12
McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
2743
Dr. Duke's Phytochemical and Ethnobotanical Databases. Ethnobotanical uses: Andrographis paniculata. www.ars-grin.gov/cgi-bin/duke/ethnobot.pl?andrographis%20pnaiculata (Accessed 27 January 2000).
2744
Caceres DD, Hancke JL, Burgos RA, et al. Use of visual analogue scale measurements (VAS) to assess the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized, double-blind, placebo study. Phytomedicine 1999;6:217-23..
View abstract.
2746
Indian Herbs. Andrographis paniculata. www.indianherbs.com (Accessed 23 June 2004).
2748
Thamlikitkul V, Dechatiwongse T, Theerapong S, et al. Efficacy of Andrographis paniculata, Nees for pharyngotonsillitis in adults. J Med Assoc Thai 1991;74:437-42.
View abstract.
2750
Madav S, Tripathi HC, Tandan SK, et al. Antiallergic activity of andrographolide. Indian J Pharm Sci 1998;60:176-8.
2751
Gupta PP, Tandon JS, Patnaik GK. Antiallergic activity of andrographolides isolated from Andrographis paniculata (Burm. F) Wall. Pharm Biol 1998;36:72-4.
2752
Kumar S, Gopal K. Screening of plant species for inhibition of bacterial population of raw water. J Environ Sci Health A Tox Hazard Subst Environ Eng 1999;34:975-87.
2753
Madav S, Tripathi HC, Tandan Mishra SK. Analgesic, antipyretic and antiulcerogenic effects of andrographolide. Indian J Pharm Sci 1995;57:121-5.
2754
Vedavathy S, Rao KN. Antipyretic activity of six indigenous medicinal plants of Tirumala Hills, Andhra Pradesh, India. J Ethnopharmacol 1991;33:193-6.
View abstract.
2755
Zhang CY, Tan BK. Mechanisms of cardiovascular activity of Andrographis paniculata in the anaesthetized rat. J Ethnopharmacol 1997;56:97-101.
View abstract.
2756
Guo ZL, Zhao HY, Zheng XH. The effect of andrographis paniculata nees (APN) in alleviating the myocardial ischemic reperfusion injury. J Tongji Med Univ 1994;14:49-51.
View abstract.
2757
Guo Z, Zhao H, Fu L. Protective effects of API0134 on myocardial ischemia and reperfusion injury. J Tongji Med Univ 1996;16:193-7.
View abstract.
2758
Zhao HY, Fang WY. Antithrombotic effects of Andrographis paniculata nees in preventing myocardial infarction. Chin Med J (Engl) 1991;104:770-5.
View abstract.
2759
Amroyan E, Gabrielian E, Panossian A, et al. Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation. Phytomedicine 1999;6:27-31.
View abstract.
2760
Zhang C, Kuroyangi M, Tan BK. Cardiovascular activity of 14-deoxy-11,12-didehydroandrographolide in the anaesthetised rat and isolated right atria. Pharmacol Res 1998;38:413-7.
View abstract.
2761
Shukla B, Visen PK, Patnaik GK, Dhawan BN. Choleretic effect of andrographolide in rats and guinea pigs. Planta Med 1992;58:146-9.
View abstract.
2762
Visen PK, Shukla B, Patnaik GK, Dhawan BN. Andrographolide protects rat hepatocytes against paracetamol-induced damage. J Ethnopharmacol 1993;40:131-6.
View abstract.
2763
Rana AC, Avadhoot Y. Hepatoprotective effects of Andrographis paniculata against carbon tetrachloride-induced liver damage. Arch Pharm Res 1991;14:93-5.
View abstract.
2764
Leelarasamee A, Trakulsomboon S, Sittisomwong N. Undetectable anti-bacterial activity of Andrographis paniculata (Burma) wall. ex ness. J Med Assoc Thai 1990;73:299-304.
View abstract.
2765
Chang RS, Ding L, Chen GQ, et al. Dehydroandrographolide succinic acid monoester as an inhibitor against the human immunodeficiency virus. Proc Soc Exp Biol Med 1991;197:59-66.
View abstract.
2766
Puri A, Saxena R, Saxena RP, et al. Immunostimulant agents from Andrographis paniculata. J Nat Prod 1993;56:995-9.
View abstract.
2767
Raj RK. Screening of indigenous plants for anthelmintic action against human Ascaris lumbricoides:Part II. Ind J Physiol Pharmacol 1975;19;47-9.
View abstract.
2768
Matsuda T, Kuroyanagi M, Sugiyama S, et al. Cell differentiation-inducing diterpenes from Andrographis paniculata Nees. Chem Pharm Bull (Tokyo)1994;42:1216-25.
View abstract.
2769
Akbarsha MA, Manivannan B, Hamid KS, Vijayan B. Antifertility effect of Andrographis paniculata (Nees) in male albino rat. Indian J Exp Biol 1990;28:421-6.
View abstract.
2770
Burgos RA, Caballero EE, Sanchez NS, et al. Testicular toxicity assessment of Andrographis paniculata dried extract in rats. J Ethnopharmacol 1997;58:219-24.
View abstract.
2771
Panossian A, Kochikian A, Gabrielian E, et al. Effect of Andrographis paniculata extract on progesterone in blood plasma of pregnant rats. Phytomedicine 1999;6:157-61.
View abstract.
2772
Caceres DD, Hancke JL, Burgos RA, Wikman GK. Prevention of common colds with Andrographis Paniculata dried extract: a pilot, double-blind trial. Phytomedicine 1997;4:101-4.
2773
Melchior J, Palm S, Wikman G. Controlled clinical study of standardized Andrographis paniculata in common cold- a pilot trial. Phytomedicine 1996;97;3:315-8.
2774
Hancke J, Burgos R, Caceres D, Wikman G. A double-blind study with a new monodrug Kan Jang: decrease of symptoms and improvement in the recovery from common colds. Phytotherapy Res 1995;9:559-62.
2776
Zoha MS, Hussain AH, Choudhury SA. Antifertility effect of andrographis paniculata in mice. Bangladesh Med Res Counc Bull 1989;15:34-7.
View abstract.
2777
Gozalbes R, Galvez J, Garcia-Domenech R, Derouin F. Molecular search of new active drugs against Toxoplasma gondii. SAR QSAR Environ Res 1999;10:47-60.
View abstract.
2778
Kapil A, Koul IB, Banerjee SK, Gupta BD. Antihepatotoxic effects of major diterpenoid constituents of Andrographis paniculata. Biochem Pharmacol 1993;46:182-5.
View abstract.
2779
Gupta S, Yadava JN, Tandon JS. Antisecretory (antidiarrheal) activity of Indian medicinal plants against Escherchia coli enterotoxin-induced secretion in rabbit and guinea pig ileal loop models. Int J Pharmacogn 1993;31:198-204.
2780
Najib NA, Rahman N, Furuta T, et al. Antimalarial activity of extracts of Malaysian medicinal plants. J Ethnopharmacol 1999;64:249-54.
View abstract.
2781
Misra P, Pal NL, Guru PY, et al. Antimalarial activity of Andrographis paniculata (Kalmegh) against Plasmodium berghei NK 65 in Mastomys natalensis. Int J Pharmacogn 1992;30:263-74.
2782
Wang DW, Zhao HY. Prevention of atherosclerotic arterial stenosis and restenosis after angioplasty with Andrographis paniculata nees and fish oil. Experimental studies of effects and mechanisms. Chin Med J (Engl) 1994;107:464-70.
View abstract.
2783
Wang DW, Zhao HY. Experimental studies on prevention of atherosclerotic arterial stenosis and restenosis after angioplasty with Andrographis Paniculata Nees and fish oil. J Tongji Med Univ 1993;13:193-8.
View abstract.
5784
Melchoir J, Spasov AA, Ostrovskij OV, et al. Double-blind, placebo-controlled pilot and phase III study of activity of standardized Andrographis paniculata Herba Nees extract fixed combination (Kan Jang) in the treatment of uncomplicated upper-respiratory tract infection. Phytomedicine 2000;7:341-50.
View abstract.
6767
Calabrese C, Berman SH, Babish JG, et al. A phase I trial of andrographolide in HIV positive patients and normal volunteers. Phytother Res 2000;14:333-8.
View abstract.
10302
Kumar RA, Sridevi K, Kumar NV, et al. Anticancer and immunostimulatory compounds from Andrographis paniculata. J Ethnopharmacol 2004;92:291-5.
View abstract.
10441
Kulichenko LL, Kireyeva LV, Malyshkina EN, Wikman G. A Randomized, Controlled Study of Kan Jang versus Amantadine in the Treatment of Influenza in Volgograd. J Herb Pharmacother 2003;3:77-92.
View abstract.
10795
Gabrielian ES, Shukarian AK, Goukasova GI, et al. A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis. Phytomedicine 2002;9:589-97..
View abstract.
12380
Poolsup N, Suthisisang C, Prathanturarug S, et al. Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials. J Clin Pharm Ther 2004;29:37-45.
View abstract.
12381
Spasov AA, Ostrovskij OV, Chernikov MV, Wikman G. Comparative controlled study of Andrographis paniculata fixed combination, Kan Jang and an Echinacea preparation as adjuvant, in the treatment of uncomplicated respiratory disease in children. Phytother Res 2004;18:47-53.
View abstract.
12382
Amaryan G, Astvatsatryan V, Gabrielyan E, et al. Double-blind, placebo-controlled, randomized, pilot clinical trial of ImmunoGuard--a standardized fixed combination of Andrographis paniculata Nees, with Eleutherococcus senticosus Maxim, Schizandra chinensis Bail. and Glycyrrhiza glabra L. extracts in patients with Familial Mediterranean Fever. Phytomedicine 2003;10:271-85.
View abstract.
13016
Coon JT, Ernst E. Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Planta Med 2004;70:293-8.
View abstract.
31200
Chiou, W. F., Chen, C. F., and Lin, J. J. Mechanisms of suppression of inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells by andrographolide. Br.J.Pharmacol. 2000;129(8):1553-1560.
View abstract.
31202
Panossian, A., Hovhannisyan, A., Mamikonyan, G., Abrahamian, H., Hambardzumyan, E., Gabrielian, E., Goukasova, G., Wikman, G., and Wagner, H. Pharmacokinetic and oral bioavailability of andrographolide from Andrographis paniculata fixed combination Kan Jang in rats and human. Phytomedicine. 2000;7(5):351-364.
View abstract.
31205
Panossian, A., Davtyan, T., Gukassyan, N., Gukasova, G., Mamikonyan, G., Gabrielian, E., and Wikman, G. Effect of andrographolide and Kan Jang--fixed combination of extract SHA-10 and extract SHE-3--on proliferation of human lymphocytes, production of cytokines and immune activation markers in the whole blood cells culture. Phytomedicine. 2002;9(7):598-605.
View abstract.
31209
Iruretagoyena, M. I., Tobar, J. A., Gonzalez, P. A., Sepulveda, S. E., Figueroa, C. A., Burgos, R. A., Hancke, J. L., and Kalergis, A. M. Andrographolide interferes with T cell activation and reduces experimental autoimmune encephalomyelitis in the mouse. J.Pharmacol.Exp Ther. 2005;312(1):366-372.
View abstract.
31210
Hidalgo, M. A., Romero, A., Figueroa, J., Cortes, P., Concha, I. I., Hancke, J. L., and Burgos, R. A. Andrographolide interferes with binding of nuclear factor-kappaB to DNA in HL-60-derived neutrophilic cells. Br.J.Pharmacol. 2005;144(5):680-686.
View abstract.
31213
Kligler, B., Ulbricht, C., Basch, E., Kirkwood, C. D., Abrams, T. R., Miranda, M., Singh Khalsa, K. P., Giles, M., Boon, H., and Woods, J. Andrographis paniculata for the treatment of upper respiratory infection: a systematic review by the natural standard research collaboration. Explore.(NY) 2006;2(1):25-29.
View abstract.
31214
Jada, S. R., Hamzah, A. S., Lajis, N. H., Saad, M. S., Stevens, M. F., and Stanslas, J. Semisynthesis and cytotoxic activities of andrographolide analogues. J Enzyme Inhib.Med Chem 2006;21(2):145-155.
View abstract.
31215
Smith, P. L., Maloney, K. N., Pothen, R. G., Clardy, J., and Clapham, D. E. Bisandrographolide from Andrographis paniculata activates TRPV4 channels. J Biol Chem 10-6-2006;281(40):29897-29904.
View abstract.
31216
Li, W., Xu, X., Zhang, H., Ma, C., Fong, H., van Breemen, R., and Fitzloff, J. Secondary metabolites from Andrographis paniculata. Chem Pharm Bull.(Tokyo) 2007;55(3):455-458.
View abstract.
31218
Wibudi, A., Kiranadi, B., Manalu, W., winarto, A., and Suyono, S. The traditional plant, Andrographis paniculata (Sambiloto), exhibits insulin-releasing actions in vitro. Acta Med Indones. 2008;40(2):63-68.
View abstract.
31219
Cui, L., Chan, W., Qiu, F., Cai, Z., and Yao, X. Identification of four urea adducts of andrographolide in humans. Drug Metab Lett. 2008;2(4):261-268.
View abstract.
31220
Burgos, R. A., Hancke, J. L., Bertoglio, J. C., Aguirre, V., Arriagada, S., Calvo, M., and Caceres, D. D. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial. Clin Rheumatol. 2009;28(8):931-946.
View abstract.
31222
Saxena, R. C., Singh, R., Kumar, P., Yadav, S. C., Negi, M. P., Saxena, V. S., Joshua, A. J., Vijayabalaji, V., Goudar, K. S., Venkateshwarlu, K., and Amit, A. A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upper respiratory tract infection. Phytomedicine. 2010;17(3-4):178-185.
View abstract.
31223
Tang, T., Targan, S. R., Li, Z. S., Xu, C., Byers, V. S., and Sandborn, W. J. Randomised clinical trial: herbal extract HMPL-004 in active ulcerative colitis - a double-blind comparison with sustained release mesalazine. Aliment.Pharmacol Ther 2011;33(2):194-202.
View abstract.
31224
Akbar, S. Andrographis paniculata: a review of pharmacological activities and clinical effects. Altern.Med Rev. 2011;16(1):66-77.
View abstract.
31227
Lim, J. C., Chan, T. K., Ng, D. S., Sagineedu, S. R., Stanslas, J., and Wong, W. S. Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer. Clin Exp.Pharmacol Physiol 2012;39(3):300-310.
View abstract.
31230
Chen, Q., Liu, Y., Liu, Y. M., Liu, G. Y., Zhang, M. Q., Jia, J. Y., Lu, C., and Yu, C. Pharmacokinetics and tolerance of dehydroandrographolide succinate injection after intravenous administration in healthy Chinese volunteers. Acta Pharmacol Sin. 2012;33(10):1332-1336.
View abstract.
31231
Sandborn, W. J., Targan, S. R., Byers, V. S., Rutty, D. A., Mu, H., Zhang, X., and Tang, T. Andrographis paniculata extract (HMPL-004) for active ulcerative colitis. Am J Gastroenterol. 2013;108(1):90-98.
View abstract.
31232
Singh, P., Singh, I. N., Mondal, S. C., Singh, L., and Garg, V. K. Platelet-activating factor (PAF)-antagonists of natural origin. Fitoterapia 2013;84:180-201.
View abstract.
31233
Melchior, J., Palm, S., and Wikman, G. Controlled clinical study of standardized Andrographis paniculata extract in common cold - a pilot trial. Phytomedicine. 1997;3(4):315-318.
View abstract.
31235
Borhanuddin, M., Shamsuzzoha, M., and Hussain, A. H. Hypoglycaemic effects of Andrographis paniculata Nees on non-diabetic rabbits. Bangladesh Med.Res.Counc.Bull. 1994;20(1):24-26.
View abstract.
31236
Guo, Z. L., Zhao, H. Y., and Zheng, X. H. An experimental study of the mechanism of andrographis paniculata nees (APN) in alleviating the Ca(2+)-overloading in the process of myocardial ischemic reperfusion. J.Tongji Med.Univ 1995;15(4):205-208.
View abstract.
31237
Zhang, C. Y. and Tan, B. K. Hypotensive activity of aqueous extract of Andrographis paniculata in rats. Clin Exp Pharmacol.Physiol 1996;23(8):675-678.
View abstract.
31238
Chiou, W. F., Lin, J. J., and Chen, C. F. Andrographolide suppresses the expression of inducible nitric oxide synthase in macrophage and restores the vasoconstriction in rat aorta treated with lipopolysaccharide. Br.J.Pharmacol. 1998;125(2):327-334.
View abstract.
31240
Madav, S., Tripathi, H. C., and Tanden Mishra, S. K. Analgesic, antipyretic and antiulcerogenic effects of Andrographolide. Indian J Pharm Sci 1995;57:121-125.
31241
Caceres, D. D., Hancke, J. L., Burgos, R. A., and Wikman, G. K. Prevention of common colds with Andrographis paniculata dried extract: A pilot double blind trial. Phytomedicine 1997;4:101-104.
31242
Hancke, J., Burgos, R., Caceres, D., and Wikman, G. A double-blind study with a new monodrug Kan Jang: decrease of symptoms and improvement in the recovery from common colds. Phytother Res. 1995;1995(9):-559.
91837
Balap A, Atre B, Lohidasan S, et al. Pharmacokinetic and pharmacodynamic herb-drug interaction of Andrographis paniculata (Nees) extract and andrographolide with etoricoxib after oral administration in rats. J Ethnopharmacol. 2016 May 13;183:9-17.
View abstract.
91838
Bertoglio JC, Baumgartner M, Palma R, et al. Andrographis paniculata decreases fatigue in patients with relapsing-remitting multiple sclerosis: a 12-month double-blind placebo-controlled pilot study. BMC Neurol. 2016; 16(1):77.
View abstract.
91839
Phunikhom K, Khampitak K, Aromdee C, et al. Effect of Andrographis paniculata Extract on Triglyceride Levels of the Patients with Hypertriglyceridemia: A Randomized Controlled Trial. J Med Assoc Thai. 2015; 98 Suppl 6:S41-7.
View abstract.
91841
Suwankesawong W, Saokaew S, Permsuwan U, et al. Characterization of hypersensitivity reactions reported among Andrographis paniculata users in Thailand using Health Product Vigilance Center (HPVC) database. BMC Complement Altern Med. 2014; 14:515.
View abstract.
91842
Tan ML, Lim LE. The effects of Andrographis paniculata (Burm.f.) Nees extract and diterpenoids on the CYP450 isoforms' activities, a review of possible herb-drug interaction risks. Drug Chem Toxicol. 2015;38(3):241-53.
View abstract.
98222
Hu XY, Wu RH, Logue M, et al. Andrographis paniculata (Chuan Xin Lián) for symptomatic relief of acute respiratory tract infections in adults and children: a systematic review and meta-analysis. PLoS One 2017;12(8):e0181780.
View abstract.
101116
Hancke JL, Srivastav S, Cáceres DD, Burgos RA. A double-blind, randomized, placebo-controlled study to assess the efficacy of Andrographis paniculate standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis. Phytother Res. 2019;33(5):1469-1479.
View abstract.
101117
Widjajakusuma EC, Jonosewojo A, Hendriati L, et al. Phytochemical screening and preliminary clinical trials of the aqueous extract mixture of Andrographis paniculata (Burm. f.) Wall. ex Nees and Syzygium polyanthum (Wight.) Walp leaves in metformin treated patients with type 2 diabetes. Phytomedicine. 2019;55:137-147.
View abstract.
104821
Ciampi E, Uribe-San-Martin R, Cárcamo C, et al. Efficacy of andrographolide in not active progressive multiple sclerosis: a prospective exploratory double-blind, parallel-group, randomized, placebo-controlled trial. BMC Neurol 2020;20(1):173.
View abstract.
104822
Dimpfel W, Schombert L, Keplinger-Dimpfel IK, et al. Effects of an adaptogenic extract on electrical activity of the brain in elderly subjects with mild cognitive impairment: a randomized, double-blind, placebo-controlled, two-armed cross-over study. Pharmaceuticals (Basel) 2020;13(3):45.
View abstract.
107471
Narimanyan M, Jamalyan K, Balyan A, et al. Early intervention with Kan Jang® to treat upper-respiratory tract infections: A randomized, quadruple-blind study. J Tradit Complement Med 2021;11(6):552-562.
View abstract.
107473
Vikelis M, Dermitzakis EV, Vlachos GS, et al. Open Label Prospective Experience of Supplementation with a Fixed Combination of Magnesium, Vitamin B2, Feverfew, Andrographis Paniculata and Coenzyme Q10 for Episodic Migraine Prophylaxis. J Clin Med 2020;10(1):67.
View abstract.
107783
Worakunphanich W, Thavorncharoensap M, Youngkong S, Thadanipon K, Thakkinstian A. Safety of Andrographis paniculata: A systematic review and meta-analysis. Pharmacoepidemiol Drug Saf 2021;30(6):727-739.
View abstract.
107784
Rajanna M, Bharathi B, Shivakumar BR, et al. Immunomodulatory effects of Andrographis paniculata extract in healthy adults - An open-label study. J Ayurveda Integr Med 2021;12(3):529-534.
View abstract.
112916
More SJ, Tandulwadkar SS, Balap AR, Lohidasan S, Sinnathambi A, Mahadik KR. Effect of Andrographis paniculata extract and Andrographolide on the pharmacokinetics of Aceclofenac and Celecoxib in rats. Futur J Pharm Sci. 2023;9(1):1.
View abstract.
112917
Sundhani E, Nugroho AE, Nurrochmad A, Puspitasari I, Amalia Prihati D, Lukitaningsih E. Pharmacokinetic Herb-Drug Interactions of Glipizide with Andrographis paniculata (Burm. f.) and Andrographolide in Normal and Diabetic Rats by Validated HPLC Method. Molecules 2022;27(20):6901.
View abstract.
112918
Tarigan TJE, Purwaningsih EH, Yusra, et al. Effects of Sambiloto (Andrographis paniculata) on GLP-1 and DPP-4 Concentrations between Normal and Prediabetic Subjects: A Crossover Study. Evid Based Complement Alternat Med 2022;2022:1535703.
View abstract.
112919
Tanwettiyanont J, Piriyachananusorn N, Sangsoi L, et al. Use of Andrographis paniculata (Burm.f.) Wall. ex Nees and risk of pneumonia in hospitalised patients with mild coronavirus disease 2019: A retrospective cohort study. Front Med (Lausanne) 2022;9:947373.
View abstract.
112920
Shanker K, Rangnekar H, Wele A, et al. A randomized controlled pilot study of add-on therapy of CIM-MEG19 (standardized Andrographis paniculata formulation) in mild to moderate COVID-19. Phytomed Plus 2023;3(1):100398.
View abstract.
112921
Shang YX, Shen C, Stub T, et al. Adverse Effects of Andrographolide Derivative Medications Compared to the Safe use of Herbal Preparations of Andrographis paniculata: Results of a Systematic Review and Meta-Analysis of Clinical Studies. Front Pharmacol 2022;13:773282.
View abstract.