Tri Andro by Primeval Labs

INSUFFICIENT RELIABLE EVIDENCE to RATE

• Athletic performance. It is unclear if oral 1-androsterone is beneficial for athletic performance. Details: Preliminary clinical research in healthy males undergoing resistance training shows that taking 1-androsterone 330 mg orally daily for 4 weeks moderately improves back squat performance when compared with placebo. Taking a-androsterone also decreased body fat mass by 3 kg and increase lean body mass by 5 kg when compared with placebo (91095). More evidence is needed to rate 1-androsterone for this use.

(Read more about 1-ANDROSTERONE)

There is insufficient evidence about the effectiveness of 4-androsterone.

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INSUFFICIENT RELIABLE EVIDENCE to RATE

• Athletic performance. Although there is interest in using oral epiandrosterone for athletic performance, there is insufficient reliable information about the clinical effects of epiandrosterone for this purpose.
• Erectile dysfunction (ED). Although there is interest in using oral epiandrosterone for ED, there is insufficient reliable information about the clinical effects of epiandrosterone for this purpose.
• Exercise-induced muscle damage. Although there is interest in using oral epiandrosterone for muscle recovery after exercise, there is insufficient reliable information about the clinical effects of epiandrosterone for this purpose.
• Muscle strength. Although there is interest in using oral epiandrosterone for increasing muscle strength, there is insufficient reliable information about the clinical effects of epiandrosterone for this purpose.
• Obesity. Although there is interest in using oral epiandrosterone for weight loss, there is insufficient reliable information about the clinical effects of epiandrosterone for this purpose.
• Psychological well-being. Although there is interest in using oral epiandrosterone for improving well-being, there is insufficient reliable information about the clinical effects of epiandrosterone for this purpose.
• Sexual arousal. Although there is interest in using oral epiandrosterone for increasing sexual arousal, there is insufficient reliable information about the clinical effects of epiandrosterone for this purpose. More evidence is needed to rate epiandrosterone for these uses.

(Read more about EPIANDROSTERONE)

POSSIBLY UNSAFE ...when used orally. Although the safety of 4-androsterone has not been studied in clinical trials, this prohormone might cause serious anabolic steroid-like side effects including stroke, kidney failure, and liver injury (91094,91095).

PREGNANCY AND LACTATION:
Insufficient information available; avoid use.

(Read more about 4-ANDROSTERONE)

POSSIBLY UNSAFE ...when used orally. Anabolic androgenic steroids, such as epiandrosterone, can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, gynecomastia (in males), hair loss, acne, and behavioral changes. Anabolic androgenic steroid use has also been associated with hepatotoxicity and increased risk for heart disease. The US Food and Drug Administration and other regulatory agencies warn that dietary supplements containing anabolic steroids are dangerous (91094).

PREGNANCY AND LACTATION: POSSIBLY UNSAFE
when used orally. Anabolic androgenic steroids, such as epiandrosterone, can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss, acne, and behavioral changes. Anabolic androgenic steroid use has also been associated with hepatotoxicity and increased risk for heart disease. The US Food and Drug Administration and other regulatory agencies warn that dietary supplements containing anabolic steroids are dangerous (91094). Avoid using.

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TESTOSTERONE Interaction Rating = Moderate Be cautious with this combination. Severity = Moderate •  Occurrence = Possible •  Level of Evidence = D Theoretically, taking 1-androsterone with testosterone might increase the risk for additive adverse effects such as mood disturbances and cardiovascular, kidney, or liver problems.  Details 1-Androsterone is converted to 1-testosterone and other androgens upon ingestion (90399,91095).

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(Read more about 4-ANDROSTERONE)

(Read more about EPIANDROSTERONE)

General ...There is currently a limited amount of information on the adverse effects of 1-androsterone. A thorough evaluation of safety outcomes has not been conducted.
Most Common Adverse Effects:
Orally: Dyslipidemia, transaminitis, renal dysfunction.

Cardiovascular ...Significant increases in LDL cholesterol of around 29 mg/dL and significant decreases in HDL cholesterol of around 19 mg/dL have been reported in patients taking 1-androsterone for 4-weeks (91095).

Hepatic ...Significant increases in AST of around 15. 4 IU/L have been reported in patients taking 1-androsterone daily for 4 weeks. Despite the elevation, average AST levels did not go much beyond 40 IU/L, the upper limit of normal for AST (91095).

Renal ...Significant increases in serum creatinine of around 0. 2 mg/dL and significant decreases in GFR of around 16.4 mL/min/1.72m² have been reported in patients taking 1-androsterone for 4 weeks. Serum creatinine remained within normal range despite the elevation, GFR dropped below 89 mL/min/1.72m2, which is suggestive of renal impairment (91095).

(Read more about 1-ANDROSTERONE)

General ...There is insufficient information available about adverse effects associated with 4-androsterone. It is purported that 4-androsterone is metabolized to anabolic compounds. Therefore, in theory, there is concern that it might cause serious anabolic steroid-like side effects including stroke, kidney failure, and liver injury.

(Read more about 4-ANDROSTERONE)

General ...A thorough evaluation of adverse effects has not been conducted. However, epiandrosterone is an anabolic androgenic steroid. This drug class is associated with cardiac, hepatic, and hormonal adverse effects.

(Read more about EPIANDROSTERONE)