Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.

Merck Index, 12th ed. Whitehouse Station: Merck Research Laboratories, 1996.

Tapiainen T, Luotonen L, Kontiokari T, et al. Xylitol administered only during respiratory infections failed to prevent acute otitis media. Pediatrics 2002;109:E19. View abstract.

Lee B, Sue D. Xylitol for prevention of dental caries. DICP 1989;23:691-2.

Uhari M, Kontiokari T, Koskela M, Niemela M. Xylitol chewing gum in prevention of acute otitis media: double-blind, randomized trial. BMJ 1996;313:1180-4. View abstract.

Uhari M, Kontiokari T, Niemela M. A novel use of xylitol sugar in preventing acute otitis media. Pediatrics 1998;102:879-84. View abstract.

Soderling E, Isokangas P, Pienihakkinen K, Tenovuo J. Influence of maternal xylitol consumption on acquisition of mutans streptococci by infants. J Dent Res 2000;79:882-7. View abstract.

Makinen KK. Can the pentitol-hexitol theory explain the clinical observations made with xylitol? Med Hypotheses 2000;54:603-13. View abstract.

Crapo PA. Use of alternative sweeteners in diabetic diet. Diabetes Care 1988;11:174-82. View abstract.

Makinen KK. The rocky road of xylitol to its clinical application. J Dent Res 2000;79:1352-5.

Gales MA, Nguyen TM. Sorbitol compared with xylitol in prevention of dental caries. Ann Pharmacother 2000;34:98-100. View abstract.

Gales MA, Nguyen TM. Sorbitol compared with xylitol in prevention of dental caries. Ann Pharmacother 2000;34:98-100. View abstract.

Everything added to food in the US. US Food and Drug Administration, November 2011. Available at: http://www.fda.gov/Food/FoodIngredientsPackaging/ucm115326.htm

Antonio AG, Pierro VS, Maia LC. Caries preventive effects of xylitol-based candies and lozenges: a systematic review. J Public Health Dent 2011;71:117-24. View abstract.

Azarpazhooh A, Limeback H, Lawrence HP, Shah PS. Xylitol for preventing acute otitis media in children up to 12 years of age. Cochrane Database Syst Rev 2011Nov 9;(11):CD007095. View abstract.

Azarpazhooh A, Lawrence HP, Shah PS. Xylitol for preventing acute otitis media in children up to 12 years of age. Cochrane Database Syst Rev 2016 Aug 3;(8):CD007095. View abstract.

Cocco F, Carta G, Cagetti MG, Strohmenger L, Lingström P, Campus G. The caries preventive effect of 1-year use of low-dose xylitol chewing gum. A randomized placebo-controlled clinical trial in high-caries-risk adults. Clin Oral Investig 2017 Mar 16. View abstract.

Janakiram C, Deepan Kumar CV, Joseph J. Xylitol in preventing dental caries: A systematic review and meta-analyses. J Nat Sci Biol Med 2017;8:16-21. View abstract.

Lin L, Tang X, Wei J, Dai F, Sun G. Xylitol nasal irrigation in the treatment of chronic rhinosinusitis. Am J Otolaryngol 2017;38:383-389. View abstract.

Marghalani AA, Guinto E, Phan M, Dhar V, Tinanoff. Effectiveness of xylitol in reducing dental caries in children. Pediatr Dent 2017;39:103-110. View abstract.

Mickenautsch S, Yengopal V. Effect of xylitol versus sorbitol: a quantitative systematic review of clinical trials. Int Dent J 2012;62:175-88. View abstract.

Simões Moraes R, Modesto A, Regina Netto Dos Santos K, Drake D. The effect of 1% chlorhexidine varnish and 40% xylitol solution on Streptococcus mutans and plaque accumulation in children. Pediatr Dent 2011;33:484-90. View abstract.

Thorild I, Lindau B, Twetman S. Long-term effect of maternal xylitol exposure on their children's caries prevalence. Eur Arch Paediatr Dent 2012;13:305-7. View abstract.

Weissman JD, Fernandez F, Hwang PH. Xylitol nasal irrigation in the management of chronic rhinosinusitis: a pilot study. Laryngoscope 2011;121:2468-72. View abstract.

Moyer VA; US Preventive Services Task Force. Prevention of dental caries in children from birth through age 5 years: US Preventive Services Task Force recommendation statement. Pediatrics 2014;133:1102-11. View abstract.

Riley P, Moore D, Ahmed F, Sharif MO, Worthington HV. Xylitol-containing products for preventing dental caries in children and adults. Cochrane Database Syst Rev 2015;(3):CD010743. View abstract.

Rethman MP, Beltrán-Aguilar ED, Billings RJ, et al.; American Dental Association Council on Scientific Affairs Expert Panel on Nonfluoride Caries-Preventive Agents. Nonfluoride caries-preventive agents: executive summary of evidence-based clinical recommendations. J Am Dent Assoc 2011;142(9):1065-1071. View abstract.

Okamoto K, Kagami M, Kawai M, et al. Anaphylaxis to xylitol diagnosed by skin prick test and basophil activation test. Allergol Int. 2019;68(1):130-131. View abstract.

Aluckal E, Ankola AV. Effectiveness of xylitol and polyol chewing gum on salivary streptococcus mutans in children: A randomized controlled trial. Indian J Dent Res. 2018;29(4):445-449. View abstract.

Electronic Code of Federal Regulations. Title 21. Part 101.80 - Health claims: dietary noncariogenic carbohydrate sweeteners and dental caries. Available at: https://www.ecfr.gov/cgi-bin/text-idx?SID=c7e427855f12554dbc292b4c8a7545a0&mc=true&node=pt21.2.101&rgn=div5#se21.2.101_180. Accessed August 17, 2020.

Silva CFFSD, Silva FERD, Pauna HF, Hurtado JGGM, Santos MC. Symptom assessment after nasal irrigation with xylitol in the postoperative period of endonasal endoscopic surgery. Braz J Otorhinolaryngol 2020:S1808-8694(20)30093-8. Online ahead of print. View abstract.

Badia P, Andersen H, Haslam D, et al. Improving oral health and modulating the oral microbiome to reduce bloodstream infections from oral organisms in pediatric and young adult hematopoietic stem cell transplantation recipients: a randomized controlled trial. Biol Blood Marrow Transplant 2020;26(9):1704-10. View abstract.

Ballini A, Cantore S, Signorini L, et al. Efficacy of Sea Salt-Based Mouthwash and Xylitol in Improving Oral Hygiene among Adolescent Population: A Pilot Study. Int J Environ Res Public Health 2020;18(1):44. View abstract.

Meyer-Gerspach AC, Drewe J, Verbeure W, et al. Effect of the Natural Sweetener Xylitol on Gut Hormone Secretion and Gastric Emptying in Humans: A Pilot Dose-Ranging Study. Nutrients 2021;13(1):174. View abstract.

Rabago D, Kille T, Mundt M, Obasi C. Results of a RCT assessing saline and xylitol nasal irrigation for CRS and fatigue in Gulf War illness. Laryngoscope Investig Otolaryngol 2020;5(4):613-620. View abstract.

Sánchez-Blanco I, Rodríguez-Téllez M, Corcuera-Flores JR, et al. Effectiveness of salivary stimulation using xylitol-malic acid tablets as coadjuvant treatment in patients with gastro-oesophageal reflux disease: early findings. Med Oral Patol Oral Cir Bucal 2020;25(6):e818-e826. View abstract.

Shaalan O, Gad HMA, Riad MI. Comparison of antibacterial effect of probiotic yogurt and xylitol-containing chewing gum in geriatric patients: A randomized controlled clinical trial. Acta Stomatol Croat 2021;55(4):380-389. View abstract.

Soler E, de Mendoza A, Cuello VI, et al. Intranasal xylitol for the treatment of COVID-19 in the outpatient setting: A pilot study. Cureus. 2022 Jul 23;14(7):e27182. View abstract.

Nasseripour M, Newton JT, Warburton F, et al. A systematic review and meta-analysis of the role of sugar-free chewing gum on plaque quantity in the oral cavity. Front Oral Health. 2022 Mar 30;3:845921. View abstract.

Hsu YC, Szu SY. Effects of gum chewing on recovery from postoperative ileus: A randomized clinical trial. J Nurs Res. 2022 Sep 5. doi: 10.1097/jnr.0000000000000510. View abstract.

Elkan Kiyat Z, Kahyaoglu Sut H. The effect of xylitol gum chewing after cesarean on bowel functions: A randomized controlled study. J Perianesth Nurs. 2022 Jun 21:S1089-9472(22)00073-9. View abstract.

Rodríguez-Agurto A, Bravo M, Magán-Fernandez A, et al. Randomized clinical trial on the clinical effects of a toothpaste containing extra virgin olive oil, xylitol, and betaine in gingivitis. Sci Rep 2023;13(1):6294. View abstract.

Bordier V, Teysseire F, Senner F, et al. Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study. Int J Mol Sci 2022;23(17):9867. View abstract.

Wołyniec W, Szwarc A, Kasprowicz K, et al. Impact of hydration with beverages containing free sugars or xylitol on metabolic and acute kidney injury markers after physical exercise. Front Physiol 2022;13:841056. View abstract.

He S, Choong EKM, Duangthip D, Chu CH, Lo ECM. Clinical interventions with various agents to prevent early childhood caries: A systematic review with network meta-analysis. Int J Paediatr Dent 2023. View abstract.

Witkowski M, Nemet I, Li XS, et al. Xylitol is prothrombotic and associated with cardiovascular risk. Eur Heart J. 2024 Jun 6:ehae244. View abstract.

Persaud N, Azarpazhooh A, Keown-Stoneman C, et al. Xylitol for the prevention of acute otitis media episodes in children aged 1-5 years: a randomised controlled trial. Arch Dis Child 2024;109(2):121-124. View abstract.

Bordier V, Teysseire F, Drewe J, et al. Effects of a 5-week intake of erythritol and xylitol on vascular function, abdominal fat and glucose tolerance in humans with obesity: a pilot trial. BMJ Nutr Prev Health 2023;6(2):264-272. View abstract.

Winnier JJ, Ratnaparkhi I, Joshi A, Haradwala Z, Manoj R, Naik SS. Evaluation of the effectiveness of sucrose versus xylitol application in minimizing pain related to dental injection in 5-7-year-old children - A randomized controlled pilot study. J Indian Soc Pedod Prev Dent 2023;41(3):216-221. View abstract.

Liang NL, Luo BW, Sun IG, Chu CH, Duangthip D. Clinical effects of sugar substitutes on cariogenic bacteria: A systematic review and meta-analysis. Int Dent J 2024. View abstract.

Margulis I, Cohen-Kerem R, Stein N, et al. Xylitol nasal spray for prevention of recurrent acute otitis media in children: A prospective two-center cohort study. Int J Pediatr Otorhinolaryngol 2024;176:111818. View abstract.

Luo BW, Liang NL, Townsend JA, Lo ECM, Chu CH, Duangthip D. Sugar substitutes on caries prevention in permanent teeth among children and adolescents: a systematic review and meta-analysis. J Dent 2024;146:105069. View abstract.