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Ceylon Leadwort
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Panda S, Naik D, Kamble A. Population structure and genetic diversity of the perennial medicinal shrub Plumbago. AoB PLANTS. 2015;7: plv048.
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Giday M, Teklehaymanot T, Animut A, Mekonnen Y. Medicinal plants of the Shinasha, Agew-awi and Amhara peoples in northwest Ethiopia. J Ethnopharmacol. 2007 Apr 4;110(3):516-25. View abstract.
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Teshome K, Gebre-Mariam T, Asres K, Perry F, Engidawork E. Toxicity studies on dermal application of plant extract of Plumbago zeylanica used in Ethiopian traditional medicine. J Ethnopharmacol. 2008 May 8;117(2):236-48. View abstract.
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Sandeep G, Dheeraj A, Sharma NK, Jhade D, Bharti A. Effect of plumbagin free alcohol extract of Plumbago zeylanica Linn. root on reproductive system of female Wistar rats. Asian Pac J Trop Med. 2011 Dec;4(12):978-84. View abstract.
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Kumar D, Patil PA, Roy S, Kholkute SD, Hegde HV, Nair V. Comparative toxicity profiles of Plumbago zeylanica L. root petroleum ether, acetone and hydroalcoholic extracts in Wistar rats. Ayu. 2015 Jul-Sep;36(3):329-34. View abstract.
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Vijayakumar R, Senthilvelan M, Ravindran R, Devi RS. Plumbago zeylanica action on blood coagulation profile with and without blood volume reduction. Vascul Pharmacol. 2006 Aug;45(2):86-90. View abstract.
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Olagunju JA, Jobi AA, Oyedapo OO. An investigation into the biochemical basis of the observed hyperglycaemia in rats treated with ethanol root extract of plumbago zeylanica. Phytother Res. 1999 Jun;13(4):346-8. View abstract.
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Chen A, Zhou X, Tang S, Liu M, Wang X. Evaluation of the inhibition potential of plumbagin against cytochrome P450 using LC-MS/MS and cocktail approach. Sci Rep. 2016 Jun 22;6:28482. View abstract.
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Galal AM, Raman V, Avula B, Wang YH, Rumalla CS, Weerasooriya AD, Khan IA. Comparative study of three Plumbago L. species (Plumbaginaceae) by microscopy, UPLC-UV and HPTLC. J Nat Med. 2013 Jul;67(3):554-61. View abstract.
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Cong HJ, Zhang SW, Shen Y, Zheng Y, Huang YJ, Wang WQ, Leng Y, Xuan LJ. Guanidine alkaloids from Plumbago zeylanica. J Nat Prod. 2013 Jul 26;76(7):1351-7. View abstract.
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Lin LC, Yang LL, Chou CJ. Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica. Phytochemistry. 2003 Feb;62(4):619-22. View abstract.
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Nguyen AT, Malonne H, Duez P, Vanhaelen-Fastre R, Vanhaelen M, Fontaine J. Cytotoxic constituents from Plumbago zeylanica. Fitoterapia. 2004 Jul;75(5):500-4. View abstract.
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Aqil F, Ahmad I, Owais M. Evaluation of anti-methicillin-resistant Staphylococcus aureus (MRSA) activity and synergy of some bioactive plant extracts. Biotechnol J. 2006 Oct;1(10):1093-102. View abstract.
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Ahmad I, Aqil F. In vitro efficacy of bioactive extracts of 15 medicinal plants against ESbetaL-producing multidrug-resistant enteric bacteria. Microbiol Res. 2007;162(3):264-75. View abstract.
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Saritha K, Rajesh A, Manjulatha K, Setty OH, Yenugu S. Mechanism of antibacterial action of the alcoholic extracts of Hemidesmus indicus (L.) R. Br. ex Schult, Leucas aspera (Wild.), Plumbago zeylanica L., and Tridax procumbens (L.) R. Br. ex Schult. Front Microbiol. 2015 Jun 9;6:577. View abstract.
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Abdul KM, Ramchender RP. Modulatory effect of plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) on macrophage functions in BALB/c mice. I. Potentiation of macrophage bactericidal activity. Immunopharmacology. 1995 Sep;30(3):231-6. View abstract.
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Aziz MH, Dreckschmidt NE, Verma AK. Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer. Cancer Res. 2008 Nov 1;68(21):9024-32. View abstract.
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Nazeem S, Azmi AS, Hanif S, Ahmad A, Mohammad RM, Hadi SM, Kumar KS. Plumbagin induces cell death through a copper-redox cycle mechanism in human cancer cells. Mutagenesis. 2009 Sep;24(5):413-8. View abstract.
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Xu KH, Lu DP. Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo. Leuk Res. 2010 May;34(5):658-65. View abstract.
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Sandur SK, Pandey MK, Sung B, Aggarwal BB. 5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization. Mol Cancer Res. 2010 Jan;8(1):107-18. View abstract.
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Sand JM, Bin Hafeez B, Jamal MS, Witkowsky O, Siebers EM, Fischer J, Verma AK. Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), isolated from Plumbago zeylanica, inhibits ultraviolet radiation-induced development of squamous cell carcinomas. Carcinogenesis. 2012 Jan;33(1):184-90. View abstract.
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Yan W, Tu B, Liu YY, Wang TY, Qiao H, Zhai ZJ, Li HW, Tang TT. Suppressive Effects of Plumbagin on Invasion and Migration of Breast Cancer Cells via the Inhibition of STAT3 Signaling and Down-regulation of Inflammatory Cytokine Expressions. Bone Res. 2013 Dec 31;1(4):362-70. View abstract.
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Jamal MS, Parveen S, Beg MA, Suhail M, Chaudhary AG, Damanhouri GA, Abuzenadah AM, Rehan M. Anticancer compound plumbagin and its molecular targets: a structural insight into the inhibitory mechanisms using computational approaches. PLoS One. 2014 Feb 27;9(2):e87309. View abstract.
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Sunil C, Duraipandiyan V, Agastian P, Ignacimuthu S. Antidiabetic effect of plumbagin isolated from Plumbago zeylanica L. root and its effect on GLUT4 translocation in streptozotocin-induced diabetic rats. Food Chem Toxicol. 2012 Dec;50(12):4356-63. View abstract.
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Edwin S, Joshi SB, Jain DC. Antifertility activity of leaves of Plumbago zeylanica Linn. in female albino rats. Eur J Contracept Reprod Health Care. 2009 Jun;14(3):233-9. View abstract.
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Purohit A, Vyas SK, Vyas KB. Contraceptive efficacy of Plumbago zeylanica root extract (50% etoh) in male albino rats with special emphasis on testicular cell population dynamics. Anc Sci Life. 2008 Jan;27(3):31-5. View abstract.
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Checker R, Sharma D, Sandur SK, Khanam S, Poduval TB. Anti-inflammatory effects of plumbagin are mediated by inhibition of NF-kappaB activation in lymphocytes. Int Immunopharmacol. 2009 Jul;9(7-8):949-58. View abstract.
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Sheeja E, Joshi SB, Jain DC. Bioassay-guided isolation of anti-inflammatory and antinociceptive compound from Plumbago zeylanica leaf. Pharm Biol. 2010 Apr;48(4):381-7. View abstract.
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Wang YC, Huang TL. Anti-Helicobacter pylori activity of Plumbago zeylanica L. FEMS Immunol Med Microbiol. 2005 Mar 1;43(3):407-12. View abstract.
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Jia Y, Jing J, Bai Y, Li Z, Liu L, Luo J, Liu M, Chen H. Amelioration of experimental autoimmune encephalomyelitis by plumbagin through down-regulation of JAK-STAT and NF-?B signaling pathways. PLoS One. 2011;6(10):e27006. View abstract.
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Poosarla A, D N R, Athota RR, Sunkara VG. Modulation of T cell proliferation and cytokine response by Plumbagin, extracted from Plumbago zeylanica in collagen induced arthritis. BMC Complement Altern Med. 2011 Nov 16;11:114. View abstract.
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Hsieh YJ, Lin LC, Tsai TH. Measurement and pharmacokinetic study of plumbagin in a conscious freely moving rat using liquid chromatography/tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Nov 21;844(1):1-5. Epub 2006 Jul 11. View abstract.
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Szmulewicz AG, Valerio MP, Smith JM. Switch to mania after ayahuasca consumption in a man with bipolar disorder: a case report. Int J Bipolar Disord. 2015 Feb 24;3:4. View abstract.