Four tablets contain: Gamma Oryzanol 50 mg • Inosine 200 mg • Testicular Glan 600 mg • L-Ornithine 700 mg • Beta-Sitosterol 200 mg • Adrenal 400 mg • Thymus 400 mg.
Brand name products often contain multiple ingredients. To read detailed information about each ingredient, click on the link for the individual ingredient shown above.
This product has been discontinued by the manufacturer.
This product has been discontinued by the manufacturer.
Below is general information about the effectiveness of the known ingredients contained in the product Muscle Builder. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
There is insufficient reliable information available about the effectiveness of adrenal extract.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Muscle Builder. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY UNSAFE ...when used parenterally. Use of injectable adrenal extract has been associated with at least 50 cases of serious bacterial infections at injection sites (6620). Adrenal extracts are derived from animals so there is concern about contamination with diseased animal parts. So far, there are no reports of disease transmission to humans due to use of contaminated adrenal extracts. There is insufficient reliable information available about the safety of adrenal extract for its other uses.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
LIKELY SAFE ...when used orally and appropriately. Beta-sitosterol has been safely used at a dose of 130 mg daily for up to 18 months or a dose of up to 21.1 grams daily for up to 3 months (5327,5328,5329,5330,5331,5332,5333,5334,5336,5337) (7198,10638). There is insufficient reliable information available about the safety of beta-sitosterol when used topically.
CHILDREN: LIKELY SAFE
when used orally and appropriately.
Beta-sitosterol has been safely used at a dose of 2-4 grams three times daily for up to 3 months (3889,5331,5332,5333,5334,35067).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
POSSIBLY SAFE ...when used orally and appropriately. Gamma-oryzanol 300 mg daily has been used most commonly in clinical research without reports of adverse events (751,752,753,754,755,51111). ...when used topically and appropriately (51112).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
POSSIBLY SAFE ...when used orally and appropriately. Inosine has been used with apparent safety at doses of up to 3 grams daily for up to 24 months or at doses of up to 2 grams daily for 36 months (95287,95289,95290,95291,106854,106857,112396).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
POSSIBLY SAFE ...when used orally and appropriately, short-term. Ornithine hydrochloride has been used with apparent safety at doses up to 500 mg daily for up to 8 weeks and at doses up to 12 grams daily for up to 4 weeks (95226,110717).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
POSSIBLY SAFE . .when used orally and appropriately. Purified thymus extract has been used with apparent safety in clinical trials (938,1010,1175,1176,1177,1178,6691,6694,6696,6697,6698,6699). There is some concern for contamination with diseased animal parts (1825). However, so far there are no reports of disease transmission to humans due to use of contaminated thymus extract. There is insufficient reliable information available about the safety of thymus extract when used parenterally.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Muscle Builder. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Inosine might reduce the effects of antigout medications.
 Details
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Patients using immunosuppressive drugs are cautioned to avoid thymus extract products, unless they are certified pathogen-free. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), and other corticosteroids (glucocorticoids).
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Below is general information about the adverse effects of the known ingredients contained in the product Muscle Builder. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, no adverse reactions have been reported; however, adrenal extracts are derived from raw cow, pig, or sheep adrenal glands gathered from slaughterhouses and possibly from sick or diseased animals (6620).
Products made from contaminated or diseased organs might present a human health hazard. There is also some concern that adrenal extracts produced from cows in countries where bovine spongiform encephalitis (BSE) has been reported might be contaminated with diseased tissue (1825); however, there have been no reports of BSE transfer to humans from contaminated adrenal extract products.
Intravenously, adrenal extract can cause infection and abscess at the site of injection (6620). In 1996, the FDA issued a nationwide alert regarding an injectable adrenal cortex extract after more than 50 cases of serious bacterial infections at injection sites were reported (6620).
Dermatologic ...Intravenously, adrenal extract can cause infection and abscess at the site of injection (6620). In 1996, the FDA issued a nationwide alert regarding an injectable adrenal cortex extract after more than 50 cases of serious bacterial infections at injection sites were reported (6620).
Other ...Adrenal extracts are derived from raw cow, pig, or sheep adrenal glands gathered from slaughterhouses and possibly from sick or diseased animals (6620). Products made from contaminated or diseased organs might present a human health hazard. There is also some concern that adrenal extracts produced from cows in countries where bovine spongiform encephalitis (BSE) has been reported might be contaminated with diseased tissue. Countries where BSE has been reported include Great Britain, France, The Netherlands, Portugal, Luxembourg, Ireland, Switzerland, Oman, Belgium, and others (1825); however, there have been no reports of BSE transfer to humans from contaminated adrenal extract products. Until more is known, tell patients to avoid these products unless country of origin can be determined. Patients should avoid products that are produced in countries where BSE has been found.
General
...Orally, beta-sitosterol is generally well tolerated.
Topically, beta-sitosterol seems to be well tolerated.
Most Common Adverse Effects:
Orally: Constipation, diarrhea, gas, indigestion, and nausea.
Dermatologic ...Orally, beta-sitosterol can worsen acne when taken alone or in combination with saw palmetto (5331,15550).
Gastrointestinal
...Orally, beta-sitosterol can cause nausea, indigestion, gas, diarrhea, or constipation (5327,5328).
Beta-sitosterol can also reduce the appetite (5334). There is a case report of acute pancreatitis thought to be associated with taking beta-sitosterol in a 57-year-old male. Symptoms started the first day of use, but did not return when he stopped taking beta-sitosterol (106080).
Single reports of reduced appetite, flatulence, and diarrhea have been reported for patients taking a combination of saw palmetto and beta-sitosterol (15550).
Genitourinary ...Orally, beta-sitosterol can cause erectile dysfunction and loss of libido (5327,5329).
General ...Gamma-oryzanol is generally well tolerated. No adverse effects have been reported. However, a thorough evaluation of safety outcomes has not been conducted.
General
...Orally, inosine seems to be well tolerated.
Most Common Adverse Effects:
Orally: Hyperuricemia, nephrolithiasis, uric acid crystals, urinary tract stones.
Serious Adverse Effects (Rare):
Orally: Hypertension, kidney dysfunction.
Cardiovascular ...Orally, inosine was reported to cause mild elevation of blood pressure in 6% of patients in one clinical trial (95289).
Endocrine ...Orally, inosine increases serum uric acid levels in a dose-dependent manner, which can cause non-symptomatic hyperuricemia (95288,95289).
Gastrointestinal ...Orally, inosine has been reported to cause nausea (95289,106854).
Genitourinary ...Orally, inosine has been reported to cause uric acid crystals and symptomatic uric acid kidney stones. Uric acid kidney stones occurred more frequently when inosine was taken concurrently with calcium supplements (95287,95289,95290,106854,112395).
Renal ...Orally, inosine 1-2 grams daily has been reported to cause acute renal colic in patients with multiple sclerosis (95288). Inosine has also been reported to cause reversible reductions in kidney function (106854).
General
...Orally, ornithine seems to be well-tolerated.
However, a thorough evaluation of safety outcomes has not been conducted.
Most Common Adverse Effects:
Orally: Gastrointestinal symptoms (unspecified)
Gastrointestinal ...Orally, ornithine might cause adverse gastrointestinal effects. In a small, uncontrolled trial, gastrointestinal symptoms were reported in around 22% of individuals taking ornithine 3.2-12 grams daily (110717).
Genitourinary ...Orally, ornithine has been associated with one case of hematuria. In a small, uncontrolled trial, hematuria was reported in one individual taking ornithine, which resolved quickly without treatment when ornithine was discontinued. While the researchers suspected the hematuria was not related to ornithine supplementation, no cause could be determined (110717).
General ...Orally, thymus extract seems to be well tolerated. No adverse effects have been reported in clinical trials (938,1010,1175,1176,1177,1178,6691,6694,6696,6697,6698,6699). However, there is some concern about potential contamination. Thymus extract is derived from raw bovine thymus glands gathered from slaughterhouses, possibly from sick or diseased animals (6620). Products made from contaminated or diseased organs might present a human health hazard. There is also concern that thymus extract produced from cows in countries where bovine spongiform encephalitis (BSE) has been reported might be unsafe (1825). However, there are no reports of disease transfer to humans from contaminated thymus extract.
Immunologic ...In one case report, severe anaphylactic reaction associated with thymostimulin administration occurred in a 36-year-old male being treated for a neck tumor (78453).
Other
...Thymus extract is derived from raw bovine thymus glands gathered from slaughterhouses, possibly from sick or diseased animals (6620).
Products made from contaminated or diseased organs might present a human health hazard. However, there are no reports of disease transfer to humans from contaminated thymus extract.
There is also some concern that thymus extract that is obtained from cows in countries where bovine spongiform encephalitis (BSE) has been reported might be unsafe. However, there are no reports of BSE transfer to humans from contaminated thymus extract. Countries where BSE has been reported include Great Britain, France, The Netherlands, Portugal, Luxembourg, Ireland, Switzerland, Oman, and Belgium (1825). Until more is known, tell patients to avoid these products unless country of origin can be determined. Patients should avoid products that are produced in countries where BSE has been found.
