Full Spectrum Sceletium Tortuosum 50 mg [Discontinued] by Swanson Premium Brand

INSUFFICIENT RELIABLE EVIDENCE to RATE

• Alcohol use disorder. Although there has been interest in using oral sceletium for alcohol use disorder, there is insufficient reliable information about the clinical effects of sceletium for this purpose.
• Anxiety. Although there has been interest in using oral sceletium for anxiety, there is insufficient reliable information about the clinical effects of sceletium for this purpose.
• Athletic performance. It is unclear if oral sceletium extract is beneficial for athletic performance. Details: A small clinical study in recreationally trained adults shows that taking a specific sceletium extract (Zembrin, HG&H Pharmaceuticals) 25 mg orally daily for 8 days does not seem to improve reaction time or reactive agility during reactive performance testing when compared with placebo (103894).
• Depression. Although there has been interest in using oral sceletium for depression, there is insufficient reliable information about the clinical effects of sceletium for this purpose.
• Obesity. Although there has been interest in using oral sceletium for obesity, there is insufficient reliable information about the clinical effects of sceletium for this purpose.
• Stress. Although there has been interest in using oral sceletium for stress, there is insufficient reliable information about the clinical effects of sceletium for this purpose. More evidence is needed to rate sceletium for these uses.

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There is insufficient reliable information available about the safety of sceletium.

PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.

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CNS DEPRESSANTS Interaction Rating = Moderate Be cautious with this combination. Severity = High •  Occurrence = Possible •  Level of Evidence = D Theoretically, concomitant use of sceletium and CNS depressants might result in additive sedative effects.  Details Some evidence suggests that sceletium has sedative properties (17580).

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General ...There is currently a limited amount of information on the adverse effects of sceletium. A thorough evaluation of safety outcomes has not been conducted.
Most Common Adverse Effects:
Orally: Anxiety, headache, insomnia, irritability, nausea.

Cardiovascular ...Orally, a sceletium extract has been reported to cause hypertension (106745).

Gastrointestinal ...Orally, a sceletium extract has been reported to cause nausea (106745). There are anecdotal reports that chewing sceletium can cause loss of appetite (17580).

Neurologic/CNS ...Orally, a sceletium extract has been reported to cause anxiety, headache, insomnia, and irritability (106745). There are also anecdotal reports that chewing sceletium can cause headache, depression, and listlessness (17580). Additionally, anecdotal reports suggest that sceletium can cause euphoric effects when inhaled or taken orally in high doses (100649).

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