Each tablet contains: Salabmisri 78 mg • Kokilaksha 38 mg • Vanya Kahu 20 mg • Kapikachchhu 20 mg • Suvarnavang 20 mg • Vriddadaru extract 38 mg • Gokshura extract 38 mg • Jeevanti extract 38 mg • Shaileyam extract 20 mg.
Brand name products often contain multiple ingredients. To read detailed information about each ingredient, click on the link for the individual ingredient shown above.
Below is general information about the effectiveness of the known ingredients contained in the product Extra Time. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
There is insufficient reliable information available about the effectiveness of Hawaiian baby woodrose.
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Extra Time. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
POSSIBLY SAFE ...when used orally and appropriately. Powdered formulations of cowhage seed that are standardized to provide levodopa 75-400 mg daily have been used with apparent safety for up to 20 weeks (7020,7203,97266).
POSSIBLY UNSAFE ...when the hair of the cowhage bean pod is used orally or topically. The bean pod hairs are strong irritants and can cause severe itching, burning, and inflammation (18).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
LIKELY UNSAFE ...when used orally (17,5301). The seeds of Hawaiian baby woodrose have effects similar to the hallucinogen lysergic acid diethylamide (LSD), including flashbacks and hallucinations. In one case, severe agitation led to death due to jumping from a high point (5301,97867,103857,103858,103860).
PREGNANCY AND LACTATION: LIKELY UNSAFE
when used orally (17,5301); avoid using.
LIKELY UNSAFE ...when the spine-covered fruit is used orally. There have been reports of bilateral pneumothorax and bronchial polyp after oral consumption of the spine-covered fruit (818).
PREGNANCY: POSSIBLY UNSAFE
when used orally.
Animal research suggests that tribulus might adversely affect fetal development (12674); avoid using.
LACTATION:
Insufficient reliable information available; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Extra Time. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
 Details
Cowhage contains levodopa (7020,7205,46334,46336,94723,94724). Use of levodopa with cyclopropane or halogenated hydrocarbon anesthesia has led to arrhythmias. Other anesthetics have not been implicated (15). Use other anesthetics in patients taking cowhage or tell patients to stop taking cowhage at least 2 weeks before surgery.
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Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
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Animal research shows that cowhage might have hypoglycemic effects (7221).
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Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
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Theoretically, concomitant use of cowhage and guanethidine might increase the risk of hypotension.
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Concomitant use can increase the risk of levodopa-related adverse effects.
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Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
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Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
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Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.
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Theoretically, concomitant use may increase the risk for serotonergic adverse effects.
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Hawaiian baby woodrose contains chemicals which might increase serotonin levels. Combining serotonergic drugs with Hawaiian baby woodrose might increase the risk of serotonergic side effects including serotonin syndrome and cerebral vasoconstrictive disorders (8056).
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Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
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Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications (97327).
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Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
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Theoretically, tribulus might increase the levels and clinical effects of lithium.
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Tribulus is thought to have diuretic properties (12681). Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
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Below is general information about the adverse effects of the known ingredients contained in the product Extra Time. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, adverse effects to cowhage seem to be rare; however, a thorough safety evaluation has not been conducted.
Topically, cowhage bean pod or seed may be unsafe.
Most Common Adverse Effects:
Orally: Diarrhea, flatulence, mucosal irritation.
Topically: Erythema, pruritus, rash.
Cardiovascular ...Orally, cowhage has been reported to cause palpitations (7021,7203)
Dermatologic
...Orally, ingestion of hairs from the bean pod or seed can result in significant mucosal irritation and should be avoided.
Topically, hairs on cowhage bean pod or seed can cause severe pruritus (6898). Symptoms include severe itching, burning, inflammation, and erythematous macular rashes (18,6898). Symptoms resolve spontaneously within several hours, but may also be relieved with antihistamines (6898). The hairs can be removed from the skin by washing, but the hairs can also be retained, and transferred to other people, in fabrics and carpets. Clothing and other materials that come in contact with cowhage hairs should also be thoroughly washed (6898).
Gastrointestinal ...Orally, cowhage has been reported to cause flatulence, diarrhea, and dry mouth (7021,7203). Orally, a specific powdered cowhage seed extract (Zandopa, formerly HP-200; Zandu Pharmaceuticals) has been reported to cause nausea, abdominal distention, and vomiting in clinical research when taken in amounts of 22.5-67.5 grams divided into 2-5 doses per day (7020).
Musculoskeletal ...Orally, dyskinesia has been reported in clinical research in about 3% of patients taking a specific powdered cowhage seed extract (Zandopa, formerly HP-200; Zandu Pharmaceuticals) 22. 5-67.5 grams divided into 2-5 doses daily (7020).
Neurologic/CNS ...Orally, cowhage has been reported to cause headaches (7021,7203). Orally, insomnia has been reported in clinical research in about 3% of patients taking a specific powdered cowhage seed extract (Zandopa, formerly HP-200; Zandu Pharmaceuticals) 22.5 grams to 67.5 grams divided into 2-5 doses daily (7020).
Psychiatric ...In a case report, cowhage caused an outbreak of acute toxic psychosis. Symptoms of psychosis included confusion, giddiness, agitation, hallucinations, and paranoid delusions. The cowhage-induced psychosis was successfully treated with intravenous chlorpromazine (7021).
Other ...Orally, cowhage has been reported to cause sweating and changes in urine color, (7021,7203). Theoretically, due to the levodopa constituent, cowhage is likely to cause the same adverse effects that have been attributed to purified, prescription levodopa. Some of these side effects include elevated liver enzymes, respiratory disturbances, urinary retention, muscle cramps, and priapism (15). However, these effects have not yet been reported for cowhage.
General
...Hawaiian baby woodrose is generally regarded as unsafe for use.
Any benefits of therapy may not outweigh the risk of toxicity. The number of seeds needed to produce adverse effects differs for each individual.
Most Common Adverse Effects:
Orally: Dizziness, fatigue, hallucinations, hypertension, mydriasis, paranoia, sweating, tachycardia.
Cardiovascular ...Orally, approximately four homogenized Hawaiian baby woodrose seeds have been reported to cause temporary blood pressure elevation (103857). In one 18-year-old male, consuming 15 Hawaiian baby woodrose seeds resulted in tachycardia and hypertension. The patient also used cannabis, but symptoms were thought to be related to Hawaiian baby woodrose (103858). The number of seeds needed to produce adverse effects differs for each individual. Additionally, the alkaloid and lysergic acid amide contents vary from batch to batch (103857).
Dermatologic ...Orally, Hawaiian baby woodrose seeds can cause sweating (5301).
Gastrointestinal ...Orally, four homogenized Hawaiian baby woodrose seeds have been reported to cause nausea and vomiting (103857). The number of seeds needed to produce adverse effects differs for each individual. Additionally, the alkaloid and lysergic acid amide contents vary from batch to batch (103857).
Neurologic/CNS ...Orally, four homogenized Hawaiian baby woodrose seeds have been reported to cause fatigue lasting for 2 hours and tremor of the hands lasting for about 9 hours in one person (103857). Weakness, vertigo, and heaviness in the legs have also been reported (103857). The seeds have also been reported to cause auditory hallucinations and altered visual perception (5301,103857,103860). The number of seeds needed to produce adverse effects differs for each individual. Additionally, the alkaloid and lysergic acid amide contents vary from batch to batch (103857). Lysergic acid amide 2-5 mg is enough to cause hallucinations, with effects lasting 4-8 hours (5301,5304,97867).
Ocular/Otic ...Orally, Hawaiian baby woodrose seeds can cause blurred vision, dilated pupils, and involuntary, rapid, rhythmic movement of eyeballs (5301,103857).
Psychiatric
...Orally, four homogenized Hawaiian baby woodrose seeds has been reported to cause difficulty expressing thoughts, fits of laughter, and paranoia in one person (103857).
The seed has also been reported to cause mood elevation and anxiety (103857,103860). In an 18-year-old male, ingestion of 15 seeds resulted in erratic and bizarre behavior accompanying suicidal and homicidal ideation and depression. The patient also used cannabis, but symptoms were thought to be related to Hawaiian baby woodrose (103858). In one case report of a 29-year-old male, consuming an unknown quantity of soaked Hawaiian baby woodrose seeds and smoking cannabis resulted in severe agitation leading to a jump from a fourth-floor window and death (97867). In a 17-year-old female, ingestion of 6 seeds initially resulted in a euphoric and energetic mood, with increased socializing and school performance. The patient then developed problems with concentration, thinking, and sleep, with nightmares, anxiety, suspiciousness, and crying, resulting in hospital admission and treatment for psychosis with aripiprazole 10 mg daily and lorazepam as needed. Most symptoms resolved within 7 weeks; however, problems with concentration continued for several more weeks. Aripiprazole was discontinued 22 weeks after discharge (109536).
The number of seeds needed to produce adverse effects differs for each individual. Additionally, the alkaloid and lysergic acid amide contents vary from batch to batch (103857). Lysergic acid amide 2-5 mg is enough to cause hallucinations (97867).
General
...Orally, tribulus seems to be well tolerated.
Serious Adverse Effects (Rare):
Orally: Cases of liver and kidney injury, seizures, and chronic painful erection with impaired sexual function have been reported. Pneumothorax and bronchial polyp after consuming the spine-covered tribulus fruit have been reported.
Gastrointestinal ...Orally, tribulus can cause abdominal pain, cramping, nausea, vomiting, diarrhea, and constipation (92022,92027). However, in one study, the rates of these gastrointestinal complaints were similar for patients taking tribulus and those receiving placebo (92022).
Genitourinary ...In one case report, a patient taking two tribulus tablets (unknown dose) daily for 15 days presented to the local emergency department with a painful erection lasting 72 hours. The priapism was resolved with medical management; however, post-episode sexual function was impaired (92023).
Hepatic ...In one case report, a patient drinking tribulus water 2 liters daily for two days presented with lower limb weakness, seizures, hepatitis, and acute kidney injury. The patient's condition improved after hemodialysis and discontinuation of tribulus water (92069).
Neurologic/CNS ...Orally, tribulus has been reported to cause general excitation and insomnia. These symptoms were reversed upon discontinuation of the drug or decreasing the dose (78867). In one case report, a patient drinking tribulus water 2 liters daily for two days presented with lower limb weakness, seizures, hepatitis, and acute kidney injury. The patient's condition improved after hemodialysis and discontinuation of tribulus water (92069).
Pulmonary/Respiratory ...In one case report, a patient developed a bilateral pneumothorax after consuming the spine-covered fruit of tribulus (818). In another case report, a patient developed a polyp in the lobar bronchus of the right interior lobe due to the presence of a tribulus fruit spine (78852).
Renal ...In one case report, a patient drinking tribulus water 2 liters daily for two days presented with lower limb weakness, seizures, hepatitis, and acute kidney injury. The patient's condition improved after hemodialysis and discontinuation of the tribulus water (92069). In another case report, a healthy male taking one tribulus tablet (unknown dose) daily for a few months for bodybuilding purposes developed hyperbilirubinemia followed by acute kidney failure 2-3 weeks later. The patient was managed with intravenous fluids and a low-salt, low-protein diet (92025).
Other ...In one case report, gynecomastia was observed in a male weightlifter taking an herbal combination product containing tribulus. However, it is not clear if this adverse effect can be attributed to tribulus alone (78859).
