References
Malic Acid
3262
Russell IJ, Michalek JE, Flechas JD, Abraham GE. Treatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo controlled, crossover pilot study. J Rheumatol 1995;22:953-8. View abstract.
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Leonhardt M, Balkan B, Langhans W. Effect of hydroxycitrate on respiratory quotient, energy expenditure, and glucose tolerance in male rats after a period of restrictive feeding. Nutrition 2004;20(10):911-915. View abstract.
26968
Fiume, Z. Final report on the safety assessment of malic acid and sodium malate. Int J Toxicol 2001;20 Suppl 1:47-55. View abstract.
26969
Electronic Code of Federal Regulations. Title 21. Part 184 - Direct Food Substances Affirmed as Generally Recognized as Safe. Available at: http://www.ecfr.gov/cgi-bin/text-idx?c=ecfr&sid=786bafc6f6343634fbf79fcdca7061e1&rgn=div5&view=text&node=21:3.0.1.1.14&idno=21#se21.3.184_11069.
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Saleem R, Ahmad M, Naz A, et al. Hypotensive and toxicological study of citric acid and other constituents from Tagetes patula roots. Arch Pharm Res 2004;27(10):1037-42. View abstract.
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Kelebek H, Selli S, Canbas A. Cabaroglu T. HPLC determination of organic acids, sugars, phenolic compositions and antioxidant capacity of orange juice and orange wine made from a Turkish cv. Kozan. Microchem J 2009;91(2):187-192.
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Gardner WH. "Chapter 5: Acidulants in food processing." CRC Handbook of Food Additives, Second Edition, Volume 1. Ed. Furia TE. Boca Raton, FL: CRC Press LLC, 1968.
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Baldo A, Bezzola P, Curatolo S, Florio T, Lo Guzzo G, Lo Presti M, Sala GP, Serra F, Tonin E, Pellicano M, Pimpinelli N. Efficacy of an alpha-hydroxy acid (AHA)-based cream, even in monotherapy, in patients with mild-moderate acne. G Ital Dermatol Venereol. 2010 Jun;145(3):319-22. View abstract.
92211
Gómez-Moreno G, Guardia J, Aguilar-Salvatierra A, Cabrera-Ayala M, Maté-Sánchez de-Val JE, Calvo-Guirado JL. Effectiveness of malic acid 1% in patients with xerostomia induced by antihypertensive drugs. Med Oral Patol Oral Cir Bucal. 2013 Jan 1;18(1):e49-55. View abstract.
92213
Gómez-Moreno G, Aguilar-Salvatierra A, Guardia J, Uribe-Marioni A, Cabrera-Ayala M, Delgado-Ruiz RA, Calvo-Guirado JL. The efficacy of a topical sialogogue spray containing 1% malic acid in patients with antidepressant-induced dry mouth: a double-blind, randomized clinical trial. Depress Anxiety. 2013 Feb;30(2):137-42. View abstract.
95564
Chiriac A, Brzezinski P. Topical malic acid in combination with citric acid: an option to treat recalcitrant warts. Dermatol Ther. 2015;28(6):336-8. View abstract.
95565
Gómez-Moreno G, Cabrera-Ayala M, Aguilar-Salvatierra A, et al. Evaluation of the efficacy of a topical sialogogue spray containing malic acid 1% in elderly people with xerostomia: a double-blind, randomized clinical trial. Gerodontology. 2014;31(4):274-80. View abstract.
95594
CFR - Code of Federal Regulations Title 21 SUBCHAPTER B. 184.1069 Malic Acid. Food and Drug Administration Department Of Health And Human Services. Updated April 1, 2017. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1069. Accessed January 23, 2018.
95595
Amended Safety Assessment of Malic Acid and Sodium Malate as Used in Cosmetics. Cosmetic Ingredient Review Expert Panel. Updated May 19, 2017. http://www.cir-safety.org/sites/default/files/malic%20acid.pdf. Accessed January 24, 2018.
101174
Bardellini E, Amadori F, Conti G, Veneri F, Majorana A. Effectiveness of a spray containing 1% malic acid in patients with xerostomia induced by graft-versus-host disease. Med Oral Patol Oral Cir Bucal. 2019;24(2):e190-e194. View abstract.
104757
Sanchez-Blanco I, Rodriguez-Tellez M, Corcuera-Flores JR, et al. Effectiveness of salivary stimulation using xylitol-malic acid tablets as coadjuvant treatment in patients with gastro-oesophageal reflux disease: early findings. Med Oral Patol Oral Cir Bucal. 2020 Nov 1;25(6):e818-e826. View abstract.
104778
da Mata ADSP, Amaral JPAR, Thomson WM, et al. Patient-related outcomes in Sjögren syndrome treated with stimulants of salivary secretion: Randomized clinical trial. Oral Dis. 2020 Mar;26(2):313-324. View abstract.
107916
Liu G, Qiu X, Tan X, Miao R, Tian W, Jing W. Efficacy of a 1% malic acid spray for xerostomia treatment: a systematic review and meta-analysis. Oral Dis 2021. View abstract.
107917
Marín C, Díaz-de-Valdés L, Conejeros C, Martínez R, Niklander S. Interventions for the treatment of xerostomia: a randomized controlled clinical trial. J Clin Exp Dent 2021;13(2):e104-e111. View abstract.
111742
Burnett CL, Bergfeld WF, Belsito DV, et al. Amended Safety Assessment of Malic Acid and Sodium Malate as Used in Cosmetics. Int J Toxicol 2022;41(3_suppl):69-76. View abstract.
111743
Muhamed SA, Moussa EM, Aboasy NK, Gaweesh YY. Effect of 1% malic acid spray on diabetes mellitus-induced xerostomia: A randomized clinical trial. Oral Dis 2022. View abstract.