Wang XD, Zhang JM, Yang HH, Hu GY. Modulation of NMDA receptor by huperzine A in rat cerebral cortex. Chung Kuo Yao Li Hsueh Pao 1999;20:31-5. View abstract.

Skolnick AA. Old Chinese herbal medicine used for fever yields possible new Alzheimer Disease therapy. JAMA 1997;277:776.

Wang H, Tang XC. Anticholinesterase effects of huperzine A, E2020, and tacrine in rats. Chung Kuo Yao Li Hsueh Pao 1998;19:27-30. View abstract.

Xiong ZQ, Cheng DH, Tang XC. Effects of huperzine A on nucleus basalis magnocellularis lesion-induced spatial working memory deficit. Chung Kuo Yao Li Hsueh Pao 1998;19:128-32. View abstract.

Ye JW, Cai JX, Wang LM, Tang XC. Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment. J Pharmacol Exp Ther 1999;288:814-9.. View abstract.

Wang T, Tang XC. Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine. Eur J Pharmacol 1998;349:137-42. View abstract.

Cheng DH, Tang XC. Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities. Pharmacol Biochem Behav 1998;60:377-86. View abstract.

Lallement G, Veyret J, Masqueliez C, et al. Efficacy of huperzine in preventing soman-induced seizures, neuropathological changes and lethality. Fundam Clin Pharmacol 1997;11:387-94. View abstract.

Xu SS, Gao ZX, Weng Z, et al. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease. Zhongguo Yao Li Xue Bao 1995;16:391-5. View abstract.

Grunwald J, Raveh L, Doctor BP, Ashani Y. Huperzine A as a pretreatment candidate drug against nerve agent toxicity. Life Sci 1994;54:991-7. View abstract.

Zhang RW, Tang XC, Han YY, et al. [Drug evaluation of huperzine A in the treatment of senile memory disorders]. Chung Kuo Yao Li Hsueh Pao 1991;12:250-2. View abstract.

Tang XC, De Sarno P, Sugaya K, Giacobini E. Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat. J Neurosci Res 1989;24:276-85. View abstract.

Safety Briefs, ISMP Medication Safety Alert, vol.4, #4. Institute for Safe Medication Practices, Warminster, PA. February 24, 1999.

Zhang SL. [Therapeutic effects of huperzine A on the aged with memory impairment]. New Drugs and Clinical Remedies 1986;5:260-2.

Cheng YS, Lu CZ, Ying ZL, et al. [128 cases of myasthenia gravis treated with huperzine A]. New Drugs and Clinical Remedies 1986;5:197-9.

Pepping J. Huperzine A. Am J Health Syst Pharm 2000;57:530-4.

Xu SS, Cai ZY, Qu ZW, et al. Huperzine-A in capsules and tablets for treating patients with Alzheimer disease. Zhongguo Yao Li Xue Bao 1999;20:486-90. View abstract.

Camps P, Cusack B, Mallender WD, et al. Huprine X is a novel high-affinity inhibitor of acetylcholinesterase that is of interest for treatment of Alzheimer's disease. Mol Pharmacol 2000;57:409-17. View abstract.

Sun QQ, Xu SS, Pan JL, et al. Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students. Chung Kuo Yao Li Hsueh Pao 1999;20:601-3. View abstract.

Felgenhauer N, Zilker T, Worek F, Eyer P. Intoxication with huperzine A, a potent anticholinesterase found in the fir club moss. J Toxicol Clin Toxicol 2000;38:803-8.. View abstract.

Xiao, X. Q., Yang, J. W., and Tang, X. C. Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury. Neurosci.Lett 11-12-1999;275(2):73-76. View abstract.

Ricordel, I. and Meunier, J. [Chemical weapons: antidotes. View about the real means, perspectives]. Ann Pharm Fr. 2000;58(1):5-12. View abstract.

Lallement, G. [Pretreatment of organophosphate poisoning: potential interests of huperzine A]. Ann Pharm Fr. 2000;58(1):13-17. View abstract.

Xiao, X. Q., Wang, R., Han, Y. F., and Tang, X. C. Protective effects of huperzine A on beta-amyloid(25-35) induced oxidative injury in rat pheochromocytoma cells. Neurosci.Lett 6-9-2000;286(3):155-158. View abstract.

Wang, L. M., Han, Y. F., and Tang, X. C. Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats. Eur J Pharmacol 6-9-2000;398(1):65-72. View abstract.

Ye, J. W., Shang, Y. Z., Wang, Z. M., and Tang, X. C. Huperzine A ameliorates the impaired memory of aged rat in the Morris water maze performance. Acta Pharmacol Sin. 2000;21(1):65-69. View abstract.

Tonduli, L. S., Testylier, G., Masqueliez, C., Lallement, G., and Monmaur, P. Effects of Huperzine used as pre-treatment against soman-induced seizures. Neurotoxicology 2001;22(1):29-37. View abstract.

Wang, R., Xiao, X. Q., and Tang, X. C. Huperzine A attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells. Neuroreport 8-28-2001;12(12):2629-2634. View abstract.

Zhou, J., Zhang, H. Y., and Tang, X. C. Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils. Neurosci.Lett 11-9-2001;313(3):137-140. View abstract.

Xiao, X. Q., Zhang, H. Y., and Tang, X. C. Huperzine A attenuates amyloid beta-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation. J Neurosci.Res 1-1-2002;67(1):30-36. View abstract.

Finkelstein, B. L., Benner, E. A., Hendrixson, M. C., Kranis, K. T., Rauh, J. J., Sethuraman, M. R., and McCann, S. F. Tricyclic cyanoguanidines: synthesis, site of action and insecticidal activity of a novel class of reversible acetylcholinesterase inhibitors. Bioorg.Med Chem 2002;10(3):599-613. View abstract.

Filliat, P., Foquin, A., and Lallement, G. Effects of chronic administration of huperzine A on memory in guinea pigs. Drug Chem Toxicol 2002;25(1):9-24. View abstract.

Gordon, R. K., Nigam, S. V., Weitz, J. A., Dave, J. R., Doctor, B. P., and Ved, H. S. The NMDA receptor ion channel: a site for binding of Huperzine A. J Appl Toxicol 2001;21 Suppl 1:S47-S51. View abstract.

Lallement, G., Baille, V., Baubichon, D., Carpentier, P., Collombet, J. M., Filliat, P., Foquin, A., Four, E., Masqueliez, C., Testylier, G., Tonduli, L., and Dorandeu, F. Review of the value of huperzine as pretreatment of organophosphate poisoning. Neurotoxicology 2002;23(1):1-5. View abstract.

Zhang, Z., Wang, X., Chen, Q., Shu, L., Wang, J., and Shan, G. [Clinical efficacy and safety of huperzine Alpha in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial]. Zhonghua Yi Xue Za Zhi 7-25-2002;82(14):941-944. View abstract.

Zhou, J. and Tang, X. C. Huperzine A attenuates apoptosis and mitochondria-dependent caspase-3 in rat cortical neurons. FEBS Lett 8-28-2002;526(1-3):21-25. View abstract.

Ma, X. C., Xin, J., Wang, H. X., Zhang, T., and Tu, Z. H. Acute effects of huperzine A and tacrine on rat liver. Acta Pharmacol Sin. 2003;24(3):247-250. View abstract.

Zhang, H. Y. and Tang, X. C. Huperzine A attenuates the neurotoxic effect of staurosporine in primary rat cortical neurons. Neurosci.Lett 4-10-2003;340(2):91-94. View abstract.

Wang, L. S., Zhou, J., Shao, X. M., and Tang, X. C. [Huperzine A attenuates cognitive deficits and brain injury after hypoxia-ischemic brain damage in neonatal rats]. Zhonghua Er.Ke Za Zhi 2003;41(1):42-45. View abstract.

Tang, L. L., Wang, R., and Tang, X. C. Huperzine A protects SHSY5Y neuroblastoma cells against oxidative stress damage via nerve growth factor production. Eur J Pharmacol 9-5-2005;519(1-2):9-15. View abstract.

Wang, G., Zhang, S. Q., and Zhan, H. [Effect of huperzine A on cerebral cholinesterase and acetylcholine in elderly patients during recovery from general anesthesia]. Nan Fang Yi Ke Da Xue Xue Bao 2006;26(11):1660-1662. View abstract.

Yue, P., Tao, T., Zhao, Y., Ren, J., and Chai, X. Huperzine A in rat plasma and CSF following intranasal administration. Int J Pharm 6-7-2007;337(1-2):127-132. View abstract.

Tao, T., Zhao, Y., Yue, P., Dong, W. X., and Chen, Q. H. [Preparation of huperzine A nasal in situ gel and evaluation of its brain targeting following intranasal administration]. Yao Xue Xue Bao 2006;41(11):1104-1110. View abstract.

Zhang, Z. J., Tong, Y., Wang, X. Y., Yao, S. M., Jin, G. X., and Wang, X. P. Huperzine A as add-on therapy in patients with treatment-resistant schizophrenia: an open-labeled trial. Schizophr.Res 2007;92(1-3):273-275. View abstract.

Little, J. T., Walsh, S., and Aisen, P. S. An update on huperzine A as a treatment for Alzheimer's disease. Expert.Opin.Investig.Drugs 2008;17(2):209-215. View abstract.

Ye, J. C., Zeng, S., Zheng, G. L., and Chen, G. S. Pharmacokinetics of Huperzine A after transdermal and oral administration in beagle dogs. Int J Pharm 5-22-2008;356(1-2):187-192. View abstract.

Li, Y. X., Zhang, R. Q., Li, C. R., and Jiang, X. H. Pharmacokinetics of huperzine A following oral administration to human volunteers. Eur J Drug Metab Pharmacokinet. 2007;32(4):183-187. View abstract.

Li, J., Wu, H. M., Zhou, R. L., Liu, G. J., and Dong, B. R. Huperzine A for Alzheimer's disease. Cochrane Database Syst.Rev 2008;(2):CD005592. View abstract.

Chow, T. W. Review: insufficient evidence on Huperzine A for Alzheimer's. Evid Based Ment.Health 2008;11(4):112. View abstract.

Hao, Z., Liu, M., Liu, Z., and Lv, D. Huperzine A for vascular dementia. Cochrane Database Syst.Rev 2009;(2):CD007365. View abstract.

Xiong, Z. Q. and Tang, X. C. Effect of huperzine A, a novel acetylcholinesterase inhibitor, on radial maze performance in rats. Pharmacol Biochem Behav 1995;51(2-3):415-419. View abstract.

Qian, B. C., Wang, M., Zhou, Z. F., Chen, K., Zhou, R. R., and Chen, G. S. Pharmacokinetics of tablet huperzine A in six volunteers. Zhongguo Yao Li Xue.Bao. 1995;16(5):396-398. View abstract.

Cheng, D. H., Ren, H., and Tang, X. C. Huperzine A, a novel promising acetylcholinesterase inhibitor. Neuroreport 12-20-1996;8(1):97-101. View abstract.

Tang XC and Han YF. Pharmacological profile of huperzine A, a novel acetylcholinesterase inhibitor from Chinese herb. Cns Drug Reviews 1999;5(3):281-300.

Kuang, M. Clinical evaluation of huperzine A in improving interlligent disorder in patients with Alzheimer's disease. Zhongguo Linchuang Kangfu 2004;8(7):1216.

Zhang, M. Evaluation of clinical effect and safety of huperzine A in treating 52 Alzheimer's disease. Journal of New Drugs and Clinical Remedies 2006;25:693.

Xue, SW., Ding, JM., Zhong, P., Liang, K., An, HY., and Bo, Y. Impacts of huperzine A on the level of Fas, Apo2.7 and Bcl-2 on the platelet membrane and the cognitive function in patients with Alzheimer disease. Zhongguo Linchuang Kangfu 2005;9(9):188.

Yang, C. Efficacy and reliability of huperzine a in mild and moderate alzheimer's disease. Zhongguo Linchuang Kangfu 2003;7(31):4258.

Chen M, Gao Z, Deng H, and et al. Huperzine A capsules vs tablets in treatment of Alzheimer disease: multicenter studies. Chinese Journal of New Drugs and Clinical Remedies 2000;19(1):10-12.

Wang, W. Effect of huperzine A on memory function of patients with mild cognitive impairment. Zhongguo Linchuang Kangfu 2005;9(8):23.

Du ZM, Li SL, and Yang CF. [A randomised study of huperzine: a therapy on senile amnestic syndrome]. Chinese Journal of Geriatrics 1996;15(3):180.

Li, K. Change of thyroid function in patients with Alzheimer disease after treatment of huperzine A. Zhongguo Linchuang Kangfu 2006;10(22):70.

Xu SS, Gao ZX, Weng Z, and et al. Efficacy of tablet huperzine-A on memory, cognition and behavior in Alzheimer's disease. Int Med J 1997;4(2):127-131.

Wang, Z, Ren, G, Zhao, Y, and et al. A double-blind study of huperzine A and piracetam in patients with age-associated memory impairment and dementia. Herbal Medicines for Neuropsychiatric Diseases 1999;39-50.

Liu FG, Fang YS, Gao ZX, and et al. [Double-blind randomised controlled trial of huperzine-A in 28 patients with Alzheimer disease]. Journal of Pharmacoepidemiology 1995;4(4):196-198.

Mazurek A. An open label trial of huperzine A in the treatment of Alzheimer's disease. Altern Ther 1999;5(2):97-98.

Aisen, P. A Multi-Center, Double-Blind, Placebo-Controlled Therapeutic Trial to Determine Whether Natural Huperzine A Improves Cognitive Function. Georgetown University Medical Center, Memory Disorders Program 2004;

Cheng YS, Lu CZ, Ying ZL, and et al. [128 cases of myasthenia gravis treated with huperzine A]. New Drugs Clin Remedies 1986;5(4):197-199.

Li YX, Zhang RQ, Li CR, Jiang XH. Pharmacokinetics of huperzine A following oral administration to human volunteers. Eur J Drug Metab Pharmacokinet 2007;32(4):183-7. View abstract.

Zheng W, Xiang YQ, Li XB, et al. Adjunctive huperzine A for cognitive deficits in schizophrenia: a systematic review and meta-analysis. Hum Psychopharmacol 2016;31(4):286-95. View abstract.

Rafii MS, Walsh S, Little JT, et al.; Alzheimer's Disease Cooperative Study. A phase II trial of huperzine A in mild to moderate Alzheimer disease. Neurology 2011;76(16):1389-94. View abstract.

Wang BS, Wang H, Wei ZH, Song YY, Zhang L, Chen HZ. Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis. J Neural Transm (Vienna) 2009;116(4):457-65. View abstract.

Xu ZQ, Liang XM, Juan-Wu, Zhang YF, Zhu CX, Jiang XJ. Treatment with Huperzine A improves cognition in vascular dementia patients. Cell Biochem Biophys 2012;62(1):55-8. View abstract.

Yang G, Wang Y, Tian J, Liu JP. Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. PLoS One 2013;8(9):e74916. View abstract.

De La Garza R 2nd, Verrico CD, Newton TF, Mahoney JJ 3rd, Thompson-Lake DG. Safety and preliminary efficacy of the acetylcholinesterase inhibitor Huperzine A as a treatment for cocaine use disorder. Int J Neuropsychopharmacol 2015;19(3):pyv098. View abstract.

Zheng W, Xiang YQ, Ungvari GS, et al. Huperzine A for treatment of cognitive impairment in major depressive disorder: a systematic review of randomized controlled trials. Shanghai Arch Psychiatry 2016;28(2):64-71. View abstract.

Gul A, Bakht J, Mehmood F. Huperzine-A response to cognitive impairment and task switching deficits in patients with Alzheimer's disease. J Chin Med Assoc 2019;82(1):40-3. doi: 10.1016/j.jcma.2018.07.004. View abstract.

Cui CC, Sun Y, Wang XY, Zhang Y, Xing Y. The effect of anti-dementia drugs on Alzheimer disease-induced cognitive impairment: A network meta-analysis. Medicine (Baltimore) 2019 Jul;98(27):e16091. doi: 10.1097/MD.0000000000016091. View abstract.

Wessinger CM, Inman CL, Weinstock J, Weiss EP. Effect of Huperzine A on Cognitive Function and Perception of Effort during Exercise: A Randomized Double-Blind Crossover Trial. Int J Exerc Sci 2021;14(2):727-741. View abstract.