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Papaya
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Manufacturer: Walgreens. Deerfield, IL.
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Marotta, F., Tajiri, H., Barreto, R., Brasca, P., Ideo, G. M., Mondazzi, L., Safran, P., Bobadilla, J., and Ideo, G. Cyanocobalamin absorption abnormality in alcoholics is improved by oral supplementation with a fermented papaya-derived antioxidant. Hepatogastroenterology 2000;47(34):1189-1194. View abstract.
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Rimbach, G., Guo, Q., Akiyama, T., Matsugo, S., Moini, H., Virgili, F., and Packer, L. Ferric nitrilotriacetate induced DNA and protein damage: inhibitory effect of a fermented papaya preparation. Anticancer Res 2000;20(5A):2907-2914. View abstract.
67860
Lohiya, N. K., Kothari, L. K., Manivannan, B., Mishra, P. K., and Pathak, N. Human sperm immobilization effect of Carica papaya seed extracts: an in vitro study. Asian J Androl 2000;2(2):103-109. View abstract.
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Ncube, T. N., Greiner, T., Malaba, L. C., and Gebre-Medhin, M. Supplementing lactating women with puréed papaya and grated carrots improved vitamin A status in a placebo-controlled trial. J Nutr 2001;131(5):1497-1502. View abstract.
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Marotta, F., Safran, P., Tajiri, H., Princess, G., Anzulovic, H., Ideo, G. M., Rouge, A., Seal, M. G., and Ideo, G. Improvement of hemorheological abnormalities in alcoholics by an oral antioxidant. Hepatogastroenterology 2001;48(38):511-517. View abstract.
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Wilson, R. K., Kwan, T. K., Kwan, C. Y., and Sorger, G. J. Effects of papaya seed extract and benzyl isothiocyanate on vascular contraction. Life Sci 6-21-2002;71(5):497-507. View abstract.
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Oderinde, O., Noronha, C., Oremosu, A., Kusemiju, T., and Okanlawon, O. A. Abortifacient properties of aqueous extract of Carica papaya (Linn) seeds on female Sprague-Dawley rats. Niger.Postgrad.Med J 2002;9(2):95-98. View abstract.
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Deiana, M., Dessi, M. A., Ke, B., Liang, Y. F., Higa, T., Gilmour, P. S., Jen, L. S., Rahman, I., and Aruoma, O. I. The antioxidant cocktail effective microorganism X (EM-X) inhibits oxidant-induced interleukin-8 release and the peroxidation of phospholipids in vitro. Biochem.Biophys.Res Commun. 9-6-2002;296(5):1148-1151. View abstract.
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Rimbach, G., Park, Y. C., Guo, Q., Moini, H., Qureshi, N., Saliou, C., Takayama, K., Virgili, F., and Packer, L. Nitric oxide synthesis and TNF-alpha secretion in RAW 264.7 macrophages: mode of action of a fermented papaya preparation. Life Sci 6-30-2000;67(6):679-694. View abstract.
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Giuliano, A. R., Siegel, E. M., Roe, D. J., Ferreira, S., Baggio, M. L., Galan, L., Duarte-Franco, E., Villa, L. L., Rohan, T. E., Marshall, J. R., and Franco, E. L. Dietary intake and risk of persistent human papillomavirus (HPV) infection: the Ludwig-McGill HPV Natural History Study. J Infect.Dis. 11-15-2003;188(10):1508-1516. View abstract.
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Mojica-Henshaw, M. P., Francisco, A. D., De, Guzman F., and Tigno, X. T. Possible immunomodulatory actions of Carica papaya seed extract. Clin Hemorheol.Microcirc. 2003;29(3-4):219-229. View abstract.
67884
Dawkins, G., Hewitt, H., Wint, Y., Obiefuna, P. C., and Wint, B. Antibacterial effects of Carica papaya fruit on common wound organisms. West Indian Med J 2003;52(4):290-292. View abstract.
67885
Datla, K. P., Bennett, R. D., Zbarsky, V., Ke, B., Liang, Y. F., Higa, T., Bahorun, T., Aruoma, O. I., and Dexter, D. T. The antioxidant drink effective microorganism-X (EM-X) pre-treatment attenuates the loss of nigrostriatal dopaminergic neurons in 6-hydroxydopamine-lesion rat model of Parkinson's disease. J Pharm Pharmacol 2004;56(5):649-654. View abstract.
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Marotta, F., Barreto, R., Tajiri, H., Bertuccelli, J., Safran, P., Yoshida, C., and Fesce, E. The aging/precancerous gastric mucosa: a pilot nutraceutical trial. Ann.N.Y.Acad.Sci 2004;1019:195-199. View abstract.
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Menon, V., Ram, M., Dorn, J., Armstrong, D., Muti, P., Freudenheim, J. L., Browne, R., Schunemann, H., and Trevisan, M. Oxidative stress and glucose levels in a population-based sample. Diabet.Med 2004;21(12):1346-1352. View abstract.
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Mourvaki, E., Gizzi, S., Rossi, R., and Rufini, S. Passionflower fruit-a "new" source of lycopene? J Med Food 2005;8(1):104-106. View abstract.
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Marotta, F., Pavasuthipaisit, K., Yoshida, C., Albergati, F., and Marandola, P. Relationship between aging and susceptibility of erythrocytes to oxidative damage: in view of nutraceutical interventions. Rejuvenation.Res 2006;9(2):227-230. View abstract.
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Marotta, F., Weksler, M., Naito, Y., Yoshida, C., Yoshioka, M., and Marandola, P. Nutraceutical supplementation: effect of a fermented papaya preparation on redox status and DNA damage in healthy elderly individuals and relationship with GSTM1 genotype: a randomized, placebo-controlled, cross-over study. Ann.N.Y.Acad.Sci 2006;1067:400-407. View abstract.
67900
Nakamura, Y. and Miyoshi, N. Cell death induction by isothiocyanates and their underlying molecular mechanisms. Biofactors 2006;26(2):123-134. View abstract.
67901
Aruoma, O. I., Colognato, R., Fontana, I., Gartlon, J., Migliore, L., Koike, K., Coecke, S., Lamy, E., Mersch-Sundermann, V., Laurenza, I., Benzi, L., Yoshino, F., Kobayashi, K., and Lee, M. C. Molecular effects of fermented papaya preparation on oxidative damage, MAP Kinase activation and modulation of the benzo[a]pyrene mediated genotoxicity. Biofactors 2006;26(2):147-159. View abstract.
67902
Danese, C., Esposito, D., D'Alfonso, V., Cirene, M., Ambrosino, M., and Colotto, M. Plasma glucose level decreases as collateral effect of fermented papaya preparation use. Clin Ter. 2006;157(3):195-198. View abstract.
67903
Zhang, J., Mori, A., Chen, Q., and Zhao, B. Fermented papaya preparation attenuates beta-amyloid precursor protein: beta-amyloid-mediated copper neurotoxicity in beta-amyloid precursor protein and beta-amyloid precursor protein Swedish mutation overexpressing SH-SY5Y cells. Neuroscience 11-17-2006;143(1):63-72. View abstract.
67904
Miyoshi, N., Uchida, K., Osawa, T., and Nakamura, Y. Selective cytotoxicity of benzyl isothiocyanate in the proliferating fibroblastoid cells. Int J Cancer 2-1-2007;120(3):484-492. View abstract.
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Marotta, F., Yoshida, C., Barreto, R., Naito, Y., and Packer, L. Oxidative-inflammatory damage in cirrhosis: effect of vitamin E and a fermented papaya preparation. J Gastroenterol.Hepatol. 2007;22(5):697-703. View abstract.
67910
Owoyele, B. V., Adebukola, O. M., Funmilayo, A. A., and Soladoye, A. O. Anti-inflammatory activities of ethanolic extract of Carica papaya leaves. Inflammopharmacology. 2008;16(4):168-173. View abstract.
67913
Chota, A., Sikasunge, C. S., Phiri, A. M., Musukwa, M. N., Haazele, F., and Phiri, I. K. A comparative study of the efficacy of piperazine and Carica papaya for the control of helminth parasites in village chickens in Zambia. Trop.Anim Health Prod. 2010;42(3):315-318. View abstract.
67914
Otsuki, N., Dang, N. H., Kumagai, E., Kondo, A., Iwata, S., and Morimoto, C. Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects. J Ethnopharmacol. 2-17-2010;127(3):760-767. View abstract.
67924
Ballot, D., Baynes, R. D., Bothwell, T. H., Gillooly, M., MacFarlane, B. J., MacPhail, A. P., Lyons, G., Derman, D. P., Bezwoda, W. R., Torrance, J. D., and . The effects of fruit juices and fruits on the absorption of iron from a rice meal. Br J Nutr 1987;57(3):331-343. View abstract.
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Vallis, C. P. and Lund, M. H. Effect of treatment with Carica papaya on resolution of edema and ecchymosis following rhinoplasty. Curr.Ther.Res.Clin.Exp. 1969;11(6):356-359. View abstract.
67929
Costanza, D. J. Carotenemia associated with papaya ingestion. Calif.Med 1968;109(4):319-320. View abstract.
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Wimalawansa, S. J. Papaya in the treatment of chronic infected ulcers. Ceylon Med J 1981;26(3):129-132. View abstract.
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Jayarajan, P., Reddy, V., and Mohanram, M. Effect of dietary fat on absorption of beta carotene from green leafy vegetables in children. Indian J Med Res 1980;71:53-56. View abstract.
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Giordani, R., Cardenas, M. L., Moulin-Traffort, J., and Regli, P. Fungicidal activity of latex sap from Carica papaya and antifungal effect of D(+)-glucosamine on Candida albicans growth. Mycoses 1996;39(3-4):103-110. View abstract.
67939
Potischman, N. and Brinton, L. A. Nutrition and cervical neoplasia. Cancer Causes Control 1996;7(1):113-126. View abstract.
67940
Odani, S., Yokokawa, Y., Takeda, H., Abe, S., and Odani, S. The primary structure and characterization of carbohydrate chains of the extracellular glycoprotein proteinase inhibitor from latex of Carica papaya. Eur.J Biochem. 10-1-1996;241(1):77-82. View abstract.
67941
Lohsoonthorn, P. and Danvivat, D. Colorectal cancer risk factors: a case-control study in Bangkok. Asia Pac.J Public Health 1995;8(2):118-122. View abstract.
67942
Iliev, D. and Elsner, P. Generalized drug reaction due to papaya juice in throat lozenges. Dermatology 1997;194(4):364-366. View abstract.
93083
Andersen HA, Bernatz PE, Grindlay JH. Perforation of the esophagus after use of a digestant agent: report of case and experimental study. Ann Otol Rhinol Laryngol 1959;68:890-6. View abstract.
93084
Asghar N, Naqvi SA, Hussain Z, et al. Compositional difference in antioxidant and antibacterial activity of all parts of the Carica papaya using different solvents. Chem Cent J 2016;10:5. View abstract.
93085
Aziz J, Abu Kassim NL, Abu Kasim NH, Haque N, Rahman MT. Carica papaya induces in vitro thrombopoietic cytokines secretion by mesenchymal stem cells and haematopoietic cells. BMC Complement Altern Med 2015;15:215. View abstract.
93086
de Azeredo EL, Monteiro RQ, de-Oliveira Pinto LM. Thrombocytopenia in dengue: interrelationship between virus and the imbalance between coagulation and fibrinolysis and inflammatory mediators. Mediators Inflamm 2015;2015:313842. View abstract.
93087
Deiana L, Marini S, Mariotti S. Ingestion of large amounts of papaya fruit and impaired effectiveness of levothyroxine therapy. Endocr Pract 2012;18(1):98-100. View abstract.
93090
Kharaeva ZF, Zhanimova LR, Mustafaev MSh, et al. Effects of standardised fermented papaya gel on clinical symptoms, inflammatory cytokines, and nitric oxide metabolites in patients with chronic periodontitis: an open randomised clinical study. Mediators Inflamm 2016;2016:9379840. View abstract.
93091
Murthy MB, Murthy BK, Bhave S. Comparison of safety and efficacy of papaya dressing with hydrogen peroxide solution on wound bed preparation in patients with wound gape. Indian J Pharmacol 2012;44(6):784-7. View abstract.
93092
Nguyen TT, Parat MO, Shaw PN, Hewavitharana AK, Hodson MP. Traditional aboriginal preparation alters the chemical profile of Carica papaya leaves and impacts on cytotoxicity towards human squamous cell carcinoma. PLoS One 2016;11(2):e0147956. View abstract.
93093
Rodrigues M, Alves G, Francisco J, Fortuna A, Falcão A. Herb-drug pharmacokinetic interaction between Carica papaya extract and amiodarone in rats. J Pharm Pharm Sci 2014;17(3):302-15. View abstract.
99861
Saliasi I, Llodra JC, Bravo M, et al. Effect of a toothpaste/mouthwash containing Carica papaya leaf extract on interdental gingival bleeding: a randomized controlled trial. Int J Environ Res Public Health 2018;15(12). pii: E2660. View abstract.
99862
Sharma N, Mishra KP, Chanda S, et al. Evaluation of anti-dengue activity of Carica papaya aqueous leaf extract and its role in platelet augmentation. Arch Virol 2019;164(4):1095-110. View abstract.
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Monti R, Basilio CA, Trevisan HC, Contiero J. Purification of papain from fresh latex of Carica papaya. Brazilian Archives of Biology and Technology. 2000;43(5):501-7.
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Rajapakse S, de Silva NL, Weeratunga P, Rodrigo C, Sigera C, Fernando SD. Carica papaya extract in dengue: a systematic review and meta-analysis. BMC Complement Altern Med. 2019;19(1):265. View abstract.
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Sathyapalan DT, Padmanabhan A, Moni M, et al. Efficacy & safety of Carica papaya leaf extract (CPLE) in severe thrombocytopenia (≤30,000/μl) in adult dengue - Results of a pilot study. PLoS One. 2020;15(2):e0228699. View abstract.
103304
Alkhouli M, Laflouf M, Alhaddad M. Efficacy of Aloe-vera use for prevention of chemotherapy-induced oral mucositis in children with acute lymphoblastic leukemia: A randomized controlled clinical trial. Compr Child Adolesc Nurs. 2020:1-14. View abstract.
103863
Agada R, Usman WA, Shehu S, Thagariki D. In vitro and in vivo inhibitory effects of Carica papaya seed on α-amylase and α-glucosidase enzymes. Heliyon. 2020;6(3):e03618. View abstract.
105908
Hampilos K, Corn J, Hodsdon W, et al. Effect Of Carica Papaya Leaf Extract On Platelet Count In Chronic Immune Thrombocytopenic Purpura: A Case Series. Integr Med (Encinitas). 2019;18(5):30-35. View abstract.
110433
Cespedes D, Mendez J, Villasanti U. Carica papaya mouthrinse as an inhibitor of Streptococcus mutans: Randomized controlled clinical trial. Am J Dent 2021;34(5):273-276. View abstract.
110434
Rao DG, Havale R, Sara SS, Bemalgi N, Fatima BO, Kumar AY. Antibacterial efficacy of Carica papaya leaf extract, probiotics, kidodent, and placebo mouthwashes in reduction of salivary Streptococcus mutans: A double-blinded parallel designed randomized controlled trial. J Indian Soc Pedod Prev Dent 2021;39(3):291-298. View abstract.
111719
Mayer W, Weibel M, De Luca C, et al. Biomolecules of Fermented Tropical Fruits and Fermenting Microbes as Regulators of Human Hair Loss, Hair Quality, and Scalp Microbiota. Biomolecules 2023;13(4):699. View abstract.