Each 2 drop serving contains: extra virgin Olive Oil , Wild Sage Oil.
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Below is general information about the effectiveness of the known ingredients contained in the product Oil of Sage. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
INSUFFICIENT RELIABLE EVIDENCE to RATE
INSUFFICIENT RELIABLE EVIDENCE to RATE
Below is general information about the safety of the known ingredients contained in the product Oil of Sage. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
LIKELY SAFE ...when olive fruit is used orally and appropriately in amounts commonly found in foods.
POSSIBLY SAFE ...when olive leaf extract is used orally and appropriately. Olive leaf extract providing 51-100 mg oleuropein daily has been used with apparent safety for 6-8 weeks (92245,92247,101860). There is insufficient reliable information available about the safety of olive fruit extract when used in amounts greater than those found in foods.
PREGNANCY AND LACTATION:
Insufficient reliable information available; stick with amounts commonly found in foods.
LIKELY SAFE ...when used orally in amounts commonly found in foods. Sage is approved for use as a food in the United States (4912).
POSSIBLY SAFE ...when used orally in medicinal doses, short-term. Common sage (Salvia officinalis) and Spanish sage (Salvia lavandulaefolia) have been used with apparent safety when taken orally in doses of 280 mg daily for up to 8 weeks (10334,10810,17177,105338). ...when used topically. Common sage (Salvia officinalis) has been used with apparent safety as a single agent or in combination products for up to one week (10437,72619,107023). ...when the essential oil is inhaled as aromatherapy, short-term (72658).
POSSIBLY UNSAFE ...when used orally in high doses or long-term (12,1304). Some species of sage, including common sage (Salvia officinalis), contain a thujone constituent that can be toxic if consumed in large enough quantities (12,1304).
PREGNANCY: LIKELY UNSAFE
when used orally.
The constituent thujone can have menstrual stimulant and abortifacient effects (19).
LACTATION: POSSIBLY UNSAFE
when used orally; sage is thought to reduce the supply of mother's milk (19).
Below is general information about the interactions of the known ingredients contained in the product Oil of Sage. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
Theoretically, sage might decrease the clinical effects of anticholinergic drugs.
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Theoretically, sage might interfere with the clinical effects of anticonvulsant drugs.
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Some species of sage can cause convulsions when consumed in large quantities (10812).
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Theoretically, taking sage with antidiabetes drugs might increase the risk of hypoglycemia.
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In patients with polycystic ovary syndrome (PCOS) or inadequately controlled type 2 diabetes, common sage (Salvia officinalis) has demonstrated hypoglycemic activity (91971,103380). However, other clinical research in patients with inadequately controlled type 2 diabetes shows that common sage extract does not lower fasting blood glucose levels (105340).
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Theoretically, sage might increase or decrease the effects of antihypertensive drugs.
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Animal research suggests that common sage (Salvia officinalis) can cause prolonged blood pressure reduction (4152). However, clinical research suggests that Spanish sage (Salvia lavandulaefolia) can increase blood pressure in some people with hypertension (10334). Until more is known, use with caution.
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Theoretically, taking sage might increase the sedative and adverse effects of benzodiazepines.
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In vitro evidence suggests that certain components of common sage (Salvia officinalis) can bind to benzodiazepine receptors (72588). This effect has not been reported in humans.
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Theoretically, sage might have additive effects when used with cholinergic drugs.
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Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.
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Some constituents of sage have CNS depressant activity (10334).
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Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C19.
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In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2C19 (10848). So far, this interaction has not been reported in humans.
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Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C9.
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In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2C9 (10848). So far, this interaction has not been reported in humans.
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Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2D6.
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Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
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Animal research suggests that drinking common sage (Salvia officinalis) tea increases the expression of CYP2E1 (72627). So far, this interaction has not been reported in humans.
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Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
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Theoretically, sage might interfere with hormone therapy.
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In vitro evidence suggests that geraniol, a constituent of Spanish sage (Salvia lavandulaefolia), exerts estrogenic activity (39572). The clinical significance of this effect is unclear.
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Theoretically, sage might increase levels of drugs transported by P-glycoprotein.
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In vitro research suggests that common sage (Salvia officinalis) can inhibit the multi-drug transporter protein, P-glycoprotein (72641). This effect has not been reported in humans.
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Below is general information about the adverse effects of the known ingredients contained in the product Oil of Sage. Some ingredients may not be listed. This information does NOT represent a recommendation for or a test of this specific product as a whole.
General
...Orally, olive fruit is well tolerated when used in typical food amounts.
Olive leaf extract seems to be well tolerated.
Most Common Adverse Effects:
Orally: Headache and stomach discomfort.
Dermatologic ...Orally, one patient in one clinical trial reported bad skin and acne after using olive leaf extract (101860).
Gastrointestinal ...Orally, three patients in one clinical trial reported stomach ache after using olive leaf extract (101860).
Neurologic/CNS ...Orally, three patients in one clinical trial reported headache after using olive leaf extract (101860).
Psychiatric ...In one case report, a 67-year-old female experienced irritability, anger, a lack of control, and feelings of sadness and negativity after consuming a multi-ingredient product containing olive leaf extract 5 grams, horseradish root, and eyebright daily for 38 days. All psychiatric symptoms disappeared within days of stopping the combined product. It is hypothesized that the hydroxytyrosol component of olive leaf extract contributed to these symptoms due to its chemical similarity to dopamine; however, it is not clear if these symptoms were due to the olive leaf extract or to the other ingredients (96245).
Pulmonary/Respiratory ...Olive tree pollen can cause seasonal respiratory allergy (1543).
General
...Orally, topically, and when inhaled, sage seems to be well tolerated.
Most Common Adverse Effects:
Orally: Abdominal pain, agitation, diarrhea, dizziness, nausea, and vomiting.
Topically: Burning, dermatitis, pain.
Serious Adverse Effects (Rare):
Orally: Generalized tonic-clonic seizures associated with the thujone, camphor, and/or cineol constituents.
Cardiovascular ...By inhalation, sage essential oil has been reported to increase the blood pressure of hypertensive patients (10334).
Dermatologic
...Orally, sage extract has been reported to cause acneiform skin eruptions in one patient in a clinical trial (91970).
Topically, sage leaves can cause contact dermatitis (46902,72661,72710). Sage extract can cause burning and pain (10437).
Gastrointestinal
...Orally, sage can cause nausea, vomiting, abdominal pain, and diarrhea (10810,17177).
Topically, sage extract sprayed into the mouth and throat can cause dryness or mild burning of the throat (72619).
Neurologic/CNS ...Orally, sage can cause dizziness or agitation (10810,17177). Thujone, a constituent of common sage (Salvia officinalis), is a neurotoxin and can cause seizures (10812,12868). Camphor and cineol, constituents of common sage and Spanish sage, can also cause neurotoxicity and seizures in high doses (10334,12868). Generalized tonic-clonic seizures have been reported in adults, children, and infants after ingestion of sage oil (12868,72666).
Pulmonary/Respiratory
...Orally, sage can cause wheezing (10810,17177).
Occupational exposure to sage dust can cause reduction in ventilatory capacity and chronic respiratory impairment (72672,72682,72686).