Bourin M, Bougerol T, Guitton B, Broutin E. A combination of plant extracts in the treatment of outpatients with adjustment disorder with anxious mood: controlled study vs placebo. Fundam Clin Pharmacol 1997;11:127-32. View abstract.

Schmidt U, Kuhn U, Ploch M, Hubner WD. Efficacy of the Hawthorne (Crataegus) Preparation LI 132 in 78 patients with chronic congestive heart failure defined as NYHA functional class II. Phytomedicine 1994;1:17-24. View abstract.

Zapfe jun G. Clinical efficacy of crataegus extract WS 1442 in congestive heart failure NYHA class II. Phytomedicine 2001;8:262-6. View abstract.

Tauchert M. Efficacy and safety of crataegus extract WS 1442 in comparison with placebo in patients with chronic stable New York Heart Association class-III heart failure. Am Heart J 2002;143:910-5. View abstract.

Degenring FH, Suter A, Weber M, Saller R. A randomised double blind placebo controlled clinical trial of a standardised extract of fresh Crataegus berries (Crataegisan) in the treatment of patients with congestive heart failure NYHA II. Phytomedicine 2003;10:363-9. View abstract.

Schwinger RH, Pietsch M, Frank K, Brixius K. Crataegus special extract WS 1442 increases force of contraction in human myocardium cAMP-independently. J Cardiovasc Pharmacol 2000;35:700-7. View abstract.

Jouad H, Lemhadri A, Maghrani M, et al. Hawthorn evokes a potent anti-hyperglycemic capacity in streptozotocin-induced diabetic rats. Journal of Herbal Pharmacotherapy 2003;3:19-29.

Hanus M, Lafon J, Mathieu M. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate anxiety disorders. Curr Med Res Opin 2004;20:63-71. View abstract.

Chang Q, Zuo Z, Harrison F, Chow MS. Hawthorn. J Clin Pharmacol 2002;42:605-12. View abstract.

Zick SM, Gillespie B, Aaronson KD. The effect of Crataegus oxycantha Special Extract WS 1442 on clinical progression in patients with mild to moderate symptoms of heart failure. Eur J Heart Fail 2008;10:587-93. View abstract.

Holubarsch CJ, Colucci WS, Meinertz T, et al. The efficacy and safety of Crataegus extract WS 1442 in patients with heart failure: the SPICE trial. Eur J Heart Fail 2008;10:1255-63. View abstract.

Zand J, Lanza F, Garg HK, Bryan NS. All-natural nitrite and nitrate containing dietary supplement promotes nitric oxide production and reduces triglycerides in humans. Nutr Res 2011;31(4):262-9. View abstract.

Pittler MH, Guo R, and Ernst E. Hawthorn extract for treating chronic heart failure. Cochrane.Database.Syst Rev 2008:CD005312. View abstract.

Zick SM, Vautaw BM, Gillespie B, Aaronson KD. Hawthorn Extract Randomized Blinded Chronic Heart Failure (HERB CHF) trial. Eur J Heart Fail. 2009;11:990-99. View abstract.

Forster A, Forster K, Buhring M, et al. Crataegus bei massig reduzierter linksventrikularer Auswurffraktion. Ergospirometrische Verlaufsuntersuchung bei 72 Patienten in doppel-blindem Vergleich mit Plazebo. [Crataegus for moderately reduced left ventricular ejection fraction. Ergospirometric monitoring study with 72 patients in a double-blind comparison with placebo]. Munch Med Wschr 1994;136:s21-s26.

Iwamoto M, Sato T, Ishizaki T. [The clinical effect of Crataegus in heart disease of ischemic or hypertensive origin. A multicenter double-blind study]. Planta Med 1981;42:1-16. View abstract.

Von Holubarsch, CJ, Niestroj M, Wassmer A, et al. [Hawthorn extract WS 1442 in the treatment of patients with heart failure and LVEF of 25%-35%]. MMW.Fortschr.Med 7-1-2010;152:56-61. View abstract.

Weikl A, Assmus KD, Neukum-Schmidt A, et al. [Crataegus Special Extract WS 1442. Assessment of objective effectiveness in patients with heart failure (NYHA II)]. Fortschr Med 1996;114:291-6. View abstract.

Leuchtgens H. [Crataegus Special Extract WS 1442 in NYHA II heart failure. A placebo controlled randomized double-blind study]. Fortschr Med 1993;111:352-4. View abstract.

Tauchert M, Ploch M, and Hubner WD. Effectiveness of hawthorn extract LI 132 compared with the ACE inhibitor Captopril: Multicenter double-blind study with 132 NYHA Stage II. Munch Med Wochenschr 1994;136:S27-S33.

Werner NS, Duschek S, and Schandry R. D-camphor-crataegus berry extract combination increases blood pressure and cognitive functioning in the elderly - a randomized, placebo controlled double blind study. Phytomedicine. 2009;16:1077-82. View abstract.

Dalli E, Colomer E, Tormos MC, et al. Crataegus laevigata decreases neutrophil elastase and has hypolipidemic effect: a randomized, double-blind, placebo-controlled trial. Phytomedicine. 6-15-2011;18:769-75. View abstract.

Weng WL, Zhang WQ, Liu FZ, and et al. Therapeutic effect of Crataegus pinnatifida on 46 cases of angina pectoris--a double blind study. J Tradit Chin Med 1984;4:293-94. View abstract.

Maek-a-nantawat W, Phonrat B, Dhitavat J, et al. Safety and efficacy of CKBM-A01, a Chinese herbal medicine, among asymptomatic HIV patients. Southeast Asian J Trop.Med Public Health 2009;40:494-501. View abstract.

Asher GN, Viera AJ, Weaver MA, et al. Effect of hawthorn standardized extract on flow mediated dilation in prehypertensive and mildly hypertensive adults: a randomized, controlled cross-over trial. BMC.Complement Altern.Med 2012;12:26. View abstract.

Walker AF, Marakis G, Simpson E, et al. Hypotensive effects of hawthorn for patients with diabetes taking prescription drugs: a randomised controlled trial. Br J Gen.Pract 2006;56:437-43. View abstract.

Shi KQ, Fan YC, Liu WY, et al. Traditional Chinese medicines benefit to nonalcoholic fatty liver disease: a systematic review and meta-analysis. Mol.Biol Rep. 2012;39:9715-22. View abstract.

Daniele C, Mazzanti G, Pittler MH, et al. Adverse-event profile of Crataegus spp.: a systematic review. Drug Saf 2006;29:523-35. View abstract.

Tankanow R, Tamer HR, Streetman DS, et al. Interaction study between digoxin and a preparation of hawthorn (Crataegus oxyacantha). J.Clin.Pharmacol. 2003;43:637-42. View abstract.

Schmidt, U., Albrecht, M., and Schmidt, S. [Effects of an herbal crataegus-camphor combination on the symptoms of cardiovascular diseases]. Arzneimittelforschung 2000;50(7):613-619. View abstract.

Belz, G. G., Butzer, R., Gaus, W., and Loew, D. Camphor-Crataegus berry extract combination dose-dependently reduces tilt induced fall in blood pressure in orthostatic hypotension. Phytomedicine. 2002;9(7):581-588. View abstract.

Belz, G. G. and Loew, D. Dose-response related efficacy in orthostatic hypotension of a fixed combination of D-camphor and an extract from fresh crataegus berries and the contribution of the single components. Phytomedicine. 2003;10 Suppl 4:61-67. View abstract.

Kroll, M., Ring, C., Gaus, W., and Hempel, B. A randomized trial of Korodin Herz-Kreislauf-Tropfen as add-on treatment in older patients with orthostatic hypotension. Phytomedicine 2005;12(6-7):395-402. View abstract.

Hempel, B., Kroll, M., and Schneider, B. [Efficacy and safety of a herbal drug containing hawthorn berries and D-camphor in hypotension and orthostatic circulatory disorders/results of a retrospective epidemiologic cohort study]. Arzneimittelforschung 2005;55(8):443-450. View abstract.

Islam, J., Uretsky, B. F., and Sierpina, V. S. Heart failure improvement with CoQ10, Hawthorn, and magnesium in a patient scheduled for cardiac resynchronization-defibrillator therapy: a case study. Explore.(NY) 2006;2(4):339-341. View abstract.

Tauchert, M., Gildor, A., and Lipinski, J. [High-dose Crataegus extract WS 1442 in the treatment of NYHA stage II heart failure]. Herz 1999;24(6):465-474. View abstract.

Min, B. S., Kim, Y. H., Lee, S. M., Jung, H. J., Lee, J. S., Na, M. K., Lee, C. O., Lee, J. P., and Bae, K. Cytotoxic triterpenes from Crataegus pinnatifida. Arch Pharm Res 2000;23(2):155-158. View abstract.

Holubarsch, C. J., Colucci, W. S., Meinertz, T., Gaus, W., and Tendera, M. Survival and prognosis: investigation of Crataegus extract WS 1442 in congestive heart failure (SPICE)--rationale, study design and study protocol. Eur J Heart Fail. 2000;2(4):431-437. View abstract.

Schroder, D., Weiser, M., and Klein, P. Efficacy of a homeopathic Crataegus preparation compared with usual therapy for mild (NYHA II) cardiac insufficiency: results of an observational cohort study. Eur.J.Heart Fail. 2003;5(3):319-326. View abstract.

Rechcinski, T. and Kurpesa, M. [Oligomeric procyanidins from hawthorn extract as supplementary therapy in patients with left ventricle systolic dysfunction]. Przegl.Lek. 2005;62(4):243-244. View abstract.

Zick, S. M., Blume, A., and Aaronson, K. D. The prevalence and pattern of complementary and alternative supplement use in individuals with chronic heart failure. J Card Fail. 2005;11(8):586-589. View abstract.

Koller, M., Lorenz, W., Aubke, W., Jensen, A., Gerlach, F. M., Kuhl, J., Pfeil, T., Regitz-Zagrosek, V., Rusche, H., and Rychlik, R. [Crataegus special extract WS 1442 in the treatment of early stages of CHD-associated heart failure]. MMW Fortschr Med 2-9-2006;148(6):42. View abstract.

Furey, A. and Tassell, M. Towards a systematic scientific approach in the assessment of efficacy of an herbal preparation: Hawthorn (Crataegus spp.). Eur J Heart Fail. 2008;10(12):1153-1157. View abstract.

Horoz, M., Gok, E., Genctoy, G., Ozcan, T., Olmaz, R., Akca, M., Kiykim, A., and Gurses, I. Crataegus orientalis associated multiorgan hypersensitivity reaction and acute renal failure. Intern.Med 2008;47(23):2039-2042. View abstract.

Baklykova, O. B., Sizova, ZhM, and Shikh, E. V. [Possible use of standardized Crataegus sanguinea extract in correction of cardiac rhythm impairment in patients with chronic heart failure]. Antibiot.Khimioter. 2009;54(1-2):47-52. View abstract.

Raudonis, R., Jakstas, V., Burdulis, D., Benetis, R., and Janulis, V. Investigation of contribution of individual constituents to antioxidant activity in herbal drugs using postcolumn HPLC method. Medicina (Kaunas.) 2009;45(5):382-394. View abstract.

Moon, H. I., Kim, T. I., Cho, H. S., and Kim, E. K. Identification of potential and selective collagenase, gelatinase inhibitors from Crataegus pinnatifida. Bioorg.Med Chem Lett. 2-1-2010;20(3):991-993. View abstract.

Mahmood, Z. A., Sualeh, M., Mahmood, S. B., and Karim, M. A. Herbal treatment for cardiovascular disease the evidence based therapy. Pak J Pharm Sci 2010;23(1):119-124. View abstract.

Crataegus oxyacantha (Hawthorn). Monograph. Altern.Med Rev. 2010;15(2):164-167. View abstract.

Rasmussen, P. Hawthorn--Crataegus monogyna (common hawthorn) or Crataegus laevigata (midland hawthorn; Crataegus oxyacantha); also known as haw, thornapple, maythorn, whitethorn. J Prim.Health Care 2011;3(1):63-64. View abstract.

Dalli, E., Valles, J., Cosin-Sales, J., Santos, M. T., Moscardo, A., Milara, J., and Sotillo, J. F. Effects of hawthorn (Crataegus laevigata) on platelet aggregation in healthy volunteers. Thromb.Res 2011;128(4):398-400. View abstract.

Zumdick, S., Deters, A., and Hensel, A. In vitro intestinal transport of oligomeric procyanidins (DP 2 to 4) across monolayers of Caco-2 cells. Fitoterapia 2012;83(7):1210-1217. View abstract.

O'Conolly M, Jansen W, Bernhoft G, and et al. [Treatment of decreasing cardiac performance. Therapy using standardized crataegus extract in advanced age]. Fortschr Med 11-13-1986;104(42):805-808. View abstract.

Beier A, Konigstein RP, and Samec V. [Clinical experiences with a crataegus pentaerythrityl-tetranitrate combination drug in heart diseases due to coronary sclerosis in old age]. Wien Med Wochenschr 6-15-1974;124(24):378-381. View abstract.

Rogov VD. [Toxiderma due to the fruits of the hawthorn]. Vestn Dermatol Venerol 1984;7(7):46-47. View abstract.

Weihmayr T and Ernst E. [Therapeutic effectiveness of Crataegus]. Fortschr Med 1-20-1996;114(1-2):27-29. View abstract.

Rakotoarison DA, Gressier B, Trotin F, and et al. Antioxidant activities of polyphenolic extracts from flowers, in vitro callus and cell suspension cultures of Crataegus monogyna. Pharmazie 1997;52(1):60-64. View abstract.

Chatterjee SS, Koch E, Jaggy H, and et al. [In vitro and in vivo studies on the cardioprotective action of oligomeric procyanidins in a Crataegus extract of leaves and blooms]. Arzneimittelforschung 1997;79:821-825. View abstract.

Schmidt U, Kuhn U, Ploch M, and et al. Efficacy of the hawthorn extract LI 132 (600mg/d) during eight weeks' treatment. Placebo-controlled double-blind trial with 78 NYHA stage II heart failure patients. Munch Med Wochenschr 1994;136(suppl 1):s13-s19.

Ventura P, Girola M, and Lattuada V. [Clinical evaluation and tolerability of a drug with garlic and hawthorn]. Acta Toxicol Ther 1990;11(4):365-372.

Hanack T and Bruckel MH. [The treatment of mild stable forms of angina pectoris using Crategutt novo]. Therapiewoche 1983;33:4331-4333.

O'Conolly M, Bernhoft G, and Bartsch G. [Treatment of stenocardia (Angina pectoris) pain in advanced age patients with multi-morbidity]. Therapiewoche 1987;37:3587-3600.

Bodigheimer K and Chase D. [Effectiveness of hawthorn extract at a dosage of 3x100mg per day]. Munch Med Wschr 1994;136 Suppl 1:s7-s11.

Forster A, Forster K, Buhring M, and et al. Crataegus bei massig reduzierter linksventrikularer Auswurffraktion. Ergospirometrische Verlaufsuntersuchung bei 72 Patienten in doppel-blindem Vergleich mit Plazebo. [Crataegus for moderately reduced left ventricular ejection fraction. Ergospirometric monitoring study with 72 patients in a double-blind comparison with placebo]. Munch Med Wschr 1994;136(suppl 1):s21-s26.

Schmidt U, Kuhn U, Ploch M, and et al. Efficacy of hawthorn (crataegus) preparation LI 132 in 78 patients with chronic congestive heart failure defined as NYHA functional class II. Phytomedicine 1994;1:17-24.

Tauchert M, Ploch M, and Hubner WD. Effectiveness of hawthorn extract LI 132 compared with the ACE inhibitor Captopril: Multicenter double-blind study with 132 NYHA Stage II. Munch Med Wochenschr 1994;136(suppl. 1):S27-S33.

Loew D, Albrecht M, and Podzuweit H. Efficacy and tolerability of a Hawthorn preparation in patients with heart failure Stage I and II according to NYHA - a surveillance study. Phytomedicine 1996;3(Suppl 1):92.

Von Eiff M, Brunner H, Haegeli A, and et al. Hawthorn/passion flower extract and improvement in physical exercise capacity of patients with dyspnoea class II of the NYHA functional classification. Acta Therapeutica 1994;20:47-66.

Saenz MT, Ahumada MC, and Garcia MD. Extracts from Viscum and Crataegus are cytotoxic against larynx cancer cells. Z Naturforsch 1997;52c:42-44.

Bahorun T, Gressier B, Trotin F, and et al. Oxygen species scavenging activity of phenolic extracts from hawthorn fresh plant organs and pharmaceutical preparations. Arzneim-Forsch 1996;46(2):1086-1089.

Weikl A and Noh HS. The influence of Crataegus on global cardiac insufficiency. Herz Gefabe 1993;11:516-524.

Liu, P., Konstam, M. A., and Force, T. Highlights of the 2004 scientific sessions of the Heart Failure Society of America, Toronto, Canada, September 12 to 15, 2004. Journal of the American College of Cardiology 2005;45(617):625.

Eichstadt, H., Stork, T., Mockel, M., and et al. Effectiveness of and tolerance to Crataegus extract WS 1442 in patients with heart insufficiency and reduced left ventricular function. Perfusion 2001;14:212-217.

Alexander, H. A. Clinical effectiveness of Crataegus extract LI132 for treating heart insufficiency stage 2 New York: A randomized placebo-controlled double-blind study with n=73 patients. Dissertation (Dr. med). 1995;

Erfurt L, Schandry R, Rubenbauer S, Braun U. The effects of repeated administration of camphor-crataegus berry extract combination on blood pressure and on attentional performance- a randomized, placebo-controlled, double-blind study. Phytomedicine. 2014;21(11):1349-55.

Rababa'h AM, Altarabsheh SE, Haddad O, Deo SV, Obeidat Y, Al-Azzam S. Hawthorn Herb Increases the Risk of Bleeding after Cardiac Surgery: An Evidence-Based Approach. Heart Surg Forum 2016;19(4):E175-9. View abstract.

Shatoor AS, Soliman H, Al-Hashem F, Gamal BE, Othman A, El-Menshaw N. Effect of hawthorn (Crataegus aronia syn. Azarolus (L)) on platelet function in albino wistar rats. Thromb Res 2012;130(1):75-80. View abstract.

Vibes J, Lasserre B, Gleye J, Declume C. Inhibition of thromboxane A2 biosynthesis in vitro by the main components of Crataegus oxyacantha (hawthorn) flower heads. Prostaglandins Leukot Essent Fatty Acids 1994;50(4):173-5. View abstract.

Rogers KL, Grice ID, Griffiths LR. Inhibition of platelet aggregation and 5-HT release by extracts of Australian plants used traditionally as headache treatments. Eur J Pharm Sci 2000;9(4):355-63. View abstract.

Zhou CC, Huang XX, Gao PY, et al. Two new compounds from Crataegus pinnatifida and their antithrombotic activities. J Asian Nat Prod Res 2014;16(2):169-74. View abstract.

Liu S, You L, Zhao Y, Chang X. Hawthorn Polyphenol Extract Inhibits UVB-Induced Skin Photoaging by Regulating MMP Expression and Type I Procollagen Production in Mice. J Agric Food Chem. 2018;66(32):8537-8546. View abstract.

Pahlavan S, Tousi MS, Ayyari M, et al. Effects of hawthorn ( Crataegus pentagyna) leaf extract on electrophysiologic properties of cardiomyocytes derived from human cardiac arrhythmia-specific induced pluripotent stem cells. FASEB J. 2018 Mar;32(3):1440-1451. View abstract.

Trexler SE, Nguyen E, Gromek SM, Balunas MJ, Baker WL. Electrocardiographic effects of hawthorn (Crataegus oxyacantha) in healthy volunteers: A randomized controlled trial. Phytother Res. 2018;32(8):1642-1646. View abstract.

Csupor D, Viczián R, Lantos T, et al. The combination of hawthorn extract and camphor significantly increases blood pressure: A meta-analysis and systematic review. Phytomedicine. 2019 Oct;63:152984. View abstract.

Niederseer D, Ledl-Kurkowski E, Kvita K, Funk P, Niebauer J. Safety and effects of Crataegus extract WS 1442 and Nordic walking on lipid profile and endothelial function: A randomized, partially blinded pilot study in overweight volunteers. Acta Clin Croat. 2019;58(4):604-614. View abstract.

Wu M, Yang S, Liu G, et al. Treating unstable angina with detoxifying and blood-activating formulae: a randomized controlled trial. J Ethnopharmacol 2021;281:114530. View abstract.

Dodd F, Kennedy D, Wightman E, et al. The chronic effects of a combination of herbal extracts (Euphytose) on psychological mood state and response to a laboratory stressor: A randomised, placebo-controlled, double blind study in healthy humans. J Psychopharmacol 2022;36(11):1243-1256. View abstract.