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Rutin
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Cesarone, M. R., Belcaro, G., Pellegrini, L., Ledda, A., Di Renzo, A., Vinciguerra, G., Ricci, A., Gizzi, G., Ippolito, E., Fano, F., Dugall, M., Acerbi, G., and Cacchio, M. HR, 0-(beta-hydroxyethyl)-rutosides, in comparison with diosmin+hesperidin in chronic venous insufficiency and venous microangiopathy: an independent, prospective, comparative registry study. Angiology 2005;56(1):1-8. View abstract.
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72045
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72047
Titapant V, Indrasukhsri B, Lekprasert V, et al. Trihydroxyethylrutosides in the treatment of hemorrhoids of pregnancy: a double-blind placebo-controlled trial. J Med Assoc Thai 2001;84(10):1395-1400. View abstract.
72049
Incandela L, Belcaro G, Renton S, et al. HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides) in venous hypertensive microangiopathy: a prospective, placebo-controlled, randomized trial. J Cardiovasc Pharmacol Ther 2002;7 Suppl 1:S7-S10. View abstract.
72050
Incandela L, Cesarone MR, DeSanctis MT, et al. Treatment of diabetic microangiopathy and edema with HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides): a prospective, placebo-controlled, randomized study. J Cardiovasc Pharmacol Ther 2002;7 Suppl 1:S11-S15. View abstract.
72051
Cesarone MR, Belcaro G, Incandela L, et al. Flight microangiopathy in medium-to-long distance flights: prevention of edema and microcirculation alterations with HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides): a prospective, randomized, controlled trial. J Cardiovasc Pharmacol Ther 2002;7 Suppl 1:S17-S20. View abstract.
72052
Cesarone MR, Incandela L, DeSanctis MT, et al. Treatment of edema and increased capillary filtration in venous hypertension with HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides): a clinical, prospective, placebo-controlled, randomized, dose-ranging trial. J Cardiovasc Pharmacol Ther 2002;7 Suppl 1:S21-S24. View abstract.
72054
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72055
Belcaro G, Cesarone MR, Bavera P, et al. HR (Venoruton1000, Paroven, 0-[beta-hydroxyethyl]-rutosides) vs. Daflon 500 in chronic venous disease and microangiopathy: an independent prospective, controlled, randomized trial. J Cardiovasc Pharmacol Ther 2002;7(3):139-145. View abstract.
72057
Belcaro G, Cesarone MR, Nicolaides AN, et al. The LONFLIT4-VENORUTON study: a randomized trial prophylaxis of flight-edema in normal subjects. Clin Appl Thromb Hemost 2003;9(1):19-23. View abstract.
72058
Cesarone MR, Belcaro G, Geroulakos G, et al. Flight microangiopathy on long-haul flights: prevention of edema and microcirculation alterations with Venoruton. Clin Appl Thromb Hemost 2003;9(2):109-114. View abstract.
72059
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72061
De Cecco L. [Effects of administration of 50 mg heparan sulfate tablets to patients with varicose dilatation of the hemorrhoid plexus (hemorrhoids)]. Minerva Ginecol 1992;44(11):599-604. View abstract.
72063
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72064
Cesarone MR, Belcaro G, Pellegrini L, et al. HR, 0-(beta-hydroxyethyl)-rutosides; (Venoruton): rapid relief of signs/symptoms in chronic venous insufficiency and microangiopathy: a prospective, controlled study. Angiology 2005;56(2):165-172. View abstract.
72065
Cesarone MR, Laurora G, Ricci A, et al. Acute effects of hydroxyethylrutosides on capillary filtration in normal volunteers, patients with venous hypertension and in patients with diabetic microangiopathy (a dose comparison study). Vasa 1992;21(1):76-80. View abstract.
72066
Cesarone MR, Belcaro G, Ricci A, et al. Prevention of edema and flight microangiopathy with Venoruton (HR), (0-[beta-hydroxyethyl]-rutosides) in patients with varicose veins. Angiology 2005;56(3):289-293. View abstract.
72067
Bergstein NA. Clinical study on the efficacy of O-(beta-hydroxyethyl)rutoside (HR) in varicosis of pregnancy. J Int Med Res 1975;3(3):189-193. View abstract.
72068
Lefebvre G, Lacombe C. [Venous insufficiency in the pregnant woman. Rheological correction by troxerutin]. Rev Fr Gynecol Obstet 1991;86(2 Pt 2):206-208. View abstract.
72069
Marhic C. [Clinical and rheological efficacy of troxerutin in obstetric gynecology]. Rev Fr Gynecol Obstet 1991;86(2 Pt 2):209-212. View abstract.
72070
Rehn D, Hennings G, Nocker W, et al. Time course of the anti-oedematous effect of O-(beta-hydroxyethyl)-rutosides in healthy volunteers. Eur J Clin Pharmacol 1991;40(6):625-627. View abstract.
72071
Wright DD, Franks PJ, Blair SD, et al. Oxerutins in the prevention of recurrence in chronic venous ulceration: randomized controlled trial. Br J Surg 1991;78(10):1269-1270. View abstract.
72072
Auteri A, Blardi P, Frigerio C, et al. Pharmacodynamics of troxerutine in patients with chronic venous insufficiency: correlations with plasma drug levels. Int J Clin Pharmacol Res 1990;10(4):235-241. View abstract.
72074
Belcaro G, Rulo A, Candiani C. Evaluation of the microcirculatory effects of Venoruton in patients with chronic venous hypertension by laserdoppler flowmetry, transcutaneous PO2 and PCO2 measurements, leg volumetry and ambulatory venous pressure measurements. Vasa 1989;18(2):146-151. View abstract.
72075
Roztocil K, Oliva I, Prerovsky I, et al. The effect of hydroxyethylrutoside and its combination with acetylsalicylic acid in patients with obliterative atherosclerosis. Cor Vasa 1989;31(2):128-133. View abstract.
72076
Belcaro G, Errichi BM, Laurora G, et al. Treatment of acute superficial thrombosis and follow-up by computerized thermography. Vasa 1989;18(3):227-234. View abstract.
72077
Nocker W, Diebschlag W, Lehmacher W. [A 3-month, randomized double-blind dose-response study with 0-(beta-hydroxyethyl)-rutoside oral solutions]. Vasa 1989;18(3):235-238. View abstract.
72078
de Jongste AB, Jonker JJ, Huisman MV, et al. A double blind three center clinical trial on the short-term efficacy of 0-(beta-hydroxyethyl)-rutosides in patients with post-thrombotic syndrome. Thromb Haemost 1989;62(3):826-829. View abstract.
72079
Casley-Smith JR, Casley-Smith JR, Johnson AF, et al. Benzo-pyrones in the treatment of chronic schizophrenic diseases. Psychiatry Res 1986;18(3):267-273. View abstract.
72081
Piller NB, Morgan RG, Casley-Smith JR. A double-blind, cross-over trial of O-(beta-hydroxyethyl)-rutosides (benzo-pyrones) in the treatment of lymphoedema of the arms and legs. Br J Plast Surg 1988;41(1):20-27. View abstract.
72082
Annoni F, Boccasanta P, Chiurazzi D, et al. [Treatment of acute symptoms of hemorrhoid disease with high-dose oral O-(beta-hydroxyethyl)-rutosides]. Minerva Med 1986;77(37):1663-1668. View abstract.
72083
Stegmann W, Hubner K, Deichmann B, et al. [Efficacy of O-(beta-hydroxyethyl)-rutosides in the treatment of venous leg ulcers]. Phlebologie 1987;40(1):149-156. View abstract.
72084
Cappelli R, Pecchi S, Oberhauser V, et al. Efficacy of O-(beta-hydroxyethyl)-rutosides at high dosage in counteracting the unwanted activity of oral contraceptives on venous function. Int J Clin Pharmacol Res 1987;7(4):291-299. View abstract.
72085
Gallasch G, Dorfer C, Schmitt T, et al. [Efficacy of troxerutin on the flow properties of blood under defined conditions of circulation. A double-blind study of patients with diabetic retinopathy and arteriosclerotic retinopathy]. Klin Monatsbl Augenheilkd 1985;187(1):30-35. View abstract.
72086
Pulvertaft TB. Paroven in the treatment of chronic venous insufficiency. Practitioner 1979;223(1338):838-841. View abstract.
72087
Prerovsky I, Roztocil K, Hlavova A, et al. The effect of hydroxyethylrutosides after acute and chronic oral administration in patients with venous diseases. A double-blind study. Angiologica 1972;9(3-6):408-414. View abstract.
72088
Pischnamazzadeh M. [Prevention of radiation-induced skin reactions in breast cancer]. Strahlentherapie 1983;159(1):9-12. View abstract.
72089
Pulvertaft TB. General practice treatment of symptoms of venous insufficiency with oxerutins. Results of a 660 patient multicentre study in the UK. Vasa 1983;12(4):373-376. View abstract.
72090
Moser M, Ranacher G, Wilmot TJ, et al. A double-blind clinical trial of hydroxyethylrutosides in Meniere's disease. J Laryngol Otol 1984;98(3):265-272. View abstract.
72091
Artaria LG. [Prevention of cystoid macular edema with O-beta-hydroxyethyl-rutoside (Venoruton) in a double-blind study]. Klin Monatsbl Augenheilkd 1982;180(6):568-570. View abstract.
72092
Forconi S, Guerrini M, Pecchi S, et al. Effect of HR (O-(beta-hydroxyethyl)-rutosides) on the impaired venous function of young females taking oral contraceptives. A strain gauge plethysmographic and clinical open controlled study. Vasa 1980;9(4):324-330. View abstract.
72093
Bergqvist D, Hallbook T, Lindblad B, et al. A double-blind trial of O-(beta-hydroxyethyl)-rutoside in patients with chronic venous insufficiency. Vasa 1981;10(3):253-260. View abstract.
72094
Balmer A, Limoni C. [Clinical, placebo-controlled double-blind study of venoruton in the treatment of chronic venous insufficiency. Importance of the selection of patients]. Vasa 1980;9(1):76-82. View abstract.
72095
Neumann HA, van den Broek MJ. A comparative clinical trial of graduated compression stockings and O-(beta-hydroxyethyl)-rutosides (HR) in the treatment of patients with chronic venous insufficiency. Z Lymphol 1995;19(1):8-11. View abstract.
72097
Sohn C, Jahnichen C, Bastert G. [Effectiveness of beta-hydroxyethylrutoside in patients with varicose veins in pregnancy]. Zentralbl Gynakol 1995;117(4):190-197. View abstract.
72098
Renton S, Leon M, Belcaro G, et al. The effect of hydroxyethylrutosides on capillary filtration in moderate venous hypertension: a double blind study. Int Angiol 1994;13(3):259-262. View abstract.
72099
Glacet-Bernard A, Coscas G, Chabanel A, et al. A randomized, double-masked study on the treatment of retinal vein occlusion with troxerutin. Am J Ophthalmol 1994;118(4):421-429. View abstract.
72100
Poynard T, Valterio C. Meta-analysis of hydroxyethylrutosides in the treatment of chronic venous insufficiency. Vasa 1994;23(3):244-250. View abstract.
72101
MacLennan WJ, Wilson J, Rattenhuber V, et al. Hydroxyethylrutosides in elderly patients with chronic venous insufficiency: its efficacy and tolerability. Gerontology 1994;40(1):45-52. View abstract.
72102
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72103
Rehn D, Nocker W, Diebschlag W, et al. Time course of the anti-oedematous effect of different dose regimens of O-(beta-hydroxyethyl) rutosides in healthy volunteers. Arzneimittelforschung 1993;43(3):335-338. View abstract.
72105
Unkauf M, Rehn D, Klinger J, et al. Investigation of the efficacy of oxerutins compared to placebo in patients with chronic venous insufficiency treated with compression stockings. Arzneimittelforschung 1996;46(5):478-482. View abstract.
72106
Rehn D, Brunnauer H, Diebschlag W, et al. Investigation of the therapeutic equivalence of different galenical preparations of O-(beta-hydroxyethyl)-rutosides following multiple dose peroral administration. Arzneimittelforschung 1996;46(5):488-492. View abstract.
72107
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72109
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72111
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Bolten WW, Glade MJ, Raum S, et al. The safety and efficacy of an enzyme combination in managing knee osteoarthritis pain in adults: a randomized, double-blind, placebo-controlled trial. Arthritis. 2015;2015:251521. View abstract.
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Choi SJ, Lee SN, Kim K, et al. Biological effects of rutin on skin aging. Int J Mol Med 2016;38(1):357-63. View abstract.
92237
Dubey S, Ganeshpurkar A, Bansal D, Dubey N. Protective effect of rutin on cognitive impairment caused by phenytoin. Indian J Pharmacol 2015;47(6):627-31. View abstract.
92238
Oliveira VM, Carraro E, Auler ME, Khalil NM. Quercetin and rutin as potential agents antifungal against Cryptococcus spp. Braz J Biol 2016;76(4):1029-34. View abstract.
92239
Kreft M. Buckwheat phenolic metabolites in health and disease. Nutr Res Rev 2016;29(1):30-9. View abstract.
92240
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92333
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Taliou A, Zintzaras E, Lykouras L, Francis K. An open-label pilot study of a formulation containing the anti-inflammatory flavonoid luteolin and its effects on behavior in children with autism spectrum disorders. Clin Ther. 2013;35(5):592-602. View abstract.
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Grabs V, Kersten A, Haller B, et al. Rutoside and hydrolytic enzymes do not attenuate marathon-induced inflammation. Med Sci Sports Exerc. 2017;49(3):387-395. View abstract.
96767
Peres DA, de Oliveira CA, da Costa MS, et al. Rutin increases critical wavelength of systems containing a single UV filter and with good skin compatibility. Skin Res Technol. 2016;22(3):325-33. View abstract.
99258
Tomazelli LC, de Assis Ramos MM, Sauce R, et al. SPF enhancement provided by rutin in a multifunctional sunscreen. Int J Pharm. 2018;552(1-2):401-406. View abstract.
99259
Tasli NG, Uçak T, Karakurt Y, et al. The effects of rutin on cisplatin induced oxidative retinal and optic nerve injury: an experimental study. Cutan Ocul Toxicol. 2018;37(3):252-257. View abstract.
99260
Cândido TM, De Oliveira CA, Ariede MB, Velasco MVR, Rosado C, Baby AR. Safety and antioxidant efficacy profiles of rutin-loaded ethosomes for topical application. AAPS PharmSciTech. 2018;19(4):1773-1780. View abstract.
99467
Akhtar NM, Naseer R, Farooqi AZ, Aziz W, Nazir M. Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee--a double-blind prospective randomized study. Clin Rheumatol. 2004;23(5):410-5. View abstract.
99468
Baumhackl U, Kappos L, Radue EW, et al. A randomized, double-blind, placebo-controlled study of oral hydrolytic enzymes in relapsing multiple sclerosis. Mult Scler. 2005;11(2):166-8. View abstract.
99472
Kempf K, Manzo G, Hanifi-Moghaddam P, et al. Effect of combined oral proteases and flavonoid treatment in subjects at risk of Type 1 diabetes. Diabet Med. 2009;26(12):1309-10. View abstract.
99473
Kerkhoffs GM, Struijs PA, de Wit C, Rahlfs VW, Zwipp H, van Dijk CN. A double blind, randomised, parallel group study on the efficacy and safety of treating acute lateral ankle sprain with oral hydrolytic enzymes. Br J Sports Med. 2004;38(4):431-5. View abstract.
99476
Shetty V, Mohan A. A prospective, randomized, double-blind, placebo-controlled clinical trial comparing the efficacy of systemic enzyme therapy for edema control in orthognathic surgery using ultrasound scan to measure facial swelling. J Oral Maxillofac Surg. 2013;71(7):1261-7. View abstract.
99477
Tilwe GH, Beria S, Turakhia NH, Daftary GV, Schiess W. Efficacy and tolerability of oral enzyme therapy as compared to diclofenac in active osteoarthrosis of knee joint: an open randomized controlled clinical trial. J Assoc Physicians India. 2001;49:617-21. View abstract.
103298
Michelini S, Fiorentino A, Cardone M. Melilotus, rutin and bromelain in primary and secondary lymphedema. Lymphology 2019;52(4):177-86. View abstract.
105298
Hashizume Y, Tandia M. The reduction impact of monoglucosyl rutin on abdominal visceral fat: A randomized, placebo-controlled, double-blind, parallel-group. J Food Sci. 2020;85(10):3577-3589. View abstract.
105299
Sun C, Wang L, Sun J, Wang Z, Tang Z. Hypoglycemic and hypolipidemic effects of rutin on hyperglycemic rats. J Tradit Chin Med. 2020;40(4):640-645. View abstract.
112182
Bazyar H, Moradi L, Zaman F, Zare Javid A. The effects of rutin flavonoid supplement on glycemic status, lipid profile, atherogenic index of plasma, brain-derived neurotrophic factor (BDNF), some serum inflammatory, and oxidative stress factors in patients with type 2 diabetes mellitus: A double-blind, placebo-controlled trial. Phytother Res 2023;37(1):271-284. View abstract.