References
Diosmin
4861
Misra MC, Parshad R. Randomized clinical trial of micronized flavonoids in the early control of bleeding from acute internal haemorrhoids. Br J Surgery 2000;87:868-72. View abstract.
4898
Thanapongsathorn W, Vajrabukka T. Clinical trial of oral diosmin (Daflon) in the treatment of hemorrhoids. Dis Colon Rectum 1992;35:1085-8. View abstract.
4900
Cospite M. Double-blind, placebo-controlled evaluation of clinical activity and safety of Daflon 500 mg in the treatment of acute hemorrhoids. Angiology 1994;45:566-73. View abstract.
4919
Di Carlo G, Mascolo N, Izzo AA, Capasso F. Flavonoids: Old and new aspects of a class of natural therapeutic drugs. Life Sci 1999;65:337-53. View abstract.
4954
Villa P, Cova D, De Francesco L, et al. Protective effect of diosmetin on in vitro cell membrane damage and oxidative stress in cultured rat hepatocytes. Toxicology 1992;73:179-89. View abstract.
4959
Craig WJ. Health-promoting properties of common herbs. Am J Clin Nutr 1999;70:491-9. View abstract.
5006
Middleton E. Some biological properties of plant flavonoids. Ann Allergy 1988;61:53-7. View abstract.
8077
Ho Y, Tan M, Seow-Choen F. Micronized purified flavonidic fraction compared favorably with rubber band ligation and fiber alone in the management of bleeding hemorrhoids. Dis Colon Rectum 2000;43:66-9. View abstract.
10227
Pecking AP, Fevrier B, Wargon C, Pillion G. Efficacy of Daflon 500 mg in the treatment of lymphedema (secondary to conventional therapy of breast cancer). Angiology 1997;48:93-8.. View abstract.
10229
Guilhou JJ, Dereure O, Marzin L, et al. Efficacy of Daflon 500 mg in venous leg ulcer healing: a double-blind, randomized, controlled versus placebo trial in 107 patients. Angiology 1997;48:77-85.. View abstract.
50892
Cesarone, M. R., Belcaro, G., Rohdewald, P., Pellegrini, L., Ledda, A., Vinciguerra, G., Ricci, A., Gizzi, G., Ippolito, E., Fano, F., Dugall, M., Acerbi, G., Cacchio, M., Di Renzo, A., Hosoi, M., Stuard, S., and Corsi, M. Comparison of Pycnogenol and Daflon in treating chronic venous insufficiency: a prospective, controlled study. Clin Appl Thromb.Hemost. 2006;12(2):205-212. View abstract.
54735
Korthuis, R. J. and Gute, D. C. Adhesion molecule expression in postischemic microvascular dysfunction: activity of a micronized purified flavonoid fraction. J Vasc.Res 1999;36 Suppl 1:15-23. View abstract.
54736
Smith, P. D. Neutrophil activation and mediators of inflammation in chronic venous insufficiency. J Vasc.Res 1999;36 Suppl 1:24-36. View abstract.
54743
Keenoy, B., Vertommen, J., and De, Leeuw, I. The effect of flavonoid treatment on the glycation and antioxidant status in Type 1 diabetic patients. Diabetes Nutr Metab 1999;12(4):256-263. View abstract.
54749
Bergan, J. J., Schmid-Schonbein, G. W., and Takase, S. Therapeutic approach to chronic venous insufficiency and its complications: place of Daflon 500 mg. Angiology 2001;52 Suppl 1:S43-S47. View abstract.
54755
Jantet, G. Chronic venous insufficiency: worldwide results of the RELIEF study. Reflux assEssment and quaLity of lIfe improvEment with micronized Flavonoids. Angiology 2002;53(3):245-256. View abstract.
54799
Cesarone, M. R., Belcaro, G., Pellegrini, L., Ledda, A., Vinciguerra, G., Ricci, A., Di Renzo, A., Ruffini, I., Gizzi, G., Ippolito, E., Fano, F., Dugall, M., Acerbi, G., Cornelli, U., Hosoi, M., and Cacchio, M. Venoruton vs Daflon: evaluation of effects on quality of life in chronic venous insufficiency. Angiology 2006;57(2):131-138. View abstract.
54935
Cospite, M. and Dominici, A. Double blind study of the pharmacodynamic and clinical activities of 5682 SE in venous insufficiency. Advantages of the new micronized form. Int Angiol. 1989;8(4 Suppl):61-65. View abstract.
54948
Struckmann, J. R. and Nicolaides, A. N. Flavonoids. A review of the pharmacology and therapeutic efficacy of Daflon 500 mg in patients with chronic venous insufficiency and related disorders. Angiology 1994;45(6):419-428. View abstract.
54953
Jean, T. and Bodinier, M. C. Mediators involved in inflammation: effects of Daflon 500 mg on their release. Angiology 1994;45(6 Pt 2):554-559. View abstract.
54954
Godeberge, P. Daflon 500 mg in the treatment of hemorrhoidal disease: a demonstrated efficacy in comparison with placebo. Angiology 1994;45(6 Pt 2):574-578. View abstract.
54958
Cypriani, B., Limasset, B., Carrie, M. L., le Doucen, C., Roussie, M., de Paulet, A. C., and Damon, M. Antioxidant activity of micronized diosmin on oxygen species from stimulated human neutrophils. Biochem Pharmacol 4-6-1993;45(7):1531-1535. View abstract.
54970
Buckshee, K., Takkar, D., and Aggarwal, N. Micronized flavonoid therapy in internal hemorrhoids of pregnancy. Int J Gynaecol Obstet 1997;57(2):145-151. View abstract.
54972
Guilhou, J. J., Fevrier, F., Debure, C., Dubeaux, D., Gillet-Terver, M. N., Guillot, B., Levesque, H., Marzin, L., Mignot, J., Ouvry, P., Pillion, G., Van, Landuyt H., Zuccarelli, F., and Nicolaides, A. N. Benefit of a 2-month treatment with a micronized, purified flavonoidic fraction on venous ulcer healing. A randomized, double-blind, controlled versus placebo trial. Int.J.Microcirc.Clin.Exp. 1997;17 Suppl 1:21-26. View abstract.
54977
Rizk, S. M and Sabri, N. A. Evaluation of Clinical Activity and Safety of Dalfon® 500mg in Type 2 Diabetic Femal Patients. Saudi Pharmacetical Journal 3-17-2009;199-209.
54984
Glinski, W, Chodynicka, B., Roszkiewicz, J., and et al. The beneficial augmentative effect of micronised purified flavonoid fraction (MPFF) on the healing of leg ulcers: an open, multicentre, controlled, randomised study. Phlebology. 1999;14(4):151-157.
93885
Giannini I, Amato A, Basso L, Tricomi N, Marranci M, Pecorella G, Tafuri S, Pennisi D, Altomare DF. Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial. Tech Coloproctol. 2015 Jun;19(6):339-45. View abstract.
93886
Kumar RM, Van Gompel JJ, Bower R, Rabinstein AA. Spontaneous intraventricular hemorrhage associated with prolonged diosmin therapy. Neurocrit Care. 2011 Jun;14(3):438-40. View abstract.
93887
Milano G, Leone S, Fucile C, Zuccoli ML, Stimamiglio A, Martelli A, Mattioli F. Uncommon serum creatine phosphokinase and lactic dehydrogenase increase during diosmin therapy: two case reports. J Med Case Rep. 2014 Jun 16;8:194. View abstract.
93888
Rajnarayana K, Venkatesham A, Krishna DR. Bioavailability of diclofenac sodium after pretreatment with diosmin in healthy volunteers. Drug Metabol Drug Interact. 2007;22(2-3):165-74. View abstract.
93889
Rajnarayana K, Venkatesham A, Nagulu M, Srinivas M, Krishna DR. Influence of diosmin pretreatment on the pharmacokinetics of chlorzoxazone in healthy male volunteers. Drug Metabol Drug Interact. 2008;23(3-4):311-21. View abstract.
93890
Yoo HH, Lee M, Chung HJ, Lee SK, Kim DH. Effects of diosmin, a flavonoid glycoside in citrus fruits, on P-glycoprotein-mediated drug efflux in human intestinal Caco-2 cells. J Agric Food Chem. 2007 Sep 5;55(18):7620-5. View abstract.
95039
Bedada SK, Neerati P. Modulation of CYP3A enzyme activity by diosmin and its consequence on carbamazepine pharmacokinetics in rats. Naunyn Schmiedebergs Arch Pharmacol. 2018;391(2):115-21. View abstract.
95040
Burkina V, Zlabek V, Halsne R, Ropstad E, Zamaratskaia G. In vitro effects of the citrus flavonoids diosmin, naringenin and naringin on the hepatic drug-metabolizing CYP3A enzyme in human, pig, mouse and fish. Biochem Pharmacol. 2016;110-111:109-16 View abstract.
95041
Bedada SK, Boga PK. Influence of diosmin on the metabolism and disposition of carbamazepine in healthy subjects. Xenobiotica. 2017;47(10):879-84. View abstract.
95042
Bedada SK, Boga PK, Kotakonda HK. The effect of diosmin on the pharmacokinetics of fexofenadine in healthy human volunteers. Xenobiotica. 2017;47(3):230-35. View abstract.
95043
Wang Y, Fang X, Ye L, Li Y, Shi H, Cao Y. A Randomized Controlled Trial Evaluating the Effects of Diosmin in the Treatment of Radicular Pain. Biomed Res Int. 2017;2017:6875968. View abstract.
98041
Shoeb M, Ramana KV. Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages. Free Radic Biol Med 2012;52(1):182-90. View abstract.
98594
Russo R, Chandradhara D, De Tommasi N. Comparative bioavailability of two diosmin formulations after oral administration to healthy volunteers. Molecules. 2018;23(9). pii: E2174. View abstract.
98596
Poór M, Boda G, Mohos V, et al. Pharmacokinetic interaction of diosmetin and silibinin with other drugs: Inhibition of CYP2C9-mediated biotransformation and displacement from serum albumin. Biomed Pharmacother. 2018;102:912-921. View abstract.
98597
Danielsson G, Jungbeck C, Peterson K, Norgren L. A randomised controlled trial of micronized purified flavonoid fraction vs placebo in patients with chronic venous disease. Eur J Vasc Endovasc Surg. 2002;23(1):73-6. View abstract.
98609
Rabe E, Agus GB, Roztocil K. Analysis of the effects of micronized purified flavonoid fraction versus placebo on symptoms and quality of life in patients suffering from chronic venous disease: from a prospective randomized trial. Int Angiol. 2015;34(5):428-36. View abstract.
101642
Agir MS, Eraslan G. The effect of diosmin against liver damage caused by cadmium in rats. J Food Biochem. 2019;43(9):e12966. View abstract.
101644
Attia TM. Efficacy and Safety of Daflon in the Treatment of Idiopathic Epistaxis. Am J Rhinol Allergy. 2019;33(1):62-68. View abstract.
101645
Bozdag M, Eraslan G. The effect of diosmin against lead exposure in rats. Naunyn Schmiedebergs Arch Pharmacol. 2019. View abstract.
101646
Cacchio A, Prencipe R, Bertone M, et al. Effectiveness and safety of a product containing diosmin, coumarin, and arbutin (Linfadren) in addition to complex decongestive therapy on management of breast cancer-related lymphedema. Support Care Cancer. 2019;27(4):1471-1480. View abstract.
101647
Feldo M, Wójciak-Kosior M, Sowa I, et al. Effect of Diosmin Administration in Patients with Chronic Venous Disorders on Selected Factors Affecting Angiogenesis. Molecules. 2019;24(18). pii: E3316. View abstract.
105282
Sheikh P, Lohsiriwat V, Shelygin Y. Micronized purified flavonoid fraction in hemorrhoid disease: A systematic review and meta-analysis. Adv Ther. 2020;37(6):2792-2812. View abstract.
105283
Bogachev VY, Boldin BV, Turkin PY. Administration of micronized purified flavonoid fraction during sclerotherapy of reticular veins and telangiectasias: Results of the national, multicenter, observational program VEIN ACT PROLONGED-C1. Adv Ther. 2018l;35(7):1001-1008. View abstract.
105285
Sirlak M, Akar AR, Eryilmaz S, et al. Micronized purified flavonoid fraction in pretreating CABG patients. Tex Heart Inst J. 2010;37(2):172-7. View abstract.
105286
Khryshchanovich VY, Nebylitsin YS, Kosinets VA. Efficacy of micronized purified flavonoid fraction-based venoactive therapy after endovenous mechanochemical obliteration: Prospective comparative study. Drugs Real World Outcomes. 2021. View abstract.
105287
Gavrilov SG, Karalkin AV, Moskalenko YP, Grishenkova AS. Efficacy of two micronized purified flavonoid fraction dosing regimens in the pelvic venous pain relief. Int Angiol. 2021;40(3):180-186. View abstract.
105293
Steinbruch M, Nunes C, Gama R, et al. Is nonmicronized diosmin 600?mg as effective as micronized diosmin 900?mg plus hesperidin 100?mg on chronic venous disease symptoms? Results of a noninferiority study. Int J Vasc Med. 2020;2020:4237204. View abstract.
105294
Serra R, Ielapi N, Bitonti et al. Efficacy of a low-dose diosmin therapy on improving symptoms and quality of life in patients with chronic venous disease: Randomized, double-blind, placebo-controlled trial. Nutrients. 2021;13(3):999. View abstract.
105295
Li T, Zhu W, Liu G, Fang C, Quan S. Diosmin for the prevention of ovarian hyperstimulation syndrome. Int J Gynaecol Obstet. 2020;149(2):166-170. View abstract.
105296
Schastlivtsev I, Lobastov K, Barinov V, Kanzafarova I. Diosmin 600 in adjunction to rivaroxaban reduces the risk of post-thrombotic syndrome after femoropopliteal deep vein thrombosis: results of the RIDILOTT DVT study. Int Angiol. 2020;39(5):361-371. View abstract.
105297
Sahin A, Kutluhan MA, Yildirim C, Urkmez A, Akan S, Verit A. Results of purified micronized flavonoid fraction in the treatment of categorized type III chronic pelvic pain syndrome: a randomized controlled trial. Aging Male. 2020;23(5):1103-1108. View abstract.
108150
Akhmetzianov RV, Bredikhin RA. Clinical efficacy of conservative treatment with micronized purified flavonoid fraction in female patients with pelvic congestion syndrome. Pain Ther 2021;10(2):1567-1578. View abstract.
108151
Bagnati M, Puricelli C, Bauce G, et al. Short-term effects of supplemental L-arginine, diosmin, troxerutin, and hesperidin in diabetic patients: A Pilot Study. Biomed Res Int 2021;2021:3508281. View abstract.
112795
Bogachev V, Boldin B, Turkin P, Samenkov A, Dzhenina O. Micronized purified flavonoid fraction-based conservative treatment of chronic venous disease in a real-world setting. Future Cardiol 2022;18(10):777-785. View abstract.
112796
Mansilha A, Caldevilla H, Puskás A, Lucien A, Roby L, Kirienko A. MPFF 1000 mg chewable once daily vs. MPFF 500 mg twice daily in chronic venous disease: the double-blind, randomized, non-inferiority CHEWY trial. Int Angiol 2022;41(6):464-475. View abstract.
112797
Osama H, Hamed EO, Mahmoud MA, Abdelrahim MEA. The Effect of Hesperidin and Diosmin Individually or in Combination on Metabolic Profile and Neuropathy among Diabetic Patients with Metabolic Syndrome: A Randomized Controlled Trial. J Diet Suppl 2022. View abstract.