Each capsule contains: Polypodium Leucotomos extract 120 mg • Polypodium Leucotomos rhizome 280 mg.
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Below is general information about the effectiveness of the known ingredients contained in the product Kalawalla. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Kalawalla. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
POSSIBLY SAFE ...when used orally and appropriately. Specific Polypodium leucotomos extracts (Fernblock, Cantabria Farmaceutica; Anapsos, ASAC Pharma; others) have been used safely for up to 6 months (14365,14367,14479,99276,99282,99283,101470,105522). The most common doses used have been 360-480 mg daily. Higher doses of 960-1200 mg daily have been used for shorter durations of 2-4 weeks, although a specific extract (Fernblock, Cantabria Laboratories) has been used at a dose of 960 mg daily for 6 months (14365,99276,99282,105522). ...when used topically and appropriately, short-term. A specific Polypodium leucotomos extract (Difur, Cantabria Farmaceutica) has been safely used at doses of up to 50% in a lotion (14476).
CHILDREN: POSSIBLY SAFE
when used orally, short-term.
A specific Polypodium leucotomos extract (Anapsos, ASAC Pharma) has been safely used for up to 6 months at doses of 240 mg daily in children aged 2-5 years, 360 mg daily in children aged 6-12 years, and 480 mg daily in children over 12 years of age (99277).
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Kalawalla. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, Polypodium leucotomos might increase levels of drugs metabolized by CYP3A4.
Details
In vitro and animal research suggests that Polypodium leucotomos can decrease the metabolism of midazolam by a mechanism possibly related to the inhibition of CYP3A4. However, a small study in humans suggests that taking Polypodium leucotomos with midazolam does not affect the metabolism of midazolam (110894).
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Below is general information about the adverse effects of the known ingredients contained in the product Kalawalla. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General ...Orally and topically, Polypodium leucotomos seems to be well tolerated. However, a thorough evaluation of safety outcomes has not been conducted on the topical use of Polypodium leucotomos.
Dermatologic ...Orally, Polypodium leucotomos has rarely been associated with pruritus (101470).
Gastrointestinal ...Orally, Polypodium leucotomos has rarely been associated with gastrointestinal symptoms in some patients (14369,101470,110903).