipation. Gastrointestinal effects appear to be dose-related; those taking less than 250 mg of coleus extract did not report any diarrhea, while all patients taking 1000 mg of coleus extract reported diarrhea (100851).
Neurologic/CNS ...Inhalation of forskolin, a constituent of coleus, can cause tremor and restlessness (7281).
Ocular/Otic ...Ophthalmologically, forskolin, a constituent of coleus, can cause stinging of the eyes and conjunctival hyperemia (7283).
Pulmonary/Respiratory ...Inhalation of forskolin, a constituent of coleus, can cause throat and upper respiratory tract irritation, and mild to moderate cough (7281).