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Alleva R., Tomasetti M., Sartini D., Emanuelli M., Nasole E., Di Donato F., Borghi B., Santarelli L., Neuzil J. alpha-Lipoic acid modulates extracellular matrix and angiogenesis gene expression in non-healing wounds treated with hyperbaric oxygen therapy. Mol Med 2008;14(3-4):175-183. View abstract.

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Khanna, S., Atalay, M., Laaksonen, D. E., Gul, M., Roy, S., and Sen, C. K. Alpha-lipoic acid supplementation: tissue glutathione homeostasis at rest and after exercise. J Appl.Physiol 1999;86(4):1191-1196. View abstract.

Mitsui, Y., Schmelzer, J. D., Zollman, P. J., Mitsui, M., Tritschler, H. J., and Low, P. A. Alpha-lipoic acid provides neuroprotection from ischemia-reperfusion injury of peripheral nerve. J Neurol.Sci. 2-1-1999;163(1):11-16. View abstract.

Haak, E. S., Usadel, K. H., Kohleisen, M., Yilmaz, A., Kusterer, K., and Haak, T. The effect of alpha-lipoic acid on the neurovascular reflex arc in patients with diabetic neuropathy assessed by capillary microscopy. Microvasc.Res. 1999;58(1):28-34. View abstract.

Borcea, V., Nourooz-Zadeh, J., Wolff, S. P., Klevesath, M., Hofmann, M., Urich, H., Wahl, P., Ziegler, R., Tritschler, H., Halliwell, B., and Nawroth, P. P. alpha-Lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria. Free Radic.Biol.Med. 1999;22(11-12):1495-1500. View abstract.

Ziegler, D., Reljanovic, M., Mehnert, H., and Gries, F. A. Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. Exp Clin Endocrinol.Diabetes 1999;107(7):421-430. View abstract.

Yaworsky, K., Somwar, R., Ramlal, T., Tritschler, H. J., and Klip, A. Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytes. Diabetologia 2000;43(3):294-303. View abstract.

Jain, S. K. and Lim, G. Lipoic acid decreases lipid peroxidation and protein glycosylation and increases (Na(+) + K(+))- and Ca(++)-ATPase activities in high glucose- treated human erythrocytes. Free Radic.Biol.Med 2000;29(11):1122-1128. View abstract.

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Morcos, M., Borcea, V., Isermann, B., Gehrke, S., Ehret, T., Henkels, M., Schiekofer, S., Hofmann, M., Amiral, J., Tritschler, H., Ziegler, R., Wahl, P., and Nawroth, P. P. Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study. Diabetes Res Clin Pract 2001;52(3):175-183. View abstract.

Konrad, D., Somwar, R., Sweeney, G., Yaworsky, K., Hayashi, M., Ramlal, T., and Klip, A. The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation. Diabetes 2001;50(6):1464-1471. View abstract.

Heitzer, T., Finckh, B., Albers, S., Krohn, K., Kohlschutter, A., and Meinertz, T. Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress. Free Radic.Biol Med 7-1-2001;31(1):53-61. View abstract.

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Femiano, F. Burning mouth syndrome (BMS): an open trial of comparative efficacy of alpha-lipoic acid (thioctic acid) with other therapies. Minerva Stomatol. 2002;51(9):405-409. View abstract.

Mantovani, G., Maccio, A., Madeddu, C., Mura, L., Gramignano, G., Lusso, M. R., Massa, E., Mocci, M., and Serpe, R. Antioxidant agents are effective in inducing lymphocyte progression through cell cycle in advanced cancer patients: assessment of the most important laboratory indexes of cachexia and oxidative stress. J Mol Med 2003;81(10):664-673. View abstract.

Teichert, J., Hermann, R., Ruus, P., and Preiss, R. Plasma kinetics, metabolism, and urinary excretion of alpha-lipoic acid following oral administration in healthy volunteers. J Clin Pharmacol 2003;43(11):1257-1267. View abstract.

Smith, A. R. and Hagen, T. M. Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid. Biochem Soc Trans. 2003;31(Pt 6):1447-1449. View abstract.

Hahm, J. R., Kim, B. J., and Kim, K. W. Clinical experience with thioctacid (thioctic acid) in the treatment of distal symmetric polyneuropathy in Korean diabetic patients. J Diabetes Complications 2004;18(2):79-85. View abstract.

Kravchuk, IuA, Mekhtiev, S. N., Uspenskii, IuP, Grinevich, V. B., and Koblov, S. V. [Device laboratory and postmortem parallels in alcoholic hepatitis during combined therapy using thioctic (alpha-lipoic) acid]. Klin.Med (Mosk) 2004;82(6):55-57. View abstract.

Jang, W. G., Kim, H. S., Park, K. G., Park, Y. B., Yoon, K. H., Han, S. W., Hur, S. H., Park, K. S., and Lee, I. K. Analysis of proteome and transcriptome of tumor necrosis factor alpha stimulated vascular smooth muscle cells with or without alpha lipoic acid. Proteomics. 2004;4(11):3383-3393. View abstract.

Bruckner, I., Bustan, C., Adamescu, E., and Dobjanschi, C. Diabetic neuropathy--choices of treatment. Rom.J Intern Med 2002;40(1-4):53-60. View abstract.

Negrisanu, G., Rosu, M., Bolte, B., Lefter, D., and Dabelea, D. Effects of 3-month treatment with the antioxidant alpha-lipoic acid in diabetic peripheral neuropathy. Rom.J Intern Med 1999;37(3):297-306. View abstract.

Doggrell, S. A. Alpha-lipoic acid, an anti-obesity agent? Expert.Opin.Investig.Drugs 2004;13(12):1641-1643. View abstract.

Sola, S., Mir, M. Q., Cheema, F. A., Khan-Merchant, N., Menon, R. G., Parthasarathy, S., and Khan, B. V. Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study. Circulation 1-25-2005;111(3):343-348. View abstract.

Zakrzewska, J. M., Forssell, H., and Glenny, A. M. Interventions for the treatment of burning mouth syndrome. Cochrane.Database.Syst Rev 2005;(1):CD002779. View abstract.

Wenzel, U., Nickel, A., and Daniel, H. alpha-Lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2-*-generation. Apoptosis. 2005;10(2):359-368. View abstract.

Gregus, Z., Stein, A. F., Varga, F., and Klaassen, C. D. Effect of lipoic acid on biliary excretion of glutathione and metals. Toxicol Appl Pharmacol 1992;114(1):88-96. View abstract.

Lee, W. J., Song, K. H., Koh, E. H., Won, J. C., Kim, H. S., Park, H. S., Kim, M. S., Kim, S. W., Lee, K. U., and Park, J. Y. Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle. Biochem.Biophys.Res Commun. 7-8-2005;332(3):885-891. View abstract.

Tankova, T., Cherninkova, S., and Koev, D. Treatment for diabetic mononeuropathy with alpha-lipoic acid. Int J Clin.Pract. 2005;59(6):645-650. View abstract.

Koh, J. M., Lee, Y. S., Byun, C. H., Chang, E. J., Kim, H., Kim, Y. H., Kim, H. H., and Kim, G. S. Alpha-lipoic acid suppresses osteoclastogenesis despite increasing the receptor activator of nuclear factor kappaB ligand/osteoprotegerin ratio in human bone marrow stromal cells. J Endocrinol. 2005;185(3):401-413. View abstract.

Byun, C. H., Koh, J. M., Kim, D. K., Park, S. I., Lee, K. U., and Kim, G. S. alpha-Lipoic Acid Inhibits TNF-alpha-Induced Apoptosis in Human Bone Marrow Stromal Cells. J Bone Miner.Res 2005;20(7):1125-1135. View abstract.

Sung, M. J., Kim, W., Ahn, S. Y., Cho, C. H., Koh, G. Y., Moon, S. O., Kim, D. H., Lee, S., Kang, K. P., Jang, K. Y., and Park, S. K. Protective effect of alpha-lipoic acid in lipopolysaccharide-induced endothelial fractalkine expression. Circ.Res 10-28-2005;97(9):880-890. View abstract.

Lee, W. J., Lee, I. K., Kim, H. S., Kim, Y. M., Koh, E. H., Won, J. C., Han, S. M., Kim, M. S., Jo, I., Oh, G. T., Park, I. S., Youn, J. H., Park, S. W., Lee, K. U., and Park, J. Y. Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase. Arterioscler.Thromb.Vasc.Biol 2005;25(12):2488-2494. View abstract.

Bregovskii, V. B., Posokhina, O. V., and Karpova, I. A. [Predictors of alpha-lipoic acid treatment efficacy in diabetic polyneuropathy of the lower limbs]. Ter.Arkh. 2005;77(10):15-19. View abstract.

Tarnopolsky, M. A. and Raha, S. Mitochondrial myopathies: diagnosis, exercise intolerance, and treatment options. Med Sci Sports Exerc. 2005;37(12):2086-2093. View abstract.

Berkson, B. M., Rubin, D. M., and Berkson, A. J. The long-term survival of a patient with pancreatic cancer with metastases to the liver after treatment with the intravenous alpha-lipoic acid/low-dose naltrexone protocol. Integr.Cancer Ther 2006;5(1):83-89. View abstract.

Mantovani, G., Maccio, A., Madeddu, C., Gramignano, G., Lusso, M. R., Serpe, R., Massa, E., Astara, G., and Deiana, L. A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress. Cancer Epidemiol.Biomarkers Prev. 2006;15(5):1030-1034. View abstract.

Bergqvist-Karlsson, A., Thelin, I., and Bergendorff, O. Contact dermatitis to alpha-lipoic acid in an anti-wrinkle cream. Contact Dermatitis 2006;55(1):56-57. View abstract.

Suarez, P. and Clark, G. T. Burning mouth syndrome: an update on diagnosis and treatment methods. J Calif.Dent.Assoc. 2006;34(8):611-622. View abstract.

Jameel, N. M., Shekhar, M. A., and Vishwanath, B. S. Alpha-lipoic acid: an inhibitor of secretory phospholipase A2 with anti-inflammatory activity. Life Sci 12-14-2006;80(2):146-153. View abstract.

Dunschede, F., Erbes, K., Kircher, A., Westermann, S., Seifert, J., Schad, A., Oliver, K., Kiemer, A. K., and Theodor, J. Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by alpha-lipoic acid in humans. World J Gastroenterol 11-14-2006;12(42):6812-6817. View abstract.

Kamenova, P. Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid. Hormones.(Athens.) 2006;5(4):251-258. View abstract.

Zhang, W. J., Wei, H., Hagen, T., and Frei, B. Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway. Proc Natl Acad Sci U.S.A 3-6-2007;104(10):4077-4082. View abstract.

Rooney, J. P. The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury. Toxicology 5-20-2007;234(3):145-156. View abstract.

Tang, J., Wingerchuk, D. M., Crum, B. A., Rubin, D. I., and Demaerschalk, B. M. Alpha-lipoic acid may improve symptomatic diabetic polyneuropathy. Neurologist. 2007;13(3):164-167. View abstract.

McCormick, R. K. Osteoporosis: integrating biomarkers and other diagnostic correlates into the management of bone fragility. Altern.Med Rev. 2007;12(2):113-145. View abstract.

Moreira, P. I., Harris, P. L., Zhu, X., Santos, M. S., Oliveira, C. R., Smith, M. A., and Perry, G. Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. J Alzheimers.Dis 2007;12(2):195-206. View abstract.

Zembron-Lacny, A., Szyszka, K., and Szygula, Z. Effect of cysteine derivatives administration in healthy men exposed to intense resistance exercise by evaluation of pro-antioxidant ratio. J Physiol Sci 2007;57(6):343-348. View abstract.

Janson, M. Orthomolecular medicine: the therapeutic use of dietary supplements for anti-aging. Clin Interv.Aging 2006;1(3):261-265. View abstract.

Mignini, F., Streccioni, V., Tomassoni, D., Traini, E., and Amenta, F. Comparative crossover, randomized, open-label bioequivalence study on the bioequivalence of two formulations of thioctic acid in healthy volunteers. Clin Exp.Hypertens. 2007;29(8):575-586. View abstract.

Xiang, G. D., Sun, H. L., Zhao, L. S., Hou, J., Yue, L., and Xu, L. The antioxidant alpha-lipoic acid improves endothelial dysfunction induced by acute hyperglycaemia during OGTT in impaired glucose tolerance. Clin Endocrinol.(Oxf) 2008;68(5):716-723. View abstract.

Huang, E. A. and Gitelman, S. E. The effect of oral alpha-lipoic acid on oxidative stress in adolescents with type 1 diabetes mellitus. Pediatr.Diabetes 2008;9(3 Pt 2):69-73. View abstract.

Mantovani, G., Maccio, A., Madeddu, C., Gramignano, G., Serpe, R., Massa, E., Dessi, M., Tanca, F. M., Sanna, E., Deiana, L., Panzone, F., Contu, P., and Floris, C. Randomized phase III clinical trial of five different arms of treatment for patients with cancer cachexia: interim results. Nutrition 2008;24(4):305-313. View abstract.

Kim, E., Park, D. W., Choi, S. H., Kim, J. J., and Cho, H. S. A preliminary investigation of alpha-lipoic acid treatment of antipsychotic drug-induced weight gain in patients with schizophrenia. J Clin Psychopharmacol. 2008;28(2):138-146. View abstract.

Al'-Zamil', M. K. and Brezheva, E. V. [Implication of alpha-lipoic acid preparations in the treatment of diabetic neuropathy]. Zh.Nevrol.Psikhiatr.Im S.S.Korsakova 2008;108(2):27-30. View abstract.

Ghibu, S., Richard, C., Delemasure, S., Vergely, C., Mogosan, C., and Muresan, A. [An endogenous dithiol with antioxidant properties: alpha-lipoic acid, potential uses in cardiovascular diseases]. Ann Cardiol.Angeiol.(Paris) 2008;57(3):161-165. View abstract.

Wray, D. W., Uberoi, A., Lawrenson, L., Bailey, D. M., and Richardson, R. S. Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome. Clin Sci (Lond) 2009;116(5):433-441. View abstract.

Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. View abstract.

Bangma, H. R., Smit, G. P., Kuks, J. B., Grevink, R. G., and Wolffenbuttel, B. H. [Two patients with mitochondrial respiratory chain disease]. Ned.Tijdschr.Geneeskd. 10-18-2008;152(42):2298-2301. View abstract.

Singh, U. and Jialal, I. Alpha-lipoic acid supplementation and diabetes. Nutr Rev. 2008;66(11):646-657. [RETRACTED]. View abstract.

Spisakova, M., Cizek, Z., and Melkova, Z. Ethacrynic and alpha-lipoic acids inhibit vaccinia virus late gene expression. Antiviral Res 2009;81(2):156-165. View abstract.

Bartlett, H. E. and Eperjesi, F. Nutritional supplementation for type 2 diabetes: a systematic review. Ophthalmic Physiol Opt. 2008;28(6):503-523. View abstract.

Zembron-Lacny, A., Slowinska-Lisowska, M., Szygula, Z., Witkowski, K., and Szyszka, K. The comparison of antioxidant and hematological properties of N-acetylcysteine and alpha-lipoic acid in physically active males. Physiol Res 2009;58(6):855-861. View abstract.

Statsenko, M. E., Poletaeva, L. V., Turkina, S. V., Apukhtin, A. F., and Dudchenko, G. P. [Mildronate effects on oxidant stress in type 2 diabetic patients with diabetic peripheral (sensomotor) neuropathy]. Ter.Arkh. 2008;80(10):27-30. View abstract.

Martins, V. D., Manfredini, V., Peralba, M. C., and Benfato, M. S. Alpha-lipoic acid modifies oxidative stress parameters in sickle cell trait subjects and sickle cell patients. Clin Nutr 2009;28(2):192-197. View abstract.

Sun-Edelstein, C. and Mauskop, A. Foods and supplements in the management of migraine headaches. Clin J Pain 2009;25(5):446-452. View abstract.

Zembron-Lacny, A., Slowinska-Lisowska, M., Szygula, Z., Witkowski, K., Stefaniak, T., and Dziubek, W. Assessment of the antioxidant effectiveness of alpha-lipoic acid in healthy men exposed to muscle-damaging exercise. J Physiol Pharmacol. 2009;60(2):139-143. View abstract.

Harris, R. A., Nishiyama, S. K., Wray, D. W., Tedjasaputra, V., Bailey, D. M., and Richardson, R. S. The effect of oral antioxidants on brachial artery flow-mediated dilation following 5 and 10 min of ischemia. Eur J Appl.Physiol 2009;107(4):445-453. View abstract.

Rivinius, C. Burning mouth syndrome: Identification, diagnosis, and treatment. J Am Acad.Nurse Pract. 2009;21(8):423-429. View abstract.

Rutkove, S. B. A 52-year-old woman with disabling peripheral neuropathy: review of diabetic polyneuropathy. JAMA 10-7-2009;302(13):1451-1458. View abstract.

Wray, D. W., Nishiyama, S. K., Monnet, A., Wary, C., Duteil, S. S., Carlier, P. G., and Richardson, R. S. Antioxidants and aging: NMR-based evidence of improved skeletal muscle perfusion and energetics. Am J Physiol Heart Circ.Physiol 2009;297(5):H1870-H1875. View abstract.

Gianturco, V., Bellomo, A., D'Ottavio, E., Formosa, V., Iori, A., Mancinella, M., Troisi, G., and Marigliano, V. Impact of therapy with alpha-lipoic acid (ALA) on the oxidative stress in the controlled NIDDM: a possible preventive way against the organ dysfunction? Arch.Gerontol.Geriatr. 2009;49 Suppl 1:129-133. View abstract.

Lee, S. H., Kim, M. J., Kim, B. J., Kim, S. R., Chun, S., Ryu, J. S., Kim, G. S., Lee, M. C., Koh, J. M., and Chung, S. J. Homocysteine-lowering therapy or antioxidant therapy for bone loss in Parkinson's disease. Mov Disord. 2-15-2010;25(3):332-340. View abstract.

Donato, A. J., Uberoi, A., Bailey, D. M., Wray, D. W., and Richardson, R. S. Exercise-induced brachial artery vasodilation: effects of antioxidants and exercise training in elderly men. Am J Physiol Heart Circ.Physiol 2010;298(2):H671-H678. View abstract.

Mittermayer, F., Pleiner, J., Francesconi, M., and Wolzt, M. Treatment with alpha-lipoic acid reduces asymmetric dimethylarginine in patients with type 2 diabetes mellitus. Transl.Res 2010;155(1):6-9. View abstract.

Zembron-Lacny, A., Ostapiuk, J., and Szyszka, K. Effects of sulphur-containing compounds on plasma redox status in muscle-damaging exercise. Chin J Physiol 10-31-2009;52(5):289-294. View abstract.

Berkson, B. M., Rubin, D. M., and Berkson, A. J. Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol for people with metastatic and nonmetastatic pancreatic cancer: a report of 3 new cases. Integr Cancer Ther 2009;8(4):416-422. View abstract.

Heinisch, B. B., Francesconi, M., Mittermayer, F., Schaller, G., Gouya, G., Wolzt, M., and Pleiner, J. Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial. Eur J Clin Invest 2010;40(2):148-154. View abstract.

Fedin, A. I., Kuznetsov, M. R., Beresten', N. F., Kuznetsova, V. F., Kholopova, E. A., Ibragimov, T. M., Tugdumov, B. V., and Dubrovin, E. E. [Correction of disordered cerebral blood flow autoregulation in atherosclerosis]. Angiol.Sosud.Khir. 2009;15(3):21-26. View abstract.

Xiang GD, Pu JH, Snu HL, and Zhao LS. Alpha-lipoic acid improves endothelial dysfunction in patients with subclinical hypothyroidism. Exp.Clin Endocrinol.Diabetes 2010;118(9):625-629. View abstract.

Skalska, S., Kucera, P., Goldenberg, Z., Stefek, M., Kyselova, Z., Jariabka, P., Gajdosikova, A., Klobucnikova, K., Traubner, P., and Stolc, S. Neuropathy in a rat model of mild diabetes induced by multiple low doses of streptozotocin: effects of the antioxidant stobadine in comparison with a high-dose alpha-lipoic acid treatment. Gen.Physiol Biophys 2010;29(1):50-58. View abstract.

Mijnhout, G. S., Alkhalaf, A., Kleefstra, N., and Bilo, H. J. Alpha lipoic acid: a new treatment for neuropathic pain in patients with diabetes? Neth.J Med 2010;68(4):158-162. View abstract.

Cagini, C., Leontiadis, A., Ricci, M. A., Bartolini, A., Dragoni, A., and Pellegrino, R. M. Study of alpha-lipoic acid penetration in the human aqueous after topical administration. Clin Experiment.Ophthalmol. 2010;38(6):572-576. View abstract.

Najm, W. and Lie, D. Herbals used for diabetes, obesity, and metabolic syndrome. Prim.Care 2010;37(2):237-254. View abstract.

Palacka, P., Kucharska, J., Murin, J., Dostalova, K., Okkelova, A., Cizova, M., Waczulikova, I., Moricova, S., and Gvozdjakova, A. Complementary therapy in diabetic patients with chronic complications: a pilot study. Bratisl.Lek.Listy 2010;111(4):205-211. View abstract.

Salinthone, S., Yadav, V., Schillace, R. V., Bourdette, D. N., and Carr, D. W. Lipoic acid attenuates inflammation via cAMP and protein kinase A signaling. PLoS.One. 2010;5(9) View abstract.

Guais, A., Baronzio, G., Sanders, E., Campion, F., Mainini, C., Fiorentini, G., Montagnani, F., Behzadi, M., Schwartz, L., and Abolhassani, M. Adding a combination of hydroxycitrate and lipoic acid (METABLOC) to chemotherapy improves effectiveness against tumor development: experimental results and case report. Invest New Drugs 2012;30(1):200-211. View abstract.

Milazzo, L., Menzaghi, B., Caramma, I., Nasi, M., Sangaletti, O., Cesari, M., Zanone, Poma B., Cossarizza, A., Antinori, S., and Galli, M. Effect of antioxidants on mitochondrial function in HIV-1-related lipoatrophy: a pilot study. AIDS Res.Hum.Retroviruses 2010;26(11):1207-1214. View abstract.

Ramos, L. F., Kane, J., McMonagle, E., Le, P., Wu, P., Shintani, A., Ikizler, T. A., and Himmelfarb, J. Effects of combination tocopherols and alpha lipoic acid therapy on oxidative stress and inflammatory biomarkers in chronic kidney disease. J Ren Nutr 2011;21(3):211-218. View abstract.

Xiang, G., Pu, J., Yue, L., Hou, J., and Sun, H. alpha-lipoic acid can improve endothelial dysfunction in subjects with impaired fasting glucose. Metabolism 2011;60(4):480-485. View abstract.

Becker, S., Schmidt, C., Berghaus, A., Tschiesner, U., Olzowy, B., and Reichel, O. Does laryngopharyngeal reflux cause intraoral burning sensations? A preliminary study. Eur Arch.Otorhinolaryngol. 2011;268(9):1375-1381. View abstract.

Lopez-Erauskin, J., Fourcade, S., Galino, J., Ruiz, M., Schluter, A., Naudi, A., Jove, M., Portero-Otin, M., Pamplona, R., Ferrer, I., and Pujol, A. Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy. Ann Neurol. 2011;70(1):84-92. View abstract.

Nebbioso, M., Federici, M., Rusciano, D., Evangelista, M., and Pescosolido, N. Oxidative stress in preretinopathic diabetes subjects and antioxidants. Diabetes Technol.Ther 2012;14(3):257-263. View abstract.

Madeddu, C., Dessi, M., Panzone, F., Serpe, R., Antoni, G., Cau, M. C., Montaldo, L., Mela, Q., Mura, M., Astara, G., Tanca, F. M., Maccio, A., and Mantovani, G. Randomized phase III clinical trial of a combined treatment with carnitine + celecoxib +/- megestrol acetate for patients with cancer-related anorexia/cachexia syndrome. Clin Nutr 2012;31(2):176-182. View abstract.

de, Moraes M., do Amaral Bezerra, B. A., da Rocha Neto, P. C., de Oliveira Soares, A. C., Pinto, L. P., and de Lisboa Lopes, Costa A. Randomized trials for the treatment of burning mouth syndrome: an evidence-based review of the literature. J Oral Pathol.Med. 2012;41(4):281-287. View abstract.

McNeilly, A. M., Davison, G. W., Murphy, M. H., Nadeem, N., Trinick, T., Duly, E., Novials, A., and McEneny, J. Effect of alpha-lipoic acid and exercise training on cardiovascular disease risk in obesity with impaired glucose tolerance. Lipids Health Dis 2011;10:217. View abstract.

Mollo, R., Zaccardi, F., Scalone, G., Scavone, G., Rizzo, P., Navarese, E. P., Manto, A., Pitocco, D., Lanza, G. A., Ghirlanda, G., and Crea, F. Effect of alpha-lipoic acid on platelet reactivity in type 1 diabetic patients. Diabetes Care 2012;35(2):196-197. View abstract.

Rosa, F. T., Zulet, M. A., Marchini, J. S., and Martinez, J. A. Bioactive compounds with effects on inflammation markers in humans. Int J Food Sci Nutr 2012;63(6):749-765. View abstract.

Wray, D. W., Nishiyama, S. K., Harris, R. A., Zhao, J., McDaniel, J., Fjeldstad, A. S., Witman, M. A., Ives, S. J., Barrett-O'Keefe, Z., and Richardson, R. S. Acute reversal of endothelial dysfunction in the elderly after antioxidant consumption. Hypertension 2012;59(4):818-824. View abstract.

Pfeffer, G., Majamaa, K., Turnbull, D. M., Thorburn, D., and Chinnery, P. F. Treatment for mitochondrial disorders. Cochrane Database.Syst.Rev. 2012;4:CD004426. View abstract.

Tsai, F. J., Wang, Y. D., Chen, C. C., Hsieh, C., Cheng, Z. J., and Wu, Y. J. Evaluation of the antioxidative capability of commonly used antioxidants in dermocosmetics by in vivo detection of protein carbonylation in human stratum corneum. J Photochem.Photobiol.B 7-2-2012;112:7-15. View abstract.

Chaparro, L. E., Wiffen, P. J., Moore, R. A., and Gilron, I. Combination pharmacotherapy for the treatment of neuropathic pain in adults. Cochrane Database.Syst.Rev. 2012;7:CD008943. View abstract.

Larkin, J., Bea, L., and Sharma, A. A cost effective complement to managing the vitamin D deficient and anemic dialysis patient in the bundled world. Nephrol.News Issues 2012;26(8):22-4, 26. View abstract.

Scholich, H., Murphy, M. E., and Sies, H. Antioxidant activity of dihydrolipoate against microsomal lipid peroxidation and its dependence on alpha-tocopherol. Biochim.Biophys Acta 2-20-1989;1001(3):256-261. View abstract.

Ou, P., Tritschler, H. J., and Wolff, S. P. Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant? Biochem.Pharmacol. 6-29-1995;50(1):123-126. View abstract.

Constantinescu, A., Pick, U., Handelman, G. J., Haramaki, N., Han, D., Podda, M., Tritschler, H. J., and Packer, L. Reduction and transport of lipoic acid by human erythrocytes. Biochem.Pharmacol. 7-17-1995;50(2):253-261. View abstract.

Maitra, I., Serbinova, E., Trischler, H., and Packer, L. Alpha-lipoic acid prevents buthionine sulfoximine-induced cataract formation in newborn rats. Free Radic.Biol.Med 1995;18(4):823-829. View abstract.

Muller, U. and Krieglstein, J. Prolonged pretreatment with alpha-lipoic acid protects cultured neurons against hypoxic, glutamate-, or iron-induced injury. J Cereb.Blood Flow Metab 1995;15(4):624-630. View abstract.

Podda, M., Tritschler, H. J., Ulrich, H., and Packer, L. Alpha-lipoic acid supplementation prevents symptoms of vitamin E deficiency. Biochem.Biophys.Res.Commun. 10-14-1994;204(1):98-104. View abstract.

Kawabata, T. and Packer, L. Alpha-lipoate can protect against glycation of serum albumin, but not low density lipoprotein. Biochem.Biophys.Res.Commun. 8-30-1994;203(1):99-104. View abstract.

Handelman, G. J., Han, D., Tritschler, H., and Packer, L. Alpha-lipoic acid reduction by mammalian cells to the dithiol form, and release into the culture medium. Biochem Pharmacol 5-18-1994;47(10):1725-1730. View abstract.

Kahler, W., Kuklinski, B., Ruhlmann, C., and Plotz, C. [Diabetes mellitus--a free radical-associated disease. Results of adjuvant antioxidant supplementation]. Z Gesamte Inn.Med 1993;48(5):223-232. View abstract.

Jacob, S., Streeper, R. S., Fogt, D. L., Hokama, J. Y., Tritschler, H. J., Dietze, G. J., and Henriksen, E. J. The antioxidant alpha-lipoic acid enhances insulin-stimulated glucose metabolism in insulin-resistant rat skeletal muscle. Diabetes 1996;45(8):1024-1029. View abstract.

Gleiter, C. H., Schug, B. S., Hermann, R., Elze, M., Blume, H. H., and Gundert-Remy, U. Influence of food intake on the bioavailability of thioctic acid enantiomers. Eur.J Clin Pharmacol. 1996;50(6):513-514. View abstract.

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Henriksen, E. J., Jacob, S., Streeper, R. S., Fogt, D. L., Hokama, J. Y., and Tritschler, H. J. Stimulation by alpha-lipoic acid of glucose transport activity in skeletal muscle of lean and obese Zucker rats. Life Sci 1997;61(8):805-812. View abstract.

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Sanders LLO, de Souza Menezes CE, Chaves Filho AJM, et al. Alpha-lipoic acid as adjunctive treatment for schizophrenia: an open-label trial. J Clin Psychopharmacol. 2017 Dec;37(6):697-701. View abstract.

Cavestro C, Bedogni G, Molinari F, Mandrino S, Rota E, Frigeri MC. Alpha-lipoic acid shows promise to improve migraine in patients with insulin resistance: a 6-month exploratory study. J Med Food. 2017 Oct 4. View abstract.

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Kucukgoncu S, Zhou E, Lucas KB, Tek C. Alpha-lipoic acid (ALA) as a supplementation for weight loss: results from a meta-analysis of randomized controlled trials. Obes Rev. 2017 May;18(4):594-601. View abstract.

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Hadzik B, Grass H, Mayatepek E, Daldrup T, Hoehn T. Fata non-accidental alpha-lipoic acid intoxication in an adolescent girl. Klin Padiatr. 2014 Sep;226(5):292-4. View abstract.

Desideri I, Francolini G, Becherini C, et al. Use of an alpha lipoic, methylsulfonylmethane and bromelain dietary supplement (Opera) for chemotherapy-induced peripheral neuropathy management, a prospective study. Med Oncol. 2017 Mar;34(3):46. View abstract.

Rago R, Gallo M, Dal Lago A, et al. Controlled, prospective, observational study on the efficiency and tolerability of a combination of potential Nrf2-inducing antioxidants and micronutrients as pre-treatment for ICSI in dyspermic patients with previous failure. Eur Rev Med Pharmacol Sci. 2017;21(7):1645-1652. View abstract.

Sardu C, Santulli G, Santamaria M, et al. Effects of alpha lipoic acid on multiple cytokines and biomarkers and recurrence of atrial fibrillation within 1 year of catheter ablation. Am J Cardiol. 2017;119(9):1382-1386. View abstract.

Murina F, Graziottin A, Felice R, Gambini D. Alpha lipoic acid plus omega-3 fatty acids for vestibulodynia associated with painful bladder syndrome. J Obstet Gynaecol Can 2017;39(3):131-7. View abstract.

Li N, Yan W, Hu X, et al. Effects of oral a-lipoic acid administration on body weight in overweight or obese subjects: a crossover randomized, double-blind, placebo-controlled trial. Clin Endocrinol (Oxf) 2017;86(5):680-7. View abstract.

Karkabounas S, Papadopoulos N, Anastasiadou C, et al. Effects of a-lipoic Acid, carnosine, and thiamine supplementation in obese patients with type 2 diabetes mellitus: A randomized, double-blind study. J Med Food. 2018;21(12):1197-1203. View abstract.

Sabanovic M, Jasic M, Odobasic A, et al. Alpha lipoic acid reduces symptoms and inflammation biomarkers in patients with chronic hemorrhoidal illness. Int J Vitam Nutr Res 2018;88(5-6):281-90. View abstract.

Tromba L, Perla FM, Carbotta G, Chiesa C, Pacifico L. Effect of alpha-lipoic acid supplementation on endothelial function and cardiovascular risk factors in overweight/obese youths: a double-blind, placebo-controlled randomized trial. Nutrients 2019;11(2). pii: E375. View abstract.

Haghighatdoost F, Hariri M. Does alpha-lipoic acid affect lipid profile? A meta-analysis and systematic review on randomized controlled trials. Eur J Pharmacol 2019;847:1-10. View abstract.

Hosseinpour-Arjmand S, Amirkhizi F, Ebrahimi-Mameghani M. The effect of alpha-lipoic acid on inflammatory markers and body composition in obese patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial. J Clin Pharm Ther 2019;44(2):258-67. View abstract.

Jiang Z, Tan Z, Meng F, Li X. Curative effects of valsartan alone or combined with alpha-lipoic acid on inflammatory cytokines and renal function in early-stage diabetic kidney disease. J Coll Physicians Surg Pak. 2019;29(10):1009-1011. View abstract.

Lai S, Petramala L, Muscaritoli M, et al. a-lipoic acid in patients with autosomal dominant polycystic kidney disease. Nutrition. 2020;71:110594. View abstract.

Murray GL, Colombo J. (r)Alpha lipoic acid is a safe, effective pharmacologic therapy of chronic orthostatic hypotension associated with low sympathetic tone. Int J Angiol. 2019;28(3):188-193. View abstract.

Fruzzetti F, Fidecicchi T, Palla G, Gambacciani M. Long-term treatment with a-lipoic acid and myo-inositol positively affects clinical and metabolic features of polycystic ovary syndrome. Gynecol Endocrinol. 2020;36(2):152-155. View abstract.

Genazzani AD, Prati A, Marchini F, Petrillo T, Napolitano A, Simoncini T. Differential insulin response to oral glucose tolerance test (OGTT) in overweight/obese polycystic ovary syndrome patients undergoing to myo-inositol (MYO), alpha lipoic acid (ALA), or combination of both. Gynecol Endocrinol. 2019;35(12):1088-1093. View abstract.

Yousefi M, Kavianpour M, Hesami S, Rashidi Nooshabadi M, Khadem Haghighian H. Effect of alpha-lipoic acid at the combination with mefenamic acid in girls with primary dysmenorrhea: randomized, double-blind, placebo-controlled clinical trial. Gynecol Endocrinol. 2019;35(9):782-786. View abstract.

Moretti R, Angeletti C, Minora S. Multiple organ failure and shock following acute alpha lipoic acid (ALA) intoxication. Clin Toxicol (Phila). 2019;57(8):749-751. View abstract.

Bobe G, Michels AJ, Zhang WJ, et al. A randomized controlled trial of long-term (R)-α-lipoic acid supplementation promotes weight loss in overweight or obese adults without altering baseline elevated plasma triglyceride concentrations. J Nutr. 2020: 150(9):2336-2345. View abstract.

Passiatore M, Perna A, De-Vitis R, Taccardo G. The use of alfa-lipoic acid-R (ALA-R) in patients with mild-moderate carpal tunnel syndrome: A randomised controlled open label prospective study. Malays Orthop J. 2020;14(1):1-6. View abstract.

Jamshidi K, Abdollahzad H, Nachvak M, Rezaei M, Golpayegani MR, Sharifi Zahabi E. Effects of alpha-lipoic acid supplementation on cardiovascular disease risk factors in ß-thalassemia major patients: A clinical trial crossover study. J Blood Med. 2020;11:131-139. View abstract.

El Amrousy D, El-Afify D. Effects of alpha lipoic acid as a supplement in obese children and adolescents. Cytokine. 2020;130:155084. View abstract.

Haghighatdoost F, Gholami A, Hariri M. Alpha-lipoic acid effect on leptin and adiponectin concentrations: a systematic review and meta-analysis of randomized controlled trials. Eur J Clin Pharmacol. 2020;76(5):649-657. View abstract.

Vajdi M, Abbasalizad Farhangi M. Alpha-lipoic acid supplementation significantly reduces the risk of obesity in an updated systematic review and dose response meta-analysis of randomised placebo-controlled clinical trials. Int J Clin Pract. 2020;74(6):e13493. View abstract.

El-Nahas MR, Elkannishy G, Abdelhafez H, Elkhamisy ET, El-Sehrawy AA. Oral alpha lipoic acid treatment for symptomatic diabetic peripheral neuropathy: A randomized double-blinded placebo-controlled study. Endocr Metab Immune Disord Drug Targets. 2020. View abstract.

Mohammadshahi M, Zakizadeh E, Ahmadi-Angali K, Ravanbakhsh M, Helli B. The synergic effects of alpha-lipoic acid supplementation and electrical isotonic contraction on anthropometric measurements and the serum levels of VEGF, NO, sirtuin-1, and PGC1-α in obese people undergoing a weight loss diet. Arch Physiol Biochem. 2020:1-7. View abstract.

Kim BJ, Hunter A, Brucker AJ, et al. Orally administered alpha lipoic acid as a treatment for geographic atrophy: A randomized clinical trial. Ophthalmol Retina. 2020;4(9):889-898. View abstract.

Fruzzetti F, Benelli E, Fidecicchi T, et al. Clinical and Metabolic Effects of Alpha-Lipoic Acid Associated with Two Different Doses of Myo-Inositol in Women with Polycystic Ovary Syndrome. Int J Endocrinol. 2020;2020:2901393. View abstract.

Derosa G, D'Angelo A, Preti P, Maffioli P. Safety and efficacy of alpha lipoic acid during 4 years of observation: A retrospective, clinical trial in healthy subjects in primary prevention. Drug Des Devel Ther. 2020;14:5367-5374. View abstract.

Fogacci F, Rizzo M, Krogager C, et al. Safety evaluation of a-lipoic acid supplementation: A systematic review and meta-analysis of randomized placebo-controlled clinical studies. Antioxidants (Basel). 2020;9(10):1011. View abstract.

Isenmann E, Trittel L, Diel P. The effects of alpha lipoic acid on muscle strength recovery after a single and a short-term chronic supplementation - a study in healthy well-trained individuals after intensive resistance and endurance training. J Int Soc Sports Nutr. 2020;17(1):61. View abstract.

Polat S, Kiliçaslan Ö, Sönmez FT. Alpha-lipoic acid intoxication in an adolescent girl: Case report and review of the literature. Turk Pediatri Ars. 2020;55(3):328-330. View abstract.

Sun Y, Guan X, Wang H, et al. Randomized clinical trial of combined therapy with oral a-lipoic acid and NB-UVB for nonsegmental stable vitiligo. Dermatol Ther. 2021;34(1):e14610. View abstract.

Gilron I, Robb S, Tu D, et al. Double-blind, randomized, placebo-controlled crossover trial of alpha-lipoic acid for the treatment of fibromyalgia pain: the IMPALA trial. Pain. 2021;162(2):561-568. View abstract.

Gullo D, Evans JL, Sortino G, Goldfine ID, Vigneri R. Insulin autoimmune syndrome (Hirata Disease) in European Caucasians taking a-lipoic acid. Clin Endocrinol (Oxf). 2014;81(2):204-9. View abstract.

Yukina M, Nuralieva N, Solovyev M, Troshina E, Vasilyev E. Insulin autoimmune syndrome. Endocrinol Diabetes Metab Case Rep. 2020;2020:19-0159. View abstract.

Moffa S, Improta I, Rocchetti S, Mezza T, Giaccari A. Potential cause-effect relationship between insulin autoimmune syndrome and alpha lipoic acid: Two case reports. Nutrition. 2019;57:1-4. View abstract.

Izzo V, Greco C, Corradini D, et al. Insulin autoimmune syndrome in an Argentine woman taking a-lipoic acid: A case report and review of the literature. SAGE Open Med Case Rep. 2018;6:2050313X18819601. View abstract.

Rahmanabadi A , Mahboob S , Amirkhizi F , Hosseinpour-Arjmand S , Ebrahimi-Mameghani M . Oral a-lipoic acid supplementation in patients with non-alcoholic fatty liver disease: effects on adipokines and liver histology features. Food Funct. 2019;10(8):4941-4952. View abstract.

Hakimizad R, Soltani R, Khorvash F, Marjani M, Dastan F. The effect of acetyl-L-carnitine, alpha-lipoic acid, and coenzyme Q10 combination in preventing anti-tuberculosis drug-induced hepatotoxicity: a randomized, double-blind, placebo-controlled clinical trial. Iran J Pharm Res 2021;20(3):431-40. View abstract.

Mahmoudinezhad M, Farhangi MA. Alpha lipoic acid supplementation affects serum lipids in a dose and duration-dependent manner in different health status. Int J Vitam Nutr Res 2021. View abstract.

Vakali E, Rigopoulos D, Carrillo AE, Flouris AD, Dinas PC. Effects of alpha-lipoic acid supplementation on human diabetic nephropathy: A systematic review and meta-analysis. Curr Diabetes Rev 2021. View abstract.

Esposito C, Ugo Garzarella E, Santarcangelo C, et al. Safety and efficacy of alpha-lipoic acid oral supplementation in the reduction of pain with unknown etiology: A monocentric, randomized, double-blind, placebo-controlled clinical trial. Biomed Pharmacother 2021;144:112308. View abstract.

Sharifi-Zahabi E, Abdollahzad H, Mostafa Nachvak S, et al. Effects of alpha lipoic acid on iron overload, lipid profile and oxidative stress indices in ß-thalassemia major patients: A cross-over randomised controlled clinical trial. Int J Clin Pract 2021;75(6):e14062. View abstract.

Rezaei Kelishadi M, Alavi Naeini A, Askari G, Khorvash F, Heidari Z. The efficacy of alpha-lipoic acid in improving oxidative, inflammatory, and mood status in women with episodic migraine in a randomised, double-blind, placebo-controlled clinical trial. Int J Clin Pract 2021;75(9):e14455. View abstract.

Aslfalah H, Jamilian M, Ansarihadipour H, Abdollahi M, Khosrowbeygi A. Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study. Int J Reprod Biomed 2020;18(12):1029-1038. View abstract.

Sun F, Jiang D, Cai J. Effects of valsartan combined with a-lipoic acid on renal function in patients with diabetic nephropathy: a systematic review and meta-analysis. BMC Endocr Disord 2021;21(1):178. View abstract.

Serhiyenko VA, Serhiyenko LM, Sehin VB, Serhiyenko AA. Effect of alpha-lipoic acid on arterial stiffness parameters in type 2 diabetes mellitus patients with cardiac autonomic neuropathy. Endocr Regul 2021;55(4):224-233. View abstract.

EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, et al. Scientific opinion on the relationship between intake of alpha-lipoic acid (thioctic acid) and the risk of insulin autoimmune syndrome. EFSA J 2021;19(6):e06577. View abstract.

Vajdi M, Mahmoudi-Nezhad M, Farhangi MA. An updated systematic review and dose-response meta-analysis of the randomized controlled trials on the effects of Alpha-Lipoic acid supplementation on inflammatory biomarkers. Int J Vitam Nutr Res 2021. View abstract.

Abdelrahman KA, Ibrahim AS, Osman AM, Aly MG, Ali AS, Farrag WS. Alpha lipoic acid with pulsed radiofrequency in treatment of chronic lumbosacral radicular pain: A prospective, randomized study. Medicine (Baltimore) 2021;100(24):e26344. View abstract.

Desideri I, Lucidi S, Francolini G, et al. Use of an alfa-lipoic, methylsulfonylmethane, Boswellia serrata and bromelain dietary supplement (OPERA®) for aromatase inhibitors-related arthralgia management (AIA): a prospective phase II trial (NCT04161833). Med Oncol 2022;39(8):113. View abstract.

Dong L, Yang F, Li J, Li Y, Yu X, Zhang X. Effect of oral alpha-lipoic acid (ALA) on sperm parameters: a systematic review and meta-analysis. Basic Clin Androl 2022;32(1):23. View abstract.

Habibi M, Abbasi B, Fakhari Zavareh Z, et al. Alpha-lipoic acid ameliorates sperm DNA damage and chromatin integrity in men with high DNA damage: a triple blind randomized clinical trial. Cell J 2022;24(10):603-11. View abstract.

Hodeeb YM, El-Rewiny EM, Gaafar AM, Zayed AN, Hasan MS, Elsaie ML. The effect of alpha lipoic acid supplementation on sperm functions in idiopathic asthenozoospermic patients: a case-controlled study. Hum Fertil (Camb) 2022. View abstract.

Christy J, Noorani S, Sy F, Al-Eryani K, Enciso R. Efficacy of alpha-lipoic acid in patients with burning mouth syndrome compared to that of placebo or other interventions: a systematic review with meta-analyses. J Dent Anesth Pain Med 2022;22(5):323-38. View abstract.

Werida RH, Elshafiey RA, Ghoneim A, Elzawawy S, Mostafa TM. Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients. Support Care Cancer 2022;30(9):7281-92. View abstract.

Divkovic A, Radic K, Sabitovic D, et al. Effect of alpha-lipoic acid supplementation on low-grade squamous intraepithelial lesions-double-blind, randomized, placebo-controlled trial. Healthcare (Basel) 2022;10(12):2434. View abstract.

Mishra A, Reeta KH, Sarangi SC, Maiti R, Sood M. Effect of add-on alpha lipoic acid on psychopathology in patients with treatment-resistant schizophrenia: a pilot randomized double-blind placebo-controlled trial. Psychopharmacology (Berl) 2022;239(11):3525-35. View abstract.

De Lima DN Jr, Costa Filho CWL, Frota IJ, et al. a-Lipoic acid as adjunctive treatment for schizophrenia: a randomized double-blind study. J Clin Psychopharmacol 2023;43(1):39-45. View abstract.

Iannuzzo F, Basile GA, Campolo D, et al. Metabolic and clinical effect of alpha-lipoic acid administration in schizophrenic subjects stabilized with atypical antipsychotics: A 12-week, open-label, uncontrolled study. Curr Res Pharmacol Drug Discov 2022;3:100116. View abstract.

Kelishadi MR, Naeini AA, Khorvash F, Askari G, Heidari Z. The beneficial effect of alpha-lipoic acid supplementation as a potential adjunct treatment in episodic migraines. Sci Rep 2022;12(1):271. View abstract.

Jibril AT, Jayedi A, Shab-Bidar S. Efficacy and safety of oral alpha-lipoic acid supplementation for type 2 diabetes management: a systematic review and dose-response meta-analysis of randomized trials. Endocr Connect 2022;11(10):e220322. View abstract.

Roszkowska AM, Spinella R, Oliverio GW, et al. Effects of the topical use of the natural antioxidant alpha-lipoic acid on the ocular surface of diabetic patients with dry eye symptoms. Front Biosci (Landmark Ed) 2022;27(7):202. View abstract.

Bonetti M, Lauritano D, Ottaviani GM, et al. Oxygen-ozone therapy associated with alpha lipoic acid plus palmitoylethanolamide and myrrh versus ozone therapy in the combined treatment of sciatic pain due to herniated discs: observational study on 318 patients. Int J Environ Res Public Health 2022;19(9):5716. View abstract.

Holotiuk IS, Kryzhanivska AY, Holotiuk SI, Holotiuk VV, Maliborska SV. EFFECTIVENESS OF ALPHA-LIPOIC ACID AND IPIDACRINE HYDROCHLORIDE IN PREVENTION OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY ASSESSED BY ELECTRONEUROMYOGRAPHY OF SUPERFICIAL PERONEAL AND SURAL NERVES. Exp Oncol 2022;44(4):300-306. View abstract.

Libonati GA, Leone A, Martellucci S, et al. Prevention of Recurrent Benign Paroxysmal Positional Vertigo: The Role of Combined Supplementation with Vitamin D and Antioxidants. Audiol Res. 2022 Aug 22;12(4):445-456. View abstract.

Basile GA, Iannuzzo F, Xerra F, et al. Cognitive and Mood Effect of Alpha-Lipoic Acid Supplementation in a Nonclinical Elder Sample: An Open-Label Pilot Study. Int J Environ Res Public Health 2023;20(3):2358. View abstract.

Altunina N, Bondarchuk O. EFFECTS OF ALPHA-LIPOIC ACID ON GLYCEMIC STATUS IN 2 TYPE DIABETES PATIENTS WITH ?HRONIC CORONARY SYNDROME. Wiad Lek 2022;75(12):3074-3079. View abstract.

Su F, Xia Q. Effects of Valsartan and Amlodipine Tablets Combined with a-Lipoic Acid on T-AOC, IL-6 and ß2-MG Levels in Patients with Diabetic Nephropathy. Altern Ther Health Med 2023. View abstract.

Ahmadi M, Keshavarz SA, Abbasi B. Effects of alpha lipoic acid supplementation on serum lipid profile in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled clinical trial. ARYA Atheroscler 2022;18(4):1-8. View abstract.

Bonetti M, Lauritano D, Ottaviani GM, et al. New Approach to Chronic Back Pain Treatment: A Case Control Study. Biomedicines 2022;11(1):73. View abstract.

Sanz-González SM, Raga-Cervera J, Aguirre Lipperheide M, et al. Effect of an oral supplementation with a formula containing R-lipoic acid in glaucoma patients. Arch Soc Esp Oftalmol (Engl Ed). 2020 Mar;95(3):120-129. View abstract.

Habibi M, Fakhari Zavareh Z, Abbasi B, et al. Alpha-Lipoic Acid Supplementation for Male Partner of Couples with Recurrent Pregnancy Loss: A Post hoc analysis in Clinical Trial. Int J Fertil Steril 2023;17(1):67-74. View abstract.

Halabi Z, El Helou C, Al Balushi H, et al. Alpha Lipoic Acid Toxicity: The First Reported Mortality in an Adult Patient After Multiorgan Failure. J Emerg Med 2023;64(2):190-194. View abstract.

Banik S, Ghosh A, Sato H, Onoue S. The efficacy of alpha-lipoic acid in the management of burning mouth syndrome: An updated systematic review of randomized controlled clinical trials. Health Sci Rep 2023;6(4):e1186. View abstract.

Gilron I, Robb S, Tu D, Holden RR, Milev R, Towheed T. Combination analgesic development for enhanced clinical efficacy (the CADENCE trial): a double-blind, controlled trial of an alpha-lipoic acid-pregabalin combination for fibromyalgia pain. Pain 2023. View abstract.

Vg A, G S, C K, V A. A pilot study suggesting several benefits of alpha lipoic acid in patients with diabetes. Curr Vasc Pharmacol 2023. View abstract.

Iuliano S, Greco F, Seminara G, et al. Positive effects of dietary supplementation with nutraceuticals on male subclinical hypogonadism: a pilot study. Minerva Endocrinol (Torino) 2023. View abstract.

Corazza M, Arlotti E, Schettini N, Pacetti L, Bianchi A, Borghi A. Allergic contact dermatitis due to a-lipoic acid in a topical over-the-counter product: A case report. Contact Dermatitis 2023. View abstract.

D'Orio M, De Vitis R, Taccardo G, et al. Clinical usefulness of nutraceutics with acetyl-L-carnitine, a-lipoic acid, phosphatidylserine, curcumin, C, E and B-group vitamins in patients awaiting for carpal tunnel release during COVID-19 pandemic: a randomized controlled open label prospective study. Acta Biomed 2023;94(S2):e2023050. View abstract.

Hsieh RY, Huang IC, Chen C, Sung JY. Effects of Oral Alpha-Lipoic Acid Treatment on Diabetic Polyneuropathy: A Meta-Analysis and Systematic Review. Nutrients 2023;15(16):3634. View abstract.

Velasco-Amador JP, Prados-Carmona Á, Navarro-Triviño FJ. Contact urticaria syndrome caused by alpha-lipoic acid in a master formula for vulvar lichen sclerosus. Contact Dermatitis 2023;89(2):136-137. View abstract.

Sacchetto L, Monzani D, Apa E, et al. The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus through the Tinnitus Handicap Inventory Scores. Audiol Res 2023;13(4):484-494. View abstract.

Puliappadamb HM, Satpathy AK, Mishra BR, Maiti R, Jena M. Evaluation of Safety and Efficacy of Add-on Alpha-Lipoic Acid on Migraine Prophylaxis in an Adolescent Population: A Randomized Controlled Trial. J Clin Pharmacol 2023. View abstract.

Laky B, Bruckmann C, Blumenschein J, Durstberger G, Haririan H. Effect of a multinutrient supplement as an adjunct to nonsurgical treatment of periodontitis: A randomized placebo-controlled clinical trial. J Periodontol 2023. View abstract.

Latini E, Bonasia G, Petroselli L, et al. Alpha-Lipoic Acid, Palmitoylethanolamide, Myrrh, and Oxygen-Ozone Therapy Improve Pharmacological Therapy in Acute Painful Lumbosacral Radiculopathy due to Herniated Disc. Pain Physician 2023;26(4):E363-E373. View abstract.

Scaturro D, Vitagliani F, Tomasello S, Sconza C, Respizzi S, Letizia Mauro G. Combined Rehabilitation with Alpha Lipoic Acid, Acetyl-L-Carnitine, Resveratrol, and Cholecalciferolin Discogenic Sciatica in Young People: A Randomized Clinical Trial. Medicina (Kaunas) 2023;59(12):2197. View abstract.

Vajdi M, Noshadi N, Hassanizadeh S, Bonyadian A, Seyedhosseini-Ghaheh H, Askari G. The effects of alpha lipoic acid (ALA) supplementation on blood pressure in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials. Front Cardiovasc Med 2023;10:1272837. View abstract.

Figueiredo LP, Paim PVDSL, Cerqueira-Silva T, Barreto CC, Lessa MM. Alpha-lipoic acid does not improve olfactory training results in olfactory loss due to COVID-19: a double-blind randomized trial. Braz J Otorhinolaryngol 2023;90(1):101356. View abstract.

Kishi T, Sakuma K, Miura G, et al. Alpha Lipoic Acid for Schizophrenia: A Systematic Review and Meta-analysis. J Clin Psychopharmacol 2023;43(5):477-478. View abstract.

Orellana-Donoso M, López-Chaparro M, Barahona-Vásquez M, et al. Effectiveness of alpha-lipoic acid in patients with neuropathic pain associated with type I and type II diabetes mellitus: A systematic review and meta-analysis. Medicine (Baltimore) 2023;102(44):e35368. View abstract.

Gülsah Ö, Bekir DE. Efficacy of intravenous alpha lipoic acid in the treatment of neuropathic pain due to carpal tunnel syndrome. Ideggyogy Sz 2023;76(9-10):319-326. View abstract.

Abu-Zaid A, Baradwan S, Bukhari IA, et al. The effect of alpha-lipoic acid supplementation on anthropometric, glycemic, lipid, oxidative stress, and hormonal parameters in individuals with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials. Obstet Gynecol Sci 2023. View abstract.

Gilron I, Robb S, Tu D, et al. Randomized, double-blind, controlled trial of a combination of alpha-lipoic acid and pregabalin for neuropathic pain: the PAIN-CARE trial. Pain 2023. View abstract.

Sehgal T, Ohri U, Mittal N, Attri P, Dishant F. A Case of Insulin Autoimmune Syndrome in an Indian Male Taking Alpha-Lipoic Acid. Cureus 2023;15(8):e43743. View abstract.