References
Devil's Claw
4
Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
8
Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
19
Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
613
Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56. View abstract.
2001
Krieger D, Krieger S, Jansen O, et al. Manganese and chronic hepatic encephalopathy. Lancet 1995;346:270-4. View abstract.
6002
Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
6472
Chantre P, Cappelaere A, Leblan D, et al. Efficacy and tolerance or Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis. Phytomedicine 2000;7:177-83. View abstract.
6813
Barak AJ, Beckenhauer HC, Tuma DJ. Betaine, ethanol, and the liver: a review. Alcohol 1996;13:395-8. View abstract.
8608
Chrubasik S, Thanner J, Kunzel O, et al. Comparison of outcome measures during treatment with the proprietary Harpagophytum extract doloteffin in patients with pain in the lower back, knee or hip. Phytomedicine 2002;9:181-94. View abstract.
8609
Circosta C, Occhiuto F, Ragusa S, et al. A drug used in traditional medicine: Harpagophytum procumbens DC. II. Cardiovascular activity. J Ethnopharmacol 1984;11:259-74. View abstract.
8610
Costa De Pasquale R, Busa G, et al. A drug used in traditional medicine: Harpagophytum procumbens DC. III. Effects on hyperkinetic ventricular arrhythmias by reperfusion. J Ethnopharmacol 1985;13:193-9 . View abstract.
8611
Soulimani R, Younos C, Mortier F, Derrieu C. The role of stomachal digestion on the pharmacological activity of plant extracts, using as an example extracts of Harpagophytum procumbens. Can J Physiol Pharmacol 1994;72:1532-6. View abstract.
8612
Chrubasik S, Sporer F, Dillmann-Marschner R, et al. Physicochemical properties of harpagoside and its in vitro release from Harpagophytum procumbens extract tablets. Phytomedicine 2000;6:469-73. View abstract.
8613
Grahame R, Robinson BV. Devils's claw (Harpagophytum procumbens): pharmacological and clinical studies. Ann Rheum Dis 1981;40:632. View abstract.
8614
Lanhers MC, Fleurentin J, Mortier F, et al. Anti-inflammatory and analgesic effects of an aqueous extract of Harpagophytum procumbens. Planta Med 1992;58:117-23 . View abstract.
8615
Baghdikian B, Lanhers MC, Fleurentin J, et al. An analytical study, anti-inflammatory and analgesic effects of Harpagophytum procumbens and Harpagophytum zeyheri. Planta Med 1997;63:171-6. View abstract.
8616
Fiebich BL, Heinrich M, Hiller KO, Kammerer N. Inhibition of TNF-alpha synthesis in LPS-stimulated primary human monocytes by Harpagophytum extract SteiHap 69. Phytomedicine 2001;8:28-30.. View abstract.
8617
Whitehouse LW, Znamirowska M, Paul CJ. Devil's Claw (Harpagophytum procumbens): no evidence for anti-inflammatory activity in the treatment of arthritic disease. Can Med Assoc J 1983;129:249-51. View abstract.
10642
Moussard C, Alber D, Toubin MM, et al. A drug used in traditional medicine, harpagophytum procumbens: no evidence for NSAID-like effect on whole blood eicosanoid production in human. Prostaglandins Leukot Essent Fatty Acids. 1992;46:283-6.. View abstract.
12477
Gagnier JJ, Chrubasik S, Manheimer E. Harpgophytum procumbens for osteoarthritis and low back pain: a systematic review. BMC Complement Altern Med 2004;4:13. View abstract.
12478
Jang MH, Lim S, Han SM, et al. Harpagophytum procumbens suppresses lipopolysaccharide-stimulated expressions of cyclooxygenase-2 and inducible nitric oxide synthase in fibroblast cell line L929. J Pharmacol Sci 2003;93:367-71. View abstract.
12479
Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;18:2273-81. View abstract.
14118
Hagiwara H, Seki T, Ariga T. The effect of pre-germinated brown rice intake on blood glucose and PAI-1 levels in streptozotocin-induced diabetic rats. Biosci Biotechnol Biochem 2004;68:444-7. View abstract.
14332
Wegener T, Lupke NP. Treatment of patients with arthrosis of hip or knee with an aqueous extract of devil's claw (Harpagophytum procumbens DC). Phytother Res 2003;17:1165-72. View abstract.
14418
Chrubasik S, Kunzel O, Thanner J, et al. A 1-year follow-up after a pilot study with Doloteffin for low back pain. Phytomedicine 2005;12:1-9. View abstract.
15259
Gagnier JJ, van Tulder MW, Berman B, Bombardier C. Herbal medicine for low back pain. A Cochrane review. Spine 2007;32:82-92. View abstract.
17325
Romiti N, Tramonti G, Corti A, Chieli E. Effects of Devil's Claw (Harpagophytum procumbens) on the multidrug transporter ABCB1/P-glycoprotein. Phytomedicine 2009;16:1095-100. View abstract.
35785
Ernst, E. and Chrubasik, S. Phyto-anti-inflammatories. A systematic review of randomized, placebo-controlled, double-blind trials. Rheum.Dis Clin North Am 2000;26(1):13-27, vii. View abstract.
40237
Spelman, K., Burns, J., Nichols, D., Winters, N., Ottersberg, S., and Tenborg, M. Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Altern.Med.Rev. 2006;11(2):128-150. View abstract.
40500
Gagnier, J. J., van Tulder, M., Berman, B., and Bombardier, C. Herbal medicine for low back pain. Cochrane.Database.Syst.Rev. 2006;(2):CD004504. View abstract.
47112
Chrubasik, S., Junck, H., Breitschwerdt, H., Conradt, C., and Zappe, H. Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double- blind study. Eur.J Anaesthesiol. 1999;16(2):118-129. View abstract.
47113
Baghdikian, B., Guiraud-Dauriac, H., Ollivier, E., N'Guyen, A., Dumenil, G., and Balansard, G. Formation of nitrogen-containing metabolites from the main iridoids of Harpagophytum procumbens and H. zeyheri by human intestinal bacteria. Planta Med 1999;65(2):164-166. View abstract.
47114
Leblan, D., Chantre, P., and Fournie, B. Harpagophytum procumbens in the treatment of knee and hip osteoarthritis. Four-month results of a prospective, multicenter, double-blind trial versus diacerhein. Joint Bone Spine 2000;67(5):462-467. View abstract.
47115
Loew, D., Mollerfeld, J., Schrodter, A., Puttkammer, S., and Kaszkin, M. Investigations on the pharmacokinetic properties of Harpagophytum extracts and their effects on eicosanoid biosynthesis in vitro and ex vivo. Clin.Pharmacol.Ther. 2001;69(5):356-364. View abstract.
47116
Laudahn, D. and Walper, A. Efficacy and tolerance of Harpagophytum extract LI 174 in patients with chronic non-radicular back pain. Phytother.Res. 2001;15(7):621-624. View abstract.
47117
Gobel, H., Heinze, A., Ingwersen, M., Niederberger, U., and Gerber, D. [Effects of Harpagophytum procumbens LI 174 (devil's claw) on sensory, motor und vascular muscle reagibility in the treatment of unspecific back pain]. Schmerz. 2001;15(1):10-18. View abstract.
47118
Munkombwe, N. M. Acetylated phenolic glycosides from Harpagophytum procumbens. Phytochemistry 2003;62(8):1231-1234. View abstract.
47119
Betancor-Fernandez, A., Perez-Galvez, A., Sies, H., and Stahl, W. Screening pharmaceutical preparations containing extracts of turmeric rhizome, artichoke leaf, devil's claw root and garlic or salmon oil for antioxidant capacity. J Pharm Pharmacol 2003;55(7):981-986. View abstract.
47120
Clarkson, C., Campbell, W. E., and Smith, P. In vitro antiplasmodial activity of abietane and totarane diterpenes isolated from Harpagophytum procumbens (devil's claw). Planta Med 2003;69(8):720-724. View abstract.
47121
Boje, K., Lechtenberg, M., and Nahrstedt, A. New and known iridoid- and phenylethanoid glycosides from Harpagophytum procumbens and their in vitro inhibition of human leukocyte elastase. Planta Med 2003;69(9):820-825. View abstract.
47122
Chrubasik, S., Conradt, C., and Roufogalis, B. D. Effectiveness of Harpagophytum extracts and clinical efficacy. Phytother.Res. 2004;18(2):187-189. View abstract.
47124
Schulze-Tanzil, G., Hansen, C., and Shakibaei, M. [Effect of a Harpagophytum procumbens DC extract on matrix metalloproteinases in human chondrocytes in vitro]. Arzneimittelforschung. 2004;54(4):213-220. View abstract.
47125
Chrubasik, S. [Devil's claw extract as an example of the effectiveness of herbal analgesics]. Orthopade 2004;33(7):804-808. View abstract.
47126
Na, H. K., Mossanda, K. S., Lee, J. Y., and Surh, Y. J. Inhibition of phorbol ester-induced COX-2 expression by some edible African plants. Biofactors 2004;21(1-4):149-153. View abstract.
47127
Kaszkin, M., Beck, K. F., Koch, E., Erdelmeier, C., Kusch, S., Pfeilschifter, J., and Loew, D. Downregulation of iNOS expression in rat mesangial cells by special extracts of Harpagophytum procumbens derives from harpagoside-dependent and independent effects. Phytomedicine. 2004;11(7-8):585-595. View abstract.
47128
Chrubasik, S. Addendum to the ESCOP monograph on Harpagophytum procumbens. Phytomedicine. 2004;11(7-8):691-695. View abstract.
47129
Kundu, J. K., Mossanda, K. S., Na, H. K., and Surh, Y. J. Inhibitory effects of the extracts of Sutherlandia frutescens (L.) R. Br. and Harpagophytum procumbens DC. on phorbol ester-induced COX-2 expression in mouse skin: AP-1 and CREB as potential upstream targets. Cancer Lett. 1-31-2005;218(1):21-31. View abstract.
47131
Teut, M. and Warning, A. [Bone metastases in breast carcinoma]. Forsch Komplement.Med (2006.) 2006;13(1):46-48. View abstract.
47132
Ameye, L. G. and Chee, W. S. Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence. Arthritis Res Ther 2006;8(4):R127. View abstract.
47133
Grant, L., McBean, D. E., Fyfe, L., and Warnock, A. M. A review of the biological and potential therapeutic actions of Harpagophytum procumbens. Phytother Res 2007;21(3):199-209. View abstract.
47134
Brien, S., Lewith, G. T., and McGregor, G. Devil's Claw (Harpagophytum procumbens) as a treatment for osteoarthritis: a review of efficacy and safety. J Altern Complement Med 2006;12(10):981-993. View abstract.
47135
Erdos, A., Fontaine, R., Friehe, H., Durand, R., and Poppinghaus, T. [Contribution to the pharmacology and toxicology of different extracts as well as the harpagosid from Harpagophytum procumbens DC]. Planta Med 1978;34(1):97-108. View abstract.
47136
Occhiuto, F., Circosta, C., Ragusa, S., Ficarra, P., and Costa, De Pasquale. A drug used in traditional medicine: Harpagophytum procumbens DC. IV. Effects on some isolated muscle preparations. J Ethnopharmacol. 1985;13(2):201-208. View abstract.
47137
Eichler, O. and Koch, C. [Antiphlogistic, analgesic and spasmolytic effect of harpagoside, a glycoside from the root of Harpagophytum procumbens DC]. Arzneimittelforschung. 1970;20(1):107-109. View abstract.
47139
Fontaine, J., Elchami, A. A., Vanhaelen, M., and Vanhaelen-Fastre, R. [Biological analysis of Harpagophytum procumbens D.C. II. Pharmacological analysis of the effects of harpagoside, harpagide and harpagogenine on the isolated guinea-pig ileum (author's transl)]. J Pharm Belg. 1981;36(5):321-324. View abstract.
47140
Jadot G and Lecomte A. Activite anti-inflammatoire d'Harpagophytum procumbens DC. Lyon Mediteranee Med Sud-Est 1992;28:833-835.
47142
Chrubasik S and Eisenberg E. Treatment of rheumatic pain with Kampo medicine in Europe. The Pain Clinic 1999;11(3):171.
47143
Chrubasik S, Fiebich B, Black A, and et al. Treating low back pain with an extract of Harpagophytum procumbens that inhibits cytokine release. Eur J Anaesthesiol 2002;19:209.
47144
Belaiche P. Etude clinique de 630 cas d'artrose traites par le nebulisat aqueux d'Harpagophytum procumbens (Radix). Phytotherapy 1982;1:22-28.
47145
Guyader M. Les plantes antirhumatismales. Etude historique et pharmacologique, et etude clinique du nebulisat d'Harpagohytum procumbens DC chez 50 patients arthrosiques suivis en service hospitalier [Dissertation]. Universite Pierre et Marie Curie, 1984.
47146
Lecomte A and Costa JP. Harpagophytum dans l'arthrose: Etude en double insu contre placebo. Le Magazine 1992;15:27-30.
47147
Pinget M and Lecompte A. Etude des effets de I'harpagophytum en rhumatologie dégénérative. 37 Le magazine 1990;(10):1-10.
47148
Schrüffer H. Salus Teufelskralle-Tabletten. Ein Fortschritt in der nichtsteroidalen antirheumatischen Therapie. Die Medizinische Publikation 1980;1:1-8.
47149
Frerick H, Biller A, and Schmidt U. Stufenschema bei Coxarthrose. Der Kassenarzt 2001;5(34):41.
47150
Schmelz H, Haemmerle HD, and Springorum HW. Analgetische Wirksamkeit eines Teufels-krallenwurzel-Extraktes bei verschiedenen chronisch-degenerativen Gelenkerkrankungen. In: Chrubasik S and Wink M. Rheumatherapie mit Phytopharmaka. Stuttgart: Hippokrates;1997.
47151
Bhattacharya A and Bhattacharya SK. Anti-oxidative activity of Harpagophytum procumbens. Br J Phytother 1998;72:68-71.
47152
Langmead L, Dawson C, Hawkins C, and et al. Antioxidant effects of herbal therapies used by patients with inflammatory bowel disease: an in vitro study. Aliment Pharmacol Ther 2002;16(2):197-205.
47153
Chrubasik S, Sporer F, and Wink M. [Content of active substance in tea preparations from Harpagophytum procumbens]. Forsch Komplementarmed 1996;3:116-119.
47154
Chrubasik S, Sporer F, Wink M, and et al. Zum wirkstoffgehalt in arzneimitteln aus harpagophytum procumbens. Forsch Komplementärmed 1996;3:57-63.
47155
Chrubasik S, Zimpfer C, Schutt U, and et al. Effectiveness of Harpagophytum procumbens in treatment of acute low back pain. Phytomedicine 1996;3(1):1-10.
47158
Kikuchi T. New iridoid glucosides from Harpagophytum procumbens. Chem Pharm Bull 1983;31:2296-2301.
47159
Tunmann P and Lux R. Zur Kenntnis der Inhaltsstoffe aus der Wurzel von Harpagophytum procumbens DC. DAZ 1962;102(40):1274-1275.
47160
Ficarra P, Ficarra R, Tommasini A, and et al. [HPLC analysis of a drug in traditional medicine: Harpagophytum procumbens DC. I]. Boll Chim Farm 1986;125(7):250-253.
47161
Tunmann P and Bauersfeld HJ. Über weitere Inhaltsstoffe der Wurzel von Harpagophytum procumbens DC. Arch Pharm (Weinheim) 1975;308(8):655-657.
47162
Loew D, Schuster O, and Möllerfeld J. Stabilität und biopharmazeutische Qualität. Voraussetzung für Bioverfügbarkeit von Harpagophytum procumbens. In: Loew D and Rietbrock N. Phytopharmaka II. Forschung und klinische Anwendung. Darmstadt: Forschung und klinische Anwendung;1996.
47163
Ribbat JM and Schakau D. Behandluing chronisch aktivierter Schmerzen am Bewegungsapparat. NaturaMed 2001;16:23-30.
47164
Pinget, M. and Lecomte, A. The effect of Harpagophytum Arkocaps in degenerative rheumatism [in German]. Naturheilpraxis 1997;50:267-269.
47165
Rutten, S. and Schafer, I. Einsatz der afrikanischen Teufelskralle [Allya] bei Erkrankungen des Stutz unde Bewegungsapparates. Ergebnisse einer Anwendungscbeobachtung Acta Biol 2000;2:5-20.
47166
Usbeck, C. Teufelskralle: Devil claw: Treatment for chronic pain [in German]. Arzneimittel-Forum 2000;3:23-25.
47167
Schendel, U. Arthritis treatment: Study with Devil Claw extract [in German]. Der Kassenarzt 2001;29/30:2-5.
47168
Biller, A. Ergebnisse sweier randomisieter kontrollierter. Phyto-pharmaka 2002;7:86-88.
47169
Chrubasik S, Model A, Black A, and et al. A randomized double-blind pilot study comparing Doloteffin® and Vioxx® in the treatment of low back pain. Rheumatology 2003;42:141-148.
47170
Chrubasik S, Schmidt A, Junck H, and et al. [Effectiveness and economy of Harpagophytum extract in the treatment of acute low back pain - first results of a therapeutic cohort study]. Forsch Komplementarmed 1997;4:332-336.
47171
Chrubasik S, Sporer F, and Wink M. [Harpagoside content of different powdered dry extracts from Harpagophytum procumbens]. Forsch Komplmentarmed 1996;3:6-11.
91106
Conrozier T, Mathieu P, Bonjean M, et al. A complex of three natural anti-inflammatory agents provides relief of osteoarthritis pain. Altern Ther Health Med. 2014;20 Suppl 1:32-7. View abstract.
92017
Cuspidi C, Sala C, Tadic M, et al. Systemic hypertension induced by Harpagophytum procumbens (devil's claw): a case report. J Clin Hypertens (Greenwich) 2015;17(11):908-10. View abstract.
94689
Mahomed IM, Ojewole JAO. Oxytocin-like effect of Harpagophytum procumbens [Pedaliacae] secondary root aqueous extract on rat isolated uterus. Afr J Trad CAM 2006;3(1):82-89.
96741
More M, Gruenwald J, Pohl U, Uebelhack R. A Rosa canina - Urtica dioica - Harpagophytum procumbens/zeyheri combination significantly reduces gonarthritis symptoms in a randomized, placebo-controlled double-blind study. Planta Med. 2017 Dec;83(18):1384-91. View abstract.
96747
Carvalho RR, Donadel CD, Cortez AF, Valviesse VR, Vianna PF, Correa BB. J Bras Nefrol. 2017 Mar;39(1):79-81. View abstract.
104977
Anon. Devil's claw root: ulcers and gastrointestinal bleeding. Prescrire Int 2013;22(144):296. View abstract.
106078
Zegota Z, Gozdzik J, Glogowska-Szelag J. Prospective, multicenter evaluation of a polyherbal supplement alongside standard-of-care treatment for mild knee osteoarthritis. Adv Orthop. 2021;2021:5589597. View abstract.
106488
Vu N, Nguyen TTT, Parmenter BH, Thouas GA. Safety, efficacy and tolerability of a combination micronutrient and polyherbal preparation (GoutFighter TM) for gout: a single-arm open-label pilot study. J Complement Integr Med 2020;18(1):113-21. View abstract.
108017
Diaz-Silveira GL, Deutsch J, Little DP. DNA Barcode Authentication of Devil's Claw Herbal Dietary Supplements. Plants (Basel) 2021;10(10):2005. View abstract.