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Bucci LR, Hickson JF Jr, Wolinsky I, Pivarnik JM. Ornithine supplementation and insulin release in bodybuilders. Int J Sport Nutr 1992;2:287-91.
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Fogelholm GM, Naveri HK, Kiilavuori KT, Harkonen MH. Low-dose amino acid supplementation: no effects on serum human growth hormone and insulin in male weightlifters. Int J Sport Nutr 1993;3:290-7.
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Rees C, Oppong K, Mardini H, et al. Effect of L-Ornithine-L-Aspartate on patients with and without TIPS undergoing glutamine challenge: a double blind, placebo controlled trial. Gut 2000;47:571-4..
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O'Rourke, D. J., Ryan, S., Salomons, G., Jakobs, C., Monavari, A., and King, M. D. Guanidinoacetate methyltransferase (GAMT) deficiency: late onset of movement disorder and preserved expressive language. Dev.Med.Child Neurol. 2009;51(5):404-407.
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Chen, M. F., Li, R. C., Chen, C. H., and Gao, X. C. [Therapeutic effect of L-ornithine-L-aspartate on liver cirrhosis complicated by hepatic encephalopathy]. Di Yi.Jun.Yi.Da.Xue.Xue.Bao. 2005;25(6):718-9, 722.
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Stechmiller, J. K., Childress, B., and Cowan, L. Arginine supplementation and wound healing. Nutr.Clin.Pract. 2005;20(1):52-61.
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67392
Poo, J. L., Gongora, J., Sanchez-Avila, F., Aguilar-Castillo, S., Garcia-Ramos, G., Fernandez-Zertuche, M., Rodriguez-Fragoso, L., and Uribe, M. Efficacy of oral L-ornithine-L-aspartate in cirrhotic patients with hyperammonemic hepatic encephalopathy. Results of a randomized, lactulose-controlled study. Ann.Hepatol. 2006;5(4):281-288.
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Jiang, Q., Jiang, X. H., Zheng, M. H., and Chen, Y. P. L-Ornithine-l-aspartate in the management of hepatic encephalopathy: a meta-analysis. J.Gastroenterol.Hepatol. 2009;24(1):9-14.
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Ahmad, I., Khan, A. A., Alam, A., Dilshad, A., Butt, A. K., Shafqat, F., Malik, K., and Sarwar, S. L-ornithine-L-aspartate infusion efficacy in hepatic encephalopathy. J.Coll.Physicians Surg.Pak. 2008;18(11):684-687.
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Sugino, T., Shirai, T., Kajimoto, Y., and Kajimoto, O. L-ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism. Nutr.Res. 2008;28(11):738-743.
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Acharya, S. K., Bhatia, V., Sreenivas, V., Khanal, S., and Panda, S. K. Efficacy of L-ornithine L-aspartate in acute liver failure: a double-blind, randomized, placebo-controlled study. Gastroenterology 2009;136(7):2159-2168.
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Soarez, P. C., Oliveira, A. C., Padovan, J., Parise, E. R., and Ferraz, M. B. A critical analysis of studies assessing L-ornithine-L-aspartate (LOLA) in hepatic encephalopathy treatment. Arq Gastroenterol. 2009;46(3):241-247.
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Sikorska, H., Cianciara, J., and Wiercinska-Drapalo, A. [Physiological functions of L-ornithine and L-aspartate in the body and the efficacy of administration of L-ornithine-L-aspartate in conditions of relative deficiency]. Pol.Merkur Lekarski. 2010;28(168):490-495.
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67400
Demura, S., Yamada, T., Yamaji, S., Komatsu, M., and Morishita, K. The effect of L-ornithine hydrochloride ingestion on performance during incremental exhaustive ergometer bicycle exercise and ammonia metabolism during and after exercise. Eur.J.Clin.Nutr. 2010;64(10):1166-1171.
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67401
Ong, J. P., Oehler, G., Kruger-Jansen, C., Lambert-Baumann, J., and Younossi, Z. M. Oral L-ornithine-L-aspartate improves health-related quality of life in cirrhotic patients with hepatic encephalopathy: an open-label, prospective, multicentre observational study. Clin.Drug Investig. 2011;31(4):213-220.
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Liu, C. P. and Yu, Z. J. [Study on L-Ornithine-L-Aspartate in the treatment of acute-on-chronic liver failure]. Zhonghua Gan Zang.Bing.Za Zhi. 2011;19(1):63-64.
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67403
Ndraha, S., Hasan, I., and Simadibrata, M. The effect of L-ornithine L-aspartate and branch chain amino acids on encephalopathy and nutritional status in liver cirrhosis with malnutrition. Acta Med.Indones. 2011;43(1):18-22.
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67404
Demura, S., Morishita, K., Yamada, T., Yamaji, S., and Komatsu, M. Effect of L-ornithine hydrochloride ingestion on intermittent maximal anaerobic cycle ergometer performance and fatigue recovery after exercise. Eur.J.Appl.Physiol 2011;111(11):2837-2843.
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Mittal, V. V., Sharma, B. C., Sharma, P., and Sarin, S. K. A randomized controlled trial comparing lactulose, probiotics, and L-ornithine L-aspartate in treatment of minimal hepatic encephalopathy. Eur.J.Gastroenterol.Hepatol. 2011;23(8):725-732.
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67408
Hartung, H. D. [Amino acids prevent hepatic encephalopathy. Ornithine-aspartate in hyperammonemia--results of a study]. Fortschr.Med. 3-15-1989;107(8):56.
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Elam, R. P. Morphological changes in adult males from resistance exercise and amino acid supplementation. J.Sports Med.Phys.Fitness 1988;28(1):35-39.
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67412
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Staedt, U., Leweling, H., Gladisch, R., Kortsik, C., Hagmuller, E., and Holm, E. Effects of ornithine aspartate on plasma ammonia and plasma amino acids in patients with cirrhosis. A double-blind, randomized study using a four-fold crossover design. J.Hepatol. 1993;19(3):424-430.
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67420
Kircheis, G., Nilius, R., Held, C., Berndt, H., Buchner, M., Gortelmeyer, R., Hendricks, R., Kruger, B., Kuklinski, B., Meister, H., Otto, H. J., Rink, C., Rosch, W., and Stauch, S. Therapeutic efficacy of L-ornithine-L-aspartate infusions in patients with cirrhosis and hepatic encephalopathy: results of a placebo-controlled, double-blind study. Hepatology 1997;25(6):1351-1360.
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67421
Stauch, S., Kircheis, G., Adler, G., Beckh, K., Ditschuneit, H., Gortelmeyer, R., Hendricks, R., Heuser, A., Karoff, C., Malfertheiner, P., Mayer, D., Rosch, W., and Steffens, J. Oral L-ornithine-L-aspartate therapy of chronic hepatic encephalopathy: results of a placebo-controlled double-blind study. J.Hepatol. 1998;28(5):856-864.
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Holm E, Hess Y Leweling H Barth H-O Hagmuller E. Ornithine aspartate (OA) promotes amino acid (AA) retention in the peripheral tissues of patients with liver cirrhosis A double-blind randomized crossover study. Journal of Parenteral and Enteral Nutrition. 2000;15(1):368.
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Feher J, Lang I Gogl A Varga L Varga L Tompos G Pronai L. Effect of ornithine-aspartate infusion on elevated serum ammonia concentration in cirrhotic patients - Results of a randomized, placebo-controlled double-blind multicentre trial. Medical Science Monitor. 1997;3(5):669-673.
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67426
Kircheis G, Metz M Frey S Seiller E. Correlation between pharmacokinetic aspects and clinical efficacy of L-ornithine-L-aspartate (OA): results of randomized, controlled clinical trials. Journal of Hepatology. 1996;25 (Suppl 1):S131.
67427
Tsai B-H, Lee N-Y. Effect of arginine and ornithine supplementation on weightlifters' fat free mass and anaerobic power. Nutritional Sciences Journal. 1997;22(4):373-383.
67428
Yuan, Wenming. Li Jing. Xu Lin. Zhang Mingming. Lu Zhenchan. Feng Shejun. Wang Ling. L-ornithine-L-aspartate for hepatic encephalopathy. Cochrane Hepato-Biliary Group Cochrane Database of Systematic Reviews. 2009;
67429
Schmid M, Peck-Radosavljevic M König F Mittermaier C Gangl A Ferenci P. A double-blind, randomized, placebo-controlled trial of intravenous L-ornithine-L-aspartate on postural control in patients with cirrhosis. Liver Int. 2010;30(4):574-582.
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67430
Schmid M, Konig F Ferenci P Gang A Peck-Radosavljevic M. Prospective randomized pilot trial of i.v. l-ornithine-l-aspartate (LOLA) vs. placebo on postural control in patients with cirrhosis. Journal of Hepatology. 2008;48(Suppl 2):S12.
67431
Abid S, Mumtaz K Abbas Z Hamid S Jafri N Ali Shah H Jafri W. Efficacy of infusion of L-ornithine L-aspartate in cirrhotic patients with portosystemic encephalopathy: a placebo controlled study. Journal of Hepatology. 2005;42 (Supp 2):84.
67432
Nilius R, Kirecheis G. Improvement of hepatic encephalopathy (HE) in cirrhotic patients by treatment with L-ornithine-L-aspartate (OA) infusion concentrate Results of a placebo-controlled, double-blind clinical trial. Journal of Hepatology. 1992;16 (Supp 1)(S39)
67433
Hong Y, Yang ZB Wang YF. Clinical Control Study of L-ornithine-L-aspartate in the Treatment of Subclinical Hepatic Encephalopathy. West China Medical Journal. 2003;18(4):509-510.
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Stauch S, Rosch W. Effects of L-ornithine-L-aspartate granulate on hyperammonemia in cirrhotic patients with hepatic encephalopathy (HE). A placebo-controlled double-blind study. Zeitschrift fur Gastroenterologie. 1992;30(4):300-301.
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Fleig WE, Kircheis G Spengler U Zeuzem ST Gortelmeyer. Placebo-controlled, double-blind evaluation of L-ornithine-L-aspartate (LOLA) granules in patients with cirrhosis and subclinical (SHE) or mild overt hepatic encephalopathy (HE). Journal of Hepatology. 1999;30(1):65.
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Poo JL, Gongora J Sanchez-Avila JF Aguilar-Castillo S Garcia Ramos G Fernandez-Zertuche M Rodriguez-Fragoso L Uribe M. Efficacy and safety of L-ornithine-L-aspartate (LOLA) administration. Open label randomized controlled trial versus lactulose in cirrhotic patients with hyperammonemic hepatic encephalopathy. Journal of Hepatology. 2007;46(4 (Suppl 1)):S36.
67437
Anon. Therapeutic efficacy of oral L-ornithine-L-aspartate on minimal encephalopathy. EBM Reviews - Cochrane Central Register of Controlled Trials. 2008;ClinicalTrials.gov
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Lang I, Feher J Gogl A Varga L Varga L Pronai L Werling K. Ammonia-lowering effect of ornithine-aspartate infusion in cirrhotic patients with hepatic encephalopathy. Gut. 1994;35 (Suppl 4):A158.
67439
Kuttig H. Ornithine aspartate improves toleration of large-volume abdominal radiotherapy. Cochrane Central Register of Controlled TrialsTHERAPIEWOCHE. 1983;33(25):3495-3511.
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Rees C, Oppong K Al-Mardini H Hudson M Rose J Record C. The effect of L-Ornithine-L-asparate on tips patients undergoing glutamine challenge. European Journal of Gastroenterology & Hepatology. 1996;8(Suppl 5):A1.
67441
Reynolds N, Downie S Smith K Kircheis G Rennie MJ. Treatment with L-ornithine-L-aspartate (LOLA) infusion restores muscle protein synthesis responsiveness to feeding in patients with cirrhosis. Journal of Hepatology. 1999;30(Suppl 1):65.
67442
Rees CJ, Oppong K Al-Mardini H Hudson M Rose J. The effect of L-ornithine-L-aspartate on TIPS patients undergoing glutamine challenge. Advances in hepatic encephalopathy & metabolism in liver disease. 1997;56:407-411.
67443
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67444
Neki NS, Batra KS Talwar AS Sharma RK Sharma N Multani LS. A comparative study of silymarin and l-ornithine - l-asparate in the treatment of viral hepatitis. The Journal of the Association of Physicians of India. 2000;
95224
Hol JW, van Lier F, Valk M, Klimek M, Stolker RJ, Fekkes D. Effect of major and minor surgery on plasma levls of arginine, citrulline, nitric oxide metabolites, and ornithine in humans. Ann Surg 2013;258(6):1072-8.
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95225
Horiuchi M, Kanesada H, Miyata T, et al. Ornithine ingestion improved sleep disturbances but was not associated with correction of blood tryptophan ratio in Japanese Antarctica expedition members
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95226
Miyake M, Kirisako T, Kokubo T, et al. Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers. Nutr J 2014;13:53.
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95227
Zajac A, Poprzecki S, Zebrowska A, Chalimoniuk M, Langfort J. Arginine and ornithine supplementation increases growth hormone and insulin-like growth factor-1 serum levels after heavy-resistance exercise in strength-trained athletes. J Strength Cond Res 2010;24(4):1082-90.
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Ito N, Seki S, Ueda F. Effects of Composite Supplement Containing Collagen Peptide and Ornithine on Skin Conditions and Plasma IGF-1 Levels-A Randomized, Double-Blind, Placebo-Controlled Trial. Mar Drugs. 2018;16(12). pii: E482.
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Fukuda T, Haraguchi A, Takahashi M, et al. A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the human circadian clock. Chronobiol Int 2018;35(10):1445-55.
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Shynkevych VI, Kolomiiets SV, Kaidashev IP. Effects of l-arginine and l-ornithine supplementations on the treatment of chronic periodontitis: A preliminary randomized short-term clinical trial. Heliyon. 2021;7(11):e08353.
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110715
Takakura M, Nagamachi S, Nishigawa T, Takahashi Y, Furuse M. Supplementation of L-Ornithine Could Increase Sleep-like Behavior in the Mouse Pups. Metabolites 2022;12(12):1241.
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Taniguchi E, Hattori A, Kurogi K, et al. Temporal patterns of increased growth hormone secretion in mice after oral administration of L-ornithine: possible involvement of ghrelin receptors. J Vet Med Sci 2022;84(9):1283-1287.
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110717
Miura N, Morishita K, Yasuda T, Akiduki S, Matsumoto H. Subchronic tolerance trials of graded oral supplementation with ornithine hydrochloride or citrulline in healthy adults. Amino Acids 2023;55(3):299-311.
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