| Ingredients | Amount Per Serving |
|---|---|
|
(Cinnamomum loureiroi)
|
1000 mg |
Cellulose, Glycerin, Water
Below is general information about the effectiveness of the known ingredients contained in the product Cinnamon 1000 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Cinnamon 1000 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when used orally in amounts commonly found in foods. Saigon cinnamon is Generally Recognized as Safe (GRAS) in the US when used as a spice or seasoning (4912). However, Saigon cinnamon contains coumarin, which has been linked with adverse effects. The European Food Safety Authority (EFSA) established a tolerable daily intake (TDI) level for coumarin in foods of 0.1 mg/kg, which is about 7 mg of coumarin daily for a person weighing 70 kg (154 lbs). Saigon cinnamon contains coumarin at a concentration of about 7 mg/gram (92558). Therefore, a person weighing approximately 70 kg should avoid using Saigon cinnamon in foods in amounts greater than 1 gram daily (about 0.25 tsp).
POSSIBLY UNSAFE ...when used orally in higher doses, long-term. Saigon cinnamon contains higher levels of coumarin than other cinnamon species (92558). Coumarin has been shown to cause hepatotoxicity in animal models (15299,21920). In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued (15302). In most cases, ingestion of Saigon cinnamon will not provide a high enough amount of coumarin to cause significant toxicity. A person weighing 70 kg would need to take approximately 7 grams of Saigon cinnamon daily to obtain doses of coumarin of 50 mg daily. However, in especially sensitive people, such as those with liver disease, prolonged ingestion of large amounts of Saigon cinnamon might exacerbate the condition. There is insufficient reliable information available about the safety of Saigon cinnamon when used orally in smaller medicinal amounts.
PREGNANCY AND LACTATION:
Insufficient reliable information available; avoid using.
Below is general information about the interactions of the known ingredients contained in the product Cinnamon 1000 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, Saigon cinnamon might cause additive effects when used with hepatotoxic drugs.
 Details
Saigon cinnamon contains coumarin (92558). Coumarin has caused hepatotoxicity in animal models (15299,21920). In otherwise healthy humans, very high doses of coumarin, from 50-7000 mg daily, can result in hepatotoxicity that resolves when coumarin use is discontinued (15302). Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.
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Below is general information about the adverse effects of the known ingredients contained in the product Cinnamon 1000 mg. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General ...No adverse effects have been reported. However, a thorough evaluation of safety outcomes has not been conducted.
Hepatic ...There is some concern about the safety of ingesting large amounts of Saigon cinnamon for extended durations due to its coumarin content. Saigon cinnamon contains higher levels of coumarin than other cinnamon species (92558). In humans, very high doses of coumarin from 50-7000 mg daily can result in hepatotoxicity that resolves when coumarin is discontinued (15302).
