References
Glucomannan
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Staiano A, Simeone D, Del Giudice E, et al. Effect of the dietary fiber glucomannan on chronic constipation in neurologically impaired children. J Pediatr 2000;136:41-5. View abstract.
11357
Chen HL, Sheu WH, Tai TS, et al. Konjac supplement alleviated hypercholesterolemia and hyperglycemia in type 2 diabetic subjects--a randomized double-blind trial. J Am Coll Nutr 2003;22:36-42. View abstract.
11358
Vuksan V, Sievenpiper JL, Owen R, et al. Beneficial effects of viscous dietary fiber from Konjac-mannan in subjects with the insulin resistance syndrome: results of a controlled metabolic trial. Diabetes Care 2000;23:9-14. View abstract.
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Vuksan V, Jenkins DJ, Spadafora P, et al. Konjac-mannan (glucomannan) improves glycemia and other associated risk factors for coronary heart disease in type 2 diabetes. A randomized controlled metabolic trial. Diabetes Care 1999;22:913-9. View abstract.
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Doi K, Matsuura M, Kawara A, et al. Influence of dietary fiber (konjac mannan) on absorption of vitamin B12 and vitamin E (abstract). Tohoku J Exp Med 1983;141:677-81. View abstract.
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Nakajima, N., Ishihara, K., and Matsuura, Y. Dietary-fiber-degrading enzymes from a human intestinal Clostridium and their application to oligosaccharide production from nonstarchy polysaccharides using immobilized cells. Appl.Microbiol.Biotechnol. 2002;59(2-3):182-189. View abstract.
57774
Gonzalez, Canga A., Fernandez, Martinez N., Sahagun, A. M., Garcia Vieitez, J. J., Diez Liebana, M. J., Calle Pardo, A. P., Castro Robles, L. J., and Sierra, Vega M. [Glucomannan: properties and therapeutic applications]. Nutr.Hosp. 2004;19(1):45-50. View abstract.
57775
Loening-Baucke, V., Miele, E., and Staiano, A. Fiber (glucomannan) is beneficial in the treatment of childhood constipation. Pediatrics 2004;113(3 Pt 1):e259-e264. View abstract.
57776
McCarty, M. F. Nutraceutical resources for diabetes prevention--an update. Med Hypotheses 2005;64(1):151-158. View abstract.
57777
Villaverde, A. F., Benlloch, S., Berenguer, M., Miguel, Rayon J., Pina, R., and Berenguer, J. Acute hepatitis of cholestatic type possibly associated with the use of glucomannan (amorphophalus konjac). J Hepatol. 2004;41(6):1061-1062. View abstract.
57778
Onishi, N., Kawamoto, S., Nishimura, M., Nakano, T., Aki, T., Shigeta, S., Shimizu, H., Hashimoto, K., and Ono, K. The ability of konjac-glucomannan to suppress spontaneously occurring dermatitis in NC/Nga mice depends upon the particle size. Biofactors 2004;21(1-4):163-166. View abstract.
57779
Martino, F., Martino, E., Morrone, F., Carnevali, E., Forcone, R., and Niglio, T. Effect of dietary supplementation with glucomannan on plasma total cholesterol and low density lipoprotein cholesterol in hypercholesterolemic children. Nutr.Metab Cardiovasc.Dis. 2005;15(3):174-180. View abstract.
57780
Keithley, J. and Swanson, B. Glucomannan and obesity: a critical review. Altern.Ther.Health Med 2005;11(6):30-34. View abstract.
57781
Yoshida, M., Vanstone, C. A., Parsons, W. D., Zawistowski, J., and Jones, P. J. Effect of plant sterols and glucomannan on lipids in individuals with and without type II diabetes. Eur.J Clin Nutr. 2006;60(4):529-537. View abstract.
57783
Chen, H. L., Cheng, H. C., Liu, Y. J., Liu, S. Y., and Wu, W. T. Konjac acts as a natural laxative by increasing stool bulk and improving colonic ecology in healthy adults. Nutrition 2006;22(11-12):1112-1119. View abstract.
57784
Wood, R. J., Fernandez, M. L., Sharman, M. J., Silvestre, R., Greene, C. M., Zern, T. L., Shrestha, S., Judelson, D. A., Gomez, A. L., Kraemer, W. J., and Volek, J. S. Effects of a carbohydrate-restricted diet with and without supplemental soluble fiber on plasma low-density lipoprotein cholesterol and other clinical markers of cardiovascular risk. Metabolism 2007;56(1):58-67. View abstract.
57785
Vanderbeek, P. B., Fasano, C., O'Malley, G., and Hornstein, J. Esophageal obstruction from a hygroscopic pharmacobezoar containing glucomannan. Clin Toxicol.(Phila) 2007;45(1):80-82. View abstract.
57786
Kraemer, W. J., Vingren, J. L., Silvestre, R., Spiering, B. A., Hatfield, D. L., Ho, J. Y., Fragala, M. S., Maresh, C. M., and Volek, J. S. Effect of adding exercise to a diet containing glucomannan. Metabolism 2007;56(8):1149-1158. View abstract.
57788
Onishi, N., Kawamoto, S., Suzuki, H., Hide, M., and Ono, K. Development of autoantibody responses in NC/Nga mice: its prevention by pulverized konjac glucomannan feeding. Arch.Dermatol.Res 2008;300(2):95-99. View abstract.
57789
Bernstein, J. A., Crandall, M. S., and Floyd, R. Respiratory sensitization of a food manufacturing worker to konjac glucomannan. J Asthma 2007;44(8):675-680. View abstract.
57790
Salas-Salvado, J., Farres, X., Luque, X., Narejos, S., Borrell, M., Basora, J., Anguera, A., Torres, F., Bullo, M., and Balanza, R. Effect of two doses of a mixture of soluble fibres on body weight and metabolic variables in overweight or obese patients: a randomised trial. Br.J Nutr. 2008;99(6):1380-1387. View abstract.
57791
Chearskul, S., Sangurai, S., Nitiyanant, W., Kriengsinyos, W., Kooptiwut, S., and Harindhanavudhi, T. Glycemic and lipid responses to glucomannan in Thais with type 2 diabetes mellitus. J Med Assoc.Thai. 2007;90(10):2150-2157. View abstract.
57792
Ruszova, E., Pavek, S., Hajkova, V., Jandova, S., Velebny, V., Papezikova, I., and Kubala, L. Photoprotective effects of glucomannan isolated from Candida utilis. Carbohydr.Res 2-25-2008;343(3):501-511. View abstract.
57793
Azezli, A. D., Bayraktaroglu, T., and Orhan, Y. The use of konjac glucomannan to lower serum thyroid hormones in hyperthyroidism. J Am.Coll.Nutr. 2007;26(6):663-668. View abstract.
57794
Tapola, N. S., Lyyra, M. L., Kolehmainen, R. M., Sarkkinen, E. S., and Schauss, A. G. Safety aspects and cholesterol-lowering efficacy of chitosan tablets. J Am.Coll.Nutr. 2008;27(1):22-30. View abstract.
57795
Chen, H. L., Cheng, H. C., Wu, W. T., Liu, Y. J., and Liu, S. Y. Supplementation of konjac glucomannan into a low-fiber Chinese diet promoted bowel movement and improved colonic ecology in constipated adults: a placebo-controlled, diet-controlled trial. J Am.Coll.Nutr. 2008;27(1):102-108. View abstract.
57796
Vasques, C. A., Rossetto, S., Halmenschlager, G., Linden, R., Heckler, E., Fernandez, M. S., and Alonso, J. L. Evaluation of the pharmacotherapeutic efficacy of Garcinia cambogia plus Amorphophallus konjac for the treatment of obesity. Phytother.Res 2008;22(9):1135-1140. View abstract.
57797
Sood, N., Baker, W. L., and Coleman, C. I. Effect of glucomannan on plasma lipid and glucose concentrations, body weight, and blood pressure: systematic review and meta-analysis. Am.J Clin Nutr. 2008;88(4):1167-1175. View abstract.
57798
Huang, C. Y., Zhang, M. Y., Peng, S. S., Hong, J. R., Wang, X., Jiang, H. J., Zhang, F. L., Bai, Y. X., Liang, J. Z., Yu, Y. R., and . Effect of Konjac food on blood glucose level in patients with diabetes. Biomed.Environ.Sci 1990;3(2):123-131. View abstract.
57799
Zhang, M. Y., Huang, C. Y., Wang, X., Hong, J. R., and Peng, S. S. The effect of foods containing refined Konjac meal on human lipid metabolism. Biomed.Environ.Sci 1990;3(1):99-105. View abstract.
57800
Cesa, F., Mariani, S., Fava, A., Rauseo, R., and Zanetti, H. [The use of vegetable fibers in the treatment of pregnancy diabetes and/or excessive wight gain during pregnancy]. Minerva Ginecol. 1990;42(6):271-274. View abstract.
57802
Marzio, L., Del, Bianco R., Donne, M. D., Pieramico, O., and Cuccurullo, F. Mouth-to-cecum transit time in patients affected by chronic constipation: effect of glucomannan. Am.J Gastroenterol. 1989;84(8):888-891. View abstract.
57803
Kawamura, Y. and Horio, T. [Effects of chewing exercise on the maximum biting force and chewing performance]. Shika.Kiso.Igakkai Zasshi 1989;31(3):281-290. View abstract.
57804
Kneepkens, C. M., Fernandes, J., and Vonk, R. J. Dumping syndrome in children. Diagnosis and effect of glucomannan on glucose tolerance and absorption. Acta Paediatr.Scand. 1988;77(2):279-286. View abstract.
57805
Hopman, W. P., Houben, P. G., Speth, P. A., and Lamers, C. B. Glucomannan prevents postprandial hypoglycaemia in patients with previous gastric surgery. Gut 1988;29(7):930-934. View abstract.
57807
Fanelli, V., Angelico, F., Stefanutti, C., Calvieri, A., and Fazio, S. [Effects of the integration of a habitual diet with glucomannan fiber in hypercholesterolemia. A clinical study in familial and sporadic hyperlipoproteinemia with lipo-proteic phenotype IIa and IIb]. Clin Ter. 10-15-1986;119(1):17-23. View abstract.
57808
Scalfi, L., Coltorti, A., D'Arrigo, E., Carandente, V., Mazzacano, C., Di, Palo M., and Contaldo, F. Effect of dietary fibre on postprandial thermogenesis. Int.J Obes. 1987;11 Suppl 1:95-99. View abstract.
57810
Shichijo, K., Kobayashi, Y., Fueki, R., Shimoyama, K., and Masaya, M. [2 cases of konjac bronchial asthma found outside the "konnyaku" producing district]. Arerugi 1969;18(2):97-100. View abstract.
57814
Rosado, J. L. and Diaz, M. [Physico-chemical properties related to gastrointestinal function of 6 sources of dietary fiber]. Rev.Invest Clin 1995;47(4):283-289. View abstract.
57816
Marsicano, L. J., Berrizbeitia, M. L., and Mondelo, A. [Use of glucomannan dietary fiber in changes in intestinal habit]. G.E.N. 1995;49(1):7-14. View abstract.
57817
Doi, K., Matsuura, M., Kawara, A., and Baba, S. Treatment of diabetes with glucomannan (konjac mannan). Lancet 5-5-1979;1(8123):987-988. View abstract.
57818
Signorelli, P., Croce, P., and Dede, A. [A clinical study of the use of a combination of glucomannan with lactulose in the constipation of pregnancy]. Minerva Ginecol. 1996;48(12):577-582. View abstract.
57819
Nakajima, N. and Matsuura, Y. Purification and characterization of konjac glucomannan degrading enzyme from anaerobic human intestinal bacterium, Clostridium butyricum-Clostridium beijerinckii group. Biosci.Biotechnol.Biochem. 1997;61(10):1739-1742. View abstract.
57821
Matsuura, Y. Degradation of konjac glucomannan by enzymes in human feces and formation of short-chain fatty acids by intestinal anaerobic bacteria. J Nutr.Sci Vitaminol.(Tokyo) 1998;44(3):423-436. View abstract.
57822
Venter, C. S., Kruger, H. S., Vorster, H. H., Serfontein, W. J., Ubbink, J. B., and De Villiers, L. S. The effects of the dietary fibre component konjac-glucomannan on serum cholesterol levels of hypercholesterolemic subjects. Hum Nut:Food Serv Nutr 1987;41F:55-61.
92002
Brand-Miller JC, Atkinson FS, Gahler RJ, et al. Effects of PGX, a novel functional fibre, on acute and delayed postprandial glycaemia. Eur J Clin Nutr 2010;64(12):1488-93. View abstract.
92003
Brand-Miller JC, Atkinson FS, Gahler RJ, et al. Effects of added PGX, a novel functional fibre, on the glycaemic index of starchy foods. Br J Nutr 2012;108(2):245-8. View abstract.
92004
Carabin IG, Lyon MR, Wood S, et al. Supplementation of the diet with the functional fiber PolyGlycoplex is well tolerated by healthy subjects in a clinical trial. Nutr J 2009;8:9. View abstract.
92005
Chmielewska A, Horvath A, Dziechciarz P, Szajewska H. Glucomannan is not effective for the treatment of functional constipation in children: a double-blind, placebo-controlled, randomized trial. Clin Nutr 2011;30(4):462-8. View abstract.
92006
Horvath A, Dziechciarz P, Szajewska H. Glucomannan for abdominal pain-related functional gastrointestinal disorders in children: a randomized trial. World J Gastroenterol 2013;19(20):3062-8. View abstract.
92007
Jenkins AL, Kacinik V, Lyon MR, Wolever TM. Reduction of postprandial glycemia by the novel viscous polysaccharide PGX, in a dose-dependent manner, independent of food form. J Am Coll Nutr 2010;29(2):92-8. View abstract.
92008
Kaats GR, Bagchi D, Preuss HG. Konjac glucomannan dietary supplementation causes significant fat loss in compliant overweight adults. J Am Coll Nutr 2015; Online ahead of print. View abstract.
92009
Keithley JK, Swanson B, Mikolaitis SL, et al. Safety and efficacy of glucomannan for weight loss in overweight and moderately obese adults. J Obes 2013;2013:610908. View abstract.
92010
Lyon MR, Reichert RG. The effect of a novel viscous polysaccharide along with lifestyle changes on short-term weight loss and associated risk factors in overweight and obese adults: an observational retrospective clinical program analysis. Altern Med Rev 2010;15(1):68-75. View abstract.
92011
Lyon M, Wood S, Pelletier X, et al. Effects of a 3-month supplementation with a novel soluble highly viscous polysaccharide on anthropometry and blood lipids in nondieting overweight or obese adults. J Hum Nutr Diet 2011;24(4):351-9. View abstract.
92014
Onakpoya I, Posadzki P, Ernst E. The efficacy of glucomannan supplementation in overweight and obesity: a systematic review and meta-analysis of randomized clinical trial. J Am Coll Nutr 2014;33(1):70-8. View abstract.
97935
Han Y, Zhang L, Liu XQ, Zhao ZJ, Lv LX. Effect of glucomannan on functional constipation in children: a systematic review and meta-analysis of randomised controlled trials. Asia Pac J Clin Nutr 2017;26(3):471-7. View abstract.
97936
Ho HVT, Jovanovski E, Zurbau A, et al. A systematic review and meta-analysis of randomized controlled trials of the effect of konjac glucomannan, a viscous soluble fiber, on LDL cholesterol and the new lipid targets non-HDL cholesterol and apolipoprotein B. Am J Clin Nutr 2017;105(5):1239-47. View abstract.
101509
Questions and Answers on Dietary Fiber. Available at: https://www.fda.gov/food/food-labeling-nutrition/questions-and-answers-dietary-fiber?utm_campaign=CFSANCU_Citizen_Petition_Glucomannan_Dietary_Fiber&utm_medium=email&utm_source=Eloqua#fda_actions. Accessed January 14, 2020.
106410
Health Canada Safety Alert. Health Canada Advises Canadians that natural health products containing glucomannan may cause serious choking if used with insufficient fluid. January 29, 2010. Alert # RA-110003825. https://healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2010/13439a-eng.php
106411
Mortensen A, Aguilar F, Crebelli, et al. EFSA Panel on Food Additives and Nutrient Sources added to Food. Re-evaluation of konjac gum (E 425 i) and konjac glucomannan (E425 ii) as food additives. EFSA Journal 2017;15(6):4864. View abstract.
111223
Nagasawa T, Kimura T, Yoshida A, et al. Konjac Glucomannan Attenuated Triglyceride Metabolism during Rice Gruel Tolerance Test. Nutrients 2021;13(7):2191. View abstract.
111224
Li Y, Kang Y, Du Y, et al. Effects of Konjaku Flour on the Gut Microbiota of Obese Patients. Front Cell Infect Microbiol 2022;12:771748. View abstract.
111225
Mirzababaei A, Zandkarimi R, Moradi S, et al. The effect of Glucomannan on fasting and postprandial blood glucose in adults: a systematic review and meta-analysis of randomized controlled trials. J Diabetes Metab Disord 2022;21(1):1055-1063. View abstract.
112430
Fernandes ACS, Muxfeldt L, Motta NG, et al. Gummies candy enriched with Konjac glucomannan reduces hunger intensity and waist circumference of overweight individuals. Int J Biol Macromol 2023;226:72-76. View abstract.
112701
Jenko Pražnikar Z, Mohorko N, Gmajner D, Kenig S, Petelin A. Effects of Four Different Dietary Fibre Supplements on Weight Loss and Lipid and Glucose Serum Profiles during Energy Restriction in Patients with Traits of Metabolic Syndrome: A Comparative, Randomized, Placebo-Controlled Study. Foods 2023;12(11):2122. View abstract.
112702
Zhang Z, Zhang Y, Tao X, Wang Y, Rao B, Shi H. Effects of Glucomannan Supplementation on Type II Diabetes Mellitus in Humans: A Meta-Analysis. Nutrients 2023;15(3):601. View abstract.
112703
Zhang Y, Aldamarany WAS, Song G, et al. Influence of konjac glucomannan and its derivatives on the oral pharmacokinetics of antimicrobial agent in antibiotics cocktails: Keep vigilant on dietary fiber supplement. Int J Biol Macromol 2023;251:126306. View abstract.