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Leman ES, Sisken BF, Zimmer S, Anderson KW. Studies of the interactions between melatonin and 2 Hz, 0.3 mT PEMF on the proliferation and invasion of human breast cancer cells. Bioelectromagnetics 2001;22:178-84.. View abstract.

Tjon Pian Gi CV, Broeren JP, Starreveld JS, A Versteegh FG. Melatonin for treatment of sleeping disorders in children with attention deficit/hyperactivity disorder: a preliminary open label study. Eur J Pediatr 2003;162:554-5. View abstract.

Lewy AJ, Bauer VK, Cutler NL, Sack RL. Melatonin treatment of winter depression: a pilot study. Psychiatry Res 1998;77:57-61.. View abstract.

Pei Z, Pang SF, Cheung RT. Administration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. Stroke 2003;34:770-5.. View abstract.

Secreto G, Chiechi LM, Amadori A, et al. Soy isoflavones and melatonin for the relief of climacteric symptoms: a multicenter, double-blind, randomized study. Maturitas 2004;47:11-20. View abstract.

Peres MFP, Zukerman E, da Cunha Tanuri F, et al. Melatonin, 3 mg, is effective for migraine prevention. Neurology 2004;63:757. View abstract.

Buscemi N, Vandermeer B, Pandya R, et al. Melatonin for treatment of sleep disorders. Summary, Evidence Report/Technology Assessment #108. (Prepared by the Univ of Alberta Evidence-based Practice Center, under Contract#290-02-0023.) AHRQ Publ #05-E002-2. Rockville, MD: Agency for Healthcare Research & Quality. November 2004.

Song GH, Leng PH, Gwee KA, et al. Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised double blind placebo controlled study. Gut 2005;54:1402-7. View abstract.

Buscemi N, Vandermeer B, Hooton N, et al. Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis. BMJ 2006;332:385-93. View abstract.

van Heukelom RO, Prins JB, Smits MG, Bleijenberg G. Influence of melatonin on fatigue severity in patients with chronic fatigue syndrome and late melatonin secretion. Eur J Neurol 2006;13:55-60. View abstract.

Buscemi N, Vandermeer B, Hooton N, et al. The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis. J Gen Intern Med 2005;20:1151-8. View abstract.

Weiss MD, Wasdell MB, Bomben MM, et al. Sleep hygiene and melatonin treatment for children and adolescents with ADHD and initial insomnia. J Am Acad Child Adolesc Psychiatry 2006;45:512-9. View abstract.

Saha L, Malhotra S, Rana S, et al. A preliminary study of melatonin in irritable bowel syndrome. J Clin Gastroenterol 2007;41:29-32. View abstract.

Periera Rde S. Regression of gastroesophageal reflux disease symptoms using dietary supplementation with melatonin, vitamins and aminoacids: comparison with omeprazole. J Pineal Res 2006;41:195-200. View abstract.

Hussain, SA, Khadim, HM, Khalaf, BH, et al. Effects of melatonin and zinc on glycemic control in type 2 diabetic patients poorly controlled with metformin. Saudi Med J 2006;27:1483-8. View abstract.

Kadhim, HM, Ismail, SH, Hussein, KI, et al. Effects of melatonin and zinc on lipid profile and renal function in type 2 diabetic patients poorly controlled with metformin. J Pineal Res 2006;41:189-93. View abstract.

Mutluay R. Elbeg S. Karakus R. et al. The Impact of Melatonin on Glucose Homeostasis. Turkish Journal of Endocrinology and Metabolism 2009;13:52-55.

Mulder H, Nagorny CL, Lyssenko V, et al. Melatonin receptors in pancreatic islets: good morning to a novel type 2diabetes gene. Diabetologia. 2009 Jul;52:1240-9. View abstract.

Gringras P, Gamble C, Jones AP, et al; MENDS Study Group. Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial. BMJ. 2012 Nov 5;345:e6664. View abstract.

Wright KP Jr, Badia P, Myers BL, et al. Caffeine and light effects on nighttime melatonin and temperature levels in sleep-deprived humans. Brain Res. 1997;747(1):78-84. View abstract.

Peuhkuri K, Sihvola N, Korpela R. Dietary factors and fluctuating levels of melatonin. Food Nutr Res. 2012;56. doi: 10.3402/fnr.v56i0.17252. Epub 2012 Jul 20. View abstract.

Gibb JW, Bush L, Hanson GR. Exacerbation of methamphetamine-induced neurochemical deficits by melatonin. J Pharmacol Exp Ther. 1997;283(2):630-5. View abstract.

Sunami E, Usuda K, Nishiyama Y, et al. A preliminary study of fluvoxamine maleate on depressive state and serum melatonin levels in patients after cerebral infarction. Intern Med. 2012;51(10):1187-93. View abstract.

Millan-Plano, S., Piedrafita, E., Miana-Mena, F. J., Fuentes-Broto, L., Martinez-Ballarin, E., Lopez-Pingarron, L., Saenz, M. A., and Garcia, J. J. Melatonin and structurally-related compounds protect synaptosomal membranes from free radical damage. Int J Mol.Sci 2010;11(1):312-328. View abstract.

Chaudhary, G., Sharma, U., Jagannathan, N. R., and Gupta, Y. K. Evaluation of Withania somnifera in a middle cerebral artery occlusion model of stroke in rats. Clin Exp.Pharmacol Physiol 2003;30(5-6):399-404. View abstract.

Babkoff, H., French, J., Whitmore, J., and Sutherlin, R. Single-dose bright light and/or caffeine effect on nocturnal performance. Aviat.Space Environ.Med. 2002;73(4):341-350. View abstract.

Scott, G. N. and Elmer, G. W. Update on natural product--drug interactions. Am J Health Syst.Pharm 2-15-2002;59(4):339-347. View abstract.

Rossignol, D. A. Novel and emerging treatments for autism spectrum disorders: a systematic review. Ann.Clin Psychiatry 2009;21(4):213-236. View abstract.

Mishima, K., Tozawa, T., Satoh, K., Matsumoto, Y., Hishikawa, Y., and Okawa, M. Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer's type with disturbed sleep-waking. Biol Psychiatry 2-15-1999;45(4):417-421. View abstract.

Yeleswaram, K., Vachharajani, N., and Santone, K. Involvement of cytochrome P-450 isozymes in melatonin metabolism and clinical implications. J Pineal Res 1999;26(3):190-191. View abstract.

Li, X. J., Zhang, L. M., Gu, J., Zhang, A. Z., and Sun, F. Y. Melatonin decreases production of hydroxyl radical during cerebral ischemia-reperfusion. Zhongguo Yao Li Xue.Bao. 1997;18(5):394-396. View abstract.

Shah, J., Langmuir, V., and Gupta, S. K. Feasibility and functionality of OROS melatonin in healthy subjects. J Clin Pharmacol 1999;39(6):606-612. View abstract.

Jan, J. E., Connolly, M. B., Hamilton, D., Freeman, R. D., and Laudon, M. Melatonin treatment of non-epileptic myoclonus in children. Dev.Med Child Neurol. 1999;41(4):255-259. View abstract.

Raghavendra, V. and Kulkarni, S. K. Reversal of morphine tolerance and dependence by melatonin: possible role of central and peripheral benzodiazepine receptors. Brain Res 7-10-1999;834(1-2):178-181. View abstract.

Luboshitzky, R., Levi, M., Shen-Orr, Z., Blumenfeld, Z., Herer, P., and Lavie, P. Long-term melatonin administration does not alter pituitary-gonadal hormone secretion in normal men. Hum Reprod. 2000;15(1):60-65. View abstract.

Pepping, J. Melatonin. Am J Health Syst.Pharm 12-15-1999;56(24):2520, 2523-2524, 2527. View abstract.

Luboshitzky, R., Shen-Orr, Z., Shochat, T., Herer, P., and Lavie, P. Melatonin administered in the afternoon decreases next-day luteinizing hormone levels in men: lack of antagonism by flumazenil. J Mol.Neurosci. 1999;12(1):75-80. View abstract.

Zaslavskaia, R. M., Shakirova, A. N., Komarov, F. I., Teiblium, M. M., and Akhmetov, K. Z. [Effects of melatonin alone and in combination with aceten on chronostructure of diurnal hemodynamic rhythms in patients with hypertension stage II]. Ter Arkh. 1999;71(12):21-24. View abstract.

Bersani G, Garavini A. Melatonin add-on in manic patients with treatment resistant insomnia. Prog Neuropsychopharmacol Biol Psychiatry 2000;24(2):185-91. View abstract.

Zaslavskaia, R. M., Komarov, F. I., Shakirova, A. N., Teiblium, M. M., and Akhmetov, K. Z. [Effect of moxonidine monotherapy and in combination with melatonin on hemodynamic parameters in patients with arterial hypertension]. Klin.Med (Mosk) 2000;78(4):41-44. View abstract.

Jan, J. E., Hamilton, D., Seward, N., Fast, D. K., Freeman, R. D., and Laudon, M. Clinical trials of controlled-release melatonin in children with sleep- wake cycle disorders. J Pineal Res 2000;29(1):34-39. View abstract.

Shamir, E., Barak, Y., Plopsky, I., Zisapel, N., Elizur, A., and Weizman, A. Is melatonin treatment effective for tardive dyskinesia? J Clin Psychiatry 2000;61(8):556-558. View abstract.

Cagnacci, A., Arangino, S., Angiolucci, M., Melis, G. B., Tarquini, R., Renzi, A., and Volpe, A. Different circulatory response to melatonin in postmenopausal women without and with hormone replacement therapy. J Pineal Res 2000;29(3):152-158. View abstract.

Marelli, M. M., Limonta, P., Maggi, R., Motta, M., and Moretti, R. M. Growth-inhibitory activity of melatonin on human androgen-independent DU 145 prostate cancer cells. Prostate 11-1-2000;45(3):238-244. View abstract.

Edwards, B. J., Atkinson, G., Waterhouse, J., Reilly, T., Godfrey, R., and Budgett, R. Use of melatonin in recovery from jet-lag following an eastward flight across 10 time-zones. Ergonomics 2000;43(10):1501-1513. View abstract.

Fourtillan, J. B., Brisson, A. M., Fourtillan, M., Ingrand, I., Decourt, J. P., and Girault, J. Melatonin secretion occurs at a constant rate in both young and older men and women. Am J Physiol Endocrinol Metab 2001;280(1):E11-E22. View abstract.

Bartsch, H., Buchberger, A., Franz, H., Bartsch, C., Maidonis, I., Mecke, D., and Bayer, E. Effect of melatonin and pineal extracts on human ovarian and mammary tumor cells in a chemosensitivity assay. Life Sci 11-3-2000;67(24):2953-2960. View abstract.

Okatani, Y., Wakatsuki, A., and Reiter, R. J. Melatonin counteracts potentiation by homocysteine of KCL-induced vasoconstriction in human umbilical artery: relation to calcium influx. Biochem Biophys Res Commun. 1-26-2001;280(3):940-944. View abstract.

Cagnacci, A., Arangino, S., Angiolucci, M., Melis, G. B., Facchinetti, F., Malmusi, S., and Volpe, A. Effect of exogenous melatonin on vascular reactivity and nitric oxide in postmenopausal women: role of hormone replacement therapy. Clin Endocrinol (Oxf) 2001;54(2):261-266. View abstract.

Maestroni, G. J. The immunotherapeutic potential of melatonin. Expert.Opin Investig Drugs 2001;10(3):467-476. View abstract.

Zaslavskaia, R. M., Biiasilov, N. S., Akhmetov, K. Z., and Teiblium, M. M. [Capozide-50 alone and in combination with melatonin in therapy of hypertension]. Klin.Med (Mosk) 2000;78(11):39-41. View abstract.

Cugini, P., Touitou, Y., Bogdan, A., Auzeby, A., Pellegrino, A. M., Fontana, S., Vacca, K., Siena, G. D., Di Rosa, R., Zannella, F. P., Zannella, P., Zannella, A., Sepe, F. A., and Sepe, L. Is melatonin circadian rhythm a physiological feature associated with healthy longevity? A study of long-living subjects and their progeny. Chronobiol Int 2001;18(1):99-107. View abstract.

Reiter, R. J., Calvo, J. R., Karbownik, M., Qi, W., and Tan, D. X. Melatonin and its relation to the immune system and inflammation. Ann N.Y.Acad Sci 2000;917:376-386. View abstract.

Munoz-Hoyos, A., Hubber, E., Escames, G., Molina-Carballo, A., Macias, M., Valenzuela-Ruiz, A., Fernandez-Garcia, J. M., and Acuna-Castroviejo, D. Effect of propranolol plus exercise on melatonin and growth hormone levels in children with growth delay. J Pineal Res 2001;30(2):75-81. View abstract.

Hartter, S., Wang, X., Weigmann, H., Friedberg, T., Arand, M., Oesch, F., and Hiemke, C. Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatonin. J Clin Psychopharmacol 2001;21(2):167-174. View abstract.

Graw, P., Werth, E., Krauchi, K., Gutzwiller, F., Cajochen, C., and Wirz-Justice, A. Early morning melatonin administration impairs psychomotor vigilance. Behav Brain Res 2001;121(1-2):167-172. View abstract.

Wakatsuki, A., Okatani, Y., Ikenoue, N., Kaneda, C., and Fukaya, T. Effects of short-term melatonin administration on lipoprotein metabolism in normolipidemic postmenopausal women. Maturitas 4-20-2001;38(2):171-177. View abstract.

Atkinson, G., Buckley, P., Edwards, B., Reilly, T., and Waterhouse, J. Are there hangover-effects on physical performance when melatonin is ingested by athletes before nocturnal sleep? Int J Sports Med 2001;22(3):232-234. View abstract.

Dai, J., Ram, P. T., Yuan, L., Spriggs, L. L., and Hill, S. M. Transcriptional repression of RORalpha activity in human breast cancer cells by melatonin. Mol.Cell Endocrinol 5-15-2001;176(1-2):111-120. View abstract.

Ninomiya, T., Iwatani, N., Tomoda, A., and Miike, T. Effects of exogenous melatonin on pituitary hormones in humans. Clin Physiol 2001;21(3):292-299. View abstract.

Norman, T. R., Piccolo, J., Voudouris, N., and Burrows, G. D. The effect of single oral doses of zopiclone on nocturnal melatonin secretion in healthy male volunteers. Prog Neuropsychopharmacol.Biol Psychiatry 2001;25(4):825-833. View abstract.

Kim, B. C., Shon, B. S., Ryoo, Y. W., Kim, S. P., and Lee, K. S. Melatonin reduces X-ray irradiation-induced oxidative damages in cultured human skin fibroblasts. J Dermatol Sci 2001;26(3):194-200. View abstract.

Kitajima, T., Kanbayashi, T., Saitoh, Y., Ogawa, Y., Sugiyama, T., Kaneko, Y., Sasaki, Y., Aizawa, R., and Shimisu, T. The effects of oral melatonin on the autonomic function in healthy subjects. Psychiatry Clin Neurosci. 2001;55(3):299-300. View abstract.

Karasek, M., Kowalski, A. J., and Zylinska, K. Serum melatonin circadian profile in women suffering from the genital tract cancers. Neuroendocrinol.Lett 2000;21(2):109-113. View abstract.

Reiter, R. J., Acuna-Castroviejo, D., Tan, D. X., and Burkhardt, S. Free radical-mediated molecular damage. Mechanisms for the protective actions of melatonin in the central nervous system. Ann N Y Acad Sci 2001;939:200-215. View abstract.

Sjoblom, M., Jedstedt, G., and Flemstrom, G. Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. J Clin Invest 2001;108(4):625-633. View abstract.

Harris, A. S., Burgess, H. J., and Dawson, D. The effects of day-time exogenous melatonin administration on cardiac autonomic activity. J Pineal Res 2001;31(3):199-205. View abstract.

Granzotto, M., Rapozzi, V., Decorti, G., and Giraldi, T. Effects of melatonin on doxorubicin cytotoxicity in sensitive and pleiotropically resistant tumor cells. J Pineal Res 2001;31(3):206-213. View abstract.

Wakatsuki, A., Okatani, Y., Ikenoue, N., Shinohara, K., Watanabe, K., and Fukaya, T. Melatonin protects against oxidized low-density lipoprotein-induced inhibition of nitric oxide production in human umbilical artery. J Pineal Res 2001;31(3):281-288. View abstract.

Sharkey, K. M., Fogg, L. F., and Eastman, C. I. Effects of melatonin administration on daytime sleep after simulated night shift work. J Sleep Res 2001;10(3):181-192. View abstract.

Gitto, E., Karbownik, M., Reiter, R. J., Tan, D. X., Cuzzocrea, S., Chiurazzi, P., Cordaro, S., Corona, G., Trimarchi, G., and Barberi, I. Effects of melatonin treatment in septic newborns. Pediatr Res 2001;50(6):756-760. View abstract.

Pei, Z., Ho, H. T., and Cheung, R. T. Pre-treatment with melatonin reduces volume of cerebral infarction in a permanent middle cerebral artery occlusion stroke model in the rat. Neurosci.Lett. 2-1-2002;318(3):141-144. View abstract.

Iuvone, P. M., Brown, A. D., Haque, R., Weller, J., Zawilska, J. B., Chaurasia, S. S., Ma, M., and Klein, D. C. Retinal melatonin production: role of proteasomal proteolysis in circadian and photic control of arylalkylamine N-acetyltransferase. Invest Ophthalmol.Vis.Sci. 2002;43(2):564-572. View abstract.

Wirz-Justice, A., Werth, E., Renz, C., Muller, S., and Krauchi, K. No evidence for a phase delay in human circadian rhythms after a single morning melatonin administration. J Pineal Res 2002;32(1):1-5. View abstract.

Mohanan, P. V. and Yamamoto, H. A. Preventive effect of melatonin against brain mitochondria DNA damage, lipid peroxidation and seizures induced by kainic acid. Toxicol.Lett. 3-24-2002;129(1-2):99-105. View abstract.

Awney, H. A., Attih, A. M., Habib, S. L., and Mostafa, M. H. Effect of melatonin on the production of microsomal hydrogen peroxide and cytochrome P-450 content in rat treated with aflatoxin B(1). Toxicology 3-20-2002;172(2):143-148. View abstract.

Blask, D. E., Sauer, L. A., and Dauchy, R. T. Melatonin as a chronobiotic/anticancer agent: cellular, biochemical, and molecular mechanisms of action and their implications for circadian-based cancer therapy. Curr.Top.Med Chem. 2002;2(2):113-132. View abstract.

Acuna, C. D., Escames, G., Carazo, A., Leon, J., Khaldy, H., and Reiter, R. J. Melatonin, mitochondrial homeostasis and mitochondrial-related diseases. Curr.Top.Med Chem. 2002;2(2):133-151. View abstract.

Feng, Y., Zhang, L. X., and Chao, D. M. [Role of melatonin in spatial learning and memory in rats and its mechanism]. Sheng Li Xue.Bao. 2-25-2002;54(1):65-70. View abstract.

Reiter, R. J., Tan, D. X., Manchester, L. C., and El Sawi, M. R. Melatonin reduces oxidant damage and promotes mitochondrial respiration: implications for aging. Ann.N.Y.Acad.Sci 2002;959:238-250. View abstract.

Calvo, J. R., Guerrero, J. M., Osuna, C., Molinero, P., and Carrillo-Vico, A. Melatonin triggers Crohn's disease symptoms. J Pineal Res 2002;32(4):277-278. View abstract.

Gupta, Y. K., Chaudhary, G., and Sinha, K. Enhanced protection by melatonin and meloxicam combination in a middle cerebral artery occlusion model of acute ischemic stroke in rat. Can J Physiol Pharmacol. 2002;80(3):210-217. View abstract.

Bilici, D., Suleyman, H., Banoglu, Z. N., Kiziltunc, A., Avci, B., Ciftcioglu, A., and Bilici, S. Melatonin prevents ethanol-induced gastric mucosal damage possibly due to its antioxidant effect. Dig.Dis.Sci. 2002;47(4):856-861. View abstract.

Lewinski, A. and Karbownik, M. REVIEW. Melatonin and the thyroid gland. Neuroendocrinol.Lett 2002;23 Suppl 1:73-78. View abstract.

Sewerynek, E. Melatonin and the cardiovascular system. Neuroendocrinol.Lett 2002;23 Suppl 1:79-83. View abstract.

Celebi, S., Dilsiz, N., Yilmaz, T., and Kukner, A. S. Effects of melatonin, vitamin E and octreotide on lipid peroxidation during ischemia-reperfusion in the guinea pig retina. Eur.J Ophthalmol. 2002;12(2):77-83. View abstract.

Koc, M., Buyukokuroglu, M. E., and Taysi, S. The effect of melatonin on peripheral blood cells during total body irradiation in rats. Biol.Pharm Bull. 2002;25(5):656-657. View abstract.

Tailleux, A., Torpier, G., Bonnefont-Rousselot, D., Lestavel, S., Lemdani, M., Caudeville, B., Furman, C., Foricher, R., Gardes-Albert, M., Lesieur, D., Rolando, C., Teissier, E., Fruchart, J. C., Clavey, V., Fievet, C., and Duriez, P. Daily melatonin supplementation in mice increases atherosclerosis in proximal aorta. Biochem.Biophys.Res Commun. 5-10-2002;293(3):1114-1123. View abstract.

Luboshitzky, R., Shen-Orr, Z., Nave, R., Lavi, S., and Lavie, P. Melatonin administration alters semen quality in healthy men. J Androl 2002;23(4):572-578. View abstract.

Lewy, A. J., Emens, J. S., Sack, R. L., Hasler, B. P., and Bernert, R. A. Low, but not high, doses of melatonin entrained a free-running blind person with a long circadian period. Chronobiol.Int 2002;19(3):649-658. View abstract.

Johnson, K., Page, A., Williams, H., Wassemer, E., and Whitehouse, W. The use of melatonin as an alternative to sedation in uncooperative children undergoing an MRI examination. Clin Radiol. 2002;57(6):502-506. View abstract.

Pappolla, M. A., Simovich, M. J., Bryant-Thomas, T., Chyan, Y. J., Poeggeler, B., Dubocovich, M., Bick, R., Perry, G., Cruz-Sanchez, F., and Smith, M. A. The neuroprotective activities of melatonin against the Alzheimer beta- protein are not mediated by melatonin membrane receptors. J Pineal Res 2002;32(3):135-142. View abstract.

Pei, Z., Pang, S. F., and Cheung, R. T. Pretreatment with melatonin reduces volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. J Pineal Res 2002;32(3):168-172. View abstract.

Pita, M. L., Hoyos, M., Martin-Lacave, I., Osuna, C., Fernandez-Santos, J. M., and Guerrero, J. M. Long-term melatonin administration increases polyunsaturated fatty acid percentage in plasma lipids of hypercholesterolemic rats. J Pineal Res 2002;32(3):179-186. View abstract.

Allegra, M., Gentile, C., Tesoriere, L., and Livrea, M. A. Protective effect of melatonin against cytotoxic actions of malondialdehyde: an in vitro study on human erythrocytes. J Pineal Res 2002;32(3):187-193. View abstract.

Sahna, E., Olmez, E., and Acet, A. Effects of physiological and pharmacological concentrations of melatonin on ischemia-reperfusion arrhythmias in rats: can the incidence of sudden cardiac death be reduced? J Pineal Res 2002;32(3):194-198. View abstract.

Reiter, R. J. and Tan, D. X. Melatonin: an antioxidant in edible plants. Ann.N.Y.Acad.Sci. 2002;957:341-344. View abstract.

Koyama, H., Nakade, O., Takada, Y., Kaku, T., and Lau, K. H. Melatonin at pharmacologic doses increases bone mass by suppressing resorption through down-regulation of the RANKL-mediated osteoclast formation and activation. J Bone Miner.Res 2002;17(7):1219-1229. View abstract.

Antolin, I., Mayo, J. C., Sainz, R. M., del Brio, Mde L., Herrera, F., Martin, V., and Rodriguez, C. Protective effect of melatonin in a chronic experimental model of Parkinson's disease. Brain Res 7-12-2002;943(2):163-173. View abstract.

Valenti, S. and Giusti, M. Melatonin participates in the control of testosterone secretion from rat testis: an overview of our experience. Ann.N.Y.Acad.Sci. 2002;966:284-289. View abstract.

Lee, Y. M., Chen, H. R., Hsiao, G., Sheu, J. R., Wang, J. J., and Yen, M. H. Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo. J Pineal Res 2002;33(2):72-80. View abstract.

Bonnefont-Rousselot, D., Cheve, G., Gozzo, A., Tailleux, A., Guilloz, V., Caisey, S., Teissier, E., Fruchart, J. C., Delattre, J., Jore, D., Lesieur, D., Duriez, P., and Gardes-Albert, M. Melatonin related compounds inhibit lipid peroxidation during copper or free radical-induced LDL oxidation. J Pineal Res 2002;33(2):109-117. View abstract.

Blask, D. E., Dauchy, R. T., Sauer, L. A., Krause, J. A., and Brainard, G. C. Light during darkness, melatonin suppression and cancer progression. Neuroendocrinol.Lett. 2002;23 Suppl 2:52-56. View abstract.

Edwards, R. B., Manzana, E. J., and Chen, W. J. Melatonin (an antioxidant) does not ameliorate alcohol-induced Purkinje cell loss in the developing cerebellum. Alcohol Clin Exp.Res 2002;26(7):1003-1009. View abstract.

Gulcin, I., Buyukokuroglu, M. E., Oktay, M., and Kufrevioglu, O. I. On the in vitro antioxidative properties of melatonin. J Pineal Res 2002;33(3):167-171. View abstract.

Bilici, D., Akpinar, E., and Kiziltunc, A. Protective effect of melatonin in carrageenan-induced acute local inflammation. Pharmacol.Res 2002;46(2):133-139. View abstract.

Adams, J. D., Jr., Yang, J., Mishra, L. C., and Singh, B. B. Effects of ashwagandha in a rat model of stroke. Altern Ther Health Med 2002;8(5):18-19. View abstract.

Fischer, T. W., Scholz, G., Knoll, B., Hipler, U. C., and Elsner, P. Melatonin suppresses reactive oxygen species in UV-irradiated leukocytes more than vitamin C and trolox. Skin Pharmacol.Appl.Skin Physiol 2002;15(5):367-373. View abstract.

Montilla-Lopez, P., Munoz-Agueda, M. C., Feijoo, Lopez M., Munoz-Castaneda, J. R., Bujalance-Arenas, I., and Tunez-Finana, I. Comparison of melatonin versus vitamin C on oxidative stress and antioxidant enzyme activity in Alzheimer's disease induced by okadaic acid in neuroblastoma cells. Eur.J Pharmacol. 9-20-2002;451(3):237-243. View abstract.

Rufo-Campos, M. [Melatonin and epilepsy]. Rev Neurol. 2002;35 Suppl 1:S51-S58. View abstract.

Sahna, E., Acet, A., Ozer, M. K., and Olmez, E. Myocardial ischemia-reperfusion in rats: reduction of infarct size by either supplemental physiological or pharmacological doses of melatonin. J Pineal Res 2002;33(4):234-238. View abstract.

Todisco, M. and Rossi, N. Melatonin for refractory idiopathic thrombocytopenic purpura: a report of 3 cases. Am.J Ther 2002;9(6):524-526. View abstract.

Kaptanoglu, E., Palaoglu, S., Demirpence, E., Akbiyik, F., Solaroglu, I., and Kilinc, A. Different responsiveness of central nervous system tissues to oxidative conditions and to the antioxidant effect of melatonin. J Pineal Res 2003;34(1):32-35. View abstract.

Tan, D. X., Manchester, L. C., Hardeland, R., Lopez-Burillo, S., Mayo, J. C., Sainz, R. M., and Reiter, R. J. Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin. J Pineal Res 2003;34(1):75-78. View abstract.

Reiter, R. J. and Tan, D. X. What constitutes a physiological concentration of melatonin? J Pineal Res 2003;34(1):79-80. View abstract.

Fowler, G., Daroszewska, M., and Ingold, K. U. Melatonin does not "directly scavenge hydrogen peroxide": demise of another myth. Free Radic.Biol.Med 1-1-2003;34(1):77-83. View abstract.

Singh, P., Bhargava, V. K., and Garg, S. K. Effect of melatonin and beta-carotene on indomethacin induced gastric mucosal injury. Indian J Physiol Pharmacol. 2002;46(2):229-234. View abstract.

Wang, F., Li, J., Wu, C., Yang, J., Xu, F., and Zhao, Q. The GABA(A) receptor mediates the hypnotic activity of melatonin in rats. Pharmacol.Biochem.Behav 2003;74(3):573-578. View abstract.

Cardinali, D. P., Ladizesky, M. G., Boggio, V., Cutrera, R. A., and Mautalen, C. Melatonin effects on bone: experimental facts and clinical perspectives. J Pineal Res 2003;34(2):81-87. View abstract.

Chung, S. Y. and Han, S. H. Melatonin attenuates kainic acid-induced hippocampal neurodegeneration and oxidative stress through microglial inhibition. J Pineal Res 2003;34(2):95-102. View abstract.

Pei, Z., Fung, P. C., and Cheung, R. T. Melatonin reduces nitric oxide level during ischemia but not blood-brain barrier breakdown during reperfusion in a rat middle cerebral artery occlusion stroke model. J Pineal Res 2003;34(2):110-118. View abstract.

Zhang, Z. and Yu, C. X. [Effect of melatonin on learning and memory impairment induced by aluminum chloride and its mechanism]. Yao Xue.Xue.Bao. 2002;37(9):682-686. View abstract.

Zhou, Y. H., Huo, Z. Y., and Qiu, X. C. [Inhibitory effect of melatonin on morphine withdrawal syndromes and the content of NO in plasma and brain tissue in morphine dependent mice]. Yao Xue.Xue.Bao. 2002;37(3):175-177. View abstract.

Zhang, J., Guo, J. D., Xing, S. H., Gu, S. L., and Dai, T. J. [The protective effects of melatonin on global cerebral ischemia-reperfusion injury in gerbils]. Yao Xue.Xue.Bao. 2002;37(5):329-333. View abstract.

Ardura, J., Gutierrez, R., Andres, J., and Agapito, T. Emergence and evolution of the circadian rhythm of melatonin in children. Horm.Res 2003;59(2):66-72. View abstract.

Mayo, J. C., Tan, D. X., Sainz, R. M., Natarajan, M., Lopez-Burillo, S., and Reiter, R. J. Protection against oxidative protein damage induced by metal-catalyzed reaction or alkylperoxyl radicals: comparative effects of melatonin and other antioxidants. Biochim.Biophys.Acta 3-17-2003;1620(1-3):139-150. View abstract.

Dericks-Tan, J. S., Schwinn, P., and Hildt, C. Dose-dependent stimulation of melatonin secretion after administration of agnus castus. Exp.Clin Endocrinol.Diabetes 2003;111(1):44-46. View abstract.

Cheung, R. T. The utility of melatonin in reducing cerebral damage resulting from ischemia and reperfusion. J Pineal Res 2003;34(3):153-160. View abstract.

Taysi, S., Koc, M., Buyukokuroglu, M. E., Altinkaynak, K., and Sahin, Y. N. Melatonin reduces lipid peroxidation and nitric oxide during irradiation-induced oxidative injury in the rat liver. J Pineal Res 2003;34(3):173-177. View abstract.

Pei, Z. and Cheung, R. T. Melatonin protects SHSY5Y neuronal cells but not cultured astrocytes from ischemia due to oxygen and glucose deprivation. J Pineal Res 2003;34(3):194-201. View abstract.

Sener, G., Sehirli, A. O., Paskaloglu, K., Dulger, G. A., and Alican, I. Melatonin treatment protects against ischemia/reperfusion-induced functional and biochemical changes in rat urinary bladder. J Pineal Res 2003;34(3):226-230. View abstract.

Sainz, R. M., Mayo, J. C., Tan, D. X., Lopez-Burillo, S., Natarajan, M., and Reiter, R. J. Antioxidant activity of melatonin in Chinese hamster ovarian cells: changes in cellular proliferation and differentiation. Biochem.Biophys.Res Commun. 3-14-2003;302(3):625-634. View abstract.

Delagrange, P., Atkinson, J., Boutin, J. A., Casteilla, L., Lesieur, D., Misslin, R., Pellissier, S., Penicaud, L., and Renard, P. Therapeutic perspectives for melatonin agonists and antagonists. J Neuroendocrinol. 2003;15(4):442-448. View abstract.

Todisco, M., Casaccia, P., and Rossi, N. Severe bleeding symptoms in refractory idiopathic thrombocytopenic purpura: a case successfully treated with melatonin. Am.J Ther 2003;10(2):135-136. View abstract.

Tan, D. X., Hardeland, R., Manchester, L. C., Poeggeler, B., Lopez-Burillo, S., Mayo, J. C., Sainz, R. M., and Reiter, R. J. Mechanistic and comparative studies of melatonin and classic antioxidants in terms of their interactions with the ABTS cation radical. J Pineal Res 2003;34(4):249-259. View abstract.

Chen, J. C., Ng, C. J., Chiu, T. F., and Chen, H. M. Altered neutrophil apoptosis activity is reversed by melatonin in liver ischemia-reperfusion. J Pineal Res 2003;34(4):260-264. View abstract.

Lopez-Burillo, S., Tan, D. X., Mayo, J. C., Sainz, R. M., Manchester, L. C., and Reiter, R. J. Melatonin, xanthurenic acid, resveratrol, EGCG, vitamin C and alpha-lipoic acid differentially reduce oxidative DNA damage induced by Fenton reagents: a study of their individual and synergistic actions. J Pineal Res 2003;34(4):269-277. View abstract.

Gulcin, I., Buyukokuroglu, M. E., and Kufrevioglu, O. I. Metal chelating and hydrogen peroxide scavenging effects of melatonin. J Pineal Res 2003;34(4):278-281. View abstract.

Karasek, M., Gruszka, A., Lawnicka, H., Kunert-Radek, J., and Pawlikowski, M. Melatonin inhibits growth of diethylstilbestrol-induced prolactin-secreting pituitary tumor in vitro: possible involvement of nuclear RZR/ROR receptors. J Pineal Res 2003;34(4):294-296. View abstract.

Reiter, R. J. and Tan, D. X. Melatonin: a novel protective agent against oxidative injury of the ischemic/reperfused heart. Cardiovasc.Res 4-1-2003;58(1):10-19. View abstract.

Sener, G., Tosun, O., Sehirli, A. O., Kacmaz, A., Arbak, S., Ersoy, Y., and Ayanoglu-Dulger, G. Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion. Life Sci. 5-2-2003;72(24):2707-2718. View abstract.

Chen, Z., Chua, C. C., Gao, J., Hamdy, R. C., and Chua, B. H. Protective effect of melatonin on myocardial infarction. Am.J Physiol Heart Circ.Physiol 2003;284(5):H1618-H1624. View abstract.

Arias, J., Melean, E., Valero, N., Pons, H., Chacin-Bonilla, L., Larreal, Y., and Bonilla, E. [Effect of melatonin on lymphocyte proliferation and production of interleukin-2 (IL-2) and interleukin-1 beta (IL-1 beta) in mice splenocytes]. Invest Clin 2003;44(1):41-50. View abstract.

Sahna, E., Parlakpinar, H., Ozturk, F., Cigremis, Y., and Acet, A. The protective effects of physiological and pharmacological concentrations of melatonin on renal ischemia-reperfusion injury in rats. Urol.Res 2003;31(3):188-193. View abstract.

Chen, G., Huo, Y., Tan, D. X., Liang, Z., Zhang, W., and Zhang, Y. Melatonin in Chinese medicinal herbs. Life Sci. 5-23-2003;73(1):19-26. View abstract.

Leppamaki, S., Partonen, T., Vakkuri, O., Lonnqvist, J., Partinen, M., and Laudon, M. Effect of controlled-release melatonin on sleep quality, mood, and quality of life in subjects with seasonal or weather-associated changes in mood and behaviour. Eur.Neuropsychopharmacol. 2003;13(3):137-145. View abstract.

Reiter, R. J. Melatonin: clinical relevance. Best.Pract.Res Clin Endocrinol.Metab 2003;17(2):273-285. View abstract.

Bizzarri, M., Cucina, A., Valente, M. G., Tagliaferri, F., Borrelli, V., Stipa, F., and Cavallaro, A. Melatonin and vitamin D3 increase TGF-beta1 release and induce growth inhibition in breast cancer cell cultures. J Surg Res 2003;110(2):332-337. View abstract.

Mayo, J. C., Tan, D. X., Sainz, R. M., Lopez-Burillo, S., and Reiter, R. J. Oxidative damage to catalase induced by peroxyl radicals: functional protection by melatonin and other antioxidants. Free Radic.Res 2003;37(5):543-553. View abstract.

Bikjdaouene, L., Escames, G., Leon, J., Ferrer, J. M., Khaldy, H., Vives, F., and Acuna-Castroviejo, D. Changes in brain amino acids and nitric oxide after melatonin administration in rats with pentylenetetrazole-induced seizures. J Pineal Res 2003;35(1):54-60. View abstract.

Sener, G., Sehirli, A. O., and Ayanoglu-Dulger, G. Protective effects of melatonin, vitamin E and N-acetylcysteine against acetaminophen toxicity in mice: a comparative study. J Pineal Res 2003;35(1):61-68. View abstract.

Jonage-Canonico, M. B., Lenoir, V., Martin, A., Scholler, R., and Kerdelhue, B. Long term inhibition by Estradiol or Progesterone of Melatonin secretion after administration of a mammary carcinogen, the dimethyl benz(a)anthracene, in Sprague-Dawley female rat; inhibitory effect of Melatonin on mammary carcinogenesis. Breast Cancer Res Treat. 2003;79(3):365-377. View abstract.

Reiter, R. J., Sainz, R. M., Lopez-Burillo, S., Mayo, J. C., Manchester, L. C., and Tan, D. X. Melatonin ameliorates neurologic damage and neurophysiologic deficits in experimental models of stroke. Ann.N.Y.Acad.Sci. 2003;993:35-47. View abstract.

Koc, M., Taysi, S., Emin, Buyukokuroglu M., and Bakan, N. The effect of melatonin against oxidative damage during total-body irradiation in rats. Radiat.Res 2003;160(2):251-255. View abstract.

Ray, C. A. Melatonin attenuates the sympathetic nerve responses to orthostatic stress in humans. J Physiol 9-15-2003;551(Pt 3):1043-1048. View abstract.

Cabeza, J., Alarcon-de-la-Lastra, C., Jimenez, D., Martin, M. J., and Motilva, V. Melatonin modulates the effects of gastric injury in rats: role of prostaglandins and nitric oxide. Neurosignals. 2003;12(2):71-77. View abstract.

Chen, K. B., Lin, A. M., and Chiu, T. H. Oxidative injury to the locus coeruleus of rat brain: neuroprotection by melatonin. J Pineal Res 2003;35(2):109-117. View abstract.

Topsakal, C., Kilic, N., Ozveren, F., Akdemir, I., Kaplan, M., Tiftikci, M., and Gursu, F. Effects of Prostaglandin E1, Melatonin, and Oxytetracycline on Lipid Peroxidation, Antioxidant Defense System, Paraoxonase (PON1) Activities, and Homocysteine Levels in an Animal Model of Spinal Cord Injury. Spine 8-1-2003;28(15):1643-1652. View abstract.

Ursing, C., Wikner, J., Brismar, K., and Rojdmark, S. Caffeine raises the serum melatonin level in healthy subjects: an indication of melatonin metabolism by cytochrome P450(CYP)1A2. J.Endocrinol.Invest 2003;26(5):403-406. View abstract.

Shiu, S. Y., Law, I. C., Lau, K. W., Tam, P. C., Yip, A. W., and Ng, W. T. Melatonin slowed the early biochemical progression of hormone-refractory prostate cancer in a patient whose prostate tumor tissue expressed MT1 receptor subtype. J Pineal Res 2003;35(3):177-182. View abstract.

Rogers, N. L., Kennaway, D. J., and Dawson, D. Neurobehavioural performance effects of daytime melatonin and temazepam administration. J Sleep Res 2003;12(3):207-212. View abstract.

Lissoni, P., Barni, S., Ardizzoia, A., Brivio, F., Tancini, G., Conti, A., and Maestroni, G. J. Immunological effects of a single evening subcutaneous injection of low- dose interleukin-2 in association with the pineal hormone melatonin in advanced cancer patients. J Biol Regul Homeost.Agents 1992;6(4):132-136. View abstract.

Rajaratnam, S. M., Dijk, D. J., Middleton, B., Stone, B. M., and Arendt, J. Melatonin phase-shifts human circadian rhythms with no evidence of changes in the duration of endogenous melatonin secretion or the 24-hour production of reproductive hormones. J Clin Endocrinol.Metab 2003;88(9):4303-4309. View abstract.

Sandyk, R. Melatonin and maturation of REM sleep. Int J Neurosci 1992;63(1-2):105-114. View abstract.

L'Hermite-Baleriaux, M. and de Launoit, Y. Is melatonin really an in vitro inhibitor of human breast cancer cell proliferation? In Vitro Cell Dev.Biol 1992;28A(9-10):583-584. View abstract.

Sletten, T., Burgess, H., Savic, N., Gilbert, S., and Dawson, D. The effects of bright light and nighttime melatonin administration on cardiac activity. J Hum.Ergol.(Tokyo) 2001;30(1-2):273-278. View abstract.

Smits, M. G., van Stel, H. F., van der, Heijden K., Meijer, A. M., Coenen, A. M., and Kerkhof, G. A. Melatonin improves health status and sleep in children with idiopathic chronic sleep-onset insomnia: a randomized placebo-controlled trial. J Am Acad.Child Adolesc.Psychiatry 2003;42(11):1286-1293. View abstract.

Hack, L. M., Lockley, S. W., Arendt, J., and Skene, D. J. The effects of low-dose 0.5-mg melatonin on the free-running circadian rhythms of blind subjects. J Biol.Rhythms 2003;18(5):420-429. View abstract.

Boeve, B. F., Silber, M. H., and Ferman, T. J. Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients. Sleep Med. 2003;4(4):281-284. View abstract.

Ressmeyer, A. R., Mayo, J. C., Zelosko, V., Sainz, R. M., Tan, D. X., Poeggeler, B., Antolin, I., Zsizsik, B. K., Reiter, R. J., and Hardeland, R. Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction. Redox.Rep. 2003;8(4):205-213. View abstract.

Fischer, S., Smolnik, R., Herms, M., Born, J., and Fehm, H. L. Melatonin acutely improves the neuroendocrine architecture of sleep in blind individuals. J Clin Endocrinol.Metab 2003;88(11):5315-5320. View abstract.

Hartter, S., Nordmark, A., Rose, D. M., Bertilsson, L., Tybring, G., and Laine, K. Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity. Br.J.Clin.Pharmacol. 2003;56(6):679-682. View abstract.

van der Helm-van Mil AH, van Someren, E. J., van den, Boom R., van Buchem, M. A., de Craen, A. J., and Blauw, G. J. No influence of melatonin on cerebral blood flow in humans. J Clin Endocrinol.Metab 2003;88(12):5989-5994. View abstract.

Paul, M. A., Gray, G., Kenny, G., and Pigeau, R. A. Impact of melatonin, zaleplon, zopiclone, and temazepam on psychomotor performance. Aviat.Space Environ.Med 2003;74(12):1263-1270. View abstract.

Leger, D., Laudon, M., and Zisapel, N. Nocturnal 6-sulfatoxymelatonin excretion in insomnia and its relation to the response to melatonin replacement therapy. Am J Med 1-15-2004;116(2):91-95. View abstract.

Kunz, D., Mahlberg, R., Muller, C., Tilmann, A., and Bes, F. Melatonin in patients with reduced REM sleep duration: two randomized controlled trials. J Clin Endocrinol.Metab 2004;89(1):128-134. View abstract.

Scheer, F. A., Van Montfrans, G. A., van Someren, E. J., Mairuhu, G., and Buijs, R. M. Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension 2004;43(2):192-197. View abstract.

Drake, M. J., Mills, I. W., and Noble, J. G. Melatonin pharmacotherapy for nocturia in men with benign prostatic enlargement. J Urol. 2004;171(3):1199-1202. View abstract.

Paul MA, Gray G, Sardana TM, Pigeau RA. Melatonin and zopiclone as facilitators of early circadian sleep in operational air transport crews. Aviat Space Environ Med 2004;75(5):439-43. View abstract.

Gitto, E., Reiter, R. J., Cordaro, S. P., La Rosa, M., Chiurazzi, P., Trimarchi, G., Gitto, P., Calabro, M. P., and Barberi, I. Oxidative and inflammatory parameters in respiratory distress syndrome of preterm newborns: beneficial effects of melatonin. Am J Perinatol. 2004;21(4):209-216. View abstract.

Nakagawa, H., Sack, R. L., and Lewy, A. J. Sleep propensity free-runs with the temperature, melatonin and cortisol rhythms in a totally blind person. Sleep 1992;15(4):330-336. View abstract.

Brzezinski, A., Fibich, T., Cohen, M., Schenker, J. G., and Laufer, N. Effects of melatonin on progesterone production by human granulosa lutein cells in culture. Fertil.Steril. 1992;58(3):526-529. View abstract.

Kemp, S., Biswas, R., Neumann, V., and Coughlan, A. The value of melatonin for sleep disorders occurring post-head injury: a pilot RCT. Brain Inj. 2004;18(9):911-919. View abstract.

Coppola, G., Iervolino, G., Mastrosimone, M., La Torre, G., Ruiu, F., and Pascotto, A. Melatonin in wake-sleep disorders in children, adolescents and young adults with mental retardation with or without epilepsy: a double-blind, cross-over, placebo-controlled trial. Brain Dev. 2004;26(6):373-376. View abstract.

Campos FL, Silva-Junior FP, de Bruin VM, de Bruin PF. Melatonin improves sleep in asthma: a randomized, double-blind, placebo-controlled study. Am J Respir Crit Care Med. 11-1-2004;170(9):947-951. View abstract.

Acil, M., Basgul, E., Celiker, V., Karagoz, A. H., Demir, B., and Aypar, U. Perioperative effects of melatonin and midazolam premedication on sedation, orientation, anxiety scores and psychomotor performance. Eur.J.Anaesthesiol. 2004;21(7):553-557. View abstract.

Rajaratnam, S. M., Middleton, B., Stone, B. M., Arendt, J., and Dijk, D. J. Melatonin advances the circadian timing of EEG sleep and directly facilitates sleep without altering its duration in extended sleep opportunities in humans. J Physiol 11-15-2004;561(Pt 1):339-351. View abstract.

Gupta, M., Gupta, Y. K., Agarwal, S., Aneja, S., and Kohli, K. A randomized, double-blind, placebo controlled trial of melatonin add-on therapy in epileptic children on valproate monotherapy: effect on glutathione peroxidase and glutathione reductase enzymes. Br.J.Clin.Pharmacol. 2004;58(5):542-547. View abstract.

Gupta, M., Gupta, Y. K., Agarwal, S., Aneja, S., Kalaivani, M., and Kohli, K. Effects of add-on melatonin administration on antioxidant enzymes in children with epilepsy taking carbamazepine monotherapy: a randomized, double-blind, placebo-controlled trial. Epilepsia 2004;45(12):1636-1639. View abstract.

Mazzoccoli, G., Giuliani, A., Carughi, S., De Cata, A., Puzzolante, F., La Viola, M., Urbano, N., Perfetto, F., and Tarquini, R. The hypothalamic-pituitary-thyroid axis and melatonin in humans: possible interactions in the control of body temperature. Neuro.Endocrinol.Lett. 2004;25(5):368-372. View abstract.

Buscemi, N., Vandermeer, B., Pandya, R., Hooton, N., Tjosvold, L., Hartling, L., Baker, G., Vohra, S., and Klassen, T. Melatonin for treatment of sleep disorders. Evid.Rep.Technol.Assess.(Summ.) 2004;(108):1-7. View abstract.

Danilenko, K. V. and Putilov, A. A. Melatonin treatment of winter depression following total sleep deprivation: waking EEG and mood correlates. Neuropsychopharmacology 2005;30(7):1345-1352. View abstract.

Hancock, E., O'Callaghan, F., English, J., and Osborne, J. P. Melatonin excretion in normal children and in tuberous sclerosis complex with sleep disorder responsive to melatonin. J Child Neurol. 2005;20(1):21-25. View abstract.

Hancock, E., O'Callaghan, F., and Osborne, J. P. Effect of melatonin dosage on sleep disorder in tuberous sclerosis complex. J.Child Neurol. 2005;20(1):78-80. View abstract.

Gupta M, Aneja S, Kohli K. Add-on melatonin improves sleep behavior in children with epilepsy: randomized, double-blind, placebo-controlled trial. J Child Neurol 2005;20(2):112-5. View abstract.

Sanchez-Barcelo, E. J., Cos, S., Mediavilla, D., Martinez-Campa, C., Gonzalez, A., and Alonso-Gonzalez, C. Melatonin-estrogen interactions in breast cancer. J Pineal Res 2005;38(4):217-222. View abstract.

Wiechmann, A. F. and O'Steen, W. K. Melatonin increases photoreceptor susceptibility to light-induced damage. Invest Ophthalmol Vis Sci 1992;33(6):1894-1902. View abstract.

Samarkandi, A., Naguib, M., Riad, W., Thalaj, A., Alotibi, W., Aldammas, F., and Albassam, A. Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study. Eur.J.Anaesthesiol. 2005;22(3):189-196. View abstract.

Cavallo, A., Ris, M. D., Succop, P., and Jaskiewicz, J. Melatonin treatment of pediatric residents for adaptation to night shift work. Ambul.Pediatr. 2005;5(3):172-177. View abstract.

Dowling GA, Mastick J, Colling E, et al. Melatonin for sleep disturbances in Parkinson's disease. Sleep Med 2005;6(5):459-66. View abstract.

Faber, M. S., Jetter, A., and Fuhr, U. Assessment of CYP1A2 activity in clinical practice: why, how, and when? Basic Clin Pharmacol Toxicol. 2005;97(3):125-134. View abstract.

Mills, E., Wu, P., Seely, D., and Guyatt, G. Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis. J Pineal Res 2005;39(4):360-366. View abstract.

Revell, V. L., Burgess, H. J., Gazda, C. J., Smith, M. R., Fogg, L. F., and Eastman, C. I. Advancing human circadian rhythms with afternoon melatonin and morning intermittent bright light. J Clin Endocrinol.Metab 2006;91(1):54-59. View abstract.

Lu, W. Z., Gwee, K. A., Moochhalla, S., and Ho, K. Y. Melatonin improves bowel symptoms in female patients with irritable bowel syndrome: a double-blind placebo-controlled study. Aliment.Pharmacol Ther 11-15-2005;22(10):927-934. View abstract.

Perras, B., Ozcan, S., Fehm, H. L., and Born, J. Melatonin does not inhibit hypothalamic-pituitary-adrenal activity in waking young men. J Neuroendocrinol. 2005;17(12):811-816. View abstract.

Wang, J. Z. and Wang, Z. F. Role of melatonin in Alzheimer-like neurodegeneration. Acta Pharmacol Sin. 2006;27(1):41-49. View abstract.

Cagnacci, A., Cannoletta, M., Renzi, A., Baldassari, F., Arangino, S., and Volpe, A. Prolonged melatonin administration decreases nocturnal blood pressure in women. Am J Hypertens. 2005;18(12 Pt 1):1614-1618. View abstract.

Kasimay, O., Cakir, B., Devseren, E., and Yegen, B. C. Exogenous melatonin delays gastric emptying rate in rats: role of CCK2 and 5-HT3 receptors. J Physiol Pharmacol 2005;56(4):543-553. View abstract.

Cagnacci, A., Elliott, J. A., and Yen, S. S. Melatonin: a major regulator of the circadian rhythm of core temperature in humans. J Clin Endocrinol.Metab 1992;75(2):447-452. View abstract.

Yi, C., Pan, X., Yan, H., Guo, M., and Pierpaoli, W. Effects of melatonin in age-related macular degeneration. Ann.N.Y Acad.Sci. 2005;1057:384-392. View abstract.

Gorfine, T., Assaf, Y., Goshen-Gottstein, Y., Yeshurun, Y., and Zisapel, N. Sleep-anticipating effects of melatonin in the human brain. Neuroimage. 5-15-2006;31(1):410-418. View abstract.

Jansen, S. L., Forbes, D. A., Duncan, V., and Morgan, D. G. Melatonin for cognitive impairment. Cochrane.Database.Syst.Rev. 2006;(1):CD003802. View abstract.

Mero, A. A., Vahalummukka, M., Hulmi, J. J., Kallio, P., and von Wright, A. Effects of resistance exercise session after oral ingestion of melatonin on physiological and performance responses of adult men. Eur.J Appl.Physiol 2006;96(6):729-739. View abstract.

Peres, M. F., Masruha, M. R., Zukerman, E., Moreira-Filho, C. A., and Cavalheiro, E. A. Potential therapeutic use of melatonin in migraine and other headache disorders. Expert.Opin.Investig.Drugs 2006;15(4):367-375. View abstract.

Sury, M. R. and Fairweather, K. The effect of melatonin on sedation of children undergoing magnetic resonance imaging. Br.J Anaesth. 2006;97(2):220-225. View abstract.

Capuzzo, M., Zanardi, B., Schiffino, E., Buccoliero, C., Gragnaniello, D., Bianchi, S., and Alvisi, R. Melatonin does not reduce anxiety more than placebo in the elderly undergoing surgery. Anesth.Analg. 2006;103(1):121-3, table. View abstract.

Weekley, L. B. Melatonin-induced relaxation of rat aorta: interaction with adrenergic agonists. J Pineal Res 1991;11(1):28-34. View abstract.

Pignone, A. M., Rosso, A. D., Fiori, G., Matucci-Cerinic, M., Becucci, A., Tempestini, A., Livi, R., Generini, S., Gramigna, L., Benvenuti, C., Carossino, A. M., Conforti, M. L., and Perfetto, F. Melatonin is a safe and effective treatment for chronic pulmonary and extrapulmonary sarcoidosis. J Pineal Res 2006;41(2):95-100. View abstract.

Ibrahim, M. G., Bellomo, R., Hart, G. K., Norman, T. R., Goldsmith, D., Bates, S., and Egi, M. A double-blind placebo-controlled randomised pilot study of nocturnal melatonin in tracheostomised patients. Crit Care Resusc. 2006;8(3):187-191. View abstract.

Grossman, E., Laudon, M., Yalcin, R., Zengil, H., Peleg, E., Sharabi, Y., Kamari, Y., Shen-Orr, Z., and Zisapel, N. Melatonin reduces night blood pressure in patients with nocturnal hypertension. Am J Med 2006;119(10):898-902. View abstract.

Vriend, J., Sheppard, M. S., and Borer, K. T. Melatonin increases serum growth hormone and insulin-like growth factor I (IGF-I) levels in male Syrian hamsters via hypothalamic neurotransmitters. Growth Dev.Aging 1990;54(4):165-171. View abstract.

Turkistani, A., Abdullah, K. M., Al Shaer, A. A., Mazen, K. F., and Alkatheri, K. Melatonin premedication and the induction dose of propofol. Eur.J Anaesthesiol. 2007;24(5):399-402. View abstract.

Naguib, M., Samarkandi, A. H., Moniem, M. A., Mansour, Eel, Alshaer, A. A., Al Ayyaf, H. A., Fadin, A., and Alharby, S. W. The effects of melatonin premedication on propofol and thiopental induction dose-response curves: a prospective, randomized, double-blind study. Anesth.Analg. 2006;103(6):1448-1452. View abstract.

Dominguez-Rodriguez, A., Abreu-Gonzalez, P., Garcia-Gonzalez, M. J., Kaski, J. C., Reiter, R. J., and Jimenez-Sosa, A. A unicenter, randomized, double-blind, parallel-group, placebo-controlled study of Melatonin as an Adjunct in patients with acute myocaRdial Infarction undergoing primary Angioplasty The Melatonin Adjunct in the acute myocaRdial Infarction treated with Angioplasty (MARIA) trial: study design and rationale. Contemp.Clin Trials 2007;28(4):532-539. View abstract.

Ravindra, T., Lakshmi, N. K., and Ahuja, Y. R. Melatonin in pathogenesis and therapy of cancer. Indian J Med Sci. 2006;60(12):523-535. View abstract.

Jaworek, J. Ghrelin and melatonin in the regulation of pancreatic exocrine secretion and maintaining of integrity. J Physiol Pharmacol 2006;57 Suppl 5:83-96. View abstract.

van der Heijden, K. B., Smits, M. G., van Someren, E. J., Ridderinkhof, K. R., and Gunning, W. B. Effect of melatonin on sleep, behavior, and cognition in ADHD and chronic sleep-onset insomnia. J Am Acad.Child Adolesc.Psychiatry 2007;46(2):233-241. View abstract.

Suresh Kumar PN, Andrade C, Bhakta SG, and Singh NM. Melatonin in schizophrenic outpatients with insomnia: a double-blind, placebo-controlled study. J Clin Psychiatry 2007;68(2):237-41. View abstract.

Medeiros CA, Carvalhedo de Bruin PF, Lopes LA, et al. Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson's disease. A randomized, double blind, placebo-controlled study. J Neurol 2007;254(4):459-64. View abstract.

Berk, L., Berkey, B., Rich, T., Hrushesky, W., Blask, D., Gallagher, M., Kudrimoti, M., McGarry, R. C., Suh, J., and Mehta, M. Randomized phase II trial of high-dose melatonin and radiation therapy for RPA class 2 patients with brain metastases (RTOG 0119). Int.J Radiat.Oncol.Biol.Phys. 7-1-2007;68(3):852-857. View abstract.

Klupinska, G., Poplawski, T., Drzewoski, J., Harasiuk, A., Reiter, R. J., Blasiak, J., and Chojnacki, J. Therapeutic effect of melatonin in patients with functional dyspepsia. J.Clin.Gastroenterol. 2007;41(3):270-274. View abstract.

Forrest, C. M., Mackay, G. M., Stoy, N., Stone, T. W., and Darlington, L. G. Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin. Br.J Clin Pharmacol 2007;64(4):517-526. View abstract.

Vandewalle, G., Middleton, B., Rajaratnam, S. M., Stone, B. M., Thorleifsdottir, B., Arendt, J., and Dijk, D. J. Robust circadian rhythm in heart rate and its variability: influence of exogenous melatonin and photoperiod. J Sleep Res 2007;16(2):148-155. View abstract.

Bjorvatn, B., Stangenes, K., Oyane, N., Forberg, K., Lowden, A., Holsten, F., and Akerstedt, T. Randomized placebo-controlled field study of the effects of bright light and melatonin in adaptation to night work. Scand.J Work Environ.Health 2007;33(3):204-214. View abstract.

Vissers, F. H., Knipschild, P. G., and Crebolder, H. F. Is melatonin helpful in stopping the long-term use of hypnotics? A discontinuation trial. Pharm.World Sci. 2007;29(6):641-646. View abstract.

Wade AG, Ford I, Crawford G, et al. Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of sleep and next-day alertness outcomes. Curr Med Res Opin 2007;23(10):2597-605. View abstract.

Peles, E., Hetzroni, T., Bar-Hamburger, R., Adelson, M., and Schreiber, S. Melatonin for perceived sleep disturbances associated with benzodiazepine withdrawal among patients in methadone maintenance treatment: a double-blind randomized clinical trial. Addiction 2007;102(12):1947-1953. View abstract.

Lopez-Gonzalez, M. A., Santiago, A. M., and Esteban-Ortega, F. Sulpiride and melatonin decrease tinnitus perception modulating the auditolimbic dopaminergic pathway. J Otolaryngol. 2007;36(4):213-219. View abstract.

Caumo, W., Torres, F., Moreira, N. L., Jr., Auzani, J. A., Monteiro, C. A., Londero, G., Ribeiro, D. F., and Hidalgo, M. P. The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesth.Analg. 2007;105(5):1263-71, table. View abstract.

Lemoine P, Nir T, Laudon M, Zisapel N. Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects. J Sleep Res 2007;16(4):372-80. View abstract.

Dowling GA, Burr RL, Van Someren EJ, et al. Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease. J Am Geriatr Soc 2008;56(2):239-46. View abstract.

Reiter, R. J., Tan, D. X., Manchester, L. C., and Tamura, H. Melatonin defeats neurally-derived free radicals and reduces the associated neuromorphological and neurobehavioral damage. J Physiol Pharmacol 2007;58 Suppl 6:5-22. View abstract.

Konturek, S. J., Konturek, P. C., Brzozowski, T., and Bubenik, G. A. Role of melatonin in upper gastrointestinal tract. J Physiol Pharmacol 2007;58 Suppl 6:23-52. View abstract.

Wirtz, P. H., Spillmann, M., Bartschi, C., Ehlert, U., and von Kanel, R. Oral melatonin reduces blood coagulation activity: a placebo-controlled study in healthy young men. J Pineal Res 2008;44(2):127-133. View abstract.

Liang, R., Nickkholgh, A., Hoffmann, K., Kern, M., Schneider, H., Sobirey, M., Zorn, M., Buchler, M. W., and Schemmer, P. Melatonin protects from hepatic reperfusion injury through inhibition of IKK and JNK pathways and modification of cell proliferation. J.Pineal Res. 2009;46(1):8-14. View abstract.

Vazquez, M. I., Forcada, F., Casao, A., Sosa, C., Palacin, I., and Abecia, J. A. Effects of melatonin and undernutrition on the viability of ovine embryos during anestrus and the breeding season. Anim Reprod.Sci. 2009;112(1-2):83-94. View abstract.

Ortiz-Lopez, L., Morales-Mulia, S., Ramirez-Rodriguez, G., and Benitez-King, G. ROCK-regulated cytoskeletal dynamics participate in the inhibitory effect of melatonin on cancer cell migration. J.Pineal Res. 2009;46(1):15-21. View abstract.

Kang, J. T., Koo, O. J., Kwon, D. K., Park, H. J., Jang, G., Kang, S. K., and Lee, B. C. Effects of melatonin on in vitro maturation of porcine oocyte and expression of melatonin receptor RNA in cumulus and granulosa cells. J.Pineal Res. 2009;46(1):22-28. View abstract.

Manjunatha, B. M., Devaraj, M., Gupta, P. S., Ravindra, J. P., and Nandi, S. Effect of taurine and melatonin in the culture medium on buffalo in vitro embryo development. Reprod.Domest.Anim 2009;44(1):12-16. View abstract.

Baykara, B., Tekmen, I., Pekcetin, C., Ulukus, C., Tuncel, P., Sagol, O., Ormen, M., and Ozogul, C. The protective effects of carnosine and melatonin in ischemia-reperfusion injury in the rat liver. Acta Histochem. 2009;111(1):42-51. View abstract.

Sarabia, L., Maurer, I., and Bustos-Obregon, E. Melatonin prevents damage elicited by the organophosphorous pesticide diazinon on the mouse testis. Ecotoxicol.Environ.Saf 2009;72(3):938-942. View abstract.

Sarabia, L., Maurer, I., and Bustos-Obregon, E. Melatonin prevents damage elicited by the organophosphorous pesticide diazinon on mouse sperm DNA. Ecotoxicol.Environ.Saf 2009;72(2):663-668. View abstract.

Korkmaz, A., Sanchez-Barcelo, E. J., Tan, D. X., and Reiter, R. J. Role of melatonin in the epigenetic regulation of breast cancer. Breast Cancer Res.Treat. 2009;115(1):13-27. View abstract.

Valero, N., Nery, A., Bonilla, E., Espina, L. M., Chacin-Bonilla, L., Anez, F., Maldonado, M., and Melean, E. Antagonistic effect of luzindole in mice treated with melatonin during the infection with the venezuelan equine encephalomyelitis virus. Neurochem.Res. 2009;34(2):268-273. View abstract.

Guizar-Sahagun, G., Rodriguez-Balderas, C. A., Franco-Bourland, R. E., Martinez-Cruz, A., Grijalva, I., Ibarra, A., and Madrazo, I. Lack of neuroprotection with pharmacological pretreatment in a paradigm for anticipated spinal cord lesions. Spinal Cord. 2009;47(2):156-160. View abstract.

Lu, W. Z., Song, G. H., Gwee, K. A., and Ho, K. Y. The effects of melatonin on colonic transit time in normal controls and IBS patients. Dig.Dis.Sci. 2009;54(5):1087-1093. View abstract.

Scott, P. R., Sargison, N. D., Macrae, A. I., and Gough, M. R. Melatonin treatment prior to the normal breeding season increases fetal number in United Kingdom sheep flocks. Vet.J. 2009;182(2):198-202. View abstract.

Manda, K., Ueno, M., and Anzai, K. Cranial irradiation-induced inhibition of neurogenesis in hippocampal dentate gyrus of adult mice: attenuation by melatonin pretreatment. J.Pineal Res. 2009;46(1):71-78. View abstract.

Korkmaz, A., Tamura, H., Manchester, L. C., Ogden, G. B., Tan, D. X., and Reiter, R. J. Combination of melatonin and a peroxisome proliferator-activated receptor-gamma agonist induces apoptosis in a breast cancer cell line. J.Pineal Res. 2009;46(1):115-116. View abstract.

Ramadan, T. A., Taha, T. A., Samak, M. A., and Hassan, A. Effectiveness of exposure to longday followed by melatonin treatment on semen characteristics of Damascus male goats during breeding and non-breeding seasons. Theriogenology 2009;71(3):458-468. View abstract.

Rimmele, U., Spillmann, M., Bartschi, C., Wolf, O. T., Weber, C. S., Ehlert, U., and Wirtz, P. H. Melatonin improves memory acquisition under stress independent of stress hormone release. Psychopharmacology (Berl) 2009;202(4):663-672. View abstract.

Luchetti, F., Betti, M., Canonico, B., Arcangeletti, M., Ferri, P., Galli, F., and Papa, S. ERK MAPK activation mediates the antiapoptotic signaling of melatonin in UVB-stressed U937 cells. Free Radic.Biol.Med. 2-1-2009;46(3):339-351. View abstract.

Caumo, W., Levandovski, R., and Hidalgo, M. P. Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study. J.Pain 2009;10(1):100-108. View abstract.

Li, H. L., Kang, Y. M., Yu, L., Xu, H. Y., and Zhao, H. Melatonin reduces blood pressure in rats with stress-induced hypertension via GABAA receptors. Clin.Exp.Pharmacol.Physiol 2009;36(4):436-440. View abstract.

Cagnacci, A., Elliott, J. A., and Yen, S. S. Amplification of pulsatile LH secretion by exogenous melatonin in women. J Clin Endocrinol Metab 1991;73(1):210-212. View abstract.

Huang, L. T., Tiao, M. M., Tain, Y. L., Chen, C. C., and Hsieh, C. S. Melatonin ameliorates bile duct ligation-induced systemic oxidative stress and spatial memory deficits in developing rats. Pediatr.Res. 2009;65(2):176-180. View abstract.

Pei, M., He, F., Wei, L., and Rawson, A. Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytes. J.Pineal Res. 2009;46(2):181-187. View abstract.

Lahiri, S., Singh, P., Singh, S., Rasheed, N., Palit, G., and Pant, K. K. Melatonin protects against experimental reflux esophagitis. J.Pineal Res. 2009;46(2):207-213. View abstract.

Koch BC, Nagtegaal JE, Hagen EC, et al. The effects of melatonin on sleep-wake rhythm of daytime haemodialysis patients: a randomized, placebo-controlled, cross-over study (EMSCAP study). Br J Clin Pharmacol 2009;67(1):68-75. View abstract.

Esposito, E., Genovese, T., Caminiti, R., Bramanti, P., Meli, R., and Cuzzocrea, S. Melatonin reduces stress-activated/mitogen-activated protein kinases in spinal cord injury. J.Pineal Res. 2009;46(1):79-86. View abstract.

Caballero, B., Vega-Naredo, I., Sierra, V., Huidobro-Fernandez, C., Soria-Valles, C., De Gonzalo-Calvo, D., Tolivia, D., Pallas, M., Camins, A., Rodriguez-Colunga, M. J., and Coto-Montes, A. Melatonin alters cell death processes in response to age-related oxidative stress in the brain of senescence-accelerated mice. J.Pineal Res. 2009;46(1):106-114. View abstract.

MacFarlane, J. G., Cleghorn, J. M., Brown, G. M., and Streiner, D. L. The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs: a preliminary study. Biol.Psychiatry 8-15-1991;30(4):371-376. View abstract.

Solmaz, I., Gurkanlar, D., Gokcil, Z., Goksoy, C., Ozkan, M., and Erdogan, E. Antiepileptic activity of melatonin in guinea pigs with pentylenetetrazol-induced seizures. Neurol.Res. 2009;31(9):989-995. View abstract.

Chen, Z., Chua, C. C., Gao, J., Chua, K. W., Ho, Y. S., Hamdy, R. C., and Chua, B. H. Prevention of ischemia/reperfusion-induced cardiac apoptosis and injury by melatonin is independent of glutathione peroxdiase 1. J.Pineal Res. 2009;46(2):235-241. View abstract.

Takasaki, A., Tamura, H., Taniguchi, K., Asada, H., Taketani, T., Matsuoka, A., Yamagata, Y., Shimamura, K., Morioka, H., and Sugino, N. Luteal blood flow and luteal function. J.Ovarian.Res. 2009;2:1. View abstract.

Gehrman, P. R., Connor, D. J., Martin, J. L., Shochat, T., Corey-Bloom, J., and Ancoli-Israel, S. Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease. Am.J.Geriatr.Psychiatry 2009;17(2):166-169. View abstract.

Bharti, V. K. and Srivastava, R. S. Fluoride-induced oxidative stress in rat's brain and its amelioration by buffalo (Bubalus bubalis) pineal proteins and melatonin. Biol.Trace Elem.Res. 2009;130(2):131-140. View abstract.

Regodon, S., Ramos, A., Morgado, S., Tarazona, R., Martin-Palomino, P., Rosado, J. A., and Miguez, Mdel P. Melatonin enhances the immune response to vaccination against A1 and C strains of Dichelobacter nodosus. Vaccine 3-4-2009;27(10):1566-1570. View abstract.

Cucina, A., Proietti, S., D'Anselmi, F., Coluccia, P., Dinicola, S., Frati, L., and Bizzarri, M. Evidence for a biphasic apoptotic pathway induced by melatonin in MCF-7 breast cancer cells. J.Pineal Res. 2009;46(2):172-180. View abstract.

Diez, E. R., Prados, L. V., Carrion, A., Ponce, Z. A., and Miatello, R. M. A novel electrophysiologic effect of melatonin on ischemia/reperfusion-induced arrhythmias in isolated rat hearts. J.Pineal Res. 2009;46(2):155-160. View abstract.

Sung, J. H., Cho, E. H., Kim, M. O., and Koh, P. O. Identification of proteins differentially expressed by melatonin treatment in cerebral ischemic injury--a proteomics approach. J.Pineal Res. 2009;46(3):300-306. View abstract.

Regodon, S., del Prado, Miguez M., Jardin, I., Lopez, J. J., Ramos, A., Paredes, S. D., and Rosado, J. A. Melatonin, as an adjuvant-like agent, enhances platelet responsiveness. J.Pineal Res. 2009;46(3):275-285. View abstract.

Tajes, Orduna M., Pelegri, Gabalda C., Vilaplana, Hortensi J., Pallas, Lliberia M., and Camins, Espuny A. An evaluation of the neuroprotective effects of melatonin in an in vitro experimental model of age-induced neuronal apoptosis. J.Pineal Res. 2009;46(3):262-267. View abstract.

Tamura, E. K., Cecon, E., Monteiro, A. W., Silva, C. L., and Markus, R. P. Melatonin inhibits LPS-induced NO production in rat endothelial cells. J.Pineal Res. 2009;46(3):268-274. View abstract.

Maity, P., Bindu, S., Dey, S., Goyal, M., Alam, A., Pal, C., Reiter, R., and Bandyopadhyay, U. Melatonin reduces indomethacin-induced gastric mucosal cell apoptosis by preventing mitochondrial oxidative stress and the activation of mitochondrial pathway of apoptosis. J.Pineal Res. 2009;46(3):314-323. View abstract.

Ambriz-Tututi, M., Rocha-Gonzalez, H. I., Cruz, S. L., and Granados-Soto, V. Melatonin: a hormone that modulates pain. Life Sci. 4-10-2009;84(15-16):489-498. View abstract.

Kaji, H., Inukai, Y., Maiguma, T., Ono, H., Teshima, D., Hiramoto, K., and Makino, K. Radical scavenging activity of bisbenzylisoquinoline alkaloids and traditional prophylactics against chemotherapy-induced oral mucositis. J.Clin.Pharm.Ther. 2009;34(2):197-205. View abstract.

Vazquez, M. I., Forcada, F., Casao, A., Abecia, J. A., Sosa, C., and Palacin, I. Undernutrition and exogenous melatonin can affect the in vitro developmental competence of ovine oocytes on a seasonal basis. Reprod.Domest.Anim 2010;45(4):677-684. View abstract.

Wang, X., Figueroa, B. E., Stavrovskaya, I. G., Zhang, Y., Sirianni, A. C., Zhu, S., Day, A. L., Kristal, B. S., and Friedlander, R. M. Methazolamide and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury. Stroke 2009;40(5):1877-1885. View abstract.

Ismail, S. A. and Mowafi, H. A. Melatonin provides anxiolysis, enhances analgesia, decreases intraocular pressure, and promotes better operating conditions during cataract surgery under topical anesthesia. Anesth.Analg. 2009;108(4):1146-1151. View abstract.

Gogenur, I., Kucukakin, B., Bisgaard, T., Kristiansen, V., Hjortso, N. C., Skene, D. J., and Rosenberg, J. The effect of melatonin on sleep quality after laparoscopic cholecystectomy: a randomized, placebo-controlled trial. Anesth.Analg. 2009;108(4):1152-1156. View abstract.

Kurcer, Z., Hekimoglu, A., Aral, F., Baba, F., and Sahna, E. Effect of melatonin on epididymal sperm quality after testicular ischemia/reperfusion in rats. Fertil.Steril. 3-15-2010;93(5):1545-1549. View abstract.

Benitez-King, G., Soto-Vega, E., and Ramirez-Rodriguez, G. Melatonin modulates microfilament phenotypes in epithelial cells: implications for adhesion and inhibition of cancer cell migration. Histol.Histopathol. 2009;24(6):789-799. View abstract.

Makay, B., Makay, O., Yenisey, C., Icoz, G., Ozgen, G., Unsal, E., Akyildiz, M., and Yetkin, E. The interaction of oxidative stress response with cytokines in the thyrotoxic rat: is there a link? Mediators.Inflamm. 2009;2009:391682. View abstract.

Bekyarova, G., Tancheva, S., and Hristova, M. Protective effect of melatonin against oxidative hepatic injury after experimental thermal trauma. Methods Find.Exp.Clin.Pharmacol. 2009;31(1):11-14. View abstract.

Braam, W., Smits, M. G., Didden, R., Korzilius, H., van Geijlswijk, I. M., and Curfs, L. M. Exogenous melatonin for sleep problems in individuals with intellectual disability: a meta-analysis. Dev.Med.Child Neurol. 2009;51(5):340-349. View abstract.

Sokullu, O., Sanioglu, S., Kurc, E., Sargin, M., Deniz, H., Tartan, Z., Aka, S. A., and Bilgen, F. Does the circadian rhythm of melatonin affect ischemia-reperfusion injury after coronary artery bypass grafting? Heart Surg.Forum 2009;12(2):E95-E99. View abstract.

Wisessmith, W., Phansuwan-Pujito, P., Govitrapong, P., and Chetsawang, B. Melatonin reduces induction of Bax, caspase and cell death in methamphetamine-treated human neuroblastoma SH-SY5Y cultured cells. J.Pineal Res. 2009;46(4):433-440. View abstract.

Venkataraman, P., Krishnamoorthy, G., Selvakumar, K., and Arunakaran, J. Oxidative stress alters creatine kinase system in serum and brain regions of polychlorinated biphenyl (Aroclor 1254)-exposed rats: protective role of melatonin. Basic Clin.Pharmacol.Toxicol. 2009;105(2):92-97. View abstract.

Kesik, V., Guven, A., Vurucu, S., Tunc, T., Uysal, B., Gundogdu, G., Oztas, E., and Korkmaz, A. Melatonin and 1400 W ameliorate both intestinal and remote organ injury following mesenteric ischemia/reperfusion. J.Surg.Res. 2009;157(1):e97-e105. View abstract.

Baeza, I., Alvarado, C., Alvarez, P., Salazar, V., Castillo, C., Ariznavarreta, C., Fdez-Tresguerres, J. A., and De la Fuente, M. Improvement of leucocyte functions in ovariectomised aged rats after treatment with growth hormone, melatonin, oestrogens or phyto-oestrogens. J.Reprod.Immunol. 2009;80(1-2):70-79. View abstract.

Aladag, M. A., Turkoz, Y., Parlakpinar, H., Ozen, H., Egri, M., and Unal, S. C. Melatonin ameliorates cerebral vasospasm after experimental subarachnoidal haemorrhage correcting imbalance of nitric oxide levels in rats. Neurochem.Res. 2009;34(11):1935-1944. View abstract.

Tapias, V., Escames, G., Lopez, L. C., Lopez, A., Camacho, E., Carrion, M. D., Entrena, A., Gallo, M. A., Espinosa, A., and Acuna-Castroviejo, D. Melatonin and its brain metabolite N(1)-acetyl-5-methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice. J.Neurosci.Res. 2009;87(13):3002-3010. View abstract.

Jung-Hynes, B. and Ahmad, N. SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age-related neoplasms. FASEB J. 2009;23(9):2803-2809. View abstract.

Reiter, R. J., Tan, D. X., Manchester, L. C., Paredes, S. D., Mayo, J. C., and Sainz, R. M. Melatonin and reproduction revisited. Biol.Reprod. 2009;81(3):445-456. View abstract.

Radogna, F., Sestili, P., Martinelli, C., Paolillo, M., Paternoster, L., Albertini, M. C., Accorsi, A., Gualandi, G., and Ghibelli, L. Lipoxygenase-mediated pro-radical effect of melatonin via stimulation of arachidonic acid metabolism. Toxicol.Appl.Pharmacol. 7-15-2009;238(2):170-177. View abstract.

Gingerich, S., Wang, X., Lee, P. K., Dhillon, S. S., Chalmers, J. A., Koletar, M. M., and Belsham, D. D. The generation of an array of clonal, immortalized cell models from the rat hypothalamus: analysis of melatonin effects on kisspeptin and gonadotropin-inhibitory hormone neurons. Neuroscience 9-15-2009;162(4):1134-1140. View abstract.

Assayed, M. E. and Abd El-Aty, A. M. Protection of rat chromosomes by melatonin against gamma radiation-induced damage. Mutat.Res. 2009;677(1-2):14-20. View abstract.

Huang, J. Y., Hong, Y. T., and Chuang, J. I. Fibroblast growth factor 9 prevents MPP+-induced death of dopaminergic neurons and is involved in melatonin neuroprotection in vivo and in vitro. J.Neurochem. 2009;109(5):1400-1412. View abstract.

Bekyarova, G., Galunska, B., Ivanova, D., and Yankova, T. Effect of melatonin on burn-induced gastric mucosal injury in rats. Burns 2009;35(6):863-868. View abstract.

Dauchy, R. T., Blask, D. E., Dauchy, E. M., Davidson, L. K., Tirrell, P. C., Greene, M. W., Tirrell, R. P., Hill, C. R., and Sauer, L. A. Antineoplastic effects of melatonin on a rare malignancy of mesenchymal origin: melatonin receptor-mediated inhibition of signal transduction, linoleic acid metabolism and growth in tissue-isolated human leiomyosarcoma xenografts. J.Pineal Res. 2009;47(1):32-42. View abstract.

Renuka, K. and Joshi, B. N. Melatonin-induced changes in ovarian function in the freshwater fish Channa punctatus (Bloch) held in long days and continuous light. Gen.Comp Endocrinol. 1-1-2010;165(1):42-46. View abstract.

Ozdemir, F., Deniz, O., Kaynar, K., Arslan, M., Kavgaci, H., Yildiz, B., and Aydin, F. The effects of melatonin on human hepatoma (Hep G2) cell line. Bratisl.Lek.Listy 2009;110(5):276-279. View abstract.

Cetin, Y., Sagcan, S., Gungor, O., Ozyurtlu, N., and Uslu, B. A. Effects of CIDR-G and melatonin implants, and their combination on the efficacy of oestrus induction and fertility of Kilis goats. Reprod.Domest.Anim 2009;44(4):659-662. View abstract.

Arrebola, F. A., Abecia, J. A., Forcada, F., Garcia, A., Martin, R. A., and Mesa, O. Effects of annual rainfall and farm on lamb production after treatment with melatonin implants in Merino sheep: a 4-year study. N.Z.Vet.J. 2009;57(3):141-145. View abstract.

Girgert, R., Hanf, V., Emons, G., and Grundker, C. Membrane-bound melatonin receptor MT1 down-regulates estrogen responsive genes in breast cancer cells. J.Pineal Res. 2009;47(1):23-31. View abstract.

Ganguly, K. and Swarnakar, S. Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin. J.Pineal Res. 2009;47(1):43-55. View abstract.

Joo, S. S. and Yoo, Y. M. Melatonin induces apoptotic death in LNCaP cells via p38 and JNK pathways: therapeutic implications for prostate cancer. J.Pineal Res. 2009;47(1):8-14. View abstract.

Magnanou, E., Attia, J., Fons, R., Boeuf, G., and Falcon, J. The timing of the shrew: continuous melatonin treatment maintains youthful rhythmic activity in aging Crocidura russula. PLoS.One. 2009;4(6):e5904. View abstract.

Gimenez, F., Stornelli, M. C., Tittarelli, C. M., Savignone, C. A., Dorna, I. V., de la Sota, R. L., and Stornelli, M. A. Suppression of estrus in cats with melatonin implants. Theriogenology 9-1-2009;72(4):493-499. View abstract.

Nah, S. S., Won, H. J., Park, H. J., Ha, E., Chung, J. H., Cho, H. Y., and Baik, H. H. Melatonin inhibits human fibroblast-like synoviocyte proliferation via extracellular signal-regulated protein kinase/P21(CIP1)/P27(KIP1) pathways. J.Pineal Res. 2009;47(1):70-74. View abstract.

Velarde, E., Alonso-Gomez, A. L., Azpeleta, C., Isorna, E., and Delgado, M. J. Melatonin attenuates the acetylcholine-induced contraction in isolated intestine of a teleost fish. J.Comp Physiol B 2009;179(8):951-959. View abstract.

Kain, Z. N., MacLaren, J. E., Herrmann, L., Mayes, L., Rosenbaum, A., Hata, J., and Lerman, J. Preoperative melatonin and its effects on induction and emergence in children undergoing anesthesia and surgery. Anesthesiology 2009;111(1):44-49. View abstract.

Li, Z., Nickkholgh, A., Yi, X., Bruns, H., Gross, M. L., Hoffmann, K., Mohr, E., Zorn, M., Buchler, M. W., and Schemmer, P. Melatonin protects kidney grafts from ischemia/reperfusion injury through inhibition of NF-kB and apoptosis after experimental kidney transplantation. J.Pineal Res. 2009;46(4):365-372. View abstract.

Berlinguer, F., Leoni, G. G., Succu, S., Spezzigu, A., Madeddu, M., Satta, V., Bebbere, D., Contreras-Solis, I., Gonzalez-Bulnes, A., and Naitana, S. Exogenous melatonin positively influences follicular dynamics, oocyte developmental competence and blastocyst output in a goat model. J.Pineal Res. 2009;46(4):383-391. View abstract.

Bejarano, I., Redondo, P. C., Espino, J., Rosado, J. A., Paredes, S. D., Barriga, C., Reiter, R. J., Pariente, J. A., and Rodriguez, A. B. Melatonin induces mitochondrial-mediated apoptosis in human myeloid HL-60 cells. J.Pineal Res. 2009;46(4):392-400. View abstract.

Tahan, V., Atug, O., Akin, H., Eren, F., Tahan, G., Tarcin, O., Uzun, H., Ozdogan, O., Tarcin, O., Imeryuz, N., Ozguner, F., Celikel, C., Avsar, E., and Tozun, N. Melatonin ameliorates methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in rats. J.Pineal Res. 2009;46(4):401-407. View abstract.

Park, J. W., Hwang, M. S., Suh, S. I., and Baek, W. K. Melatonin down-regulates HIF-1 alpha expression through inhibition of protein translation in prostate cancer cells. J.Pineal Res. 2009;46(4):415-421. View abstract.

Laughlin, G. A., Loucks, A. B., and Yen, S. S. Marked augmentation of nocturnal melatonin secretion in amenorrheic athletes, but not in cycling athletes: unaltered by opioidergic or dopaminergic blockade. J Clin Endocrinol Metab 1991;73(6):1321-1326. View abstract.

Jang, S. S., Kim, W. D., and Park, W. Y. Melatonin exerts differential actions on X-ray radiation-induced apoptosis in normal mice splenocytes and Jurkat leukemia cells. J.Pineal Res. 2009;47(2):147-155. View abstract.

Shang, Y., Xu, S. P., Wu, Y., Jiang, Y. X., Wu, Z. Y., Yuan, S. Y., and Yao, S. L. Melatonin reduces acute lung injury in endotoxemic rats. Chin Med.J.(Engl.) 6-20-2009;122(12):1388-1393. View abstract.

Carretero, M., Escames, G., Lopez, L. C., Venegas, C., Dayoub, J. C., Garcia, L., and Acuna-Castroviejo, D. Long-term melatonin administration protects brain mitochondria from aging. J.Pineal Res. 2009;47(2):192-200. View abstract.

Tsiligianni, T., Valasi, I., Cseh, S., Vainas, E., Faigl, V., Samartzi, F., Papanikolaou, T., Dovolou, E., and Amiridis, G. S. Effects of melatonin treatment on follicular development and oocyte quality in Chios ewes - short communication. Acta Vet.Hung. 2009;57(2):331-335. View abstract.

Luthringer R, Muzet M, Zisapel N, Staner L. The effect of prolonged-release melatonin on sleep measures and psychomotor performance in elderly patients with insomnia. Int Clin Psychopharmacol 2009;24(5):239-49. View abstract.

Neri, G., Baffa, C., De, Stefano A., Poliandri, A., Kulamarva, G., Di, Giovanni P., Petrucci, A. G., Castriotta, A., Citraro, L., Cerrone, D., D' Orazio, F., and Croce, A. Management of tinnitus: oral treatment with melatonin and sulodexide. J.Biol.Regul.Homeost.Agents 2009;23(2):103-110. View abstract.

Paredes, S. D., Bejarano, I., Terron, M. P., Barriga, C., Reiter, R. J., and Rodriguez, A. B. Melatonin and tryptophan counteract lipid peroxidation and modulate superoxide dismutase activity in ringdove heterophils in vivo. Effect of antigen-induced activation and age. Age (Dordr.) 2009;31(3):179-188. View abstract.

Fukai, S. and Akishita, M. [Hormone replacement therapy--growth hormone, melatonin, DHEA and sex hormones]. Nihon Rinsho 2009;67(7):1396-1401. View abstract.

Bazwinsky-Wutschke, I., Muhlbauer, E., Wolgast, S., and Peschke, E. Transcripts of calcium/calmodulin-dependent kinases are changed after forskolin- or IBMX-induced insulin secretion due to melatonin treatment of rat insulinoma beta-cells (INS-1). Horm.Metab Res. 2009;41(11):805-813. View abstract.

Maciel, F. E., Ramos, B. P., Geihs, M. A., Vargas, M. A., Cruz, B. P., Meyer-Rochow, V. B., Vakkuri, O., Allodi, S., Monserrat, J. M., and Nery, L. E. Effects of melatonin in connection with the antioxidant defense system in the gills of the estuarine crab Neohelice granulata. Gen.Comp Endocrinol. 1-15-2010;165(2):229-236. View abstract.

Chang, H. M., Wu, U. I., and Lan, C. T. Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep-deprived rats. J.Pineal Res. 2009;47(3):211-220. View abstract.

Veneroso, C., Tunon, M. J., Gonzalez-Gallego, J., and Collado, P. S. Melatonin reduces cardiac inflammatory injury induced by acute exercise. J.Pineal Res. 2009;47(2):184-191. View abstract.

Samantaray, S., Das, A., Thakore, N. P., Matzelle, D. D., Reiter, R. J., Ray, S. K., and Banik, N. L. Therapeutic potential of melatonin in traumatic central nervous system injury. J.Pineal Res. 2009;47(2):134-142. View abstract.

Jung, K. H., Hong, S. W., Zheng, H. M., Lee, D. H., and Hong, S. S. Melatonin downregulates nuclear erythroid 2-related factor 2 and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model. J.Pineal Res. 2009;47(2):173-183. View abstract.

Zarazaga, L. A., Gatica, M. C., Celi, I., Guzman, J. L., and Malpaux, B. Effect of melatonin implants on sexual activity in Mediterranean goat females without separation from males. Theriogenology 10-15-2009;72(7):910-918. View abstract.

Terron, M. P., Delgado, J., Paredes, S. D., Barriga, C., Reiter, R. J., and Rodriguez, A. B. Effect of melatonin and tryptophan on humoral immunity in young and old ringdoves (Streptopelia risoria). Exp.Gerontol. 2009;44(10):653-658. View abstract.

Martin, V., Garcia-Santos, G., Rodriguez-Blanco, J., Casado-Zapico, S., Sanchez-Sanchez, A., Antolin, I., Medina, M., and Rodriguez, C. Melatonin sensitizes human malignant glioma cells against TRAIL-induced cell death. Cancer Lett. 1-28-2010;287(2):216-223. View abstract.

Zeman, M., Szantoova, K., Stebelova, K., Mravec, B., and Herichova, I. Effect of rhythmic melatonin administration on clock gene expression in the suprachiasmatic nucleus and the heart of hypertensive TGR(mRen2)27 rats. J.Hypertens.Suppl 2009;27(6):S21-S26. View abstract.

Reiter, R. J., Paredes, S. D., Manchester, L. C., and Tan, D. X. Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin. Crit Rev.Biochem.Mol.Biol. 2009;44(4):175-200. View abstract.

Cruz, A., Tasset, I., Ramirez, L. M., Arjona, A., Segura, J., Tunez, I., Montilla, P., Muntane, J., and Padillo, F. J. Effect of melatonin on myocardial oxidative stress induced by experimental obstructive jaundice. Rev.Esp.Enferm.Dig. 2009;101(7):460-463. View abstract.

Pan, L., Xu, W., Fu, J. H., and Xue, X. D. [Effect of melatonin on hyperoxia-induced oxidant/antioxidant imbalance in the lung of neonatal rats with chronic lung disease]. Zhongguo Dang.Dai Er.Ke.Za Zhi. 2009;11(7):581-584. View abstract.

Alonso-Vale, M. I., Peres, S. B., Vernochet, C., Farmer, S. R., and Lima, F. B. Adipocyte differentiation is inhibited by melatonin through the regulation of C/EBPbeta transcriptional activity. J.Pineal Res. 2009;47(3):221-227. View abstract.

Sonmez, M. F., Narin, F., Akkus, D., and Ozdamar, S. Effect of melatonin and vitamin C on expression of endothelial NOS in heart of chronic alcoholic rats. Toxicol.Ind.Health 2009;25(6):385-393. View abstract.

Tapias, V., Cannon, J. R., and Greenamyre, J. T. Melatonin treatment potentiates neurodegeneration in a rat rotenone Parkinson's disease model. J.Neurosci.Res. 2-1-2010;88(2):420-427. View abstract.

Gomez-Moreno, G., Guardia, J., Ferrera, M. J., Cutando, A., and Reiter, R. J. Melatonin in diseases of the oral cavity. Oral Dis. 2010;16(3):242-247. View abstract.

Petrosillo, G., Colantuono, G., Moro, N., Ruggiero, F. M., Tiravanti, E., Di, Venosa N., Fiore, T., and Paradies, G. Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening. Am.J.Physiol Heart Circ.Physiol 2009;297(4):H1487-H1493. View abstract.

Pan, L., Fu, J. H., Xue, X. D., Xu, W., Zhou, P., and Wei, B. Melatonin protects against oxidative damage in a neonatal rat model of bronchopulmonary dysplasia. World J.Pediatr. 2009;5(3):216-221. View abstract.

Lin, G. J., Huang, S. H., Chen, Y. W., Hueng, D. Y., Chien, M. W., Chia, W. T., Chang, D. M., and Sytwu, H. K. Melatonin prolongs islet graft survival in diabetic NOD mice. J.Pineal Res. 2009;47(3):284-292. View abstract.

Kumar, A. and Singh, A. Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation-induced behaviour modification and oxidative damage in mice. Fundam.Clin.Pharmacol. 2009;23(4):439-448. View abstract.

Santello, F. H., Del Vecchio, Filipin M., Caetano, L. C., Brazao, V., Caetano, L. N., Dos Santos, C. D., Alonso Toldo, M. P., and do Prado, J. C. J. Influence of melatonin therapy and orchiectomy on T cell subsets in male Wistar rats infected with Trypanosoma cruzi. J.Pineal Res. 2009;47(3):271-276. View abstract.

Paternoster, L., Radogna, F., Accorsi, A., Cristina, Albertini M., Gualandi, G., and Ghibelli, L. Melatonin as a modulator of apoptosis in B-lymphoma cells. Ann.N.Y.Acad.Sci. 2009;1171:345-349. View abstract.

Kuehn, C. C., Rodrigues Oliveira, L. G., Santos, C. D., Ferreira, D. S., Alonso Toldo, M. P., de, Albuquerque S., and do Prado, J. C. J. Melatonin and dehydroepiandrosterone combination: does this treatment exert a synergistic effect during experimental Trypanosoma cruzi infection? J.Pineal Res. 2009;47(3):253-259. View abstract.

Yurtcu, M., Abasiyanik, A., Bicer, S., and Avunduk, M. C. Efficacy of antioxidant treatment in the prevention of testicular atrophy in experimental testicular torsion. J.Pediatr.Surg. 2009;44(9):1754-1758. View abstract.

Martinez-Campa, C., Gonzalez, A., Mediavilla, M. D., Alonso-Gonzalez, C., Alvarez-Garcia, V., Sanchez-Barcelo, E. J., and Cos, S. Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells. Br.J.Cancer 11-3-2009;101(9):1613-1619. View abstract.

Spuch, C., Antequera, D., Isabel Fernandez-Bachiller, M., Isabel Rodriguez-Franco, M., and Carro, E. A new tacrine-melatonin hybrid reduces amyloid burden and behavioral deficits in a mouse model of Alzheimer's disease. Neurotox.Res. 2010;17(4):421-431. View abstract.

Jagota, A. and Kalyani, D. Effect of melatonin on age induced changes in daily serotonin rhythms in suprachiasmatic nucleus of male Wistar rat. Biogerontology. 2010;11(3):299-308. View abstract.

Izykowska, I., Gebarowska, E., Cegielski, M., Podhorska-Okolow, M., Piotrowska, A., Zabel, M., and Dziegiel, P. Effect of melatonin on melanoma cells subjected to UVA and UVB radiation in In vitro studies. In Vivo 2009;23(5):733-738. View abstract.

Izykowska, I., Cegielski, M., Gebarowska, E., Podhorska-Okolow, M., Piotrowska, A., Zabel, M., and Dziegiel, P. Effect of melatonin on human keratinocytes and fibroblasts subjected to UVA and UVB radiation In vitro. In Vivo 2009;23(5):739-745. View abstract.

Borah, A. and Mohanakumar, K. P. Melatonin inhibits 6-hydroxydopamine production in the brain to protect against experimental parkinsonism in rodents. J.Pineal Res. 2009;47(4):293-300. View abstract.

Cemek, M., Emin, Buyukokuroglu M., Yurumez, Y., Yavuz, Y., Aslan, A., Buyukben, A., and Aymelek, F. Tissue trace and major element levels in organophosphate insecticide fenthion (Lebaycid) toxicity in rats: prophylactic and therapeutic effect of exogenous melatonin. Ecotoxicol.Environ.Saf 2010;73(2):206-212. View abstract.

Ersoz, N., Guven, A., Cayci, T., Uysal, B., Turk, E., Oztas, E., Akgul, E. O., Korkmaz, A., and Cetiner, S. Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS. Ren Fail. 2009;31(8):704-710. View abstract.

Carbajo-Pescador, S., Martin-Renedo, J., Garcia-Palomo, A., Tunon, M. J., Mauriz, J. L., and Gonzalez-Gallego, J. Changes in the expression of melatonin receptors induced by melatonin treatment in hepatocarcinoma HepG2 cells. J.Pineal Res. 2009;47(4):330-338. View abstract.

Shi, J. M., Tian, X. Z., Zhou, G. B., Wang, L., Gao, C., Zhu, S. E., Zeng, S. M., Tian, J. H., and Liu, G. S. Melatonin exists in porcine follicular fluid and improves in vitro maturation and parthenogenetic development of porcine oocytes. J.Pineal Res. 2009;47(4):318-323. View abstract.

Kim, T. H., Jung, J. A., Kim, G. D., Jang, A. H., Ahn, H. J., Park, Y. S., and Park, C. S. Melatonin inhibits the development of 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice. J.Pineal Res. 2009;47(4):324-329. View abstract.

Shieh, J. M., Wu, H. T., Cheng, K. C., and Cheng, J. T. Melatonin ameliorates high fat diet-induced diabetes and stimulates glycogen synthesis via a PKCzeta-Akt-GSK3beta pathway in hepatic cells. J.Pineal Res. 2009;47(4):339-344. View abstract.

Geihs, M. A., Vargas, M. A., Maciel, F. E., Caldas, S. S., Cruz, B. P., Primel, E. G., Monserrat, J. M., and Nery, L. E. Effect of melatonin in the antioxidant defense system in the locomotor muscles of the estuarine crab Neohelice granulata (Decapoda, Brachyura). Gen.Comp Endocrinol. 3-1-2010;166(1):72-82. View abstract.

Franca, E. L., Feliciano, N. D., Silva, K. A., Ferrari, C. K., and Honorio-Franca, A. C. Modulatory role of melatonin on superoxide release by spleen macrophages isolated from alloxan-induced diabetic rats. Bratisl.Lek.Listy 2009;110(9):517-522. View abstract.

Danielczyk, K. and Dziegiel, P. [MT1 melatonin receptors and their role in the oncostatic action of melatonin]. Postepy Hig.Med.Dosw.(Online.) 2009;63:425-434. View abstract.

Sonmez, M. F., Narin, F., and Balcioglu, E. Melatonin and vitamin C attenuates alcohol-induced oxidative stress in aorta. Basic Clin.Pharmacol.Toxicol. 2009;105(6):410-415. View abstract.

Ortega-Gutierrez, S., Lopez-Vicente, M., Lostale, F., Fuentes-Broto, L., Martinez-Ballarin, E., and Garcia, J. J. Protective effect of melatonin against mitomycin C-induced genotoxic damage in peripheral blood of rats. J.Biomed.Biotechnol. 2009;2009:791432. View abstract.

Juszczak, M. and Boczek-Leszczyk, E. Hypothalamic gonadotropin-releasing hormone receptor activation stimulates oxytocin release from the rat hypothalamo-neurohypophysial system while melatonin inhibits this process. Brain Res.Bull. 1-15-2010;81(1):185-190. View abstract.

Rechcinski, T., Trzos, E., Wierzbowska-Drabik, K., Krzeminska-Pakula, M., and Kurpesa, M. Melatonin for nondippers with coronary artery disease: assessment of blood pressure profile and heart rate variability. Hypertens.Res. 2010;33(1):56-61. View abstract.

Yildirim, G., Attar, R., Ozkan, F., Kumbak, B., Ficicioglu, C., and Yesildaglar, N. The effects of letrozole and melatonin on surgically induced endometriosis in a rat model: a preliminary study. Fertil.Steril. 2010;93(6):1787-1792. View abstract.

Xu, S., Zhou, Z., Zhang, L., Yu, Z., Zhang, W., Wang, Y., Wang, X., Li, M., Chen, Y., Chen, C., He, M., Zhang, G., and Zhong, M. Exposure to 1800 MHz radiofrequency radiation induces oxidative damage to mitochondrial DNA in primary cultured neurons. Brain Res. 1-22-2010;1311:189-196. View abstract.

Srivastava, R. K. and Krishna, A. Melatonin affects steroidogenesis and delayed ovulation during winter in vespertilionid bat, Scotophilus heathi. J.Steroid Biochem.Mol.Biol. 2010;118(1-2):107-116. View abstract.

Faigl, V., Keresztes, M., Kulcsar, M., Nagy, S., Keresztes, Z., Amiridis, G. S., Solti, L., Huszenicza, G., and Cseh, S. Testicular function and semen characteristics of Awassi rams treated with melatonin out of the breeding season. Acta Vet.Hung. 2009;57(4):531-540. View abstract.

Zhou, W., Wang, P., and Tao, L. Effect of melatonin on proliferation of neonatal cord blood mononuclear cells. World J.Pediatr. 2009;5(4):300-303. View abstract.

Venkataraman, P., Selvakumar, K., Krishnamoorthy, G., Muthusami, S., Rameshkumar, R., Prakash, S., and Arunakaran, J. Effect of melatonin on PCB (Aroclor 1254) induced neuronal damage and changes in Cu/Zn superoxide dismutase and glutathione peroxidase-4 mRNA expression in cerebral cortex, cerebellum and hippocampus of adult rats. Neurosci.Res. 2010;66(2):189-197. View abstract.

Casao, A., Mendoza, N., Perez-Pe, R., Grasa, P., Abecia, J. A., Forcada, F., Cebrian-Perez, J. A., and Muino-Blanco, T. Melatonin prevents capacitation and apoptotic-like changes of ram spermatozoa and increases fertility rate. J.Pineal Res. 2010;48(1):39-46. View abstract.

Malekinejad, H., Farshid, A. A., and Mirzakhani, N. Liquorice plant extract reduces ochratoxin A-induced nephrotoxicity in rats. Exp.Toxicol.Pathol. 2011;63(1-2):125-130. View abstract.

Yang, F. L., Subeq, Y. M., Lee, C. J., Lee, R. P., Peng, T. C., and Hsu, B. G. Melatonin ameliorates hemorrhagic shock-induced organ damage in rats. J.Surg.Res. 5-15-2011;167(2):e315-e321. View abstract.

Murawska-Cialowicz, E., Jethon, Z., Magdalan, J., Januszewska, L., Podhorska-Okolow, M., Zawadzki, M., Sozanski, T., and Dziegiel, P. Effects of melatonin on lipid peroxidation and antioxidative enzyme activities in the liver, kidneys and brain of rats administered with benzo(a)pyrene. Exp.Toxicol.Pathol. 2011;63(1-2):97-103. View abstract.

Cernysiov, V., Gerasimcik, N., Mauricas, M., and Girkontaite, I. Regulation of T-cell-independent and T-cell-dependent antibody production by circadian rhythm and melatonin. Int.Immunol. 2010;22(1):25-34. View abstract.

Liu, Y., Zhang, H., Zhang, L., Zhang, X., Xie, Y., and Zhao, W. Melatonin modulates acute testicular damage induced by carbon ions in mice. Pharmazie 2009;64(10):685-689. View abstract.

Chowdhury, V. S., Yamamoto, K., Ubuka, T., Bentley, G. E., Hattori, A., and Tsutsui, K. Melatonin stimulates the release of gonadotropin-inhibitory hormone by the avian hypothalamus. Endocrinology 2010;151(1):271-280. View abstract.

Hamada, F., Watanabe, K., Wakatsuki, A., Nagai, R., Shinohara, K., Hayashi, Y., Imamura, R., and Fukaya, T. Therapeutic effects of maternal melatonin administration on ischemia/reperfusion-induced oxidative cerebral damage in neonatal rats. Neonatology. 2010;98(1):33-40. View abstract.

Sadowska-Woda, I., Wojcik, N., Karowicz-Bilinska, A., and Bieszczad-Bedrejczuk, E. Effect of selected antioxidants in beta-cyfluthrin-induced oxidative stress in human erythrocytes in vitro. Toxicol.In Vitro 2010;24(3):879-884. View abstract.

Maldonado, M. D., Mora-Santos, M., Naji, L., Carrascosa-Salmoral, M. P., Naranjo, M. C., and Calvo, J. R. Evidence of melatonin synthesis and release by mast cells. Possible modulatory role on inflammation. Pharmacol.Res. 2010;62(3):282-287. View abstract.

Paul MA, Miller JC, Gray GW, et al. Melatonin treatment for eastward and westward travel preparation. Psychopharmacology (Berl) 2010;208(3):377-86. View abstract.

Song, Y. M. and Chen, M. D. Effects of melatonin administration on plasma leptin concentration and adipose tissue leptin secretion in mice. Acta Biol.Hung. 2009;60(4):399-407. View abstract.

de Castro-Silva C, de Bruin VM, Cunha GM, et al. Melatonin improves sleep and reduces nitrite in the exhaled breath condensate in cystic fibrosis--a randomized, double-blind placebo-controlled study. J Pineal Res 2010;48(1):65-71. View abstract.

Srivastava, R. K. and Krishna, A. Melatonin modulates glucose homeostasis during winter dormancy in a vespertilionid bat, Scotophilus heathi. Comp Biochem.Physiol A Mol.Integr.Physiol 2010;155(3):392-400. View abstract.

Bendz, L. M. and Scates, A. C. Melatonin treatment for insomnia in pediatric patients with attention-deficit/hyperactivity disorder. Ann.Pharmacother. 2010;44(1):185-191. View abstract.

Nishimura, J., Saegusa, Y., Dewa, Y., Jin, M., Kawai, M., Kemmochi, S., Harada, T., Hayashi, S. M., Shibutani, M., and Mitsumori, K. Antioxidant enzymatically modified isoquercitrin or melatonin supplementation reduces oxidative stress-mediated hepatocellular tumor promotion of oxfendazole in rats. Arch.Toxicol. 2010;84(2):143-153. View abstract.

Dong, W., Huang, F., Fan, W., Cheng, S., Chen, Y., Zhang, W., Shi, H., and He, H. Differential effects of melatonin on amyloid-beta peptide 25-35-induced mitochondrial dysfunction in hippocampal neurons at different stages of culture. J.Pineal Res. 2010;48(2):117-125. View abstract.

Paulis, L., Pechanova, O., Zicha, J., Barta, A., Gardlik, R., Celec, P., Kunes, J., and Simko, F. Melatonin interactions with blood pressure and vascular function during L-NAME-induced hypertension. J.Pineal Res. 2010;48(2):102-108. View abstract.

Rahman, S. A., Kayumov, L., and Shapiro, C. M. Antidepressant action of melatonin in the treatment of Delayed Sleep Phase Syndrome. Sleep Med. 2010;11(2):131-136. View abstract.

Hill, S. M., Frasch, T., Xiang, S., Yuan, L., Duplessis, T., and Mao, L. Molecular mechanisms of melatonin anticancer effects. Integr.Cancer Ther. 2009;8(4):337-346. View abstract.

Rodella, L. F., Filippini, F., Bonomini, F., Bresciani, R., Reiter, R. J., and Rezzani, R. Beneficial effects of melatonin on nicotine-induced vasculopathy. J.Pineal Res. 2010;48(2):126-132. View abstract.

Suwanjang, W., Phansuwan-Pujito, P., Govitrapong, P., and Chetsawang, B. The protective effect of melatonin on methamphetamine-induced calpain-dependent death pathway in human neuroblastoma SH-SY5Y cultured cells. J.Pineal Res. 2010;48(2):94-101. View abstract.

Huang, S. H., Cao, X. J., Liu, W., Shi, X. Y., and Wei, W. Inhibitory effect of melatonin on lung oxidative stress induced by respiratory syncytial virus infection in mice. J.Pineal Res. 2010;48(2):109-116. View abstract.

Mogulkoc, R. and Baltaci, A. K. Effect of melatonin supplementation on plasma vasopressin response to different conditions in rats with hyperthyroidism induced by L-thyroxine. Regul.Pept. 4-9-2010;161(1-3):38-42. View abstract.

Azpeleta, C., Martinez-Alvarez, R. M., Delgado, M. J., Isorna, E., and De, Pedro N. Melatonin reduces locomotor activity and circulating cortisol in goldfish. Horm.Behav. 2010;57(3):323-329. View abstract.

Esteban, S., Garau, C., Aparicio, S., Moranta, D., Barcelo, P., Fiol, M. A., and Rial, R. Chronic melatonin treatment and its precursor L-tryptophan improve the monoaminergic neurotransmission and related behavior in the aged rat brain. J.Pineal Res. 2010;48(2):170-177. View abstract.

Kandil, T. S., Mousa, A. A., El-Gendy, A. A., and Abbas, A. M. The potential therapeutic effect of melatonin in Gastro-Esophageal Reflux Disease. BMC.Gastroenterol. 2010;10:7. View abstract.

Garcia, J. J., Pinol-Ripoll, G., Martinez-Ballarin, E., Fuentes-Broto, L., Miana-Mena, F. J., Venegas, C., Caballero, B., Escames, G., Coto-Montes, A., and Acuna-Castroviejo, D. Melatonin reduces membrane rigidity and oxidative damage in the brain of SAMP8 mice. Neurobiol.Aging 2011;32(11):2045-2054. View abstract.

Uluocak, N., Atilgan, D., Erdemir, F., Parlaktas, B. S., Yasar, A., Erkorkmaz, U., and Akbas, A. An animal model of ischemic priapism and the effects of melatonin on antioxidant enzymes and oxidative injury parameters in rat penis. Int.Urol.Nephrol. 2010;42(4):889-895. View abstract.

Tian, X. Z., Wen, Q., Shi, J. M., Liang, Wang, Zeng, S. M., Tian, J. H., Zhou, G. B., Zhu, S. E., and Liu, G. S. Effects of melatonin on in vitro development of mouse two-cell embryos cultured in HTF medium. Endocr.Res. 2010;35(1):17-23. View abstract.

Hoppe, J. B., Frozza, R. L., Horn, A. P., Comiran, R. A., Bernardi, A., Campos, M. M., Battastini, A. M., and Salbego, C. Amyloid-beta neurotoxicity in organotypic culture is attenuated by melatonin: involvement of GSK-3beta, tau and neuroinflammation. J.Pineal Res. 2010;48(3):230-238. View abstract.

Kaur, C., Sivakumar, V., and Ling, E. A. Melatonin protects periventricular white matter from damage due to hypoxia. J.Pineal Res. 2010;48(3):185-193. View abstract.

Sharma, S., Haldar, C., Chaube, S. K., Laxmi, T., and Singh, S. S. Long-term melatonin administration attenuates low-LET gamma-radiation-induced lymphatic tissue injury during the reproductively active and inactive phases of Indian palm squirrels (Funambulus pennanti). Br.J.Radiol. 2010;83(986):137-151. View abstract.

Dilek, M., Naziroglu, M., Baha, Oral H., Suat, Ovey, I, Kucukayaz, M., Mungan, M. T., Kara, H. Y., and Sutcu, R. Melatonin modulates hippocampus NMDA receptors, blood and brain oxidative stress levels in ovariectomized rats. J.Membr.Biol. 2010;233(1-3):135-142. View abstract.

Wiktorska, J. A., Lewinski, A., Stuss, M., Nowak, D., Pietras, T., and Sewerynek, E. Effects of certain antioxidants on lipid peroxidation process in lung homogenates of L thyroxine-receiving rats. Neuro.Endocrinol.Lett. 2010;31(1):137-146. View abstract.

Srinath, R., Acharya, A. B., and Thakur, S. L. Salivary and gingival crevicular fluid melatonin in periodontal health and disease. J.Periodontol. 2010;81(2):277-283. View abstract.

Espino, J., Bejarano, I., Ortiz, A., Lozano, G. M., Garcia, J. F., Pariente, J. A., and Rodriguez, A. B. Melatonin as a potential tool against oxidative damage and apoptosis in ejaculated human spermatozoa. Fertil.Steril. 2010;94(5):1915-1917. View abstract.

Guo, Y., Wang, J., Wang, Z., Yang, Y., Wang, X., and Duan, Q. Melatonin protects N2a against ischemia/reperfusion injury through autophagy enhancement. J.Huazhong.Univ Sci.Technolog.Med.Sci. 2010;30(1):1-7. View abstract.

Zaouali, M. A., Ben, Abdennebi H., Padrissa-Altes, S., Mahfoudh-Boussaid, A., and Rosello-Catafau, J. Pharmacological strategies against cold ischemia reperfusion injury. Expert.Opin.Pharmacother. 2010;11(4):537-555. View abstract.

Fang, Q., Chen, G., Zhu, W., Dong, W., and Wang, Z. Influence of melatonin on cerebrovascular proinflammatory mediators expression and oxidative stress following subarachnoid hemorrhage in rabbits. Mediators.Inflamm. 2009;426346. View abstract.

Pedrosa, A. M., Weinlich, R., Mognol, G. P., Robbs, B. K., Viola, J. P., Campa, A., and Amarante-Mendes, G. P. Melatonin protects CD4+ T cells from activation-induced cell death by blocking NFAT-mediated CD95 ligand upregulation. J.Immunol. 4-1-2010;184(7):3487-3494. View abstract.

Borazan, H., Tuncer, S., Yalcin, N., Erol, A., and Otelcioglu, S. Effects of preoperative oral melatonin medication on postoperative analgesia, sleep quality, and sedation in patients undergoing elective prostatectomy: a randomized clinical trial. J.Anesth. 2010;24(2):155-160. View abstract.

Akmali, M., Ahmadi, R., and Vessal, M. Pre- and post-treatment of streptozocin administered rats with melatonin: effects on some hepatic enzymes of carbohydrate metabolism. Arch.Iran Med. 2010;13(2):105-110. View abstract.

Serfaty, M. A., Osborne, D., Buszewicz, M. J., Blizard, R., and Raven, P. W. A randomized double-blind placebo-controlled trial of treatment as usual plus exogenous slow-release melatonin (6 mg) or placebo for sleep disturbance and depressed mood. Int.Clin.Psychopharmacol. 2010;25(3):132-142. View abstract.

Gonzalez, A., Martinez-Campa, C., Mediavilla, M. D., Alonso-Gonzalez, C., Alvarez-Garcia, V., Sanchez-Barcelo, E. J., and Cos, S. Inhibitory effects of melatonin on sulfatase and 17beta-hydroxysteroid dehydrogenase activity and expression in glioma cells. Oncol.Rep. 2010;23(4):1173-1178. View abstract.

Espino, J., Bejarano, I., Paredes, S. D., Gonzalez, D., Barriga, C., Reiter, R. J., Pariente, J. A., and Rodriguez, A. B. Melatonin counteracts alterations in oxidative metabolism and cell viability induced by intracellular calcium overload in human leucocytes: changes with age. Basic Clin.Pharmacol.Toxicol. 2010;107(1):590-597. View abstract.

Park, K., Lee, Y., Park, S., Lee, S., Hong, Y., Kil, Lee S., and Hong, Y. Synergistic effect of melatonin on exercise-induced neuronal reconstruction and functional recovery in a spinal cord injury animal model. J.Pineal Res. 2010;48(3):270-281. View abstract.

Whittom, S., Dumont, M., Petit, D., Desautels, A., Adam, B., Lavigne, G., and Montplaisir, J. Effects of melatonin and bright light administration on motor and sensory symptoms of RLS. Sleep Med. 2010;11(4):351-355. View abstract.

Elkhayat, H. A., Hassanein, S. M., Tomoum, H. Y., Abd-Elhamid, I. A., Asaad, T., and Elwakkad, A. S. Melatonin and sleep-related problems in children with intractable epilepsy. Pediatr.Neurol. 2010;42(4):249-254. View abstract.

Brivio, F., Fumagalli, L., Fumagalli, G., Pescia, S., Brivio, R., DI, Fede G., Rovelli, F., and Lissoni, P. Synchronization of cortisol circadian rhythm by the pineal hormone melatonin in untreatable metastatic solid tumor patients and its possible prognostic significance on tumor progression. In Vivo 2010;24(2):239-241. View abstract.

Garrido, M., Paredes, S. D., Cubero, J., Lozano, M., Toribio-Delgado, A. F., Munoz, J. L., Reiter, R. J., Barriga, C., and Rodriguez, A. B. Jerte Valley cherry-enriched diets improve nocturnal rest and increase 6-sulfatoxymelatonin and total antioxidant capacity in the urine of middle-aged and elderly humans. J.Gerontol.A Biol.Sci.Med.Sci. 2010;65(9):909-914. View abstract.

Kunz, D. and Mahlberg, R. A two-part, double-blind, placebo-controlled trial of exogenous melatonin in REM sleep behaviour disorder. J.Sleep Res. 2010;19(4):591-596. View abstract.

Baeza, I., Fdez-Tresguerres, J., Ariznavarreta, C., and De la Fuente, M. Effects of growth hormone, melatonin, oestrogens and phytoestrogens on the oxidized glutathione (GSSG)/reduced glutathione (GSH) ratio and lipid peroxidation in aged ovariectomized rats. Biogerontology. 2010;11(6):687-701. View abstract.

Braam, W., van, Geijlswijk, I, Keijzer, H., Smits, M. G., Didden, R., and Curfs, L. M. Loss of response to melatonin treatment is associated with slow melatonin metabolism. J.Intellect.Disabil.Res. 2010;54(6):547-555. View abstract.

Zaslavskaia, R. M., Shcherban', E. A., Lilitsa, G. V., and Logvinenko, S. I. [Melatonin in the combined treatment of cardiovascular diseases]. Klin.Med.(Mosk) 2010;88(3):26-30. View abstract.

Kucukakin, B., Wilhelmsen, M., Lykkesfeldt, J., Reiter, R. J., Rosenberg, J., and Gogenur, I. No effect of melatonin to modify surgical-stress response after major vascular surgery: a randomised placebo-controlled trial. Eur.J.Vasc.Endovasc.Surg. 2010;40(4):461-467. View abstract.

van Geijlswijk, I. M., van der Heijden, K. B., Egberts, A. C., Korzilius, H. P., and Smits, M. G. Dose finding of melatonin for chronic idiopathic childhood sleep onset insomnia: an RCT. Psychopharmacology (Berl) 2010;212(3):379-391. View abstract.

Strassman, R. J., Qualls, C. R., Lisansky, E. J., and Peake, G. T. Sleep deprivation reduces LH secretion in men independently of melatonin. Acta Endocrinol (Copenh) 1991;124(6):646-651. View abstract.

Mrowicka, M., Garncarek, P., Miller, E., Kedziora, J., Smigielski, J., Malinowska, K., and Mrowicki, J. [Effect of melatonin on activity of superoxide dismutase (CuZn-SOD) in erythrocytes of patients during short- and long-term hypokinesis]. Wiad.Lek. 2010;63(1):3-9. View abstract.

Rizzo, P., Raffone, E., and Benedetto, V. Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial. Eur.Rev.Med.Pharmacol.Sci. 2010;14(6):555-561. View abstract.

Wade AG, Ford I, Crawford G, et al. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety. BMC Med 2010;8:51. View abstract.

Cook, J. S. and Ray, C. A. Melatonin attenuates the vestibulosympathetic but not vestibulocollic reflexes in humans: selective impairment of the utricles. J.Appl.Physiol 2010;109(6):1697-1701. View abstract.

Al-Aama, T., Brymer, C., Gutmanis, I., Woolmore-Goodwin, S. M., Esbaugh, J., and Dasgupta, M. Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial. Int.J.Geriatr.Psychiatry 2011;26(7):687-694. View abstract.

Kucukakin, B., Klein, M., Lykkesfeldt, J., Reiter, R. J., Rosenberg, J., and Gogenur, I. No effect of melatonin on oxidative stress after laparoscopic cholecystectomy: a randomized placebo-controlled trial. Acta Anaesthesiol.Scand. 2010;54(9):1121-1127. View abstract.

Vigore, L., Messina, G., Brivio, F., Fumagalli, L., Rovelli, F., DI, Fede G., and Lissoni, P. Psychoneuroendocrine modulation of regulatory T lymphocyte system: in vivo and in vitro effects of the pineal immunomodulating hormone melatonin. In Vivo 2010;24(5):787-789. View abstract.

Alstadhaug, K. B., Odeh, F., Salvesen, R., and Bekkelund, S. I. Prophylaxis of migraine with melatonin: a randomized controlled trial. Neurology 10-26-2010;75(17):1527-1532. View abstract.

Uberos, J., Augustin-Morales, M. C., Molina, Carballo A., Florido, J., Narbona, E., and Munoz-Hoyos, A. Normalization of the sleep-wake pattern and melatonin and 6-sulphatoxy-melatonin levels after a therapeutic trial with melatonin in children with severe epilepsy. J.Pineal Res. 2011;50(2):192-196. View abstract.

Cichoz-Lach, H., Celinski, K., Konturek, P. C., Konturek, S. J., and Slomka, M. The effects of L-tryptophan and melatonin on selected biochemical parameters in patients with steatohepatitis. J.Physiol Pharmacol. 2010;61(5):577-580. View abstract.

de, Jonghe A., Korevaar, J. C., van Munster, B. C., and de Rooij, S. E. Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review. Int.J.Geriatr.Psychiatry 2010;25(12):1201-1208. View abstract.

Wade, A. G., Crawford, G., Ford, I., McConnachie, A., Nir, T., Laudon, M., and Zisapel, N. Prolonged release melatonin in the treatment of primary insomnia: evaluation of the age cut-off for short- and long-term response. Curr.Med.Res.Opin. 2011;27(1):87-98. View abstract.

Dominguez-Rodriguez, A., Abreu-Gonzalez, P., Jimenez-Sosa, A., Avanzas, P., Bosa-Ojeda, F., and Kaski, J. C. Usefulness of intraplatelet melatonin levels to predict angiographic no-reflow after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction. Am.J.Cardiol. 12-1-2010;106(11):1540-1544. View abstract.

van Geijlswijk, I. M., Korzilius, H. P., and Smits, M. G. The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis. Sleep 2010;33(12):1605-1614. View abstract.

Kozirog, M., Poliwczak, A. R., Duchnowicz, P., Koter-Michalak, M., Sikora, J., and Broncel, M. Melatonin treatment improves blood pressure, lipid profile, and parameters of oxidative stress in patients with metabolic syndrome. J.Pineal Res. 2011;50(3):261-266. View abstract.

Cook, J. S., Sauder, C. L., and Ray, C. A. Melatonin differentially affects vascular blood flow in humans. Am.J.Physiol Heart Circ.Physiol 2011;300(2):H670-H674. View abstract.

Hussain, S. A., Al-Khalifa, I. I., Jasim, N. A., and Gorial, F. I. Adjuvant use of melatonin for treatment of fibromyalgia. J.Pineal Res. 2011;50(3):267-271. View abstract.

Gonciarz, M., Gonciarz, Z., Bielanski, W., Mularczyk, A., Konturek, P. C., Brzozowski, T., and Konturek, S. J. The pilot study of 3-month course of melatonin treatment of patients with nonalcoholic steatohepatitis: effect on plasma levels of liver enzymes, lipids and melatonin. J.Physiol Pharmacol. 2010;61(6):705-710. View abstract.

Ozcengiz, D., Gunes, Y., and Ozmete, O. Oral melatonin, dexmedetomidine, and midazolam for prevention of postoperative agitation in children. J.Anesth. 2011;25(2):184-188. View abstract.

Celinski, K., Konturek, S. J., Konturek, P. C., Brzozowski, T., Cichoz-Lach, H., Slomka, M., Malgorzata, P., Bielanski, W., and Reiter, R. J. Melatonin or L-tryptophan accelerates healing of gastroduodenal ulcers in patients treated with omeprazole. J.Pineal Res. 2011;50(4):389-394. View abstract.

Guenole, F., Godbout, R., Nicolas, A., Franco, P., Claustrat, B., and Baleyte, J. M. Melatonin for disordered sleep in individuals with autism spectrum disorders: systematic review and discussion. Sleep Med.Rev. 2011;15(6):379-387. View abstract.

El-Batch, M., Hassan, A. M., and Mahmoud, H. A. Taurine is more effective than melatonin on cytochrome P450 2E1 and some oxidative stress markers in streptozotocin-induced diabetic rats. J Agric.Food Chem 5-11-2011;59(9):4995-5000. View abstract.

Nickkholgh, A., Schneider, H., Sobirey, M., Venetz, W. P., Hinz, U., Pelzl, le H., Gotthardt, D. N., Cekauskas, A., Manikas, M., Mikalauskas, S., Mikalauskene, L., Bruns, H., Zorn, M., Weigand, M. A., Buchler, M. W., and Schemmer, P. The use of high-dose melatonin in liver resection is safe: first clinical experience. J.Pineal Res. 2011;50(4):381-388. View abstract.

Chahbouni, M., Escames, G., Lopez, L. C., Sevilla, B., Doerrier, C., Munoz-Hoyos, A., Molina-Carballo, A., and Acuna-Castroviejo, D. Melatonin treatment counteracts the hyperoxidative status in erythrocytes of patients suffering from Duchenne muscular dystrophy. Clin.Biochem. 2011;44(10-11):853-858. View abstract.

Rossignol, D. A. and Frye, R. E. Melatonin in autism spectrum disorders: a systematic review and meta-analysis. Dev.Med.Child Neurol. 2011;53(9):783-792. View abstract.

Taketani, T., Tamura, H., Takasaki, A., Lee, L., Kizuka, F., Tamura, I., Taniguchi, K., Maekawa, R., Asada, H., Shimamura, K., Reiter, R. J., and Sugino, N. Protective role of melatonin in progesterone production by human luteal cells. J.Pineal Res. 2011;51(2):207-213. View abstract.

Ochoa, J. J., Diaz-Castro, J., Kajarabille, N., Garcia, C., Guisado, I. M., De, Teresa C., and Guisado, R. Melatonin supplementation ameliorates oxidative stress and inflammatory signaling induced by strenuous exercise in adult human males. J.Pineal Res. 2011;51(4):373-380. View abstract.

Eryilmaz, O. G., Devran, A., Sarikaya, E., Aksakal, F. N., Mollamahmutoglu, L., and Cicek, N. Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems. J.Assist.Reprod.Genet. 2011;28(9):815-820. View abstract.

Batioglu, A. S., Sahin, U., Gurlek, B., Ozturk, N., and Unsal, E. The efficacy of melatonin administration on oocyte quality. Gynecol.Endocrinol. 2012;28(2):91-93. View abstract.

Hurtuk, A., Dome, C., Holloman, C. H., Wolfe, K., Welling, D. B., Dodson, E. E., and Jacob, A. Melatonin: can it stop the ringing? Ann.Otol.Rhinol.Laryngol. 2011;120(7):433-440. View abstract.

Chojnacki, C., Wisniewska-Jarosinska, M., Walecka-Kapica, E., Klupinska, G., Jaworek, J., and Chojnacki, J. Evaluation of melatonin effectiveness in the adjuvant treatment of ulcerative colitis. J.Physiol Pharmacol. 2011;62(3):327-334. View abstract.

Huston, B., Mills, K., Froloff, V., and McGee, M. Bladder rupture after intentional medication overdose. Am.J.Forensic Med.Pathol. 2012;33(2):184-185. View abstract.

Merks, B. T., Burger, H., Willemsen, J., van Gool, J. D., and de Jong, T. P. Melatonin treatment in children with therapy-resistant monosymptomatic nocturnal enuresis. J.Pediatr.Urol. 2012;8(4):416-420. View abstract.

Castro, F., Carrizo, E., Prieto de, Rincon D., Rincon, C. A., Asian, T., Medina-Leendertz, S., and Bonilla, E. Effectiveness of melatonin in tardive dyskinesia. Invest Clin. 2011;52(3):252-260. View abstract.

Grossman, E., Laudon, M., and Zisapel, N. Effect of melatonin on nocturnal blood pressure: meta-analysis of randomized controlled trials. Vasc.Health Risk Manag. 2011;7:577-584. View abstract.

Bukowska, A. [Anticarcinogenic role of melatonin--potential mechanisms]. Med.Pr 2011;62(4):425-434. View abstract.

Seppi K, Weintraub D, Coelho M, et al. The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor symptoms of Parkinson's disease. Mov Disord 2011;26 Suppl 3:S42-S80. View abstract.

Friedman, O., Orvieto, R., Fisch, B., Felz, C., Freud, E., Ben-Haroush, A., and Abir, R. Possible improvements in human ovarian grafting by various host and graft treatments. Hum.Reprod. 2012;27(2):474-482. View abstract.

Maldonado, M. D., Manfredi, M., Ribas-Serna, J., Garcia-Moreno, H., and Calvo, J. R. Melatonin administrated immediately before an intense exercise reverses oxidative stress, improves immunological defenses and lipid metabolism in football players. Physiol Behav. 3-20-2012;105(5):1099-1103. View abstract.

Kotlarczyk, M. P., Lassila, H. C., O'Neil, C. K., D'Amico, F., Enderby, L. T., Witt-Enderby, P. A., and Balk, J. L. Melatonin osteoporosis prevention study (MOPS): a randomized, double-blind, placebo-controlled study examining the effects of melatonin on bone health and quality of life in perimenopausal women. J.Pineal Res. 2012;52(4):414-426. View abstract.

Sekeroglu, M. R., Huyut, Z., and Him, A. The susceptibility of erythrocytes to oxidation during storage of blood: effects of melatonin and propofol. Clin.Biochem. 2012;45(4-5):315-319. View abstract.

Wang, Y. M., Jin, B. Z., Ai, F., Duan, C. H., Lu, Y. Z., Dong, T. F., and Fu, Q. L. The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: a meta-analysis of randomized controlled trials. Cancer Chemother.Pharmacol. 2012;69(5):1213-1220. View abstract.

Laakso, M. L., Porkka-Heiskanen, T., Alila, A., Stenberg, D., and Johansson, G. Correlation between salivary and serum melatonin: dependence on serum melatonin levels. J Pineal Res 1990;9(1):39-50. View abstract.

Ucar, E., Lehtinen, E. K., Glenthoj, B. Y., and Oranje, B. The effect of acute exogenous melatonin on P50 suppression in healthy male volunteers stratified for low and high gating levels. J.Psychopharmacol. 2012;26(8):1113-1118. View abstract.

Rondanelli M, Opizzi A, Faliva M, et al. Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairment. Nutr.Neurosci 2012;15(2):46-54. View abstract.

Gooneratne, N. S., Edwards, A. Y., Zhou, C., Cuellar, N., Grandner, M. A., and Barrett, J. S. Melatonin pharmacokinetics following two different oral surge-sustained release doses in older adults. J.Pineal Res. 2012;52(4):437-445. View abstract.

Otmani, S., Metzger, D., Guichard, N., Danjou, P., Nir, T., Zisapel, N., and Katz, A. Effects of prolonged-release melatonin and zolpidem on postural stability in older adults. Hum.Psychopharmacol. 2012;27(3):270-276. View abstract.

Schernhammer, E. S., Giobbie-Hurder, A., Gantman, K., Savoie, J., Scheib, R., Parker, L. M., and Chen, W. Y. A randomized controlled trial of oral melatonin supplementation and breast cancer biomarkers. Cancer Causes Control 2012;23(4):609-616. View abstract.

No author. [Relationship between insulin, leptin, and melatonin contents in patients with metabolic syndrome]. Klin.Med.(Mosk) 2011;89(6):46-49. View abstract.

Pullman, R. E., Roepke, S. E., and Duffy, J. F. Laboratory validation of an in-home method for assessing circadian phase using dim light melatonin onset (DLMO). Sleep Med. 2012;13(6):703-706. View abstract.

Gonciarz, M., Gonciarz, Z., Bielanski, W., Mularczyk, A., Konturek, P. C., Brzozowski, T., and Konturek, S. J. The effects of long-term melatonin treatment on plasma liver enzymes levels and plasma concentrations of lipids and melatonin in patients with nonalcoholic steatohepatitis: a pilot study. J.Physiol Pharmacol. 2012;63(1):35-40. View abstract.

de Matos, Cavalcante A. G., de Bruin, P. F., de Bruin, V. M., Nunes, D. M., Pereira, E. D., Cavalcante, M. M., and Andrade, G. M. Melatonin reduces lung oxidative stress in patients with chronic obstructive pulmonary disease: a randomized, double-blind, placebo-controlled study. J.Pineal Res. 2012;53(3):238-244. View abstract.

Mantele, S., Otway, D. T., Middleton, B., Bretschneider, S., Wright, J., Robertson, M. D., Skene, D. J., and Johnston, J. D. Daily rhythms of plasma melatonin, but not plasma leptin or leptin mRNA, vary between lean, obese and type 2 diabetic men. PLoS.One. 2012;7(5):e37123. View abstract.

Yiannakopoulou, E., Nikiteas, N., Perrea, D., and Tsigris, C. Pharmacological modulation of oxidative stress response in minimally invasive surgery: systematic review. Surg.Laparosc.Endosc.Percutan.Tech. 2012;22(3):200-204. View abstract.

de Leiva, A., Tortosa, F., Peinado, M. A., Serrano, J., Rodriguez-Espinosa, J., and Puig-Domingo, M. Episodic nyctohemeral secretion of melatonin in adult humans: lack of relation with LH pulsatile pattern. Acta Endocrinol (Copenh) 1990;122(1):76-82. View abstract.

Viviani, S., Negretti, E., Orazi, A., Sozzi, G., Santoro, A., Lissoni, P., Esposti, G., and Fraschini, F. Preliminary studies on melatonin in the treatment of myelodysplastic syndromes following cancer chemotherapy. J Pineal Res 1990;8(4):347-354. View abstract.

Palazidou, E., Franey, C., Arendt, J., Stahl, S., and Checkley, S. Evidence for a functional role of alpha-1 adrenoceptors in the regulation of melatonin secretion in man. Psychoneuroendocrinology 1989;14(1-2):131-135. View abstract.

Palazidou, E., Papadopoulos, A., Sitsen, A., Stahl, S., and Checkley, S. An alpha 2 adrenoceptor antagonist, Org 3770, enhances nocturnal melatonin secretion in man. Psychopharmacology (Berl) 1989;97(1):115-117. View abstract.

Ferrari, E., Foppa, S., Bossolo, P. A., Comis, S., Esposti, G., Licini, V., Fraschini, F., and Brambilla, F. Melatonin and pituitary-gonadal function in disorders of eating behavior. J Pineal Res 1989;7(2):115-124. View abstract.

Nickelsen, T., Demisch, L., Demisch, K., Radermacher, B., and Schoffling, K. Influence of subchronic intake of melatonin at various times of the day on fatigue and hormonal levels: a placebo-controlled, double-blind trial. J Pineal Res 1989;6(4):325-334. View abstract.

Paccotti, P., Terzolo, M., Torta, M., Vignani, A., Schena, M., Piovesan, A., and Angeli, A. Acute administration of melatonin at two opposite circadian stages does not change responses to gonadotropin releasing hormone, thyrotropin releasing hormone and ACTH in healthy adult males. J Endocrinol Invest 1987;10(5):471-477. View abstract.

Cowen, P. J., Bevan, J. S., Gosden, B., and Elliott, S. A. Treatment with beta-adrenoceptor blockers reduces plasma melatonin concentration. Br J Clin Pharmacol 1985;19(2):258-260. View abstract.

Lewy, A. J., Siever, L. J., Uhde, T. W., and Markey, S. P. Clonidine reduces plasma melatonin levels. J Pharm Pharmacol 1986;38(7):555-556. View abstract.

Maestroni, G. J., Conti, A., and Pierpaoli, W. Role of the pineal gland in immunity. Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immunosuppressive effect of corticosterone. J Neuroimmunol. 1986;13(1):19-30. View abstract.

Waldhauser, F., Lieberman, H. R., Lynch, H. J., Waldhauser, M., Herkner, K., Frisch, H., Vierhapper, H., Waldhausl, W., Schemper, M., Wurtman, R. J., and . A pharmacological dose of melatonin increases PRL levels in males without altering those of GH, LH, FSH, TSH, testosterone or cortisol. Neuroendocrinology 1987;46(2):125-130. View abstract.

Valcavi, R., Dieguez, C., Azzarito, C., Edwards, C. A., Dotti, C., Page, M. D., Portioli, I., and Scanlon, M. F. Effect of oral administration of melatonin on GH responses to GRF 1-44 in normal subjects. Clin Endocrinol (Oxf) 1987;26(4):453-458. View abstract.

Brismar, K., Hylander, B., Eliasson, K., Rossner, S., and Wetterberg, L. Melatonin secretion related to side-effects of beta-blockers from the central nervous system. Acta Med Scand 1988;223(6):525-530. View abstract.

Reiter, R. J. The melatonin message: duration versus coincidence hypotheses. Life Sci 6-1-1987;40(22):2119-2131. View abstract.

Regelson, W. and Pierpaoli, W. Melatonin: a rediscovered antitumor hormone? Its relation to surface receptors; sex steroid metabolism, immunologic response, and chronobiologic factors in tumor growth and therapy. Cancer Invest 1987;5(4):379-385. View abstract.

Esposti, D., Lissoni, P., Mauri, R., Rovelli, F., Orsenigo, L., Pescia, S., Vegetti, G., Esposti, G., and Fraschini, F. The pineal gland-opioid system relation: melatonin-naloxone interactions in regulating GH and LH releases in man. J Endocrinol Invest 1988;11(2):103-106. View abstract.

Samples, J. R., Krause, G., and Lewy, A. J. Effect of melatonin on intraocular pressure. Curr Eye Res 1988;7(7):649-653. View abstract.

Nowak, R., McMillen, I. C., Redman, J., and Short, R. V. The correlation between serum and salivary melatonin concentrations and urinary 6-hydroxymelatonin sulphate excretion rates: two non-invasive techniques for monitoring human circadian rhythmicity. Clin Endocrinol (Oxf) 1987;27(4):445-452. View abstract.

Lieberman, H. R. Behavior, sleep and melatonin. J Neural Transm.Suppl 1986;21:233-241. View abstract.

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Harma, M., Laitinen, J., Partinen, M., and Suvanto, S. The effect of four-day round trip flights over 10 time zones on the circadian variation of salivary melatonin and cortisol in airline flight attendants. Ergonomics 1994;37(9):1479-1489. View abstract.

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Viggiano, S. R., Koskela, T. K., Klee, G. G., Samples, J. R., Arnce, R., and Brubaker, R. F. The effect of melatonin on aqueous humor flow in humans during the day. Ophthalmology 1994;101(2):326-331. View abstract.

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Terzolo, M., Revelli, A., Guidetti, D., Piovesan, A., Cassoni, P., Paccotti, P., Angeli, A., and Massobrio, M. Evening administration of melatonin enhances the pulsatile secretion of prolactin but not of LH and TSH in normally cycling women. Clin Endocrinol (Oxf) 1993;39(2):185-191. View abstract.

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Lissoni, P., Meregalli, S., Nosetto, L., Barni, S., Tancini, G., Fossati, V., and Maestroni, G. Increased survival time in brain glioblastomas by a radioneuroendocrine strategy with radiotherapy plus melatonin compared to radiotherapy alone. Oncology 1996;53(1):43-46. View abstract.

Cajochen, C., Krauchi, K., von Arx, M. A., Mori, D., Graw, P., and Wirz-Justice, A. Daytime melatonin administration enhances sleepiness and theta/alpha activity in the waking EEG. Neurosci.Lett. 4-5-1996;207(3):209-213. View abstract.

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Chiodera, P., Volpi, R., Capretti, L., Giuliani, N., Maffei, M. L., and Coiro, V. Effect of melatonin on arginine vasopressin secretion stimulated by physical exercise or angiotensin II in normal men. Neuropeptides 1998;32(2):125-129. View abstract.

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Wang YY, Zheng W, Ng CH, Ungvari GS, Wei W, Xiang YT. Meta-analysis of randomized, double-blind, placebo-controlled trials of melatonin in Alzheimer's disease. Int J Geriatr Psychiatry 2017;32(1):50-7. View abstract.

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Baandrup L, Lindschou J, Winkel P, Gluud C, Glenthoj BY. Prolonged-release melatonin versus placebo for benzodiazepine discontinuation in patients with schizophrenia or bipolar disorder: A randomised, placebo-controlled, blinded trial. World J Biol Psychiatry 2016;17(7):514-24. View abstract.

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Wright A, Diebold J, Otal J, et al. The Effect of Melatonin on Benzodiazepine Discontinuation and Sleep Quality in Adults Attempting to Discontinue Benzodiazepines: A Systematic Review and Meta-Analysis. Drugs Aging 2015;32(12):1009-18. View abstract.

Dominguez-Rodriguez A, Abreu-Gonzalez P, de la Torre-Hernandez JM, et al. Usefulness of Early Treatment With Melatonin to Reduce Infarct Size in Patients With ST-Segment Elevation Myocardial Infarction Receiving Percutaneous Coronary Intervention (From the Melatonin Adjunct in the Acute Myocardial Infarction Treated With Angioplasty Trial). Am J Cardiol 2017;120(4):522-26. View abstract.

Hansen MV, Danielsen AK, Hageman I, Rosenberg J, Gögenur I. The therapeutic or prophylactic effect of exogenous melatonin against depression and depressive symptoms: a systematic review and meta-analysis. Eur Neuropsychopharmacol 2014;24(11):1719-28. View abstract.

Johnston D, Zupanec S, Nicksy D, et al. Phase I dose finding study for melatonin in paediatric oncology patients with relapsed solid tumors. J Clin Oncol. 2018;36(15 Suppl):e22514-e22514. View abstract.

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Chang YS, Lin MH, Lee JH, et al. Melatonin supplementation for children with atopic dermatitis and sleep disturbance: a randomized clinical trial. JAMA Pediatr. 2016 Jan;170(1):35-42. View abstract.

Mihara T, Nakamura N, Ka K, Oba MS, Goto T. Effects of melatonin premedication to prevent emergence agitation after general anaesthesia in children: a systematic review and meta-analysis with trial sequential analysis. Eur J Anaesthesiol. 2015 Dec;32(12):862-71. View abstract.

Bondi CD, Kamal KM, Johnson DA, Witt-Enderby PA, Giannetti VJ. The effect of melatonin upon postacute withdrawal among males in a residential treatment program (M-PAWS): a randomized, double-blind, placebo-controlled trial. J Addict Med. 2018 May/Jun;12(3):201-206. View abstract.

Lui MFG, Chow HKD, Wong WMK, Tsang WNW. Melatonin affects postural control in community-dwelling older adults while dual-tasking: a randomized observation study. J Aging Phys Act. 2018 May 29:1-24. View abstract.

Scheuer C, Pommergaard HC, Rosenberg J, Gogenur I. Dose dependent sun protective effect of topical melatonin: a randomized, placebo-controlled, double-blind study. J Dermatol Sci. 2016 Nov;84(2):178-185. View abstract.

Gitto E, Maseglia L, D'Angelo G, et al. Melatonin versus midazolam premedication in children undergoing surgery: a pilot study. J Paediatr Child Health. 2016 Mar;52(3):291-5. View abstract.

Pacchiarotti A, Carlomagno G. Antonini G, Pacchiarotti A. Effect of myo-inositol and melatonin versus myo-inositol, in a randomized controlled trial, for improving in vitro fertilization of patients with polycystic ovarian syndrome. Gynecol Endocrinol. 2016;32(1):69-73. View abstract.

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Abtahi SH, Hashemi SM, Mahmoodi M, Nilforoush MH. Comparison of melatonin and sertraline therapies on tinnitus: a randomized controlled trial. Int J Prev Med. 2017 Aug 31;8:61. View abstract.

Scheuer C, Pommergaard HC, Rosenberg J, Gogenur I. Effect of topical application of melatonin cream 12.5% on cognitive parameters: a randomized, placebo-controlled, double-blind crossover study in healthy volunteers. J Dermatolog Treat. 2016 Nov;27(6):488-94. View abstract.

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Amstrup AK, Sikjaer T, Heickendorff L, Mosekilde L, Rejnmark L. Melatonin improves bone mineral density at the femoral neck in postmenopausal women with osteopenia: a randomized controlled trial. J Pineal Res. 2015;59(2):221-9. View abstract.

Ben-David MA, Elkayam R, Gelernter I, Pfeffer RM. Melatonin for Prevention of Breast Radiation Dermatitis: A Phase II, Prospective, Double-Blind Randomized Trial. Isr Med Assoc J. 2016;18(3-4):188-92. View abstract.

Bienert A, Wawrzyniak K, Wiczling P, et al. Melatonin and clonidine premedication has similar impact on the pharmacokinetics and pharmacodynamics of propofol target controlled-infusions. J Clin Pharmacol. 2015;55(3):307-16. View abstract.

Brandenberger KJ, Ingalls CP, Rupp JC, Doyle JA. Consumption of a 5-mg Melatonin Supplement Does Not Affect 32.2-km Cycling Time Trial Performance. J Strength Cond Res. 2018;32(10):2872-2877. View abstract.

El Frargy M, El-Sharkawy HM, Attia GF. Use of melatonin as an adjuvant therapy in neonatal sepsis. J Neonatal Perinatal Med. 2015;8(3):227-32. View abstract.

El-Gendy FM, El-Hawy MA, Hassan MG. Beneficial effect of melatonin in the treatment of neonatal sepsis. J Matern Fetal Neonatal Med. 2018;31(17):2299-2303. View abstract.

Hobson SR, Gurusinghe S, Lim R, et al. Melatonin improves endothelial function in vitro and prolongs pregnancy in women with early-onset preeclampsia. J Pineal Res. 2018;65(3):e12508. View abstract.

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Kirksey MA, Yoo D, Danninger T, Stundner O, Ma Y, Memtsoudis SG. Impact of Melatonin on Sleep and Pain After Total Knee Arthroplasty Under Regional Anesthesia With Sedation: A Double-Blind, Randomized, Placebo-Controlled Pilot Study. J Arthroplasty. 2015;30(12):2370-5. View abstract.

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Taghavi Ardakani A, Farrehi M, Sharif MR, et al. The effects of melatonin administration on disease severity and sleep quality in children with atopic dermatitis: A randomized, double-blinded, placebo-controlled trial. Pediatr Allergy Immunol. 2018;29(8):834-840. View abstract.

Zhang J, Wang Y, Xu H, Yang J. The Influence of Melatonin on Sleep Quality After Laparoscopic Cholecystectomy: A Meta-Analysis of Randomized Controlled Trials. Surg Laparosc Endosc Percutan Tech. 2019;29(1):1-6. View abstract.

Schroder CM, Malow BA, Maras A, et al. Pediatric Prolonged-Release Melatonin for Sleep in Children with Autism Spectrum Disorder: Impact on Child Behavior and Caregiver's Quality of Life. J Autism Dev Disord. 2019;49(8):3218-3230. View abstract.

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Shimomura ET, Briones AJ, Gordon CJ, Warren WS, Jackson GF. Case report of sudden death in a twin infant given melatonin supplementation: a challenging interpretation of postmortem toxicology. Forensic Sci Int 2019;304:109962. View abstract.

Choudhary S, Sharma S, Kumari I, Kalluraya S, Meena K, Dave T. Comparative evaluation of oral melatonin and oral clonidine for the attenuation of haemodynamic response to laryngoscopy and tracheal intubation-A prospective randomised double blind study. Indian J Anaesth. 2020;64(8):696-703. View abstract.

Bahrami M, Cheraghpour M, Jafarirad S, et al. The effect of melatonin on treatment of patients with non-alcoholic fatty liver disease: a randomized double blind clinical trial. Complement Ther Med. 2020;52:102452. View abstract.

Mansoori A, Salimi Z, Hosseini SA, et al. The effect of melatonin supplementation on liver indices in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of randomized clinical trials. Complement Ther Med. 2020;52:102398. View abstract.

Tseng PT, Yang CP, Su KP, et al. The association between melatonin and episodic migraine: A pilot network meta-analysis of randomized controlled trials to compare the prophylactic effects with exogenous melatonin supplementation and pharmacotherapy. J Pineal Res. 2020;69(2):e12663. View abstract.

Gelfand AA, Ross AC, Irwin SL, Greene KA, Qubty WF, Allen IE. Melatonin for acute treatment of migraine in children and adolescents: A pilot randomized trial. Headache. 2020;60(8):1712-1721. View abstract.

Wang Z, Li Y, Lin D, Ma J. Effect of melatonin on postoperative pain and perioperative opioid use: A meta-analysis and trial sequential analysis. Pain Pract. 2020. View abstract.

Zetner D, Andersen LPK, Alder R, Jessen ML, Tolstrup A, Rosenberg J. Pharmacokinetics and safety of intravenous, intravesical, rectal, transdermal, and vaginal melatonin in healthy female volunteers: A cross-over study. Pharmacology. 2020:1-8. View abstract.

Doosti-Irani A, Ostadmohammadi V, Mirhosseini N et al. The effects of melatonin supplementation on glycemic control: A systematic review and meta-analysis of randomized controlled trials. Horm Metab Res. 2018;50(11):783-790. View abstract.

Akbari M, Ostadmohammadi V, Mirhosseini N, et al. The effects of melatonin supplementation on blood pressure in patients with metabolic disorders: a systematic review and meta-analysis of randomized controlled trials. J Hum Hypertens. 2019;33(3):202-209. View abstract.

Barlow KM, Brooks BL, Esser MJ, et al. Efficacy of Melatonin in Children With Postconcussive Symptoms: A Randomized Clinical Trial. Pediatrics. 2020;145(4):e20192812. View abstract.

Lee TYC, Curtin JP. The effects of melatonin prophylaxis on sensory recovery and postoperative pain following orthognathic surgery: a triple-blind randomized controlled trial and biochemical analysis. Int J Oral Maxillofac Surg. 2020;49(4):446-453. View abstract.

Oh SN, Myung SK, Jho HJ. Analgesic Efficacy of Melatonin: A Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Trials. J Clin Med. 2020;9(5). pii: E1553. View abstract.

Panah F, Ghorbanihaghjo A, Argani H, et al. The effect of oral melatonin on renal ischemia-reperfusion injury in transplant patients: A double-blind, randomized controlled trial. Transpl Immunol. 2019;57:101241. View abstract.

Quested DJ, Gibson JC, Sharpley AL, et al. Melatonin In Acute Mania Investigation (MIAMI-UK). A randomised controlled trial of add-on melatonin in bipolar disorder. Bipolar Disord. 2020. View abstract.

Farrokhian A, Tohidi M, Ahanchi NS, et al. Effect of bedtime melatonin administration in patients with type 2 diabetes: A triple-blind, placebo-controlled, randomized trial. Iran J Pharm Res. 2019;18(Suppl1):258-268. View abstract.

Ahmed J, Pullattayil S AK, Robertson NJ, More K. Melatonin for neuroprotection in neonatal encephalopathy: A systematic review & meta-analysis of clinical trials. Eur J Paediatr Neurol. 2021;31:38-45. View abstract.

Baharvand P, Abbasi MR, Ziaee Ardestani S, Esmaeili A, Namazi S. Evaluation of Antipruritic Effect of Melatonin on Hemodialysis Patients with Uremic Pruritus, A Double-Blind, Randomized, Crossover Trial. Iran J Kidney Dis. 2021;1(1):38-47. View abstract.

Bellapart J, Appadurai V, Lassig-Smith M, Stuart J, Zappala C, Boots R. Effect of Exogenous Melatonin Administration in Critically Ill Patients on Delirium and Sleep: A Randomized Controlled Trial. Crit Care Res Pract. 2020;2020:3951828. View abstract.

Danilov AB, Danilov AB, Kurushina OV, Shestel EA, Zhivolupov SA, Latysheva NV. Safety and Efficacy of Melatonin in Chronic Tension-Type Headache: A Post-Marketing Real-World Surveillance Program. Pain Ther. 2020;9(2):741-750. View abstract.

Esmaely F, Mahmoudzadeh A, Cheki M, Shirazi A. The radioprotective effect of melatonin against radiation-induced DNA double-strand breaks in radiology. J Cancer Res Ther. 2020;16(Supplement):S59-S63. View abstract.

Howell DR, Potter MN, Provance AJ, Wilson PE, Kirkwood MW, Wilson JC. Sleep Problems and Melatonin Prescription After Concussion Among Youth Athletes. Clin J Sport Med. 2020. View abstract.

Khaing K, Nair BR. Melatonin for delirium prevention in hospitalized patients: A systematic review and meta-analysis. J Psychiatr Res. 2021;133:181-190. View abstract.

Madsen BK, Zetner D, Møller AM, Rosenberg J. Melatonin for preoperative and postoperative anxiety in adults. Cochrane Database Syst Rev. 2020;12:CD009861. View abstract.

Verma N, Maiti R, Mishra BR, Jha M, Jena M, Mishra A. Effect of add-on melatonin on seizure outcome, neuronal damage, oxidative stress, and quality of life in generalized epilepsy with generalized onset motor seizures in adults: A randomized controlled trial. J Neurosci Res. 2021. View abstract.

Ahmed J, Patel W, Pullattayil AK, Razak A. Melatonin for non-operating room sedation in paediatric population: a systematic review and meta-analysis. Arch Dis Child. 2021:archdischild-2020-320592. View abstract.

Alizadeh M, Karandish M, Asghari Jafarabadi M, Heidari L, Nikbakht R, Babaahmadi Rezaei H, Mousavi R. Metabolic and hormonal effects of melatonin and/or magnesium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Nutr Metab (Lond). 2021;18(1):57. View abstract.

Domínguez-Rodríguez A, Abreu-González P, Báez-Ferrer N, Reiter RJ, Avanzas P, Hernández-Vaquero D. Melatonin and Cardioprotection in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Front Cardiovasc Med. 2021;8:635083. View abstract.

Esalatmanesh K, Loghman A, Esalatmanesh R, et al. Effects of melatonin supplementation on disease activity, oxidative stress, inflammatory, and metabolic parameters in patients with rheumatoid arthritis: a randomized double-blind placebo-controlled trial. Clin Rheumatol. 2021 Sep;40(9):3591-3597. View abstract.

Javaherforoosh Zadeh F, Janatmakan F, Shafaeebejestan E, Jorairahmadi S. Effect of Melatonin on Delirium After on-Pump Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial. Iran J Med Sci. 2021 Mar;46(2):120-127. View abstract.

Kiabi FH, Emadi SA, Jamkhaneh AE, Aezzi G, Ahmadi NS. Effects of preoperative melatonin on postoperative pain following cesarean section: A randomized clinical trial. Ann Med Surg (Lond). 2021 May 12;66:102345. View abstract.

Lozano A, Marruecos J, Rubió J, et al. Randomized placebo-controlled phase II trial of high-dose melatonin mucoadhesive oral gel for the prevention and treatment of oral mucositis in patients with head and neck cancer undergoing radiation therapy concurrent with systemic treatment. Clin Transl Oncol. 2021;23(9):1801-1810. View abstract.

Seely D, Legacy M, Auer RC, et al. Adjuvant melatonin for the prevention of recurrence and mortality following lung cancer resection (AMPLCaRe): A randomized placebo controlled clinical trial. EClinicalMedicine. 2021;33:100763. View abstract.

Shokri M, Sajedi F, Mohammadi Y, Mehrpooya M. Adjuvant use of melatonin for relieving symptoms of painful diabetic neuropathy: results of a randomized, double-blinded, controlled trial. Eur J Clin Pharmacol. 2021. View abstract.

Yi M, Wang S, Wu T, Zhang X, Jiang L, Fang X. Effects of exogenous melatonin on sleep quality and menopausal symptoms in menopausal women: a systematic review and meta-analysis of randomized controlled trials. Menopause. 2021;28(6):717-725. View abstract.

Castro-Marrero J, Zaragozá MC, López-Vílchez I, et al. Effect of melatonin plus zinc supplementation on fatigue perception in myalgic encephalomyelitis/chronic fatigue syndrome: A randomized, double-blind, placebo-controlled trial. Antioxidants (Basel) 2021;10(7):1010. View abstract.

Delpino FM, Figueiredo LM. Melatonin supplementation and anthropometric indicators of obesity: A systematic review and meta-analysis. Nutrition 2021;91-92:111399. View abstract.

Hasan ZT, Atrakji DMQYMAA, Mehuaiden DAK. The effect of melatonin on thrombosis, sepsis and mortality rate in COVID-19 patients. Int J Infect Dis 2021. View abstract.

Mohammadi S, Rastmanesh R, Jahangir F, et al. Melatonin supplementation and anthropometric indices: A randomized double-blind controlled clinical trial. Biomed Res Int 2021;2021:3502325. View abstract.

Zhang N, Sundquist J, Sundquist K, Ji J. Use of melatonin is associated with lower risk of colorectal cancer in older adults. Clin Transl Gastroenterol 2021;12(8):e00396. View abstract.

Singla L, Mathew PJ, Jain A, Yaddanapudi S, Peters NJ. Oral melatonin as part of multimodal anxiolysis decreases emergence delirium in children whereas midazolam does not: A randomised, double-blind, placebo-controlled study. Eur J Anaesthesiol 2021;38(11):1130-1137. View abstract.

Hayashi M, Mishima K, Fukumizu M, et al. Melatonin treatment and adequate sleep hygiene interventions in children with autism spectrum disorder: A randomized controlled trial. J Autism Dev Disord 2021. View abstract.

Delpino FM, Figueiredo LM, Nunes BP. Effects of melatonin supplementation on diabetes: A systematic review and meta-analysis of randomized clinical trials. Clin Nutr 2021;40(7):4595-4605. View abstract.

Mousavi SA, Heydari K, Mehravaran H, et al. Melatonin effects on sleep quality and outcomes of COVID-19 patients: An open-label, randomized, controlled trial. J Med Virol 2021. View abstract.

Taher A, Shokoohmand F, Abdoli E, Mohammadi Y, Mehrpooya M. A pilot study on the melatonin treatment in patients with early septic shock: results of a single-center randomized controlled trial. Ir J Med Sci 2021. View abstract.

Esmaeili A, Nassiri Toosi M, Taher M, et al. A pilot randomized, clinical trial of the anti-pruritus effect of melatonin in patients with chronic liver disease. Iran J Pharm Res 2021;20(2):462-472. View abstract.

Li Y, Xu Z. Effects of melatonin supplementation on insulin levels and insulin resistance: A systematic review and meta-analysis of randomized controlled trials. Horm Metab Res 2021;53(9):616-624. View abstract.

Kumar R, Kumari K, Janweja S, et al. Role of melatonin in attenuation of hemodynamic response to intubation and anesthetic requirements: a randomized, controlled, double-blind study. Braz J Anesthesiol 2021. View abstract.

Farnoosh G, Akbariqomi M, Badri T, et al. Efficacy of a low dose of melatonin as an adjunctive therapy in hospitalized patients with COVID-19: A randomized, double-blind clinical trial. Arch Med Res 2021. View abstract.

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Shahrokh S, Qobadighadikolaei R, Abbasinazari M, et al. Efficacy and safety of melatonin as an adjunctive therapy on clinical, biochemical, and quality of life in patients with ulcerative colitis. Iran J Pharm Res 2021;20(2):197-205. View abstract.

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Rosas-Luna LE, Castelán-Martínez OD, Mora-Magaña I, Ángeles-Castellanos M, Ubaldo-Reyes LM. Midazolam reduction with pre-operative melatonin in abdominal hysterectomy: double-blind randomized clinical trial. Cir Cir. 2022;90(3):353-8. View abstract.

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Jouybar R, Khademi S, Razmjooie S, Bagheri N. Effect of preoperative administration of oral melatonin on pneumatic tourniquet-induced ischemia-reperfusion injury in orthopedic surgery of lower extremities: a randomized clinical trial. Iran J Med Sci. 2022;47(2):123-30. View abstract.

Liu RY, Li L, Zhang ZT, Wu T, Lin S, Zhang XT. Clinical efficacy of melatonin as adjunctive therapy to non-surgical treatment of periodontitis: a systematic review and meta-analysis. Inflammopharmacology. 2022;30(3):695-704. View abstract.

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Wang XC, Wu GL, Cai YF, Zhang SJ. The safety and efficacy of melatonin in the treatment of COVID-19: A systematic review and meta-analysis. Medicine (Baltimore) 2022;101(39):e30874. View abstract.

Yan W, Li C, Song X, Zhou W, Chen Z. Prophylactic melatonin for delirium in critically ill patients: A systematic review and meta-analysis with trial sequential analysis. Medicine (Baltimore) 2022;101(43):e31411. View abstract.

Fan R, Bu X, Yang S, et al. Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials. BMJ Open 2022;12(9):e060912. View abstract.

Román Martinez M, García Aguilar E, Martin Vílchez S, et al. Bioavailability of Oniria(®), a melatonin prolonged-release formulation, versus immediate-release melatonin in healthy volunteers. Drugs R D 2022;22(3):235-243. View abstract.

Nasseh N, Khezri MB, Farzam S, Shiravandi S, Shafikhani AA. The effect of melatonin on cardiac biomarkers after coronary artery bypass graft surgery: A double-blind, randomized pilot study. J Cardiothorac Vasc Anesth 2022;36(10):3800-3805. View abstract.

Farjallah MA, Ghattassi K, Kamoun A, et al. Melatonin supplementation alleviates cellular damage and physical performance decline induced by an intensive training period in professional soccer players. PLoS One 2022;17(9):e0273719. View abstract.

Jangra S, Ashok V, Sethi S, Ram J. Atomised intranasal dexmedetomidine versus oral melatonin in prevention of emergence delirium in children undergoing ophthalmic surgery with sevoflurane: A randomised double-blind study. Eur J Anaesthesiol 2022;39(11):868-874. View abstract.

Puliappadamb HM, Maiti R, Mishra A, Jena M, Mishra BR. Efficacy and safety of melatonin as prophylaxis for migraine in adults: A meta-analysis. J Oral Facial Pain Headache 2022;36(3-4):207-219. View abstract.

Nogueira HA, de Castro CT, da Silva DCG, Pereira M. Melatonin for sleep disorders in people with autism: Systematic review and meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry 2023;123:110695. View abstract.

Yousef EA, El Wasify MA, Baddor AA, Sobh MA. Study of exogenous melatonin as a treatment modality for sleep and psychiatric disorders in hemodialysis patients. Saudi J Kidney Dis Transpl 2022;33(1):1-15. View abstract.

Bonuccelli A, Santangelo A, Castelli F, et al. Efficacy of liposomal melatonin in sleep EEG in childhood: A double blind case control study. Int J Environ Res Public Health 2022;20(1):552. View abstract.

Tanner N, Schultz B, Calderon C, et al. Effectiveness of melatonin treatment for sleep disturbance in orthopaedic trauma patients: A prospective, randomized control trial. Injury 2022;53(12):3945-3949. View abstract.

Baradari AG, Habibi MR, Aarabi M, et al. The effect of preoperative oral melatonin on postoperative pain after lumbar disc surgery: A double-blinded randomized clinical trial. Ethiop J Health Sci 2022;32(6):1193-1202. View abstract.

Behura SS, Dhanawat A, Nayak B, Panda SK. Comparison between oral melatonin and 24% sucrose for pain management during retinopathy of prematurity screening: a randomized controlled trial. Turk J Pediatr 2022;64(6):1013-1020. View abstract.

Ameri A, Frouz Asadi M, Ziaei A, et al. Efficacy and safety of oral melatonin in patients with severe COVID-19: a randomized controlled trial. Inflammopharmacology 2023;31(1):265-274. View abstract.

Zetner D, Kamby C, Gülen S, et al. Quality-of-life outcomes following topical melatonin application against acute radiation dermatitis in patients with early breast cancer: A double-blind, randomized, placebo-controlled trial. J Pineal Res 2023;74(1):e12840. View abstract.

Maghbooli M, Alyan NajafAbadi S, MalekMahmoudi G, Molseghi MH. Effect of add-on melatonin on seizure outcomes and quality of sleep in epilepsy with idiopathic generalized tonic-clonic seizures alone in adult patients: Cross-sectional, randomized, double-blind, placebo-controlled clinical trial. Brain Behav 2023;13(2):e2860. View abstract.

Mansilla-Roselló A, Hernández-Magdalena J, Domínguez-Bastante M, et al. A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in surgical patients with severe sepsis admitted to the intensive care unit. J Pineal Res 2023;74(2):e12845. View abstract.

Cohen PA, Avula B, Wang YH, Katragunta K, Khan I. Quantity of melatonin and CBD in melatonin gummies sold in the US. JAMA. 2023;329(16):1401-1402. View abstract.

Albzea W, Almonayea L, Aljassar M, et al. Efficacy and Safety of Preoperative Melatonin for Women Undergoing Cesarean Section: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials. Medicina (Kaunas) 2023;59(6):1065. View abstract.

Yang J, Gan Y, Feng X, Chen X, Wang S, Gao J. Effects of melatonin against acute kidney injury: A systematic review and meta-analysis. Int Immunopharmacol 2023;120:110372. View abstract.

Söderman L, Böttiger Y, Edlund M, Järnbert-Pettersson H, Marions L. Adjuvant use of melatonin for pain management in endometriosis-associated pelvic pain-A randomized double-blinded, placebo-controlled trial. PLoS One 2023;18(6):e0286182. View abstract.

Beaucage-Charron J, Rinfret J, Coveney R, Williamson D. Melatonin and Ramelteon for the treatment of delirium: A systematic review and meta-analysis. J Psychosom Res 2023;170:111345. View abstract.

Tsukinaga A, Mihara T, Takeshima T, Tomita M, Goto T. Effects of melatonin on postoperative sleep quality: a systematic review, meta-analysis, and trial sequential analysis. Can J Anaesth 2023;70(5):901-914. View abstract.

Barnes J, Sewart E, Armstrong RA, et al. Does melatonin administration reduce the incidence of postoperative delirium in adults? Systematic review and meta-analysis. BMJ Open 2023;13(3):e069950. View abstract.

Sedighi Pashaki A, Sheida F, Moaddab Shoar L, et al. A Randomized, Controlled, Parallel-Group, Trial on the Long-term Effects of Melatonin on Fatigue Associated With Breast Cancer and Its Adjuvant Treatments. Integr Cancer Ther 2023;22:15347354231168624. View abstract.

Faghih Dinevari M, Jafarzadeh F, Jabbaripour Sarmadian A, Abbasian S, Nikniaz Z, Riazi A. The effect of melatonin on irritable bowel syndrome patients with and without sleep disorders: a randomized double-blinded placebo-controlled trial study. BMC Gastroenterol 2023;23(1):135. View abstract.

Zetner D, Kamby C, Christophersen C, et al. Effect of melatonin cream on acute radiation dermatitis in patients with primary breast cancer: A double-blind, randomized, placebo-controlled trial. J Pineal Res 2023;75(1):e12873. View abstract.

Campbell S, Otten H, Anand V. CYP450 Genetic Polymorphisms: Generalized Tonic-Clonic Seizure after Intentional Fluoxetine and Melatonin Overdose. S D Med 2023;76(7):305-308. View abstract.

Duan Y, Yang Y, Zhu W, et al. Melatonin intervention to prevent delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials. Front Endocrinol (Lausanne) 2023;14:1191830. View abstract.

Martorina W, Tavares A. Glycemic Variability in Patients with Type 2 Diabetes Mellitus (T2DM): The Role of Melatonin in a Crossover, Double-Blind, Placebo-Controlled, Randomized Study. Nutrients 2023;15(16):3523. View abstract.

Ramos Gonzalez M, Axler MR, Kaseman KE, et al. Melatonin supplementation reduces nighttime blood pressure but does not affect blood pressure reactivity in normotensive adults on a high-sodium diet. Am J Physiol Regul Integr Comp Physiol 2023;325(5):R465-R473. View abstract.

Zhang J, Jiang B. Influence of Melatonin Treatment on Emotion, Sleep, and Life Quality in Perimenopausal Women: A Clinical Study. J Healthc Eng 2023;2023:2198804. View abstract.