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Gurley BJ, Gardner SF, Hubbard MA, et al. In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto. Clin Pharmacol Ther 2004;76:428-40. . View abstract.
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Kocaman O, Hulagu S, Senturk O. Echinacea-induced severe acute hepatitis with features of cholestatic autoimmune hepatitis. Eur J Intern Med 2008;19:148. View abstract.
17519
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17520
Shah SA, Sander S, White CM, et al. Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis. Lancet Infect Dis 2007;7:473-80. View abstract.
17521
O'Neil J, Hughes S, Lourie A, Zweifler J. Effects of echinacea on the frequency of upper respiratory tract symptoms: a randomized, double-blind, placebo-controlled trial. Ann Allergy Asthma Immunol 2008;100:384-8. View abstract.
17522
Schoop R, Klein P, Suter A, Johnston SL. Echinacea in the prevention of induced rhinovirus colds: a meta-analysis. Clin Ther 2006;28:174-83. View abstract.
18207
Press Release: Echinacea herbal products should not be used in children under 12 years old. Medicines and Healthcare Products Regulatory Agency (UK). August 20, 2012. Available at: www.mhra.gov.uk/NewsCentre/Pressreleases/CON180627. (Accessed 21 October 2012)
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Jawad M, Schoop R, Suter A, et al. Safety and efficacy profile of Echinacea purpurea to prevent common cold episodes: A randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med 2012;2012:841315. Epub 2012 Sep 16. View abstract.
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Di Pierro F, Rapacioli G, Ferrara T, Togni S. Use of a standardized extract from Echinacea angustifolia (Polinacea) for the prevention of respiratory tract infections. Altern Med Rev 2012;17:36-41. View abstract.
20059
Barrett B, Brown R, Rakel D, Rabago D, et al. Placebo effects and the common cold: a randomized controlled trial. Ann.Fam.Med 2011;9:312-22. View abstract.
20062
Goel V, Lovlin R, Chang C, et al. A proprietary extract from the echinacea plant (Echinacea purpurea) enhances systemic immune response during a common cold. Phytother.Res 2005;19:689-94. View abstract.
20063
Wahl RA, Aldous MB, Worden KA, et al. Echinacea purpurea and osteopathic manipulative treatment in children with recurrent otitis media: a randomized controlled trial. BMC.Complement Altern.Med 2008;8:56. View abstract.
20064
Haller J, Freund, TF, Pelczer, KG, et al. The anxiolytic potential and psychotropic side effects of an echinacea preparation in laboratory animals and healthy volunteers. Phytother.Res. 2013;27:54-61. View abstract.
20066
Whitehead MT, Martin TD, Scheett TP, et al. Running economy and maximal oxygen consumption after 4 weeks of oral Echinacea supplementation. J Strength Cond Res 2012;26:1928-33. View abstract.
20068
Samuels N, Saffer A, Wexler ID, et al. Localized reduction of gingival inflammation using site-specific therapy with a topical gingival patch. J.Clin.Dent. 2012;23:64-7. View abstract.
20069
Samuels N, Grbic JT, Saffer AJ, et al. Effect of an herbal mouth rinse in preventing periodontal inflammation in an experimental gingivitis model: a pilot study. Compend.Contin.Educ.Dent. 2012;33:204-11. View abstract.
20070
Grbic J, Wexler I, Celenti R, et al. A phase II trial of a transmucosal herbal patch for the treatment of gingivitis. J Am Dent.Assoc. 2011;142:1168-75. View abstract.
20071
Cassano N, Ferrari A, Fai D, et al. Oral supplementation with a nutraceutical containing Echinacea, methionine and antioxidant/immunostimulating compounds in patients with cutaneous viral warts. G.Ital Dermatol Venereol. 2011;146:191-95. View abstract.
20072
Bockhorst H, Gollnick N, Guran S, et al. [Therapy of herpes simplex in practice. Report on the treatment of herpes simplex labialis with Esberitox]. ZFA.(Stuttgart.) 11-20-1982;58:1795-98. View abstract.
20073
Mistrangelo M, Cornaglia S, Pizzio M, et al. Immunostimulation to reduce recurrence after surgery for anal condyloma acuminata: a prospective randomized controlled trial. Colorectal Dis 2010;12:799-803. View abstract.
20077
Schapowal A, Berger D, Klein P, et al. Echinacea/sage or chlorhexidine/lidocaine for treating acute sore throats: a randomized double-blind trial. Eur.J Med Res 9-1-2009;14:406-12. View abstract.
20080
Zedan H, Hofny ER, and Ismail SA. Propolis as an alternative treatment for cutaneous warts. Int.J Dermatol 2009;48:1246-49. View abstract.
20082
Bossaer JB and Odle BL. Probable etoposide interaction with Echinacea. J.Diet.Suppl 2012;9:90-5. View abstract.
20083
Abdul MI, Jiang X, Williams KM, et al. Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects. Br J Clin.Pharmacol. 2010;69:508-15. View abstract.
48529
Hu, C. and Kitts, D. D. Studies on the antioxidant activity of Echinacea root extract. J Agric Food Chem 2000;48(5):1466-1472. View abstract.
48533
Kemp, D. E. and Franco, K. N. Possible leukopenia associated with long-term use of echinacea. J Am Board Fam.Pract. 2002;15(5):417-419. View abstract.
48560
Woelkart, K., Koidl, C., Grisold, A., Gangemi, J. D., Turner, R. B., Marth, E., and Bauer, R. Bioavailability and pharmacokinetics of alkamides from the roots of Echinacea angustifolia in humans. J Clin Pharmacol 2005;45(6):683-689. View abstract.
48562
Chen, Y., Fu, T., Tao, T., Yang, J., Chang, Y., Wang, M., Kim, L., Qu, L., Cassady, J., Scalzo, R., and Wang, X. Macrophage activating effects of new alkamides from the roots of Echinacea species. J Nat.Prod. 2005;68(5):773-776. View abstract.
48563
Morazzoni, P., Cristoni, A., Di Pierro, F., Avanzini, C., Ravarino, D., Stornello, S., Zucca, M., and Musso, T. In vitro and in vivo immune stimulating effects of a new standardized Echinacea angustifolia root extract (Polinacea). Fitoterapia 2005;76(5):401-411. View abstract.
48564
Maass, N., Bauer, J., Paulicks, B. R., Bohmer, B. M., and Roth-Maier, D. A. Efficiency of Echinacea purpurea on performance and immune status in pigs. J Anim Physiol Anim Nutr.(Berl) 2005;89(7-8):244-252. View abstract.
48565
Agnew, L. L., Guffogg, S. P., Matthias, A., Lehmann, R. P., Bone, K. M., and Watson, K. Echinacea intake induces an immune response through altered expression of leucocyte hsp70, increased white cell counts and improved erythrocyte antioxidant defences. J Clin Pharm Ther. 2005;30(4):363-369. View abstract.
48572
Liatsos, G., Elefsiniotis, I., Todorova, R., and Moulakakis, A. Severe thrombotic thrombocytopenic purpura (TTP) induced or exacerbated by the immunostimulatory herb Echinacea. Am J Hematol. 2006;81(3):224. View abstract.
48576
Woelkart, K., Marth, E., Suter, A., Schoop, R., Raggam, R. B., Koidl, C., Kleinhappl, B., and Bauer, R. Bioavailability and pharmacokinetics of Echinacea purpurea preparations and their interaction with the immune system. Int J Clin Pharmacol Ther 2006;44(9):401-408. View abstract.
48609
Hou, C. C., Chen, C. H., Yang, N. S., Chen, Y. P., Lo, C. P., Wang, S. Y., Tien, Y. J., Tsai, P. W., and Shyur, L. F. Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plants. J Nutr.Biochem. 2010;21(11):1045-1059. View abstract.
48611
Toselli, F., Matthias, A., Bone, K. M., Gillam, E. M., and Lehmann, R. P. Metabolism of the major Echinacea alkylamide N-isobutyldodeca-2E,4E,8Z,10Z-tetraenamide by human recombinant cytochrome P450 enzymes and human liver microsomes. Phytother.Res 2010;24(8):1195-1201. View abstract.
48615
Wacker, A. and Hilbig, W. [Virus-inhibition by echinacea purpurea (author's transl)]. Planta Med 1978;33(1):89-102. View abstract.
48617
Luo, Y., Pan, J., Pan, Y., Han, Z., and Zhong, R. Evaluation of the protective effects of Chinese herbs against biomolecule damage induced by peroxynitrite. Biosci.Biotechnol.Biochem. 2010;74(7):1350-1354. View abstract.
48618
Penzak, S. R., Robertson, S. M., Hunt, J. D., Chairez, C., Malati, C. Y., Alfaro, R. M., Stevenson, J. M., and Kovacs, J. A. Echinacea purpurea significantly induces cytochrome P450 3A activity but does not alter lopinavir-ritonavir exposure in healthy subjects. Pharmacotherapy 2010;30(8):797-805. View abstract.
48620
Sharma, M., Schoop, R., Suter, A., and Hudson, J. B. The potential use of Echinacea in acne: control of Propionibacterium acnes growth and inflammation. Phytother.Res 2011;25(4):517-521. View abstract.
48622
Saluk-Juszczak, J., Pawlaczyk, I., Olas, B., Kolodziejczyk, J., Ponczek, M., Nowak, P., Tsirigotis-Woloszczak, M., Wachowicz, B., and Gancarz, R. The effect of polyphenolic-polysaccharide conjugates from selected medicinal plants of Asteraceae family on the peroxynitrite-induced changes in blood platelet proteins. Int.J Biol.Macromol. 12-1-2010;47(5):700-705. View abstract.
48623
Maskatia, Z. K. and Baker, K. Hypereosinophilia associated with echinacea use. South.Med J 2010;103(11):1173-1174. View abstract.
48629
Bensch, K., Tiralongo, J., Schmidt, K., Matthias, A., Bone, K. M., Lehmann, R., and Tiralongo, E. Investigations into the antiadhesive activity of herbal extracts against Campylobacter jejuni. Phytother.Res 2011;25(8):1125-1132. View abstract.
48644
Tubaro, A., Tragni, E., Del Negro, P., Galli, C. L., and Della, Loggia R. Anti-inflammatory activity of a polysaccharidic fraction of Echinacea angustifolia. J Pharm.Pharmacol. 1987;39(7):567-569. View abstract.
48656
Mose, J. R. [Effect of Echinacin on phagocytosis and natural killer cells]. Med Welt 12-30-1983;34(51-52):1463-1467. View abstract.
48662
Steinmuller, C., Roesler, J., Grottrup, E., Franke, G., Wagner, H., and Lohmann-Matthes, M. L. Polysaccharides isolated from plant cell cultures of Echinacea purpurea enhance the resistance of immunosuppressed mice against systemic infections with Candida albicans and Listeria monocytogenes. Int.J Immunopharmacol. 1993;15(5):605-614. View abstract.
48663
Burger, R. A., Torres, A. R., Warren, R. P., Caldwell, V. D., and Hughes, B. G. Echinacea-induced cytokine production by human macrophages. Int.J Immunopharmacol. 1997;19(7):371-379. View abstract.
48664
Thompson, K. D. Antiviral activity of Viracea against acyclovir susceptible and acyclovir resistant strains of herpes simplex virus. Antiviral Res 1998;39(1):55-61. View abstract.
48680
Parnham MJ. Benefit-risk assessment of the squeezed sap of the purple coneflower (Echinacea purpurea) for long-term oral immunostimulation. Phytomed 1996;3:95-102.
88162
Schroder-Aasen T, Molden G, Nilsen OG. In vitro inhibition of CYP3A4 by the multiherbal commercial product Sambucus Force and its main constituents Echinacea purpurea and Sambucus nigra. Phytother Res 2012;26(11):1606-13. View abstract.
88163
Moltó J, Valle M, Miranda C, et al. Herb-drug interaction between Echinacea purpurea and darunavir-ritonavir in HIV-infected patients. Antimicrob Agents Chemother 2011;55(1):326-30. View abstract.
88164
Goey AK, Meijerman I, Rosing H, et al. The effect of Echinacea purpurea on the pharmacokinetics of docetaxel. Br J Clin Pharmacol 2013;76(3):467-74. View abstract.
88165
Moltó J, Valle M, Miranda C, et al. Herb-drug interaction between Echinacea purpurea and etravirine in HIV-infected patients. Antimicrob Agents Chemother 2012;56(10):5328-31. View abstract.
88166
Lawrenson JA, Walls T, Day AS. Echinacea-induced acute liver failure in a child. J Paediatr Child Health 2014;50(10):841. View abstract.
88167
Hansen TS, Nilsen OG. In vitro CYP3A4 metabolism: inhibition by Echinacea purpurea and choice of substrate for the evaluation of herbal inhibition. Basic Clin Pharmacol Toxicol 2008;103:445-9. View abstract.
89235
Hill, N., Stam, C., Tuinder, S., and van Haselen, R. A. A placebo controlled clinical trial investigating the efficacy of a homeopathic after-bite gel in reducing mosquito bite induced erythema. Eur J Clin Pharmacol 1995;49(1-2):103-108. View abstract.
91528
Gabranis I, Koufakis T1, Papakrivos I, Batala S. Echinacea-associated acute cholestatic hepatitis. J Postgrad Med. 2015;61(3):211-2. View abstract.
93578
Jalloh MA, Gregory PJ, Hein D, et al. Dietary supplement interactions with antiretrovirals: a systematic review. Int J STD AIDS. 2017 Jan;28(1):4-15. View abstract.
95649
Dall'Acqua S, Perissutti B, Grabnar I, Farra R, Comar M, Agostinis C, et al. Pharmacokinetics and immunomodulatory effect of lipophilic Echinacea extract formulated in softgel capsules. C, et al. Eur J Pharm Biopharm. 2015 Nov;97(Pt A):8-14. doi: 10.1016/j.ejpb.2015.09.021. View abstract.
95650
Raus K, Pleschka S, Klein P, Schoop R, Fisher P. Effect of an echinacea-based hot drink versus oseltamivir in Influenza treatment: a randomized, double-blind, double-dummy, multicenter, noninferiority clinical trial. . Curr Ther Res Clin Exp. 2015;20;77:66-72. doi: 10.1016/j.curtheres.2015.04.001. View abstract.
95651
Stevenson JL, Krishnan S, Inigo MM, Stamatikos AD, Gonzales JU, Cooper JA. Echinacea-based dietary supplement does not increase maximal aerobic capacity in endurance-trained men and women. J Diet Suppl. 2016;13(3):324-38. doi: 10.3109/19390211.2015.1036189. View abstract.
95652
Karsch-Völk M, Barrett B, Kiefer D, Bauer R, Ardjomand-Woelkart K, Linde K. Echinacea for preventing and treating the common cold. Cochrane Database Syst Rev.2014;(2):CD000530. doi: 10.1002/14651858.CD000530.pub3. View abstract.
95653
Karsch-Völk M1, Barrett B2, Linde K1. Echinacea for preventing and treating the common cold. JAMA. 2015;313(6):618-9. doi: 10.1001/jama.2014.17145. View abstract.
97499
Oláh A, Szabó-Papp J, Soeberdt M, et al. Echinacea purpurea-derived alkylamides exhibit potent anti-inflammatory effects and alleviate clinical symptoms of atopic eczema. J Dermatol Sci. 2017 Oct;88(1):67-77. View abstract.
101592
Hoban CL, Byard RW, Musgrave IF. Analysis of spontaneous adverse drug reactions to echinacea, valerian, black cohosh and ginkgo in Australia from 2000 to 2015. J Integr Med. 2019;17(5):338-343. View abstract.
101593
Martin TD, Green MS, Whitehead MT, Scheett TP, Webster MJ, Hudson GM. Six weeks of oral Echinacea purpurea supplementation does not enhance the production of serum erythropoietin or erythropoietic status in recreationally active males with above-average aerobic fitness. Appl Physiol Nutr Metab. 2019;44(7):791-795. View abstract.
103233
Haller J, Krecsak L, Zámbori J. Double-blind placebo controlled trial of the anxiolytic effects of a standardized Echinacea extract. Phytother Res, 2020;34(3):660-8. View abstract.
104127
Abdel-Naby Awad OG. Echinacea can help with azithromycin in prevention of recurrent tonsillitis in children. Am J Otolaryngol. 2020;41(4):102344. doi: 10.1016/j.amjoto.2019.102344. View abstract.
104128
Veraldi S, Santambroggio A, Schianchi R, Carminati G, Benzecry V. Oral echinacea for prevention of relapses of molluscum contagiosum. G Ital Dermatol Venereol. 2020 Oct 5. doi: 10.23736/S0392-0488.20.06644-4. View abstract.
105719
Ogal M, Johnston SL, Klein P, Schoop R. Echinacea reduces antibiotic usage in children through respiratory tract infection prevention: a randomized, blinded, controlled clinical trial. Eur J Med Res. 2021 Apr 8;26(1):33. View abstract.
106626
Lopresti AL, Smith SJ. An investigation into the anxiety-relieving and mood-enhancing effects of Echinacea angustifolia (EP107 ™): A randomised, double-blind, placebo-controlled study. J Affect Disord 2021;293:229-237. View abstract.
111173
Saberi Z, Etemadi M, Faghihian E. Evaluation of the efficacy of Echinacea on clinical indices of Erosive Oral Lichen Planus: A randomized double-blind clinical trial. Dent Res J (Isfahan) 2022;19:98. View abstract.
111174
Kolev E, Mircheva L, Edwards MR, et al. Echinacea Purpurea For the Long-Term Prevention of Viral Respiratory Tract Infections During Covid-19 Pandemic: A Randomized, Open, Controlled, Exploratory Clinical Study. Front Pharmacol 2022;13:856410. View abstract.
111512
Radhakrishnan A, Spencer S, Yanamala N, Malepati S. Evaluating the Efficacy and Safety of EZC Pak, a 5-Day Combination Echinacea-Zinc-Vitamin C Dose Pack with or without Vitamin D, in the Management of Outpatient Upper Respiratory Infections. Infect Drug Resist 2023;16:2561-2572. View abstract.
111530
Weishaupt R, Buchkov A, Kolev E, Klein P, Schoop R. Reduction of viral load in patients with acute sore throats: Results from an observational clinical trial with Echinacea / Salvia lozenges [published online ahead of print, 2023 Mar 8]. Complement Med Res. 2023;10. View abstract.
111540
Sumer J, Keckeis K, Scanferla G, et al. Novel Echinacea formulations for the treatment of acute respiratory tract infections in adults-A randomized blinded controlled trial. Front Med (Lausanne) 2023;10:948787. View abstract.