References
Lactoferrin
2490
Yamauchi K, Wakabayashi H, Hashimoto S, et al. Effects of orally administered bovine lactoferrin on the immune system of healthy volunteers. Adv Exp Med Biol 1998;443:261-5. View abstract.
2491
Bellamy W, Takase M, Wakabayashi H, et al. Antibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin. J Appl Bacteriol 1992;73:472-9. View abstract.
13312
Food and Drug Administration, CFSAN/Office of Food Additive Safety. Agency Response Letter GRAS Notice No. GRN 000130. 2003. Available at: http://www.cfsan.fda.gov/~rdb/opa-g130.html (Accessed 29 June 2005).
13313
Ishibashi Y, Takeda K, Tsukidate N, et al. Randomized placebo-controlled trial of interferon alpha-2b plus ribavirin with and without lactoferrin for chronic hepatitis C. Hepatol Res 2005;32:218-23. View abstract.
13314
Hirashima N, Orito E, Ohba K, et al. A randomized controlled trial of consensus interferon with or without lactoferrin for chronic hepatitis C patients with genotype 1b and high viral load. Hepatol Res 2004;29:9-12. View abstract.
13315
Zullo A, De Francesco V, Scaccianoce G, et al. Quadruple therapy with lactoferrin for Helicobacter pylori eradication: A randomised, multicentre study. Dig Liver Dis 2005;37:496-500. View abstract.
13316
Di Mario F, Aragona G, Bo ND, et al. Use of lactoferrin for Helicobacter pylori eradication. Preliminary results. J Clin Gastroenterol 2003;36:396-8. View abstract.
13317
Guttner Y, Windsor HM, Viiala CH, Marshall BJ. Human recombinant lactoferrin is ineffective in the treatment of human Helicobacter pylori infection. Aliment Pharmacol Ther 2003;17:125-9. View abstract.
13318
Troost FJ, Saris WH, Brummer RJ. Orally ingested human lactoferrin is digested and secreted in the upper gastrointestinal tract in vivo in women with ileostomies. J Nutr 2002;132:2597-600. View abstract.
13319
Troost FJ, Saris WH, Brummer RJ. Recombinant human lactoferrin ingestion attenuates indomethacin-induced enteropathy in vivo in healthy volunteers. Eur J Clin Nutr 2003;57:1579-85. View abstract.
13320
Ishii K, Takamura N, Shinohara M, et al. Long-term follow-up of chronic hepatitis C patients treated with oral lactoferrin for 12 months. Hepatol Res 2003;25:226-233. View abstract.
13321
Iwasa M, Kaito M, Ikoma J, et al. Lactoferrin inhibits hepatitis C virus viremia in chronic hepatitis C patients with high viral loads and HCV genotype 1b. Am J Gastroenterol 2002;97:766-7.
13322
Di Mario F, Aragona G, Dal Bo N, et al. Use of bovine lactoferrin for Helicobacter pylori eradication.Dig Liver Dis 2003;35:706-10. . View abstract.
13323
Okada S, Tanaka K, Sato T, et al. Dose-response trial of lactoferrin in patients with chronic hepatitis C. Jpn J Cancer Res 2002;93:1063-9. View abstract.
13324
Kaito M. Use of lactoferrin for chronic hepatitis C. Hepatol Res 2005;32:200-1. View abstract.
13325
Sherman MP, Petrak K. Lactoferrin-enhanced anoikis: A defense against neonatal necrotizing enterocolitis. Med Hypotheses 2005 Jun 9. View abstract.
13326
Pacora P, Maymon E, Gervasi MT, et al. Lactoferrin in intrauterine infection, human parturition, and rupture of fetal membranes. Am J Obstet Gynecol 2000;183:904-10. View abstract.
13327
Valenti P, Berlutti F, Conte MP, et al. Lactoferrin functions: current status and perspectives. J Clin Gastroenterol 2004;38:S127-9. View abstract.
13328
Vorland LH, Ulvatne H, Andersen J, et al. Lactoferricin of bovine origin is more active than lactoferricins of human, murine and caprine origin. Scand J Infect Dis 1998;30:513-7. View abstract.
13329
Farnaud S, Evans RW. Lactoferrin--a multifunctional protein with antimicrobial properties. Mol Immunol 2003;40:395-405. View abstract.
13330
Conneely OM. Antiinflammatory activities of lactoferrin.J Am Coll Nutr 2001;20:389S-395S. View abstract.
13331
Kruzel ML, Harari Y, Chen CY, Castro GA. The gut. A key metabolic organ protected by lactoferrin during experimental systemic inflammation in mice. Adv Exp Med Biol 1998;443:167-73. View abstract.
13332
van't Land B, van Beek NM, van den Berg JJ, M'Rabet L. Lactoferrin reduces methotrexate-induced small intestinal damage, possibly through inhibition of GLP-2-mediated epithelial cell proliferation. Dig Dis Sci 2004;49:425-33. . View abstract.
13333
Zhang GH, Mann DM, Tsai CM. Neutralization of endotoxin in vitro and in vivo by a human lactoferrin-derived peptide. Infect Immun 1999;67:1353-8. View abstract.
13334
Drobni P, Naslund J, Evander M. Lactoferrin inhibits human papillomavirus binding and uptake in vitro. Antiviral Res 2004;64:63-8. View abstract.
13335
Harmsen MC, Swart PJ, de Bethune MP, et al. Antiviral effects of plasma and milk proteins: lactoferrin shows potent activity against both human immunodeficiency virus and human cytomegalovirus replication in vitro. J Infect Dis 1995;172:380-8. View abstract.
13336
Dial EJ, Hall LR, Serna H, et al. Antibiotic properties of bovine lactoferrin on Helicobacter pylori. Dig Dis Sci 1998;43:2750-6. View abstract.
13337
Vetrugno V. Safety of milk and milk derivatives in relation to BSE: the lactoferrin example. Biometals 2004;17:353-6. View abstract.
13338
Bethell DR, Huang J. Recombinant human lactoferrin treatment for global health issues: iron deficiency and acute diarrhea. Biometals 2004;17:337-42. View abstract.
13339
Zimecki M, Wlaszczyk A, Cheneau P, et al. Immunoregulatory effects of a nutritional preparation containing bovine lactoferrin taken orally by healthy individuals. Arch Immunol Ther Exp (Warsz) 1998;46:231-40.. View abstract.
13340
Puddu P, Borghi P, Gessani S, et al. Antiviral effect of bovine lactoferrin saturated with metal ions on early steps of human immunodeficiency virus type 1 infection. Int J Biochem Cell Biol 1998;30:1055-62. View abstract.
13341
Defer MC, Dugas B, Picard O, Damais C. Impairment of circulating lactoferrin in HIV-1 infection. Cell Mol Biol (Noisy-le-grand) 1995;41:417-21. View abstract.
97781
Macciò A, Madeddu C, Gramignano G, Mulas C, Sanna E, Mantovani G. Efficacy and safety of oral lactoferrin supplementation in combination with rHuEPO-beta for the treatment of anemia in advanced cancer patients undergoing chemotherapy: open-label, randomized controlled study. Oncologist. 2010;15(8):894-902. View abstract.
97782
Laffan AM, McKenzie R, Forti J, et al. Lactoferrin for the prevention of post-antibiotic diarrhoea. J Health Popul Nutr. 2011;29(6):547-51. View abstract.
97783
Pammi M, Suresh G. Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev. 2017;6:CD007137. View abstract.
97784
Saraceno R, Gramiccia T, Chimenti S, Valenti P, Pietropaoli M, Bianchi L. Topical lactoferrin can improve stable psoriatic plaque. G Ital Dermatol Venereol. 2014;149(3):335-40. View abstract.
97785
Otsuki K, Tokunaka M, Oba T, Nakamura M, Shirato N, Okai T. Administration of oral and vaginal prebiotic lactoferrin for a woman with a refractory vaginitis recurring preterm delivery: appearance of lactobacillus in vaginal flora followed by term delivery. J Obstet Gynaecol Res. 2014;40(2):583-5. View abstract.
97786
Vitetta L, Coulson S, Beck SL, Gramotnev H, Du S, Lewis S. The clinical efficacy of a bovine lactoferrin/whey protein Ig-rich fraction (Lf/IgF) for the common cold: a double blind randomized study. Complement Ther Med. 2013;21(3):164-71. View abstract.
97787
Ochoa TJ, Chea-Woo E, Baiocchi N, et al. Randomized double-blind controlled trial of bovine lactoferrin for prevention of diarrhea in children. J Pediatr. 2013;162(2):349-56. View abstract.
97788
Abu Hashim H, Foda O, Ghayaty E. Lactoferrin or ferrous salts for iron deficiency anemia in pregnancy: A meta-analysis of randomized trials. Eur J Obstet Gynecol Reprod Biol. 2017;219:45-52. View abstract.
97789
Tong PL, West NP, Cox AJ, et al. Oral supplementation with bovine whey-derived Ig-rich fraction and lactoferrin improves SCORAD and DLQI in atopic dermatitis. J Dermatol Sci. 2017;85(2):143-146. View abstract.
97790
Manfredi M, Bizzarri B, Sacchero RI, et al. Helicobacter pylori infection in clinical practice: probiotics and a combination of probiotics + lactoferrin improve compliance, but not eradication, in sequential therapy. Helicobacter. 2012;17(4):254-63. View abstract.
104856
Gao Y, Hou L, Lu C, et al. Enteral lactoferrin supplementation for preventing sepsis and necrotizing enterocolitis in preterm infants: A meta-analysis with trial sequential analysis of randomized Controlled Trials. Front Pharmacol. 2020 Aug 7;11:1186. View abstract.
104857
Tarnow-Mordi WO, Abdel-Latif ME, Martin A, et al. The effect of lactoferrin supplementation on death or major morbidity in very low birthweight infants (LIFT): a multicentre, double-blind, randomised controlled trial. Lancet Child Adolesc Health. 2020 Jun;4(6):444-454. View abstract.
104858
ELFIN trial investigators group. Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial. Lancet. 2019 Feb 2;393(10170):423-433. doi: 10.1016/S0140-6736(18)32221-9. View abstract.
104859
Oda H, Wakabayashi H, Tanaka M, et al. Effects of lactoferrin on infectious diseases in Japanese summer: A randomized, double-blinded, placebo-controlled trial. J Microbiol Immunol Infect. 2020 Feb 26:S1684-1182(20)30038-4. View abstract.
104860
Oda H, Miyakawa M, Mizuki M, et al. Effects of lactoferrin on subjective skin conditions in winter: A preliminary, randomized, double-blinded, placebo-controlled trial. 2019 Dec 2;12:875-880. View abstract.
104861
Motoki N, Mizuki M, Tsukahara T, et al. Effects of lactoferrin-fortified formula on acute gastrointestinal symptoms in children aged 12-32 months: A randomized, double-blind, placebo-controlled trial. Front Pediatr. 2020 May 19;8:233. View abstract.
104862
Tsukahara T, Fujimori A, Misawa Y, et al. The preventive effect of lactoferrin-containing yogurt on gastroenteritis in nursery school children-intervention study for 15 weeks. Int J Environ Res Public Health. 2020 Apr 7;17(7):2534. View abstract.
104863
Russo R, Superti F, Karadja E, De Seta F. Randomised clinical trial in women with recurrent vulvovaginal candidiasis: Efficacy of probiotics and lactoferrin as maintenance treatment. Mycoses. 2019 Apr;62(4):328-335. View abstract.
104865
Lepanto MS, Rosa L, Cutone A, Conte MP, Paesano R, Valenti P. Efficacy of lactoferrin oral administration in the treatment of anemia and anemia of inflammation in pregnant and non-pregnant women: An interventional study. Front Immunol. 2018 Sep 21;9:2123. View abstract.
104866
Li F, Wu SS, Berseth CL, et al. Improved neurodevelopmental outcomes associated with bovine milk fat globule membrane and lactoferrin in infant formula: A randomized, controlled trial. J Pediatr. 2019 Dec;215:24-31.e8. View abstract.
104867
Nakano M, Yoshida A, Wakabayashi H, et al. Effect of tablets containing lactoferrin and lactoperoxidase on gingival health in adults: A randomized, double-blind, placebo-controlled clinical trial. J Periodontal Res. 2019 Dec;54(6):702-708. View abstract.
104868
Pammi M, Suresh G. Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev. 2020 Mar 31;3(3):CD007137. View abstract.
104869
Ochoa TJ, Loli S, Mendoza K, et al. Effect of bovine lactoferrin on prevention of late-onset sepsis in infants <1500g: a pooled analysis of individual patient data from two randomized controlled trials. Biochem Cell Biol. 2020 Sep 15. View abstract.
104870
Kaufman DA, Berenz A, Itell HL, et al. Dose escalation study of bovine lactoferrin in preterm infants: Getting the dose right. Biochem Cell Biol. 2020 Aug 26. View abstract.
104871
Itell HL, Berenz A, Mangan RJ, Permar SR, Kaufman DA. Systemic and mucosal levels of lactoferrin in very low birth weight infants supplemented with bovine lactoferrin. Biochem Cell Biol. 2020 Aug 25. View abstract.
104872
Russo R, Karadja E, De Seta F. Evidence-based mixture containing Lactobacillus strains and lactoferrin to prevent recurrent bacterial vaginosis: a double blind, placebo controlled, randomised clinical trial. Benef Microbes. 2019 Feb 8;10(1):19-26. View abstract.
104873
Muscedere J, Maslove DM, Boyd JG, et al. Prevention of nosocomial infections in critically ill patients with lactoferrin: A randomized, double-blind, placebo-controlled study. Crit Care Med. 2018 Sep;46(9):1450-1456. View abstract.
105405
Miranda M, Saccone G, Ammendola A, et al. Vaginal lactoferrin in prevention of preterm birth in women with bacterial vaginosis. J Matern Fetal Neonatal Med. 2019 Nov 13:1-5. View abstract.
106724
Björmsjö M, Hernell O, Lönnerdal B, Berglund SK. Reducing Iron Content in Infant Formula from 8 to 2 mg/L Does Not Increase the Risk of Iron Deficiency at 4 or 6 Months of Age: A Randomized Controlled Trial. Nutrients 2020;13(1):3. View abstract.
106725
Omar OM, Assem H, Ahmed D, Abd Elmaksoud MS. Lactoferrin versus iron hydroxide polymaltose complex for the treatment of iron deficiency anemia in children with cerebral palsy: a randomized controlled trial. Eur J Pediatr 2021;180(8):2609-2618. View abstract.
106726
Chen K, Jin S, Chen H, et al. Dose effect of bovine lactoferrin fortification on diarrhea and respiratory tract infections in weaned infants with anemia: A randomized, controlled trial. Nutrition 2021;90:111288. View abstract.
106727
Miyakawa M, Kubo S, Oda H, et al. Effects of Lactoferrin on Sleep Conditions in Children Aged 12-32 Months: A Preliminary, Randomized, Double-Blind, Placebo-Controlled Trial. Nat Sci Sleep 2020;12:671-677. View abstract.
106728
Mizuki M, Tsukahara T, Oda H, et al. Effects of Lactoferrin on Prevention of Acute Gastrointestinal Symptoms in Winter: A Randomized, Double-Blinded, Placebo-Controlled Trial for Staff of Kindergartens and Nursery Schools in Japan. Int J Environ Res Public Health 2020;17(24):9582. View abstract.
106729
Wronowski MF, Kotowska M, Banasiuk M, Kotowski A, Kuzmicka W, Albrecht P. Bovine Lactoferrin in the Prevention of Antibiotic-Associated Diarrhea in Children: A Randomized Clinical Trial. Front Pediatr 2021;9:675606. View abstract.
106730
Hablass FH, Lashen SA, Alsayed EA. Efficacy of Lactoferrin with Standard Triple Therapy or Sequential Therapy for Helicobacter pylori Eradication: A Randomized Controlled Trial. Turk J Gastroenterol 2021;32(9):742-749. View abstract.
106731
Algahtani FD, Elabbasy MT, Samak MA, Adeboye AA, Yusuf RA, Ghoniem ME. The Prospect of Lactoferrin Use as Adjunctive Agent in Management of SARS-CoV-2 Patients: A Randomized Pilot Study. Medicina (Kaunas) 2021;57(8):842. View abstract.
106732
Rosa L, Tripepi G, Naldi E, et al. Ambulatory COVID-19 Patients Treated with Lactoferrin as a Supplementary Antiviral Agent: A Preliminary Study. J Clin Med 2021;10(18):4276. View abstract.
106733
Laskow T, Langdon J, Abadir P, Xue QL, Walston J. Lactoferrin for the treatment of age-associated inflammation - A pilot study. Physiol Int 2021. View abstract.
110189
El-Hawy MA, Abd Al-Salam SA, Bahbah WA. Comparing oral iron bisglycinate chelate, lactoferrin, lactoferrin with iron and iron polymaltose complex in the treatment of children with iron deficiency anemia. Clin Nutr ESPEN 2021;46:367-371. View abstract.
110771
Dobryk D, Dobryk O, Dobryanskyy D. The effect of enteral lactoferrin supplementation in prevention of morbidity associated with immature digestive tract in premature infants: prospective cohort study. Georgian Med News 2022;(323):94-101. View abstract.
110773
Zhao X, Zhang X, Xu T, Luo J, Luo Y, An P. Comparative Effects between Oral Lactoferrin and Ferrous Sulfate Supplementation on Iron-Deficiency Anemia: A Comprehensive Review and Meta-Analysis of Clinical Trials. Nutrients 2022;14(3):543. View abstract.
110774
Ali AS, Hasan SS, Kow CS, Merchant HA. Lactoferrin reduces the risk of respiratory tract infections: A meta-analysis of randomized controlled trials. Clin Nutr ESPEN 2021;45:26-32. View abstract.
110775
Berthon BS, Williams LM, Williams EJ, Wood LG. Effect of Lactoferrin Supplementation on Inflammation, Immune Function, and Prevention of Respiratory Tract Infections in Humans: A Systematic Review and Meta-analysis. Adv Nutr 2022;13(5):1799-1819. View abstract.
110923
Edebol Carlman HMT, Rode J, König J, et al. Probiotic mixture containing Lactobacillus helveticus, Bifidobacterium longum and Lactiplantibacillus plantarum affects brain responses to an arithmetic stress task in healthy subjects: A randomised clinical trial and proof-of-concept study. Nutrients 2022;14(7):1329. View abstract.
112913
Matino E, Tavella E, Rizzi M, et al. Effect of Lactoferrin on Clinical Outcomes of Hospitalized Patients with COVID-19: The LAC Randomized Clinical Trial. Nutrients. 2023;15(5):1285. View abstract.
112914
Navarro R, Paredes JL, Tucto L, et al. Bovine lactoferrin for the prevention of COVID-19 infection in health care personnel: a double-blinded randomized clinical trial (LF-COVID). Biometals 2023;36(3):463-472. View abstract.
112915
Kazandjieva J, Dimitrova J, Sankeva M, et al. Efficacy of a retinoid complex plus anti-inflammatory component cream alone or in combination with prebiotic food supplement in adult acne: A randomized, assessor-blinded, parallel-group, multicenter trial on 184 women. J Cosmet Dermatol. 2022;21(11):5716-5722. View abstract.