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Pancreatic Enzyme Products
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Lauque, S., Nourhashemi, F., Baudouin, M., Ghisolfi-Marque, A., Beziat, F., Moreau, J., Dyard, F., Vellas, B., and Albarede, J. L. Assessment of the effectiveness of drug therapies on nutritional status in the elderly: "concerning a randomised, double-blind clinical study of the activity of pancreatic extracts and a placebo during the renutrition of elderly subjects suffering from protein caloric undernutrition". J Nutr.Health Aging 1998;2(1):18-20. View abstract.
67622
O'Keefe, S. J., Cariem, A. K., and Levy, M. The exacerbation of pancreatic endocrine dysfunction by potent pancreatic exocrine supplements in patients with chronic pancreatitis. J Clin Gastroenterol. 2001;32(4):319-323. View abstract.
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Mossner, J., Secknus, R., Meyer, J., Niederau, C., and Adler, G. Treatment of pain with pancreatic extracts in chronic pancreatitis: results of a prospective placebo-controlled multicenter trial. Digestion 1992;53(1-2):54-66. View abstract.
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Patchell, C. J., Desai, M., Weller, P. H., Macdonald, A., Smyth, R. L., Bush, A., Gilbody, J. S., and Duff, S. A. Creon 10,000 Minimicrospheres vs. Creon 8,000 microspheres--an open randomised crossover preference study. J Cyst.Fibros. 2002;1(4):287-291. View abstract.
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Elliott, R. B., Escobar, L. C., Lees, H. R., Akroyd, R. M., and Reilly, H. C. A comparison of two pancreatin microsphere preparations in cystic fibrosis. N.Z.Med.J. 3-25-1992;105(930):107-108. View abstract.
67634
Zentler-Munro, P. L., Assoufi, B. A., Balasubramanian, K., Cornell, S., Benoliel, D., Northfield, T. C., and Hodson, M. E. Therapeutic potential and clinical efficacy of acid-resistant fungal lipase in the treatment of pancreatic steatorrhoea due to cystic fibrosis. Pancreas 1992;7(3):311-319. View abstract.
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67639
Ewald, N., Bretzel, R. G., Fantus, I. G., Hollenhorst, M., Kloer, H. U., and Hardt, P. D. Pancreatin therapy in patients with insulin-treated diabetes mellitus and exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations. Results of a prospective multi-centre trial. Diabetes Metab Res Rev. 2007;23(5):386-391. View abstract.
67640
Delchier, J. C., Vidon, N., Saint-Marc Girardin, M. F., Soule, J. C., Moulin, C., Huchet, B., and Zylberberg, P. Fate of orally ingested enzymes in pancreatic insufficiency: comparison of two pancreatic enzyme preparations. Aliment.Pharmacol Ther. 1991;5(4):365-378. View abstract.
67641
Shin, S. Y., Hur, G. Y., Ye, Y. M., and Park, H. S. A case of occupational rhinitis caused by porcine pancreatic extract developing into occupational asthma. J Korean Med Sci. 2008;23(2):347-349. View abstract.
67643
Williams, J., Macdonald, A., Weller, P. H., Fields, J., and Pandov, H. Two enteric coated microspheres in cystic fibrosis. Arch Dis.Child 1990;65(6):594-597. View abstract.
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Andersen, H. O., Hjelt, K., Waever, E., and Overgaard, K. The age-related incidence of meconium ileus equivalent in a cystic fibrosis population: the impact of high-energy intake. J Pediatr Gastroenterol.Nutr 1990;11(3):356-360. View abstract.
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Stern, M., Plettner, C., and Gruttner, R. [Pancreatic enzyme replacement in mucoviscidosis (CF): clinical evaluation of a gastric acid-resistant pancreatin preparation in encapsulated microtablet form]. Klin.Padiatr. 1988;200(1):36-39. View abstract.
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Littlewood, J. M., Kelleher, J., Walters, M. P., and Johnson, A. W. In vivo and in vitro studies of microsphere pancreatic supplements. J Pediatr.Gastroenterol.Nutr. 1988;7 Suppl 1:S22-S29. View abstract.
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Ramo, O. J., Puolakkainen, P. A., Seppala, K., and Schroder, T. M. Self-administration of enzyme substitution in the treatment of exocrine pancreatic insufficiency. Scand.J Gastroenterol. 1989;24(6):688-692. View abstract.
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67650
Robinson, P. J., Olinsky, A., Smith, A. L., and Chitravanshi, S. B. High compared with standard dose lipase pancreatic supplement. Arch Dis.Child 1989;64(1):143-145. View abstract.
67651
Aparisi, L., Rodrigo, J. M., Serra, M. A., Del Olmo, J., Bisquert, M., and Raga, F. [Efficacy of a new microencapsulated pancreatin versus a conventional preparation, in the treatment of steatorrhea of pancreatic origin]. Rev.Esp.Enferm.Apar.Dig. 1989;76(1):25-30. View abstract.
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Stead, R. J., Skypala, I., and Hodson, M. E. Treatment of steatorrhoea in cystic fibrosis: a comparison of enteric-coated microspheres of pancreatin versus non-enteric-coated pancreatin and adjuvant cimetidine. Aliment.Pharmacol.Ther. 1988;2(6):471-482. View abstract.
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Ansaldi-Balocco, N., Santini, B., and Sarchi, C. Efficacy of pancreatic enzyme supplementation in children with cystic fibrosis: comparison of two preparations by random crossover study and a retrospective study of the same patients at two different ages. J Pediatr Gastroenterol.Nutr 1988;7 Suppl 1:S40-S45. View abstract.
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Carroccio, A., Pardo, F., Montalto, G., Japichino, L., Iacono, G., Collura, M., and Notarbartolo, A. Effectiveness of enteric-coated preparations on nutritional parameters in cystic fibrosis. A long-term study. Digestion 1988;41(4):201-206. View abstract.
67656
Duhamel, J. F., Vidailhet, M., Le Luyer, B., Douchain, F., Jehanne, M., Clavel, R., and Guillot, M. [Multicenter comparative study of a new formulation of pancreatin in gastro-resistant microgranules for the treatment of exocrine pancreatic insufficiency in children with mucoviscidosis]. Ann.Pediatr.(Paris) 1988;35(1):69-74. View abstract.
67657
Beverley, D. W., Kelleher, J., Macdonald, A., Littlewood, J. M., Robinson, T., and Walters, M. P. Comparison of four pancreatic extracts in cystic fibrosis. Arch Dis.Child 1987;62(6):564-568. View abstract.
67658
Stead, R. J., Skypala, I., Hodson, M. E., and Batten, J. C. Enteric coated microspheres of pancreatin in the treatment of cystic fibrosis: comparison with a standard enteric coated preparation. Thorax 1987;42(7):533-537. View abstract.
67660
Lankisch, P. G., Lembcke, B., Goke, B., and Creutzfeldt, W. Therapy of pancreatogenic steatorrhoea: does acid protection of pancreatic enzymes offer any advantage? Z.Gastroenterol. 1986;24(12):753-757. View abstract.
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Petersen, W., Heilmann, C., and Garne, S. Pancreatic enzyme supplementation as acid-resistant microspheres versus enteric-coated granules in cystic fibrosis. A double placebo-controlled cross-over study. Acta Paediatr.Scand 1987;76(1):66-69. View abstract.
67662
Halgreen, H., Pedersen, N. T., and Worning, H. Symptomatic effect of pancreatic enzyme therapy in patients with chronic pancreatitis. Scand J Gastroenterol. 1986;21(1):104-108. View abstract.
67663
Zentler-Munro, P. L., Fine, D. R., Batten, J. C., and Northfield, T. C. Effect of cimetidine on enzyme inactivation, bile acid precipitation, and lipid solubilisation in pancreatic steatorrhoea due to cystic fibrosis. Gut 1985;26(9):892-901. View abstract.
67664
Braggion, C. and Mastella, G. [Clinical trial of several preparation types of the pancreatic extract Pancrex V in the treatment of cystic fibrosis]. Minerva Pediatr 11-30-1985;37(21-22):891-896. View abstract.
67666
Silber, W. Pankreoflat in benign diseases of the oesophagus: a blind therapeutic trial. S.Afr.Med J 7-7-1973;47(26):1137-1138. View abstract.
67667
Buckle, R. M. Maintenance therapy of pancreatic steatorrhoea with concentrated pancreatic extract. Br.J Clin.Pract. 1965;19(12):683-686. View abstract.
67669
Slaff, J., Jacobson, D., Tillman, C. R., Curington, C., and Toskes, P. Protease-specific suppression of pancreatic exocrine secretion. Gastroenterology 1984;87(1):44-52. View abstract.
67670
O'Keefe, S. J. and Adam, J. Assessment of adequacy of pancreatic enzyme replacement with the multiple-phase carbon-14-triolein test. S.Afr.Med J 11-17-1984;66(20):763-765. View abstract.
67672
Isaksson, G. and Ihse, I. Pain reduction by an oral pancreatic enzyme preparation in chronic pancreatitis. Dig.Dis.Sci 1983;28(2):97-102. View abstract.
67673
Sack, J., Blau, H., Goldfarb, D., Ben-Zaray, S., and Katznelson, D. Hyperuricosuria in cystic fibrosis patients treated with pancreatic enzyme supplements. A study of 16 patients in Israel. Isr.J Med Sci. 1980;16(6):417-419. View abstract.
67676
Mischler, E. H., Parrell, S., Farrell, P. M., and Odell, G. B. Comparison of effectiveness of pancreatic enzyme preparations in cystic fibrosis. Am J Dis.Child 1982;136(12):1060-1063. View abstract.
67677
Oades, P. J., Bush, A., Ong, P. S., and Brereton, R. J. High-strength pancreatic enzyme supplements and large-bowel stricture in cystic fibrosis. Lancet 1-8-1994;343(8889):109. View abstract.
67678
Mac Sweeney, E. J., Oades, P. J., Buchdahl, R., Rosenthal, M., and Bush, A. Relation of thickening of colon wall to pancreatic-enzyme treatment in cystic fibrosis. Lancet 3-25-1995;345(8952):752-756. View abstract.
67679
Jones, R., Franklin, K., Spicer, R., and Berry, J. Colonic strictures in children with cystic fibrosis on low-strength pancreatic enzymes. Lancet 8-19-1995;346(8973):499. View abstract.
67680
Taylor, C. J. and Steiner, G. M. Fibrosing colonopathy in a child on low-dose pancreatin. Lancet 10-21-1995;346(8982):1106-1107. View abstract.
67682
Ong, P. S., Oades, P. J., Bush, A., and Brereton, R. J. Colonic stricture in a boy with cystic fibrosis. Postgrad.Med J 1995;71(835):309-312. View abstract.
67683
Malesci, A., Gaia, E., Fioretta, A., Bocchia, P., Ciravegna, G., Cantor, P., and Vantini, I. No effect of long-term treatment with pancreatic extract on recurrent abdominal pain in patients with chronic pancreatitis. Scand.J Gastroenterol. 1995;30(4):392-398. View abstract.
67685
Layer, P. and Groger, G. Fate of pancreatic enzymes in the human intestinal lumen in health and pancreatic insufficiency. Digestion 1993;54 Suppl 2:10-14. View abstract.
67686
Mossner, J. Is there a place for pancreatic enzymes in the treatment of pain in chronic pancreatitis? Digestion 1993;54 Suppl 2:35-39. View abstract.
67687
Gan, K. H., Heijerman, H. G., Geus, W. P., Bakker, W., and Lamers, C. B. Comparison of a high lipase pancreatic enzyme extract with a regular pancreatin preparation in adult cystic fibrosis patients. Aliment.Pharmacol.Ther. 1994;8(6):603-607. View abstract.
67688
Nakamura, T., Takebe, K., Kudoh, K., Ishii, M., Imamura, K., Kikuchi, H., Kasai, F., Tandoh, Y., Yamada, N., Arai, Y., and . Effects of pancreatic digestive enzymes, sodium bicarbonate, and a proton pump inhibitor on steatorrhoea caused by pancreatic diseases. J Int Med Res 1995;23(1):37-47. View abstract.
67689
Milla, C. E., Wielinski, C. L., and Warwick, W. J. High-strength pancreatic enzymes. Lancet 3-5-1994;343(8897):599. View abstract.
67690
McHugh, K., Thomson, A., and Tam, P. Case report: colonic stricture and fibrosis associated with high-strength pancreatic enzymes in a child with cystic fibrosis. Br.J Radiol. 1994;67(801):900-901. View abstract.
67692
Santini, B. and Ivaldi, A. P. [Pancreatic extract therapy in exocrine pancreatic insufficiency]. Minerva Gastroenterol.Dietol. 1993;39(3):133-137. View abstract.
67693
Nouisa-Arvanitakis, S., Stapleton, F. B., Linshaw, M. A., and Kennedy, J. Therapeutic approach to pancreatic extract-induced hyperuricosuria in cystic fibrosis. J Pediatr 1977;90(2):302-305. View abstract.
67694
Guarner, L., Rodriguez, R., Guarner, F., and Malagelada, J. R. Fate of oral enzymes in pancreatic insufficiency. Gut 1993;34(5):708-712. View abstract.
67696
Lancellotti, L., Cabrini, G., Zanolla, L., and Mastella, G. High- versus low-lipase acid-resistant enzyme preparations in cystic fibrosis: a crossover randomized clinical trial. J Pediatr.Gastroenterol.Nutr. 1996;22(1):73-78. View abstract.
67699
Van Hoozen, C. M., Peeke, P. G., Taubeneck, M., Frey, C. F., and Halsted, C. H. Efficacy of enzyme supplementation after surgery for chronic pancreatitis. Pancreas 1997;14(2):174-180. View abstract.
67701
FitzSimmons, S. C., Burkhart, G. A., Borowitz, D., Grand, R. J., Hammerstrom, T., Durie, P. R., Lloyd-Still, J. D., and Lowenfels, A. B. High-dose pancreatic-enzyme supplements and fibrosing colonopathy in children with cystic fibrosis. N.Engl.J Med 5-1-1997;336(18):1283-1289. View abstract.
67705
Stapleton, F. B., Kennedy, J., Nousia-Arvanitakis, S., and Linshaw, M. A. Hyperuricosuria due to high-dose pancreatic extract therapy in cystic fibrosis. N.Engl.J Med 7-29-1976;295(5):246-248. View abstract.
67707
Brown, A., Hughes, M., Tenner, S., and Banks, P. A. Does pancreatic enzyme supplementation reduce pain in patients with chronic pancreatitis: a meta-analysis. Am J Gastroenterol. 1997;92(11):2032-2035. View abstract.
67708
Bruno, M. J., Haverkort, E. B., Tijssen, G. P., Tytgat, G. N., and van Leeuwen, D. J. Placebo controlled trial of enteric coated pancreatin microsphere treatment in patients with unresectable cancer of the pancreatic head region. Gut 1998;42(1):92-96. View abstract.
67709
Miyoshi, H. and Kanzaki, T. Drug eruption (erythema multiforme type) due to a digestive enzyme drug. J Dermatol. 1998;25(1):28-31. View abstract.
67713
Layer, P. and Keller, J. Pancreatic enzymes: secretion and luminal nutrient digestion in health and disease. J Clin Gastroenterol. 1999;28(1):3-10. View abstract.
67714
Chazalette, J. P. A Double-Blind Placebo-Controlled Trial of a Pancreatic Enzyme Formulation (Panzytrat 25 000) in the Treatment of Impaired Lipid Digestion in Patients with Cystic Fibrosis. Drug Investigation 1993;5(5):274.
67715
Salen, G. and Prakash, A. Evaluation of enteric-coated microspheres for enzyme replacement therapy in adults with pancreatic insufficiency. Curr Ther Res 1979;25:650-656.
67716
Larvin, M., McMahon, M. J., and Thomas, W. E. G. Creon (enteric coated pancreatin microspheres) for the treatment of pain in chronic pancreatitis: A double blind randomised placebo-controlled crossover study (abstract). Gastroenterology 1991;1000:A283.
95742
Gardner TB, Munson JC, Morden NE. The FDA and Prescription Pancreatic Enzyme Product Cost. Am J Gastroenterol. 2014;109(5):624-5. View abstract.
95743
U.S. Food and Drug Administration. Updated Questions and Answers for Healthcare Professionals and the Public: Use an Approved Pancreatic Enzyme Product (PEP). Available at: https://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm204745.htm. Accessed April 24, 2019.
95744
Catarci M, Berlanda M, Grassi GB, Masedu F, Guadagni S. Pancreatic enzyme supplementation after gastrectomy for gastric cancer: a randomized controlled trial. Gastric Cancer. 2018;21(3):542-551. View abstract.
98667
Seiler CM, Izbicki J, Varga-Szabó L, et al. Randomised clinical trial: a 1-week, double-blind, placebo-controlled study of pancreatin 25 000 Ph. Eur. minimicrospheres (Creon 25000 MMS) for pancreatic exocrine insufficiency after pancreatic surgery, with a 1-year open-label extension. Aliment Pharmacol Ther. 2013;37(7):691-702. View abstract.
98674
Thorat V, Reddy N, Bhatia S, et al. Randomised clinical trial: the efficacy and safety of pancreatin enteric-coated minimicrospheres (Creon 40000 MMS) in patients with pancreatic exocrine insufficiency due to chronic pancreatitis--a double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2012;36(5):426-36. View abstract.
98675
Lee SK, Kim MS, Lee UH. Acute generalized exanthematous pustulosis induced by a digestive enzyme drug, Festal(®). Clin Exp Dermatol. 2018;43(3):321-323. View abstract.
98676
Whitcomb DC, Bodhani A, Beckmann K, et al. Efficacy and safety of pancrelipase/pancreatin in patients with exocrine pancreatic insufficiency and a medical history of diabetes mellitus. Pancreas. 2016;45(5):679-86. View abstract.
98677
Ramesh H, Reddy N, Bhatia S, et al. A 51-week, open-label clinical trial in India to assess the efficacy and safety of pancreatin 40000 enteric-coated minimicrospheres in patients with pancreatic exocrine insufficiency due to chronic pancreatitis. Pancreatology. 2013;13(2):133-9. View abstract.
99111
Saito T, Nakai Y, Isayama H, et al. A multicenter open-label randomized controlled trial of pancreatic enzyme replacement therapy in unresectable pancreatic cancer. Pancreas. 2018;47:800-806. View abstract.
99112
Satoi S, Sho M, Yanagimoto H, et al. Do pancrelipase delayed-release capsules have a protective role against non-alcoholic fatty liver disease after pancreatoduodenectomy in patients with pancreatic cancer? A randomized controlled trial. J Hepatobiliary Pancreat Sci. 2016;23(3):167-73. View abstract.
99113
Nagai M, Sho M, Satoi S, et al. Effects of pancrelipase on nonalcoholic fatty liver disease after pancreaticoduodenectomy. J Hepatobiliary Pancreat Sci. 2014;21(3):186-92. View abstract.
99114
Woo SM, Joo J, Kim SY, et al. Efficacy of pancreatic exocrine replacement therapy for patients with unresectable pancreatic cancer in a randomized trial. Pancreatology. 2016;16(6):1099-1105. View abstract.
99115
Toskes PP, Secci A, Thieroff-Ekerdt R; ZENPEP Study Group. Efficacy of a novel pancreatic enzyme product, EUR-1008 (Zenpep), in patients with exocrine pancreatic insufficiency due to chronic pancreatitis. Pancreas. 2011;40(3):376-82. View abstract.
99116
Whitcomb DC, Lehman GA, Vasileva G, et al. Pancrelipase delayed-release capsules (CREON) for exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery: A double-blind randomized trial. Am J Gastroenterol. 2010;105(10):2276-86. View abstract.
99117
Kahl S, Schütte K, Glasbrenner B, et al. The effect of oral pancreatic enzyme supplementation on the course and outcome of acute pancreatitis: a randomized, double-blind parallel-group study. JOP. 2014;15(2):165-74. View abstract.
99118
Trapnell BC, Strausbaugh SD, Woo MS, et al. Efficacy and safety of PANCREAZE® for treatment of exocrine pancreatic insufficiency due to cystic fibrosis. J Cyst Fibros. 2011;10(5):350-6. View abstract.
99119
Graff GR, Maguiness K, McNamara J, et al. Efficacy and tolerability of a new formulation of pancrelipase delayed-release capsules in children aged 7 to 11 years with exocrine pancreatic insufficiency and cystic fibrosis: a multicenter, randomized, double-blind, placebo-controlled, two-period crossover, superiority study. Clin Ther. 2010;32(1):89-103. View abstract.
99120
Trapnell BC, Maguiness K, Graff GR, Boyd D, Beckmann K, Caras S. Efficacy and safety of Creon 24,000 in subjects with exocrine pancreatic insufficiency due to cystic fibrosis. J Cyst Fibros. 2009;8(6):370-7. View abstract.
99121
Munck A, Duhamel JF, Lamireau T, et al. Pancreatic enzyme replacement therapy for young cystic fibrosis patients. J Cyst Fibros. 2009;8(1):14-8. View abstract.
99122
Taylor CJ, Thieroff-Ekerdt R, Shiff S, Magnus L, Fleming R, Gommoll C. Comparison of two pancreatic enzyme products for exocrine insufficiency in patients with cystic fibrosis. J Cyst Fibros. 2016;15(5):675-80. View abstract.
99123
Carroccio A, Guarino A, Zuin G, et al. Efficacy of oral pancreatic enzyme therapy for the treatment of fat malabsorption in HIV-infected patients. Aliment Pharmacol Ther. 2001;15(10):1619-25. View abstract.
99124
Santini B, Antonelli M, Battistini A, et al. Comparison of two enteric coated microsphere preparations in the treatment of pancreatic exocrine insufficiency caused by cystic fibrosis. Dig Liver Dis. 2000;32(5):406-11. View abstract.
99125
Brady MS, Garson JL, Krug SK, et al. An enteric-coated high-buffered pancrelipase reduces steatorrhea in patients with cystic fibrosis: a prospective, randomized study. J Am Diet Assoc. 2006;106(8):1181-6. View abstract.
99126
Stern RC, Eisenberg JD, Wagener JS, et al. A comparison of the efficacy and tolerance of pancrelipase and placebo in the treatment of steatorrhea in cystic fibrosis patients with clinical exocrine pancreatic insufficiency. Am J Gastroenterol. 2000;95(8):1932-8. View abstract.
99127
Safdi M, Bekal PK, Martin S, Saeed ZA, Burton F, Toskes PP. The effects of oral pancreatic enzymes (Creon 10 capsule) on steatorrhea: a multicenter, placebo-controlled, parallel group trial in subjects with chronic pancreatitis. Pancreas. 2006;33(2):156-62. View abstract.
99129
Trang T, Chan J, Graham DY. Pancreatic enzyme replacement therapy for pancreatic exocrine insufficiency in the 21(st) century. World J Gastroenterol. 2014;20(33):11467-85. View abstract.
99130
Guidance for Industry Exocrine Pancreatic Insufficiency Drug Products - Submitting NDAs. Available at: https://www.fda.gov/ucm/groups/fdagov-public/@fdagov-drugs-gen/documents/document/ucm071651.pdf. Accessed March 29, 2019.
102321
Singer S, Koenekoop J, Meddings J, Powell J, Desroches A, Seidman EG. Pancreatic Enzyme Supplementation in Patients with Atopic Dermatitis and Food Allergies: An Open-Label Pilot Study. Paediatr Drugs. 2019 Feb;21(1):41-45. View abstract.
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Kim H, Yoon YS, Han Y, et al. Effects of Pancreatic Enzyme Replacement Therapy on Body Weight and Nutritional Assessments After Pancreatoduodenectomy in a Randomized Trial. Clin Gastroenterol Hepatol. 2019 Sep 12. pii: S1542-3565(19)30990-5. View abstract.
106322
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Silano V, et al. Safety evaluation of a food enzyme containing trypsin and chymotrypsin from porcine pancreas. EFSA J 2021;19(1):e06369. View abstract.
106323
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Silano V, et al. Safety evaluation of a food enzyme containing trypsin, chymotrypsin, elastase and carboxypeptidase from porcine pancreas. EFSA J 2021;19(1):e06368. View abstract.
106324
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Lambré C, et al. Safety evaluation of a food enzyme containing trypsin and chymotrypsin from porcine pancreas. EFSA J 2021;19(6):e06640. View abstract.
107411
Amoateng R, Hardman B, Liu C, Austin S. Rare case of pancrelipase therapy-induced neutropaenia. BMJ Case Rep 2021;14(3):e241799. View abstract.