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Bolton-Smith, C., McMurdo, M. E., Paterson, C. R., Mole, P. A., Harvey, J. M., Fenton, S. T., Prynne, C. J., Mishra, G. D., and Shearer, M. J. Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women. J.Bone Miner.Res. 2007;22(4):509-519. View abstract.

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Crowther, M. A., Julian, J., McCarty, D., Douketis, J., Kovacs, M., Biagoni, L., Schnurr, T., McGinnis, J., Gent, M., Hirsh, J., and Ginsberg, J. Treatment of warfarin-associated coagulopathy with oral vitamin K: a randomised controlled trial. Lancet 11-4-2000;356(9241):1551-1553. View abstract.

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Fondevila, C. G., Grosso, S. H., Santarelli, M. T., and Pinto, M. D. Reversal of excessive oral anticoagulation with a low oral dose of vitamin K1 compared with acenocoumarine discontinuation. A prospective, randomized, open study. Blood Coagul.Fibrinolysis 2001;12(1):9-16. View abstract.

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Wilson, D. C., Rashid, M., Durie, P. R., Tsang, A., Kalnins, D., Andrew, M., Corey, M., Shin, J., Tullis, E., and Pencharz, P. B. Treatment of vitamin K deficiency in cystic fibrosis: Effectiveness of a daily fat-soluble vitamin combination. J.Pediatr. 2001;138(6):851-855. View abstract.

Nishiguchi, S., Shimoi, S., Kurooka, H., Tamori, A., Habu, D., Takeda, T., and Kubo, S. Randomized pilot trial of vitamin K2 for bone loss in patients with primary biliary cirrhosis. J.Hepatol. 2001;35(4):543-545. View abstract.

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Sato, Y., Kaji, M., Tsuru, T., Satoh, K., and Kondo, I. Vitamin K deficiency and osteopenia in vitamin D-deficient elderly women with Parkinson's disease. Arch.Phys.Med.Rehabil. 2002;83(1):86-91. [RETRACTED]. View abstract.

Iwamoto, J., Takeda, T., and Ichimura, S. Effect of menatetrenone on bone mineral density and incidence of vertebral fractures in postmenopausal women with osteoporosis: a comparison with the effect of etidronate. J.Orthop.Sci. 2001;6(6):487-492. View abstract.

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Preston, F. E., Laidlaw, S. T., Sampson, B., and Kitchen, S. Rapid reversal of oral anticoagulation with warfarin by a prothrombin complex concentrate (Beriplex): efficacy and safety in 42 patients. Br.J.Haematol. 2002;116(3):619-624. View abstract.

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Olson, R. E., Chao, J., Graham, D., Bates, M. W., and Lewis, J. H. Total body phylloquinone and its turnover in human subjects at two levels of vitamin K intake. Br.J.Nutr. 2002;87(6):543-553. View abstract.

Sato, Y., Honda, Y., Kaji, M., Asoh, T., Hosokawa, K., Kondo, I., and Satoh, K. Amelioration of osteoporosis by menatetrenone in elderly female Parkinson's disease patients with vitamin D deficiency. Bone 2002;31(1):114-118. [RETRACTED]. View abstract.

Ageno, W., Crowther, M., Steidl, L., Ultori, C., Mera, V., Dentali, F., Squizzato, A., Marchesi, C., and Venco, A. Low dose oral vitamin K to reverse acenocoumarol-induced coagulopathy: a randomized controlled trial. Thromb.Haemost. 2002;88(1):48-51. View abstract.

Crowther, M. A., Douketis, J. D., Schnurr, T., Steidl, L., Mera, V., Ultori, C., Venco, A., and Ageno, W. Oral vitamin K lowers the international normalized ratio more rapidly than subcutaneous vitamin K in the treatment of warfarin-associated coagulopathy. A randomized, controlled trial. Ann.Intern.Med. 8-20-2002;137(4):251-254. View abstract.

Riegert-Johnson, D. L. and Volcheck, G. W. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. Ann.Allergy Asthma Immunol. 2002;89(4):400-406. View abstract.

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Booth, S. L., Broe, K. E., Gagnon, D. R., Tucker, K. L., Hannan, M. T., McLean, R. R., Dawson-Hughes, B., Wilson, P. W., Cupples, L. A., and Kiel, D. P. Vitamin K intake and bone mineral density in women and men. Am.J.Clin.Nutr. 2003;77(2):512-516. View abstract.

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Poli, D., Antonucci, E., Lombardi, A., Gensini, G. F., Abbate, R., and Prisco, D. Safety and effectiveness of low dose oral vitamin K1 administration in asymptomatic out-patients on warfarin or acenocoumarol with excessive anticoagulation. Haematologica 2003;88(2):237-238. View abstract.

Sorensen, B., Johansen, P., Nielsen, G. L., Sorensen, J. C., and Ingerslev, J. Reversal of the International Normalized Ratio with recombinant activated factor VII in central nervous system bleeding during warfarin thromboprophylaxis: clinical and biochemical aspects. Blood Coagul.Fibrinolysis 2003;14(5):469-477. View abstract.

Tabb, M. M., Sun, A., Zhou, C., Grun, F., Errandi, J., Romero, K., Pham, H., Inoue, S., Mallick, S., Lin, M., Forman, B. M., and Blumberg, B. Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR. J Biol.Chem. 11-7-2003;278(45):43919-43927. View abstract.

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Lubetsky, A., Yonath, H., Olchovsky, D., Loebstein, R., Halkin, H., and Ezra, D. Comparison of oral vs intravenous phytonadione (vitamin K1) in patients with excessive anticoagulation: a prospective randomized controlled study. Arch.Intern.Med. 11-10-2003;163(20):2469-2473. View abstract.

Braam, L. A., Knapen, M. H., Geusens, P., Brouns, F., and Vermeer, C. Factors affecting bone loss in female endurance athletes: a two-year follow-up study. Am.J.Sports Med. 2003;31(6):889-895. View abstract.

Lubetsky, A., Hoffman, R., Zimlichman, R., Eldor, A., Zvi, J., Kostenko, V., and Brenner, B. Efficacy and safety of a prothrombin complex concentrate (Octaplex) for rapid reversal of oral anticoagulation. Thromb.Res. 2004;113(6):371-378. View abstract.

Dentali, F. and Ageno, W. Management of coumarin-associated coagulopathy in the non-bleeding patient: a systematic review. Haematologica 2004;89(7):857-862. View abstract.

Habu, D., Shiomi, S., Tamori, A., Takeda, T., Tanaka, T., Kubo, S., and Nishiguchi, S. Role of vitamin K2 in the development of hepatocellular carcinoma in women with viral cirrhosis of the liver. JAMA 7-21-2004;292(3):358-361. View abstract.

Kalkwarf, H. J., Khoury, J. C., Bean, J., and Elliot, J. G. Vitamin K, bone turnover, and bone mass in girls. Am.J.Clin.Nutr. 2004;80(4):1075-1080. View abstract.

Sasaki, N., Kusano, E., Takahashi, H., Ando, Y., Yano, K., Tsuda, E., and Asano, Y. Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG). J.Bone Miner.Metab 2005;23(1):41-47. View abstract.

Sato, Y., Kanoko, T., Satoh, K., and Iwamoto, J. Menatetrenone and vitamin D2 with calcium supplements prevent nonvertebral fracture in elderly women with Alzheimer's disease. Bone 2005;36(1):61-68. [RETRACTED]. View abstract.

Sato, Y., Honda, Y., Hayashida, N., Iwamoto, J., Kanoko, T., and Satoh, K. Vitamin K deficiency and osteopenia in elderly women with Alzheimer's disease. Arch.Phys.Med.Rehabil. 2005;86(3):576-581. [RETRACTED]. View abstract.

Yasaka, M., Sakata, T., Naritomi, H., and Minematsu, K. Optimal dose of prothrombin complex concentrate for acute reversal of oral anticoagulation. Thromb.Res. 2005;115(6):455-459. View abstract.

Villines, T. C., Hatzigeorgiou, C., Feuerstein, I. M., O'malley, P. G., and Taylor, A. J. Vitamin K1 intake and coronary calcification. Coron.Artery Dis. 2005;16(3):199-203. View abstract.

Ageno, W., Garcia, D., Silingardi, M., Galli, M., and Crowther, M. A randomized trial comparing 1 mg of oral vitamin K with no treatment in the management of warfarin-associated coagulopathy in patients with mechanical heart valves. J.Am.Coll.Cardiol. 8-16-2005;46(4):732-733. View abstract.

Shetty, H. G., Backhouse, G., Bentley, D. P., and Routledge, P. A. Effective reversal of warfarin-induced excessive anticoagulation with low dose vitamin K1. Thromb.Haemost. 1-23-1992;67(1):13-15. View abstract.

Goldstein, J. N., Thomas, S. H., Frontiero, V., Joseph, A., Engel, C., Snider, R., Smith, E. E., Greenberg, S. M., and Rosand, J. Timing of fresh frozen plasma administration and rapid correction of coagulopathy in warfarin-related intracerebral hemorrhage. Stroke 2006;37(1):151-155. View abstract.

Thijssen, H. H., Vervoort, L. M., Schurgers, L. J., and Shearer, M. J. Menadione is a metabolite of oral vitamin K. Br.J.Nutr. 2006;95(2):260-266. View abstract.

Dezee, K. J., Shimeall, W. T., Douglas, K. M., Shumway, N. M., and O'malley, P. G. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Arch.Intern.Med. 2-27-2006;166(4):391-397. View abstract.

Liu, J., Wang, Q., Gao, F., He, J. W., and Zhao, J. H. Maternal antenatal administration of vitamin K1 results in increasing the activities of vitamin K-dependent coagulation factors in umbilical blood and in decreasing the incidence rate of periventricular-intraventricular hemorrhage in premature infants. J.Perinat.Med. 2006;34(2):173-176. View abstract.

Liu, J., Wang, Q., Zhao, J. H., Chen, Y. H., and Qin, G. L. The combined antenatal corticosteroids and vitamin K therapy for preventing periventricular-intraventricular hemorrhage in premature newborns less than 35 weeks gestation. J.Trop.Pediatr. 2006;52(5):355-359. View abstract.

Dentali, F., Ageno, W., and Crowther, M. Treatment of coumarin-associated coagulopathy: a systematic review and proposed treatment algorithms. J.Thromb.Haemost. 2006;4(9):1853-1863. View abstract.

Maas, A. H., van der Schouw, Y. T., Beijerinck, D., Deurenberg, J. J., Mali, W. P., Grobbee, D. E., and van der Graaf, Y. Vitamin K intake and calcifications in breast arteries. Maturitas 3-20-2007;56(3):273-279. View abstract.

Knapen, M. H., Schurgers, L. J., and Vermeer, C. Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporos.Int. 2007;18(7):963-972. View abstract.

Jones, K. S., Bluck, L. J., Wang, L. Y., and Coward, W. A. A stable isotope method for the simultaneous measurement of vitamin K1 (phylloquinone) kinetics and absorption. Eur.J.Clin.Nutr. 2008;62(11):1273-1281. View abstract.

Hosoi, T. [Treatment of primary osteoporosis with vitamin K2]. Clin.Calcium 2007;17(11):1727-1730. View abstract.

Urquhart, D. S., Fitzpatrick, M., Cope, J., and Jaffe, A. Vitamin K prescribing patterns and bone health surveillance in UK children with cystic fibrosis. J.Hum.Nutr.Diet. 2007;20(6):605-610. View abstract.

Hotta, N., Ayada, M., Sato, K., Ishikawa, T., Okumura, A., Matsumoto, E., Ohashi, T., and Kakumu, S. Effect of vitamin K2 on the recurrence in patients with hepatocellular carcinoma. Hepatogastroenterology 2007;54(79):2073-2077. View abstract.

Nimptsch, K., Rohrmann, S., and Linseisen, J. Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). Am.J.Clin.Nutr. 2008;87(4):985-992. View abstract.

Macdonald, H. M., McGuigan, F. E., Lanham-New, S. A., Fraser, W. D., Ralston, S. H., and Reid, D. M. Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women: no evidence of gene-nutrient interaction with apolipoprotein E polymorphisms. Am.J.Clin.Nutr. 2008;87(5):1513-1520. View abstract.

Drury, D., Grey, V. L., Ferland, G., Gundberg, C., and Lands, L. C. Efficacy of high dose phylloquinone in correcting vitamin K deficiency in cystic fibrosis. J.Cyst.Fibros. 2008;7(5):457-459. View abstract.

Marti-Carvajal, A. J., Cortes-Jofre, M., and Marti-Pena, A. J. Vitamin K for upper gastrointestinal bleeding in patients with liver diseases. Cochrane.Database.Syst.Rev. 2008;(3):CD004792. View abstract.

Iwamoto, J., Takeda, T., and Sato, Y. Role of vitamin K2 in the treatment of postmenopausal osteoporosis. Curr.Drug Saf 2006;1(1):87-97. View abstract.

Hathaway, W. E., Isarangkura, P. B., Mahasandana, C., Jacobson, L., Pintadit, P., Pung-Amritt, P., and Green, G. M. Comparison of oral and parenteral vitamin K prophylaxis for prevention of late hemorrhagic disease of the newborn. J.Pediatr. 1991;119(3):461-464. View abstract.

Ishida, Y. [Vitamin K2]. Clin.Calcium 2008;18(10):1476-1482. View abstract.

Cheung, A. M., Tile, L., Lee, Y., Tomlinson, G., Hawker, G., Scher, J., Hu, H., Vieth, R., Thompson, L., Jamal, S., and Josse, R. Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial. PLoS.Med. 10-14-2008;5(10):e196. View abstract.

Inoue, T., Fujita, T., Kishimoto, H., Makino, T., Nakamura, T., Nakamura, T., Sato, T., and Yamazaki, K. Randomized controlled study on the prevention of osteoporotic fractures (OF study): a phase IV clinical study of 15-mg menatetrenone capsules. J.Bone Miner.Metab 2009;27(1):66-75. View abstract.

Kim, H. S., Park, J. W., Jang, J. S., Kim, H. J., Shin, W. G., Kim, K. H., Lee, J. H., Kim, H. Y., and Jang, M. K. Prognostic values of alpha-fetoprotein and protein induced by vitamin K absence or antagonist-II in hepatitis B virus-related hepatocellular carcinoma: a prospective study. J.Clin.Gastroenterol. 2009;43(5):482-488. View abstract.

Summaries for patients. Is vitamin K helpful for people who have taken too much warfarin? Ann.Intern.Med. 3-3-2009;150(5):I25. View abstract.

Shea, M. K., O'Donnell, C. J., Hoffmann, U., Dallal, G. E., Dawson-Hughes, B., Ordovas, J. M., Price, P. A., Williamson, M. K., and Booth, S. L. Vitamin K supplementation and progression of coronary artery calcium in older men and women. Am.J.Clin.Nutr. 2009;89(6):1799-1807. View abstract.

Iwamoto, J., Sato, Y., Takeda, T., and Matsumoto, H. High-dose vitamin K supplementation reduces fracture incidence in postmenopausal women: a review of the literature. Nutr.Res. 2009;29(4):221-228. View abstract.

Crosier, M. D., Peter, I., Booth, S. L., Bennett, G., Dawson-Hughes, B., and Ordovas, J. M. Association of sequence variations in vitamin K epoxide reductase and gamma-glutamyl carboxylase genes with biochemical measures of vitamin K status. J.Nutr.Sci.Vitaminol.(Tokyo) 2009;55(2):112-119. View abstract.

Iwamoto, J., Matsumoto, H., and Takeda, T. Efficacy of menatetrenone (vitamin K2) against non-vertebral and hip fractures in patients with neurological diseases: meta-analysis of three randomized, controlled trials. Clin.Drug Investig. 2009;29(7):471-479. [RETRACTED]. View abstract.

Yoshiji, H., Noguchi, R., Toyohara, M., Ikenaka, Y., Kitade, M., Kaji, K., Yamazaki, M., Yamao, J., Mitoro, A., Sawai, M., Yoshida, M., Fujimoto, M., Tsujimoto, T., Kawaratani, H., Uemura, M., and Fukui, H. Combination of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates cumulative recurrence of hepatocellular carcinoma. J.Hepatol. 2009;51(2):315-321. View abstract.

Stevenson, M., Lloyd-Jones, M., and Papaioannou, D. Vitamin K to prevent fractures in older women: systematic review and economic evaluation. Health Technol.Assess. 2009;13(45):iii-134. View abstract.

Iwamoto, J. [Anti-fracture efficacy of vitamin K]. Clin.Calcium 2009;19(12):1805-1814. View abstract.

Crowther, C. A., Crosby, D. D., and Henderson-Smart, D. J. Vitamin K prior to preterm birth for preventing neonatal periventricular haemorrhage. Cochrane.Database.Syst.Rev. 2010;(1):CD000229. View abstract.

Shea, M. K., Booth, S. L., Gundberg, C. M., Peterson, J. W., Waddell, C., Dawson-Hughes, B., and Saltzman, E. Adulthood obesity is positively associated with adipose tissue concentrations of vitamin K and inversely associated with circulating indicators of vitamin K status in men and women. J.Nutr. 2010;140(5):1029-1034. View abstract.

Yamauchi, M., Yamaguchi, T., Nawata, K., Takaoka, S., and Sugimoto, T. Relationships between undercarboxylated osteocalcin and vitamin K intakes, bone turnover, and bone mineral density in healthy women. Clin.Nutr. 2010;29(6):761-765. View abstract.

Nimptsch, K., Rohrmann, S., Kaaks, R., and Linseisen, J. Dietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). Am.J.Clin.Nutr. 2010;91(5):1348-1358. View abstract.

Jorgensen, F. S., Felding, P., Vinther, S., and Andersen, G. E. Vitamin K to neonates. Peroral versus intramuscular administration. Acta Paediatr.Scand. 1991;80(3):304-307. View abstract.

Novotny, J. A., Kurilich, A. C., Britz, S. J., Baer, D. J., and Clevidence, B. A. Vitamin K absorption and kinetics in human subjects after consumption of 13C-labelled phylloquinone from kale. Br.J.Nutr. 2010;104(6):858-862. View abstract.

Dougherty, K. A., Schall, J. I., and Stallings, V. A. Suboptimal vitamin K status despite supplementation in children and young adults with cystic fibrosis. Am.J.Clin.Nutr. 2010;92(3):660-667. View abstract.

Napolitano, M., Mariani, G., and Lapecorella, M. Hereditary combined deficiency of the vitamin K-dependent clotting factors. Orphanet.J.Rare.Dis. 2010;5:21. View abstract.

Rees, K., Guraewal, S., Wong, Y. L., Majanbu, D. L., Mavrodaris, A., Stranges, S., Kandala, N. B., Clarke, A., and Franco, O. H. Is vitamin K consumption associated with cardio-metabolic disorders? A systematic review. Maturitas 2010;67(2):121-128. View abstract.

Chow, C. K. Dietary intake of menaquinones and risk of cancer incidence and mortality. Am.J.Clin.Nutr. 2010;92(6):1533-1534. View abstract.

Martin-Lopez, J. E., Carlos-Gil, A. M., Rodriguez-Lopez, R., Villegas-Portero, R., Luque-Romero, L., and Flores-Moreno, S. [Prophylactic vitamin K for vitamin K deficiency bleeding of the newborn.]. Farm.Hosp. 2011;35(3):148-55. View abstract.

Yang, Y. M., Simon, N., Maertens, P., Brigham, S., and Liu, P. Maternal-fetal transport of vitamin K1 and its effects on coagulation in premature infants. J.Pediatr. 1989;115(6):1009-1013. View abstract.

Kazzi, N. J., Ilagan, N. B., Liang, K. C., Kazzi, G. M., Poland, R. L., Grietsell, L. A., Fujii, Y., and Brans, Y. W. Maternal administration of vitamin K does not improve the coagulation profile of preterm infants. Pediatrics 1989;84(6):1045-1050. View abstract.

Propranolol prevents first gastrointestinal bleeding in non-ascitic cirrhotic patients. Final report of a multicenter randomized trial. The Italian Multicenter Project for Propranolol in Prevention of Bleeding. J.Hepatol. 1989;9(1):75-83. View abstract.

Motohara, K., Endo, F., and Matsuda, I. Effect of vitamin K administration on acarboxy prothrombin (PIVKA-II) levels in newborns. Lancet 8-3-1985;2(8449):242-244. View abstract.

Morales, W. J., Angel, J. L., O'Brien, W. F., Knuppel, R. A., and Marsalisi, F. The use of antenatal vitamin K in the prevention of early neonatal intraventricular hemorrhage. Am.J.Obstet.Gynecol. 1988;159(3):774-779. View abstract.

O'Connor, M. E. and Addiego, J. E., Jr. Use of oral vitamin K1 to prevent hemorrhagic disease of the newborn infant. J.Pediatr. 1986;108(4):616-619. View abstract.

Pomerance, J. J., Teal, J. G., Gogolok, J. F., Brown, S., and Stewart, M. E. Maternally administered antenatal vitamin K1: effect on neonatal prothrombin activity, partial thromboplastin time, and intraventricular hemorrhage. Obstet.Gynecol. 1987;70(2):235-241. View abstract.

Motohara, K., Endo, F., and Matsuda, I. Vitamin K deficiency in breast-fed infants at one month of age. J.Pediatr.Gastroenterol.Nutr. 1986;5(6):931-933. View abstract.

Sutherland, J. M., Glueck, H. I., and Gleser, G. Hemorrhagic disease of the newborn. Breast feeding as a necessary factor in the pathogenesis. Am.J.Dis.Child 1967;113(5):524-533. View abstract.

Jie, K. S., Bots, M. L., Vermeer, C., Witteman, J. C., and Grobbee, D. E. Vitamin K intake and osteocalcin levels in women with and without aortic atherosclerosis: a population-based study. Atherosclerosis 1995;116(1):117-123. View abstract.

Glover, J. J. and Morrill, G. B. Conservative treatment of overanticoagulated patients. Chest 1995;108(4):987-990. View abstract.

Taberner, D. A., Thomson, J. M., and Poller, L. Comparison of prothrombin complex concentrate and vitamin K1 in oral anticoagulant reversal. Br.Med.J. 7-10-1976;2(6027):83-85. View abstract.

Maurage, C., Dalloul, C., Moussa, F., Cara, B., Dudragne, D., Lion, N., and Amedee-Manesme, O. [Efficacy of oral administration of a micellaar solution of vitamin K during the neonatal period]. Arch.Pediatr. 1995;2(4):328-332. View abstract.

Thorp, J. A., Parriott, J., Ferrette-Smith, D., Meyer, B. A., Cohen, G. R., and Johnson, J. Antepartum vitamin K and phenobarbital for preventing intraventricular hemorrhage in the premature newborn: a randomized, double-blind, placebo-controlled trial. Obstet.Gynecol. 1994;83(1):70-76. View abstract.

Pengo, V., Banzato, A., Garelli, E., Zasso, A., and Biasiolo, A. Reversal of excessive effect of regular anticoagulation: low oral dose of phytonadione (vitamin K1) compared with warfarin discontinuation. Blood Coagul.Fibrinolysis 1993;4(5):739-741. View abstract.

Dickson, R. C., Stubbs, T. M., and Lazarchick, J. Antenatal vitamin K therapy of the low-birth-weight infant. Am.J.Obstet.Gynecol. 1994;170(1 Pt 1):85-89. View abstract.

Klebanoff, M. A., Read, J. S., Mills, J. L., and Shiono, P. H. The risk of childhood cancer after neonatal exposure to vitamin K. N.Engl.J.Med. 9-23-1993;329(13):905-908. View abstract.

Cornelissen, E. A., Kollee, L. A., De Abreu, R. A., Motohara, K., and Monnens, L. A. Prevention of vitamin K deficiency in infancy by weekly administration of vitamin K. Acta Paediatr. 1993;82(8):656-659. View abstract.

Hogenbirk, K., Peters, M., Bouman, P., Sturk, A., and Buller, H. A. The effect of formula versus breast feeding and exogenous vitamin K1 supplementation on circulating levels of vitamin K1 and vitamin K-dependent clotting factors in newborns. Eur.J.Pediatr. 1993;152(1):72-74. View abstract.

Cornelissen, E. A., Kollee, L. A., van Lith, T. G., Motohara, K., and Monnens, L. A. Evaluation of a daily dose of 25 micrograms vitamin K1 to prevent vitamin K deficiency in breast-fed infants. J.Pediatr.Gastroenterol.Nutr. 1993;16(3):301-305. View abstract.

Brousson, M. A. and Klein, M. C. Controversies surrounding the administration of vitamin K to newborns: a review. CMAJ. 2-1-1996;154(3):307-315. View abstract.

Sharma, R. K., Marwaha, N., Kumar, P., and Narang, A. Effect of oral water soluble vitamin K on PIVKA-II levels in newborns. Indian Pediatr. 1995;32(8):863-867. View abstract.

White, R. H., McKittrick, T., Takakuwa, J., Callahan, C., McDonell, M., and Fihn, S. Management and prognosis of life-threatening bleeding during warfarin therapy. National Consortium of Anticoagulation Clinics. Arch.Intern.Med. 6-10-1996;156(11):1197-1201. View abstract.

Thijssen, H. H. and Drittij-Reijnders, M. J. Vitamin K status in human tissues: tissue-specific accumulation of phylloquinone and menaquinone-4. Br.J.Nutr. 1996;75(1):121-127. View abstract.

Gijsbers, B. L., Jie, K. S., and Vermeer, C. Effect of food composition on vitamin K absorption in human volunteers. Br.J.Nutr. 1996;76(2):223-229. View abstract.

Ulusahin, N., Arsan, S., and Ertogan, F. Effects of oral and intramuscular vitamin K prophylaxis on PIVKA-II assay parameters in breastfed infants in Turkey. Turk.J.Pediatr. 1996;38(3):295-300. View abstract.

Makris, M., Greaves, M., Phillips, W. S., Kitchen, S., Rosendaal, F. R., and Preston, E. F. Emergency oral anticoagulant reversal: the relative efficacy of infusions of fresh frozen plasma and clotting factor concentrate on correction of the coagulopathy. Thromb.Haemost. 1997;77(3):477-480. View abstract.

Bakhshi, S., Deorari, A. K., Roy, S., Paul, V. K., and Singh, M. Prevention of subclinical vitamin K deficiency based on PIVKA-II levels: oral versus intramuscular route. Indian Pediatr. 1996;33(12):1040-1043. View abstract.

Beker, L. T., Ahrens, R. A., Fink, R. J., O'Brien, M. E., Davidson, K. W., Sokoll, L. J., and Sadowski, J. A. Effect of vitamin K1 supplementation on vitamin K status in cystic fibrosis patients. J.Pediatr.Gastroenterol.Nutr. 1997;24(5):512-517. View abstract.

Weibert, R. T., Le, D. T., Kayser, S. R., and Rapaport, S. I. Correction of excessive anticoagulation with low-dose oral vitamin K1. Ann.Intern.Med. 6-15-1997;126(12):959-962. View abstract.

Fetrow, C. W., Overlock, T., and Leff, L. Antagonism of warfarin-induced hypoprothrombinemia with use of low-dose subcutaneous vitamin K1. J.Clin.Pharmacol. 1997;37(8):751-757. View abstract.

Lousberg, T. R., Witt, D. M., Beall, D. G., Carter, B. L., and Malone, D. C. Evaluation of excessive anticoagulation in a group model health maintenance organization. Arch.Intern.Med. 3-9-1998;158(5):528-534. View abstract.

Crowther, M. A., Donovan, D., Harrison, L., McGinnis, J., and Ginsberg, J. Low-dose oral vitamin K reliably reverses over-anticoagulation due to warfarin. Thromb.Haemost. 1998;79(6):1116-1118. View abstract.

Sato, Y., Honda, Y., Kuno, H., and Oizumi, K. Menatetrenone ameliorates osteopenia in disuse-affected limbs of vitamin D- and K-deficient stroke patients. Bone 1998;23(3):291-296. [RETRACTED]. View abstract.

Duong, T. M., Plowman, B. K., Morreale, A. P., and Janetzky, K. Retrospective and prospective analyses of the treatment of overanticoagulated patients. Pharmacotherapy 1998;18(6):1264-1270. View abstract.

Wentzien, T. H., O'Reilly, R. A., and Kearns, P. J. Prospective evaluation of anticoagulant reversal with oral vitamin K1 while continuing warfarin therapy unchanged. Chest 1998;114(6):1546-1550. View abstract.

Greer, F. R., Marshall, S. P., Severson, R. R., Smith, D. A., Shearer, M. J., Pace, D. G., and Joubert, P. H. A new mixed micellar preparation for oral vitamin K prophylaxis: randomised controlled comparison with an intramuscular formulation in breast fed infants. Arch.Dis.Child 1998;79(4):300-305. View abstract.

Shiraki M. Vitamin K2 effects on the risk of fractures and on lumbar bone mineral density in osteoporosis - a randomized prospective open-label 3-year study. Osteoporos Int 2002;13:S160.

Eisai Co.Ltd. Eisai announces the intermediate analysis of anti-osteoporosis treatment post-marketing research to investigate the benefits of menatetrenone as part of the Ministry of Health, Labour and Welfare's Pharmacoepidemiological Drug Review Program. 2005;

Pathak A, Hamm CR, Eyal FG, Walter K, Rijhsinghani A, and Bohlman M. Maternal vitamin K administration for prevention of intraventricular hemorrhage in preterm infants. Pediatric Research 1990;27:219A.

Dennis VC, Ripley TL, Planas LG, and Beach P. Dietary vitamin K in oral anticoagulation patients: clinician practices and knowledge in outpatient settings. J Pharm Technol 2008;24(2):69-76.

Abdel-Rahman MS, Alkady EA, Ahmed S. Menaquinone-7 as a novel pharmacological therapy in the treatment of rheumatoid arthritis: A clinical study. Eur J Pharmacol. 2015;761:273-8. View abstract.

Caluwé R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transplant. 2014;29(7):1385-90. View abstract.

Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015;26(3):1175-86. View abstract.

Juanola-Falgarona M, Salas-Salvadó J, Martínez-González MÁ, Corella D, Estruch R, Ros E, Fitó M, Arós F, Gómez-Gracia E, Fiol M, Lapetra J, Basora J, Lamuela-Raventós RM, Serra-Majem L, Pintó X, Muñoz MÁ, Ruiz-Gutiérrez V, Fernández-Ballart J, Bulló M. Dietary intake of vitamin K is inversely associated with mortality risk. J Nutr. 2014;144(5):743-50. View abstract.

Lanzillo R, Moccia M, Carotenuto A, Vacchiano V, Satelliti B, Panetta V, Brescia Morra V. Vitamin K cream reduces reactions at the injection site in patients with relapsing-remitting multiple sclerosis treated with subcutaneous interferon beta - VIKING study. Mult Scler. 2015;21(9):1215-6. View abstract.

Pinta F, Ponzetti A, Spadi R, Fanchini L, Zanini M, Mecca C, Sonetto C, Ciuffreda L, Racca P. Pilot clinical trial on the efficacy of prophylactic use of vitamin K1-based cream (Vigorskin) to prevent cetuximab-induced skin rash in patients with metastatic colorectal cancer. Clin Colorectal Cancer. 2014;13(1):62-7. View abstract.

Ozdemir MA, Yilmaz K, Abdulrezzak U, Muhtaroglu S, Patiroglu T, Karakukcu M, Unal E. The efficacy of vitamin K2 and calcitriol combination on thalassemic osteopathy. J Pediatr Hematol Oncol. 2013;35(8):623-7. View abstract.

Holbrook A, Schulman S, Witt DM, et al. Evidence-based management of anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012;141:e152S-e184S. View abstract.

Camacho-Barcia ML, Bulló M, Garcia-Gavilán JF, et al. Association of dietary vitamin K1 intake with the incidence of cataract surgery in an adult Mediterranean population: a secondary analysis of a randomized clinical trial. JAMA Ophthalmol. 2017;135(6):657-61. View abstract.

McFarlin BK, Henning AL, Venable AS. Oral consumption of vitamin K2 for 8 weeks associated with increased maximal cardiac output during exercise. Altern Ther Health Med. 2017;23(4):26-32. View abstract.

Bolzetta F, Veronese N, Stubbs B, et al. The relationship between dietary vitamin K and depressive symptoms in late adulthood: A cross-sectional analysis from a large cohort study. Nutrients. 2019;11(4). pii: E787. View abstract.

Shishavan NG, Gargari BP, Jafarabadi MA, Kolahi S, Haggifar S, Noroozi S. Vitamin K(1) supplementation did not alter inflammatory markers and clinical status in patients with rheumatoid arthritis. Int J Vitam Nutr Res. 2018;88(5-6):251-257. View abstract.

Löwensteyn YN, Jansen NJG, van Heerde M, et al. Increasing the dose of oral vitamin K prophylaxis and its effect on bleeding risk. Eur J Pediatr 2019;178(7):1033-42. doi: 10.1007/s00431-019-03391-y. View abstract.

Oikonomaki T, Papasotiriou M, Ntrinias T, et al. The effect of vitamin K2 supplementation on vascular calcification in haemodialysis patients: a 1-year follow-up randomized trial. Int Urol Nephrol 2019;51(11):2037-44. doi: 10.1007/s11255-019-02275-2. View abstract.

Chen HG, Sheng LT, Zhang YB, et al. Association of vitamin K with cardiovascular events and all-cause mortality: a systematic review and meta-analysis. Eur J Nutr 2019;58(6):2191-205. doi: 10.1007/s00394-019-01998-3. View abstract.

Mott A, Bradley T, Wright K, et al. Effect of vitamin K on bone mineral density and fractures in adults: an updated systematic review and meta-analysis of randomised controlled trials. Osteoporos Int 2019;30(8):1543-59. doi: 10.1007/s00198-019-04949-0. View abstract.

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